REACTOME_RESPONSE_OF_EIF2AK1_HRI_TO_HEME_DEFICIENCY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ATF5 Cyclic AMP-dependent transcription factor ATF-5 [1] -4.80[2] -4.82[3] -6.96[4] -3.98[5] -4.63[6] 0.01[7]
2 ATF4 Cyclic AMP-dependent transcription factor ATF-4 [8] -0.36[9] 0.29[10] 0.31[11] -1.37[12] -0.42[13] -1.07[14]
3 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 [15] 0.74[16] 1.23[17] 0.54[18] 1.63[19] 0.95[20] -0.22[21]
4 PPP1R15A Protein phosphatase 1 regulatory subunit 15A [22] -0.94[23] -2.35[24] -1.72[25] -0.56[26] -0.10[27] -2.48[28]
5 CEBPB CCAAT/enhancer-binding protein beta [29] -0.36[30] -1.45[31] -1.30[32] 0.24[33] 0.69[34] -0.53[35]
6 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 [36] 1.39[37] 1.21[38] 1.77[39] 2.44[40] 1.84[41] 0.85[42]
7 TRIB3 Tribbles homolog 3 [43] 1.72[44] 1.55[45] 0.56[46] -0.36[47] -0.34[48] 0.72[49]
8 DDIT3 DNA damage-inducible transcript 3 protein [50] -1.17[51] -0.86[52] -0.91[53] -0.45[54] -0.06[55] -1.05[56]
9 ATF3 Cyclic AMP-dependent transcription factor ATF-3 [57] -1.82[58] -2.17[59] -2.48[60] -1.78[61] -2.09[62] -2.27[63]
10 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 [64] 2.16[65] 1.95[66] 2.04[67] 2.06[68] 1.70[69] 1.84[70]
11 CEBPG CCAAT/enhancer-binding protein gamma [71] 0.87[72] 0.77[73] 2.03[74] 0.12[75] 0.53[76] 1.90[77]
12 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 [78] 1.08[79] 0.56[80] 0.42[81] 2.26[82] 2.23[83] 1.54[84]
13 CHAC1 Glutathione-specific gamma-glutamylcyclotransferase 1 [85] -4.58[86] -2.69[87] -0.10[88] -2.07[89] 0.32[90] -2.53[91]
14 ASNS Asparagine synthetase [glutamine-hydrolyzing] [92] 3.65[93] 3.19[94] 2.98[95] 1.60[96] 2.92[97] -0.26[98]
15 GRB10 Growth factor receptor-bound protein 10 [99] 3.32[100] -0.22[101] 2.28[102] 2.34[103] 2.72[104] 3.08[105]
[1]
ref_hepatocyte ATF5
Mean 263
Standard deviation 3.3e+02
Values 2.6 18 1.6e+02 8.1e+02 3.2e+02
[2]
HepG2 ATF5
Mean 11.9
Standard deviation 4.8
Values 8.5 15
[3]
HepG2.C3A ATF5
Mean 14.4
Standard deviation 1.2
Values 14 15
[4]
HuH.7 ATF5
Mean 2.88
Standard deviation 0.18
Values 2.7 2.9 3.1
[5]
SNU475 ATF5
Mean 9.72
Standard deviation 1.1
Values 8.9 11
[6]
THLE ATF5
Mean 9.74
Standard deviation 0.2
Values 9.6 9.9
[7]
liver ATF5
Mean 171
Standard deviation 1.7e+02
Values 4.1e+02 41 1.9e+02 50
[8]
ref_hepatocyte ATF4
Mean 212
Standard deviation 1.7e+02
Values 76 1.1e+02 4.8e+02 2.7e+02 1.3e+02
[9]
HepG2 ATF4
Mean 208
Standard deviation 25
Values 2.3e+02 1.9e+02
[10]
HepG2.C3A ATF4
Mean 397
Standard deviation 1.4e+02
Values 4.9e+02 3e+02
[11]
HuH.7 ATF4
Mean 356
Standard deviation 84
Values 3.1e+02 3.1e+02 4.5e+02
[12]
SNU475 ATF4
Mean 47.8
Standard deviation 2.6
Values 50 46
[13]
THLE ATF4
Mean 145
Standard deviation 1.3
Values 1.5e+02 1.4e+02
[14]
liver ATF4
Mean 64.9
Standard deviation 27
Values 1e+02 44 68 46
[15]
ref_hepatocyte EIF2S2
Mean 54.4
Standard deviation 26
Values 55 94 55 48 20
[16]
HepG2 EIF2S2
Mean 114
Standard deviation 1.6
Values 1.1e+02 1.2e+02
[17]
HepG2.C3A EIF2S2
Mean 196
Standard deviation 2.4
