REACTOME_RHOB_GTPASE_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOB | Rho-related GTP-binding protein RhoB | [1] | -1.53[2] | -2.15[3] | -4.45[4] | -3.10[5] | -3.78[6] | -1.14[7] |
2 | STOM | Erythrocyte band 7 integral membrane protein | [8] | -2.06[9] | -1.96[10] | -1.71[11] | -1.88[12] | -3.09[13] | 0.21[14] |
3 | FLOT1 | Flotillin-1 | [15] | -1.36[16] | -0.90[17] | -1.69[18] | -0.60[19] | -1.27[20] | -2.27[21] |
4 | FLOT2 | Flotillin-2 | [22] | -1.25[23] | -1.37[24] | -1.16[25] | -1.16[26] | -1.28[27] | -0.47[28] |
5 | DIAPH1 | Protein diaphanous homolog 1 | [29] | -0.12[30] | -0.52[31] | -0.25[32] | -0.89[33] | -0.29[34] | -0.09[35] |
6 | CAV1 | Caveolin-1 | [36] | -7.57[37] | -10.45[38] | -4.33[39] | 0.57[40] | -0.61[41] | -3.02[42] |
7 | RTKN | Rhotekin | [43] | -0.93[44] | -0.15[45] | -2.15[46] | -3.92[47] | -3.84[48] | -1.08[49] |
8 | VAMP3 | Vesicle-associated membrane protein 3 | [50] | -0.50[51] | -0.01[52] | -0.98[53] | -0.09[54] | -0.36[55] | -2.04[56] |
9 | JUP | Junction plakoglobin | [57] | 0.26[58] | -1.01[59] | -0.90[60] | -1.37[61] | -1.87[62] | -0.61[63] |
10 | TJP2 | Tight junction protein ZO-2 | [64] | 0.69[65] | 0.41[66] | 0.42[67] | -2.32[68] | 0.42[69] | -0.54[70] |
11 | SNAP23 | Synaptosomal-associated protein 23 | [71] | -0.77[72] | -0.78[73] | -1.68[74] | -0.86[75] | -0.86[76] | -1.65[77] |
12 | TFRC | Transferrin receptor protein 1 | [78] | 2.71[79] | 2.14[80] | 2.11[81] | 0.64[82] | 2.30[83] | 0.56[84] |
13 | NET1 | Neuroepithelial cell-transforming gene 1 protein | [85] | -0.43[86] | 0.12[87] | -0.02[88] | -0.63[89] | -1.13[90] | -0.61[91] |
14 | PKN1 | Serine/threonine-protein kinase N1 | [92] | 1.29[93] | 0.20[94] | 1.09[95] | 0.06[96] | 0.92[97] | -1.57[98] |
15 | VAV2 | Guanine nucleotide exchange factor VAV2 | [99] | 0.57[100] | 0.76[101] | 0.10[102] | -1.34[103] | -0.74[104] | -0.51[105] |
16 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [106] | -0.22[107] | 2.02[108] | 0.66[109] | -0.89[110] | -2.30[111] | 1.98[112] |
17 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [113] | -1.20[114] | -1.14[115] | -0.21[116] | 1.26[117] | 0.94[118] | 1.98[119] |
18 | ROCK1 | Rho-associated protein kinase 1 | [120] | -1.68[121] | -0.22[122] | 0.40[123] | 0.55[124] | 0.07[125] | 0.56[126] |
19 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [127] | 1.28[128] | 0.99[129] | 0.47[130] | 2.18[131] | 1.53[132] | 3.15[133] |
20 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [134] | 0.19[135] | 0.45[136] | 0.60[137] | 0.11[138] | 0.56[139] | -0.63[140] |
21 | ARHGEF2 | Rho guanine nucleotide exchange factor 2 | [141] | -0.09[142] | -0.23[143] | -0.30[144] | 1.04[145] | 1.60[146] | -2.10[147] |
22 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [148] | -4.74[149] | -3.55[150] | -3.48[151] | -3.11[152] | -2.85[153] | -3.42[154] |
23 | SLK | STE20-like serine/threonine-protein kinase | [155] | -1.48[156] | 0.69[157] | 0.55[158] | -0.02[159] | 0.72[160] | 0.39[161] |
