REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RAD51C DNA repair protein RAD51 homolog 3 [1] -1.10[2] -1.77[3] -1.99[4] -3.42[5] -1.97[6] -3.17[7]
2 KAT5 Histone acetyltransferase KAT5 [8] -1.47[9] -1.96[10] -3.04[11] -2.08[12] -2.25[13] -1.98[14]
3 NBN Nibrin [15] -1.10[16] -0.83[17] -1.13[18] 0.26[19] -0.71[20] 0.36[21]
4 RAD51 DNA repair protein RAD51 homolog 1 [22] -0.94[23] -2.03[24] -1.98[25] -1.42[26] -1.55[27] -4.86[28]
5 RAD50 DNA repair protein RAD50 [29] -0.54[30] 0.69[31] -0.21[32] 0.03[33] 0.42[34] 1.29[35]
6 RMI2 RecQ-mediated genome instability protein 2 [36] 0.56[37] -1.06[38] -1.15[39] -2.44[40] -2.22[41] -5.34[42]
7 RBBP8 DNA endonuclease RBBP8 [43] -0.49[44] 0.02[45] -1.41[46] 0.19[47] 0.31[48] -0.66[49]
8 TOP3A DNA topoisomerase 3-alpha [50] 1.28[51] 0.05[52] 0.29[53] 0.61[54] 0.91[55] 0.88[56]
9 PALB2 Partner and localizer of BRCA2 [57] 1.08[58] 0.47[59] 0.05[60] -0.54[61] -0.14[62] -0.24[63]
10 BRCA1 Breast cancer type 1 susceptibility protein [64] 0.98[65] 1.33[66] 1.67[67] 0.90[68] 1.34[69] 0.76[70]
11 RTEL1 Regulator of telomere elongation helicase 1 [71] -2.39[72] -2.16[73] -4.03[74] -3.53[75] -3.04[76] -2.56[77]
12 WRN Werner syndrome ATP-dependent helicase [78] -0.08[79] 0.48[80] 2.36[81] 0.46[82] 0.18[83] 1.06[84]
13 RAD51D DNA repair protein RAD51 homolog 4 [85] 0.04[86] -0.85[87] -0.17[88] -0.19[89] -0.84[90] -1.15[91]
14 RAD51AP1 RAD51-associated protein 1 [92] 0.81[93] 1.37[94] 2.01[95] 0.82[96] 1.54[97] -2.42[98]
15 RMI1 RecQ-mediated genome instability protein 1 [99] -0.11[100] 0.23[101] 0.62[102] 0.83[103] 1.59[104] 0.07[105]
16 XRCC2 DNA repair protein XRCC2 [106] -0.51[107] -0.63[108] -0.33[109] -0.44[110] -0.28[111] -3.18[112]
17 ATM Serine-protein kinase ATM [113] 2.34[114] 3.04[115] 2.71[116] 2.92[117] 2.31[118] 4.08[119]
18 RAD51B DNA repair protein RAD51 homolog 2 [120] -0.83[121] -1.62[122] -1.65[123] -1.17[124] -1.45[125] -1.46[126]
19 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2 [127] 1.07[128] 1.94[129] 1.09[130] 1.41[131] 0.98[132] 0.65[133]
20 EXO1 Exonuclease 1 [134] 1.22[135] 0.60[136] 1.72[137] 2.54[138] 1.73[139] -2.38[140]
21 XRCC3 DNA repair protein XRCC3 [141] 2.36[142] 1.63[143] 1.28[144] 1.94[145] 2.30[146] 0.80[147]
22 BRIP1 Fanconi anemia group J protein [148] 1.46[149] 1.95[150] 1.91[151] 1.97[152] 1.92[153] 1.05[154]
23 BLM Bloom syndrome protein [155] 0.86[156] 1.31[157] 2.06[158] 1.65[159] 1.64[160] -1.29[161]
24 BARD1 BRCA1-associated RING domain protein 1 [162] 0.63[163] 0.71[164] 0.68[165] 1.46[166] 1.45[167] 0.96[168]
25 BRCA2 Breast cancer type 2 susceptibility protein [169] 2.11[170] 3.70[171] 3.82[172] 3.23[173] 3.30[174] 2.52[175]
26 MRE11 Double-strand break repair protein MRE11 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte RAD51C
Mean 10.4
Standard deviation 8.5
Values 18 21 2 5.5 5.3
[2]
HepG2 RAD51C
Mean 17.2
Standard deviation 4.3
Values 14 20
[3]
HepG2.C3A RAD51C
Mean 18
Standard deviation 12
Values 9.9 26
[4]
HuH.7 RAD51C
Mean 15.4
Standard deviation 5.8
Values 18 8.8 20
[5]
SNU475 RAD51C
Mean 4.2
Standard deviation 0.92
Values 3.5 4.9