Values 2e+02 1.9e+02
[18]
HuH.7 EIF2S2
Mean 108
Standard deviation 24
Values 1.1e+02 82 1.3e+02
[19]
SNU475 EIF2S2
Mean 98.4
Standard deviation 0.71
Values 98 99
[20]
THLE EIF2S2
Mean 96.7
Standard deviation 5.6
Values 1e+02 93
[21]
liver EIF2S2
Mean 30
Standard deviation 13
Values 48 22 32 18
[22]
ref_hepatocyte PPP1R15A
Mean 46.5
Standard deviation 53
Values 18 55 1.4e+02 19 5.3
[23]
HepG2 PPP1R15A
Mean 30.6
Standard deviation 24
Values 47 14
[24]
HepG2.C3A PPP1R15A
Mean 14
Standard deviation 6.7
Values 19 9.2
[25]
HuH.7 PPP1R15A
Mean 19.2
Standard deviation 5.6
Values 14 25 18
[26]
SNU475 PPP1R15A
Mean 18.4
Standard deviation 6.4
Values 14 23
[27]
THLE PPP1R15A
Mean 40
Standard deviation 0.53
Values 40 40
[28]
liver PPP1R15A
Mean 5.39
Standard deviation 1.5
Values 5.7 3.3 6.8 5.8
[29]
ref_hepatocyte CEBPB
Mean 37.2
Standard deviation 25
Values 9 26 24 65 62
[30]
HepG2 CEBPB
Mean 36.4
Standard deviation 26
Values 55 18
[31]
HepG2.C3A CEBPB
Mean 20.9
Standard deviation 13
Values 30 12
[32]
HuH.7 CEBPB
Mean 20.5
Standard deviation 6.4
Values 13 25 23
[33]
SNU475 CEBPB
Mean 25.6
Standard deviation 11
Values 18 33
[34]
THLE CEBPB
Mean 55
Standard deviation 10
Values 48 62
[35]
liver CEBPB
Mean 16.5
Standard deviation 5.6
Values 18 16 9.1 22
[36]
ref_hepatocyte EIF2S3
Mean 33.9
Standard deviation 14
Values 44 54 23 22 26
[37]
HepG2 EIF2S3
Mean 112
Standard deviation 20
Values 1.3e+02 98
[38]
HepG2.C3A EIF2S3
Mean 120
Standard deviation 40
Values 1.5e+02 92
[39]
HuH.7 EIF2S3
Mean 157
Standard deviation 4.3
Values 1.5e+02 1.6e+02 1.6e+02
[40]
SNU475 EIF2S3
Mean 108
Standard deviation 16
Values 1.2e+02 96
[41]
THLE EIF2S3
Mean 111
Standard deviation 20
Values 97 1.3e+02
[42]
liver EIF2S3
Mean 39.5
Standard deviation 6.6
Values 44 40 44 30
[43]
ref_hepatocyte TRIB3
Mean 31.8
Standard deviation 22
Values 21 25 60 47 5.9
[44]
HepG2 TRIB3
Mean 132
Standard deviation 85
Values 1.9e+02 72
[45]
HepG2.C3A TRIB3
Mean 144
Standard deviation 1.1e+02
Values 2.2e+02 66
[46]
HuH.7 TRIB3
Mean 63.7
Standard deviation 8.9
Values 57 74 61
[47]
SNU475 TRIB3
Mean 14.5
Standard deviation 3.3
Values 12 17
[48]
THLE TRIB3
Mean 23
Standard deviation 5.7
Values 27 19
[49]
liver TRIB3
Mean 33.8
Standard deviation 26
Values 72 16 30 17
[50]
ref_hepatocyte DDIT3
Mean 23.4
Standard deviation 23
Values 7.5 13 17 64 15
[51]
HepG2 DDIT3
Mean 13.1
Standard deviation 8.7
Values 19 7
[52]
HepG2.C3A DDIT3
Mean 19.9
Standard deviation 9
Values 26 14
[53]
HuH.7 DDIT3
Mean 16.9
Standard deviation 6.4
Values 10 23 18
[54]
SNU475 DDIT3
Mean 10
Standard deviation 0.8
Values 9.5 11
[55]
THLE DDIT3
Mean 20.6
Standard deviation 4
Values 23 18
[56]
liver DDIT3
Mean 7.31
Standard deviation 5.6
Values 12 2.7 12 2.3
[57]
ref_hepatocyte ATF3
Mean 22.4
Standard deviation 17
Values 9.4 24 46 30 2.6
[58]
HepG2 ATF3
Mean 8
Standard deviation 5.7
Values 12 4
[59]
HepG2.C3A ATF3
Mean 7.63
Standard deviation 6.6
Values 12 3
[60]
HuH.7 ATF3
Mean 5.45
Standard deviation 3.7
Values 2.5 9.6 4.2
[61]
SNU475 ATF3
Mean 3.8
Standard deviation 3
Values 1.7 5.9