24 | SOWAHC | Ankyrin repeat domain-containing protein SOWAHC | [162] | -0.05[163] | 0.89[164] | -0.05[165] | -1.86[166] | -0.77[167] | 0.13[168] |
25 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [169] | 1.14[170] | 1.31[171] | 1.76[172] | -0.10[173] | 0.64[174] | -1.31[175] |
26 | ROCK2 | Rho-associated protein kinase 2 | [176] | 0.74[177] | 1.93[178] | 0.24[179] | 1.83[180] | -0.23[181] | 0.91[182] |
27 | ARHGAP2 | Rho GTPase-activating protein 21 | [183] | -0.17[184] | 0.76[185] | 1.48[186] | 2.31[187] | 1.23[188] | 0.71[189] |
28 | ARHGAP3 | Rho GTPase-activating protein 35 | [190] | 1.61[191] | 1.69[192] | 2.07[193] | 1.93[194] | 1.68[195] | 2.24[196] |
29 | DLC1 | Rho GTPase-activating protein 7 | [197] | 1.58[198] | 1.18[199] | 0.33[200] | 0.06[201] | 0.73[202] | 1.39[203] |
30 | ANLN | Anillin | [204] | 0.34[205] | 1.87[206] | 1.89[207] | 2.60[208] | 3.20[209] | -2.76[210] |
31 | ARHGAP1 | Rho GTPase-activating protein 1 | [211] | 1.05[212] | 0.60[213] | 0.93[214] | -0.31[215] | 0.07[216] | 0.61[217] |
32 | ARHGAP5 | Rho GTPase-activating protein 5 | [218] | 1.68[219] | 1.23[220] | 4.37[221] | 1.76[222] | 1.53[223] | 2.12[224] |
33 | BCR | Breakpoint cluster region protein | [225] | 1.50[226] | 0.69[227] | 0.78[228] | 0.21[229] | 0.76[230] | 0.68[231] |
34 | ECT2 | Protein ECT2 | [232] | -0.05[233] | 1.59[234] | 2.43[235] | 1.32[236] | 2.09[237] | -1.90[238] |
35 | PKN2 | Serine/threonine-protein kinase N2 | [239] | 0.23[240] | 1.48[241] | 1.42[242] | 1.34[243] | 1.35[244] | 0.83[245] |
36 | AKAP13 | A-kinase anchor protein 13 | [246] | 1.01[247] | 0.08[248] | 0.88[249] | 1.89[250] | 1.69[251] | 3.12[252] |
37 | RHPN2 | Rhophilin-2 | [253] | 0.88[254] | 0.93[255] | 2.35[256] | 0.14[257] | -1.05[258] | 0.78[259] |
38 | MCAM | Cell surface glycoprotein MUC18 | [260] | 2.68[261] | -0.13[262] | -2.31[263] | 3.47[264] | 0.84[265] | -0.79[266] |
39 | MYO9B | Unconventional myosin-IXb | [267] | 1.57[268] | 1.09[269] | 2.54[270] | 1.49[271] | 1.82[272] | 1.34[273] |
40 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | [274] | -0.37[275] | 0.59[276] | -0.40[277] | 0.01[278] | 0.23[279] | 0.94[280] |
41 | RACGAP1 | Rac GTPase-activating protein 1 | [281] | 1.37[282] | 1.78[283] | 1.86[284] | 2.37[285] | 3.09[286] | -1.73[287] |
42 | DEPDC1B | DEP domain-containing protein 1B | [288] | 0.45[289] | 1.93[290] | 1.99[291] | 0.19[292] | 0.91[293] | -4.01[294] |
43 | STARD13 | StAR-related lipid transfer protein 13 | [295] | -0.80[296] | 0.53[297] | -0.35[298] | -1.28[299] | 0.36[300] | 0.63[301] |
44 | DIAPH3 | Protein diaphanous homolog 3 | [302] | -0.77[303] | 0.26[304] | 0.58[305] | 0.75[306] | 1.79[307] | -3.61[308] |
45 | STK10 | Serine/threonine-protein kinase 10 | [309] | 0.98[310] | 0.39[311] | -0.81[312] | 0.61[313] | 0.98[314] | 0.51[315] |
46 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [316] | 1.31[317] | 1.37[318] | 0.90[319] | 2.46[320] | 1.93[321] | 1.57[322] |