[6]
THLE RAD51C
Mean 13.7
Standard deviation 0.053
Values 14 14
[7]
liver RAD51C
Mean 3.09
Standard deviation 2
Values 4.8 1.5 4.9 1.2
[8]
ref_hepatocyte KAT5
Mean 6.92
Standard deviation 2.7
Values 6 6.4 12 6.3 4.4
[9]
HepG2 KAT5
Mean 8.9
Standard deviation 0.12
Values 9 8.8
[10]
HepG2.C3A KAT5
Mean 10.6
Standard deviation 0.63
Values 11 10
[11]
HuH.7 KAT5
Mean 4.96
Standard deviation 0.22
Values 4.9 4.8 5.2
[12]
SNU475 KAT5
Mean 7.11
Standard deviation 0.33
Values 6.9 7.3
[13]
THLE KAT5
Mean 7.53
Standard deviation 0.42
Values 7.2 7.8
[14]
liver KAT5
Mean 4.69
Standard deviation 1
Values 5.5 4.1 5.7 3.5
[15]
ref_hepatocyte NBN
Mean 5.99
Standard deviation 3.6
Values 7.6 11 3.9 2.7 4.3
[16]
HepG2 NBN
Mean 9.9
Standard deviation 6.3
Values 5.4 14
[17]
HepG2.C3A NBN
Mean 20
Standard deviation 9.1
Values 14 26
[18]
HuH.7 NBN
Mean 16.2
Standard deviation 4.2
Values 20 12 17
[19]
SNU475 NBN
Mean 31.2
Standard deviation 0.96
Values 30 32
[20]
THLE NBN
Mean 19
Standard deviation 0.88
Values 20 18
[21]
liver NBN
Mean 20.5
Standard deviation 4.2
Values 19 24 24 16
[22]
ref_hepatocyte RAD51
Mean 4.73
Standard deviation 7.4
Values 17 5.6 0.36 0.2 0.24
[23]
HepG2 RAD51
Mean 8.76
Standard deviation 0.7
Values 8.3 9.3
[24]
HepG2.C3A RAD51
Mean 6.88
Standard deviation 3.6
Values 4.3 9.4
[25]
HuH.7 RAD51
Mean 7.06
Standard deviation 4.4
Values 8.8 2 10
[26]
SNU475 RAD51
Mean 7.64
Standard deviation 1.6
Values 6.5 8.8
[27]
THLE RAD51
Mean 8.38
Standard deviation 1.2
Values 7.5 9.2
[28]
liver RAD51
Mean 0.436
Standard deviation 0.3
Values 0.35 0.19 0.87 0.33
[29]
ref_hepatocyte RAD50
Mean 3.85
Standard deviation 2.1
Values 3.9 7.4 2.3 2.9 2.8
[30]
HepG2 RAD50
Mean 9.45
Standard deviation 2.3
Values 7.9 11
[31]
HepG2.C3A RAD50
Mean 36.9
Standard deviation 0.99
Values 38 36
[32]
HuH.7 RAD50
Mean 19.7
Standard deviation 4.1
Values 22 22 15
[33]
SNU475 RAD50
Mean 17
Standard deviation 2.2
Values 15 19
[34]
THLE RAD50
Mean 26.8
Standard deviation 8.4
Values 33 21
[35]
liver RAD50
Mean 25.2
Standard deviation 5.7
Values 32 26 25 18
[36]
ref_hepatocyte RMI2
Mean 3.81
Standard deviation 4.8
Values 12 1.3 2.1 1.9 1.4
[37]
HepG2 RMI2
Mean 20
Standard deviation 0.75
Values 21 19
[38]
HepG2.C3A RMI2
Mean 10.9
Standard deviation 2.5
Values 9.1 13
[39]
HuH.7 RMI2
Mean 10.1
Standard deviation 6.2
Values 13 3 15
[40]
SNU475 RMI2
Mean 3.05
Standard deviation 0.54
Values 2.7 3.4
[41]
THLE RMI2
Mean 4.24
Standard deviation 1
Values 3.5 5
[42]
liver RMI2
Mean 0.251
Standard deviation 0.18
Values 0.21 0.2 0.51 0.079
[43]
ref_hepatocyte RBBP8
Mean 3.69
Standard deviation 1.9
Values 3.5 6.7 3.6 3.4 1.2
[44]
HepG2 RBBP8
Mean 9.31
Standard deviation 4.7
Values 6 13
[45]
HepG2.C3A RBBP8
Mean 22.1
Standard deviation 12
Values 14 31
[46]
HuH.7 RBBP8
Mean 8.18
Standard deviation 3.3
Values 9.6 4.4 10
[47]
SNU475 RBBP8
Mean 18.3
Standard deviation 4.9
Values 15 22
[48]
THLE RBBP8
Mean 23.6
Standard deviation 4.7
Values 27 20
[49]
liver RBBP8
Mean 6.21
Standard deviation 1.4
Values 8.1 5.9 6.2 4.6
[50]
ref_hepatocyte TOP3A
Mean 1.96
Standard deviation 0.76
Values 1.2 1.6 3.2 2.2 1.7
[51]