[62]
THLE ATF3
Mean 4.82
Standard deviation 1.4
Values 5.8 3.8
[63]
liver ATF3
Mean 2.99
Standard deviation 2.6
Values 6.5 1 3.3 1
[64]
ref_hepatocyte EIF2AK1
Mean 20.9
Standard deviation 7.3
Values 30 14 13 24 24
[65]
HepG2 EIF2AK1
Mean 118
Standard deviation 13
Values 1.1e+02 1.3e+02
[66]
HepG2.C3A EIF2AK1
Mean 124
Standard deviation 12
Values 1.3e+02 1.2e+02
[67]
HuH.7 EIF2AK1
Mean 117
Standard deviation 4.3
Values 1.2e+02 1.1e+02 1.2e+02
[68]
SNU475 EIF2AK1
Mean 50.9
Standard deviation 14
Values 61 41
[69]
THLE EIF2AK1
Mean 62.3
Standard deviation 7
Values 57 67
[70]
liver EIF2AK1
Mean 48.3
Standard deviation 17
Values 65 37 60 31
[71]
ref_hepatocyte CEBPG
Mean 16.1
Standard deviation 5.6
Values 21 16 15 21 7.1
[72]
HepG2 CEBPG
Mean 37.3
Standard deviation 8.2
Values 43 31
[73]
HepG2.C3A CEBPG
Mean 42.2
Standard deviation 12
Values 51 34
[74]
HuH.7 CEBPG
Mean 89.7
Standard deviation 16
Values 76 1.1e+02 86
[75]
SNU475 CEBPG
Mean 10.2
Standard deviation 1.8
Values 8.9 12
[76]
THLE CEBPG
Mean 21.5
Standard deviation 4.1
Values 24 19
[77]
liver CEBPG
Mean 38.8
Standard deviation 13
Values 57 28 41 29
[78]
ref_hepatocyte EIF2S1
Mean 16
Standard deviation 10
Values 10 33 18 11 8
[79]
HepG2 EIF2S1
Mean 42.6
Standard deviation 3.9
Values 40 45
[80]
HepG2.C3A EIF2S1
Mean 36.2
Standard deviation 14
Values 26 46
[81]
HuH.7 EIF2S1
Mean 29
Standard deviation 6.1
Values 31 22 34
[82]
SNU475 EIF2S1
Mean 44.7
Standard deviation 5.8
Values 41 49
[83]
THLE EIF2S1
Mean 69.1
Standard deviation 4.7
Values 66 72
[84]
liver EIF2S1
Mean 30
Standard deviation 9.6
Values 32 25 43 21
[85]
ref_hepatocyte CHAC1
Mean 7.82
Standard deviation 13
Values 0 0.15 8.8 30 0.24
[86]
HepG2 CHAC1
Mean 0.411
Standard deviation 0.35
Values 0.66 0.16
[87]
HepG2.C3A CHAC1
Mean 1.87
Standard deviation 1.2
Values 2.7 1
[88]
HuH.7 CHAC1
Mean 9.92
Standard deviation 2.9
Values 11 6.7 12
[89]
SNU475 CHAC1
Mean 1.08
Standard deviation 0.32
Values 0.85 1.3
[90]
THLE CHAC1
Mean 8.99
Standard deviation 2
Values 10 7.5
[91]
liver CHAC1
Mean 0.871
Standard deviation 1.1
Values 2.4 0.057 0.69 0.29
[92]
ref_hepatocyte ASNS
Mean 5.66
Standard deviation 4.3
Values 6.9 2.4 7.2 11 0.45
[93]
HepG2 ASNS
Mean 89.3
Standard deviation 68
Values 1.4e+02 41
[94]
HepG2.C3A ASNS
Mean 79.4
Standard deviation 76
Values 1.3e+02 26
[95]
HuH.7 ASNS
Mean 60.8
Standard deviation 18
Values 67 41 75
[96]
SNU475 ASNS
Mean 10
Standard deviation 1.4
Values 11 9.1
[97]
THLE ASNS
Mean 39.5
Standard deviation 12
Values 48 31
[98]
liver ASNS
Mean 3.05
Standard deviation 3.8
Values 8.8 1.2 1.6 0.6
[99]
ref_hepatocyte GRB10
Mean 3.75
Standard deviation 1.1
Values 2 3.4 4.9 4.1 4.3
[100]
HepG2 GRB10
Mean 47
Standard deviation 17
Values 59 35
[101]
HepG2.C3A GRB10
Mean 4.96
Standard deviation 0.92
Values 5.6 4.3
[102]
HuH.7 GRB10
Mean 24.7
Standard deviation 7
Values 22 33 19
[103]
SNU475 GRB10
Mean 11.1
Standard deviation 1.2
Values 12 10
[104]
THLE GRB10
Mean 22.6
Standard deviation 0.57
Values 22 23
[105]
liver GRB10
Mean 20.5
Standard deviation 8.3
Values 22 21 9.1 29