REACTOME_RET_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [1] | -0.78[2] | -0.47[3] | -0.37[4] | -0.49[5] | 0.27[6] | 0.20[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | -0.03[9] | -0.31[10] | -0.05[11] | -0.82[12] | -0.79[13] | -0.76[14] |
3 | SHC1 | SHC-transforming protein 1 | [15] | -0.06[16] | 0.04[17] | 0.25[18] | 1.27[19] | 0.88[20] | -0.28[21] |
4 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [22] | -1.39[23] | -1.68[24] | -1.54[25] | -1.85[26] | -1.13[27] | -1.84[28] |
5 | DOK4 | Docking protein 4 | [29] | -0.42[30] | 0.16[31] | -0.73[32] | -1.58[33] | -1.56[34] | -1.92[35] |
6 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [36] | -1.70[37] | -1.70[38] | -0.47[39] | 0.69[40] | 0.31[41] | 1.94[42] |
7 | SOS1 | Son of sevenless homolog 1 | [43] | -1.32[44] | 0.08[45] | -0.27[46] | -0.53[47] | -1.18[48] | -0.52[49] |
8 | RAP1GAP | Rap1 GTPase-activating protein 1 | [50] | -0.02[51] | 0.54[52] | -1.73[53] | -2.59[54] | -5.94[55] | -1.14[56] |
9 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [57] | 0.65[58] | 0.75[59] | 1.50[60] | -0.67[61] | 0.01[62] | -1.35[63] |
10 | PDLIM7 | PDZ and LIM domain protein 7 | [64] | 0.79[65] | -0.86[66] | -0.43[67] | 1.82[68] | 0.75[69] | -2.12[70] |
11 | GRB10 | Growth factor receptor-bound protein 10 | [71] | 1.28[72] | -1.92[73] | 0.60[74] | -0.69[75] | 0.30[76] | 0.88[77] |
12 | SRC | Proto-oncogene tyrosine-protein kinase Src | [78] | 1.80[79] | 1.66[80] | 0.80[81] | 1.02[82] | 0.32[83] | -1.91[84] |
13 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.27[85] | 1.76[86] | 1.24[87] | 1.45[88] | 1.06[89] | -0.72[90] | |
14 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.01[91] | 0.37[92] | 0.68[93] | -0.33[94] | -0.05[95] | 0.10[96] | |
15 | GFRA1 | GDNF family receptor alpha-1 | [97] | -10.58[98] | -9.29[99] | -0.13[100] | -0.49[101] | -7.12[102] | 1.99[103] |
16 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [104] | -2.06[105] | -1.40[106] | 0.02[107] | 0.86[108] | -0.16[109] | 0.65[110] |
17 | PRKCA | Protein kinase C alpha type | [111] | 1.61[112] | 1.53[113] | 2.03[114] | 0.77[115] | 1.26[116] | 0.86[117] |
18 | IRS2 | Insulin receptor substrate 2 | [118] | -6.87[119] | [120] | -4.00[121] | -2.04[122] | 1.91[123] | 1.32[124] |
19 | NRTN | Neurturin | [125] | -3.18[126] | -2.88[127] | -3.23[128] | -6.48[129] | -5.93[130] | -3.11[131] |
20 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.60[132] | -0.09[133] | 0.24[134] | -0.25[135] | 0.08[136] | 0.85[137] | |
21 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 0.66[138] | 1.63[139] | -2.04[140] | -1.10[141] | -0.21[142] | -0.76[143] | |
22 | GRB7 | Growth factor receptor-bound protein 7 | [144] | 1.18[145] | 1.38[146] | -1.31[147] | -4.03[148] | -3.17[149] | -1.38[150] |
23 | GAB2 | GRB2-associated-binding protein 2 | [151] | 0.34[152] | 0.01[153] | 0.40[154] | -0.45[155] | -0.24[156] | -0.52[157] |
24 | FRS2 | Fibroblast growth factor receptor substrate 2 | [158] | 0.06[159] | 1.04[160] | 1.68[161] | 1.53[162] | 1.28[163] | 2.28[164] |
25 | MAPK7 | Mitogen-activated protein kinase 7 | [165] | 0.21[166] | -0.61[167] | -0.47[168] | 0.43[169] | 0.64[170] | -0.72[171] |
26 | DOK1 | Docking protein 1 | [172] | -2.52[173] | -3.04[174] | 0.30[175] | -1.12[176] | 0.41[177] | -1.34[178] |
27 | GAB1 | GRB2-associated-binding protein 1 | [179] | 0.08[180] | 1.04[181] | 1.31[182] | 0.56[183] | 0.54[184] | 1.81[185] |
28 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | [186] | -6.79[187] | -8.19[188] | [189] | -7.35[190] | -4.27[191] | -0.47[192] |
29 | DOK2 | Docking protein 2 | [193] | -6.08[194] | -6.80[195] | -7.49[196] | -8.85[197] | -9.76[198] | 0.57[199] |
30 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [200] | 0.50[201] | 0.39[202] | 1.37[203] | 1.79[204] | 0.93[205] | 1.62[206] |
31 | DOK6 | Docking protein 6 | [207] | 1.99[208] | 2.86[209] | 1.58[210] | -5.26[211] | -0.96[212] | 0.14[213] |
32 | PSPN | Persephin | [214] | -2.81[215] | -2.14[216] | -1.52[217] | -4.40[218] | -3.19[219] | -3.75[220] |
33 | GDNF | Glial cell line-derived neurotrophic factor | [221] | 3.73[222] | 1.71[223] | -3.99[224] | -2.69[225] | -0.66[226] | -1.19[227] |
34 | GFRA2 | GDNF family receptor alpha-2 | [228] | -5.93[229] | -4.44[230] | [231] | -1.65[232] | -5.81[233] | 2.40[234] |
35 | DOK5 | Docking protein 5 | [235] | [236] | [237] | [238] | -0.92[239] | 0.25[240] | -1.17[241] |
36 | ARTN | Artemin | [242] | -0.33[243] | 0.93[244] | -1.90[245] | -1.12[246] | -0.86[247] | -2.20[248] |
37 | SHC3 | SHC-transforming protein 3 | [249] | 0.89[250] | 3.14[251] | -4.21[252] | 2.08[253] | 6.11[254] | 0.76[255] |
38 | GFRA3 | GDNF family receptor alpha-3 | [256] | 0.10[257] | -0.31[258] | -1.59[259] | -3.77[260] | -1.18[261] | 0.93[262] |
39 | GFRA4 | GDNF family receptor alpha-4 | [263] | [264] | [265] | [266] | [267] | [268] | [269] |
40 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [270] | [271] | [272] | [273] | [274] | [275] | [276] |