47 | PKN3 | Serine/threonine-protein kinase N3 | [323] | 1.32[324] | 1.04[325] | 0.48[326] | 0.50[327] | 0.88[328] | -1.74[329] |
48 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | [330] | 1.84[331] | 0.49[332] | -0.50[333] | 0.65[334] | 1.07[335] | -0.88[336] |
49 | MCF2L | Guanine nucleotide exchange factor DBS | [337] | 1.54[338] | 1.68[339] | -0.68[340] | -5.43[341] | -8.47[342] | 0.49[343] |
50 | STARD8 | StAR-related lipid transfer protein 8 | [344] | -3.39[345] | -1.06[346] | -7.22[347] | 0.84[348] | -0.71[349] | 1.13[350] |
51 | ARHGAP2 | Rho GTPase-activating protein 26 | [351] | 1.93[352] | 2.22[353] | 0.58[354] | 0.98[355] | 1.14[356] | 1.26[357] |
52 | ABR | Active breakpoint cluster region-related protein | [358] | 3.22[359] | 2.74[360] | 2.11[361] | 2.62[362] | 3.51[363] | 0.82[364] |
53 | VANGL1 | Vang-like protein 1 | [365] | 2.24[366] | 1.62[367] | 0.89[368] | 3.40[369] | 3.25[370] | 1.68[371] |
54 | OPHN1 | Oligophrenin-1 | [372] | 0.98[373] | 0.94[374] | 1.36[375] | 2.38[376] | 1.13[377] | 3.72[378] |
55 | ARHGEF25 | Rho guanine nucleotide exchange factor 25 | [379] | 2.29[380] | 3.43[381] | 2.45[382] | 0.58[383] | 2.37[384] | -1.08[385] |
56 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -1.15[386] | -7.02[387] | -4.88[388] | 4.30[389] | 2.83[390] | 3.19[391] | |
57 | IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | [392] | 3.04[393] | 3.97[394] | 3.27[395] | 3.95[396] | 5.31[397] | -0.07[398] |
58 | ARHGAP3 | Rho GTPase-activating protein 32 | [399] | 3.00[400] | 2.74[401] | 1.65[402] | 3.66[403] | 2.41[404] | 3.15[405] |
59 | MYO9A | Unconventional myosin-IXa | [406] | 0.95[407] | 1.83[408] | 2.27[409] | 2.91[410] | 2.57[411] | 3.51[412] |
60 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [413] | -4.74[414] | -4.32[415] | -5.44[416] | 2.30[417] | 3.35[418] | 0.85[419] |
61 | ARHGAP3 | Rho GTPase-activating protein 39 | [420] | 2.22[421] | 2.03[422] | 1.86[423] | 1.92[424] | 0.40[425] | -0.27[426] |
62 | CIT | Citron Rho-interacting kinase | [427] | 3.52[428] | 3.95[429] | 4.72[430] | 4.48[431] | 5.29[432] | 1.03[433] |
63 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [434] | 4.46[435] | 5.06[436] | 3.56[437] | 6.94[438] | 4.92[439] | 3.33[440] |
64 | ACTC1 | Actin, alpha cardiac muscle 1 | [441] | -3.05[442] | [443] | -3.57[444] | 6.70[445] | -2.43[446] | -0.30[447] |
65 | ERBIN | Erbin | [448] | [449] | [450] | [451] | [452] | [453] | [454] |
66 | ARHGEF28 | Rho guanine nucleotide exchange factor 28 | [455] | [456] | [457] | [458] | [459] | [460] | [461] |
67 | CAVIN1 | Caveolae-associated protein 1 | [462] | [463] | [464] | [465] | [466] | [467] | [468] |
68 | PCDH7 | Protocadherin-7 | [469] | [470] | [471] | [472] | [473] | [474] | [475] |
69 | MCF2 | Proto-oncogene DBL | [476] | [477] | [478] | [479] | [480] | [481] | [482] |
70 | ARHGDIG | Rho GDP-dissociation inhibitor 3 | [483] | [484] | [485] | [486] | [487] | [488] | [489] |