HepG2 TOP3A
Mean 16.9
Standard deviation 1.9
Values 16 18
[52]
HepG2.C3A TOP3A
Mean 12
Standard deviation 1.5
Values 11 13
[53]
HuH.7 TOP3A
Mean 14.2
Standard deviation 4.3
Values 18 9.6 15
[54]
SNU475 TOP3A
Mean 13
Standard deviation 2.3
Values 11 15
[55]
THLE TOP3A
Mean 19.1
Standard deviation 2.9
Values 17 21
[56]
liver TOP3A
Mean 9.68
Standard deviation 2.3
Values 6.7 9.9 9.7 12
[57]
ref_hepatocyte PALB2
Mean 1.9
Standard deviation 1.6
Values 4.6 0.75 1.8 1.4 1
[58]
HepG2 PALB2
Mean 14.3
Standard deviation 5.9
Values 10 18
[59]
HepG2.C3A PALB2
Mean 15.7
Standard deviation 6.5
Values 11 20
[60]
HuH.7 PALB2
Mean 11.6
Standard deviation 2.8
Values 14 8.6 12
[61]
SNU475 PALB2
Mean 5.68
Standard deviation 1.3
Values 4.7 6.6
[62]
THLE PALB2
Mean 8.95
Standard deviation 1.3
Values 8 9.9
[63]
liver PALB2
Mean 4.31
Standard deviation 1.1
Values 5.7 4.4 3.8 3.3
[64]
ref_hepatocyte BRCA1
Mean 1.87
Standard deviation 0.88
Values 2.7 1.4 0.59 2.6 2
[65]
HepG2 BRCA1
Mean 13.1
Standard deviation 3
Values 11 15
[66]
HepG2.C3A BRCA1
Mean 27.8
Standard deviation 18
Values 15 40
[67]
HuH.7 BRCA1
Mean 35
Standard deviation 16
Values 49 17 39
[68]
SNU475 BRCA1
Mean 15.2
Standard deviation 6.4
Values 11 20
[69]
THLE BRCA1
Mean 24.5
Standard deviation 0.48
Values 25 24
[70]
liver BRCA1
Mean 8.47
Standard deviation 9.4
Values 22 4.3 2.5 4.5
[71]
ref_hepatocyte RTEL1
Mean 1.41
Standard deviation 0.26
Values 1.7 1.2 1.4 1.6 1.1
[72]
HepG2 RTEL1
Mean 0.952
Standard deviation 0.24
Values 0.79 1.1
[73]
HepG2.C3A RTEL1
Mean 1.86
Standard deviation 0.37
Values 2.1 1.6
[74]
HuH.7 RTEL1
Mean 0.508
Standard deviation 0.12
Values 0.61 0.37 0.54
[75]
SNU475 RTEL1
Mean 0.529
Standard deviation 0.019
Values 0.51 0.54
[76]
THLE RTEL1
Mean 0.883
Standard deviation 0.16
Values 0.99 0.77
[77]
liver RTEL1
Mean 0.636
Standard deviation 0.18
Values 0.87 0.47 0.51 0.69
[78]
ref_hepatocyte WRN
Mean 1.33
Standard deviation 0.66
Values 1.8 1.8 1.8 0.68 0.54
[79]
HepG2 WRN
Mean 4.47
Standard deviation 1.6
Values 3.3 5.6
[80]
HepG2.C3A WRN
Mean 11
Standard deviation 2.1
Values 9.5 12
[81]
HuH.7 WRN
Mean 40.4
Standard deviation 6.8
Values 43 46 33
[82]
SNU475 WRN
Mean 7.93
Standard deviation 0.72
Values 8.4 7.4
[83]
THLE WRN
Mean 7.81
Standard deviation 1.9
Values 9.2 6.5
[84]
liver WRN
Mean 7.39
Standard deviation 3.4
Values 4.3 10 4.7 10
[85]
ref_hepatocyte RAD51D
Mean 1.3
Standard deviation 0.97
Values 2.8 1.7 0.25 0.94 0.82
[86]
HepG2 RAD51D
Mean 4.75
Standard deviation 0.93
Values 4.1 5.4
[87]
HepG2.C3A RAD51D
Mean 4.26
Standard deviation 0.87
Values 3.6 4.9
[88]
HuH.7 RAD51D
Mean 6.8
Standard deviation 2.4
Values 8.6 4.1 7.7
[89]
SNU475 RAD51D
Mean 4.95
Standard deviation 0.97
Values 5.6 4.3
[90]
THLE RAD51D
Mean 3.75
Standard deviation 0.5
Values 3.4 4.1
[91]
liver RAD51D
Mean 1.56
Standard deviation 0.54
Values 2.1 1.2 1.9 1
[92]
ref_hepatocyte RAD51AP1
Mean 1.21
Standard deviation 1.3
Values 3 2.2 0.12 0.51 0.29
[93]
HepG2 RAD51AP1
Mean 7.53
Standard deviation 4.7
Values 4.2 11
[94]
HepG2.C3A RAD51AP1
Mean 18.5
Standard deviation 16
Values 7.4 30
[95]
HuH.7 RAD51AP1
Mean 28.7
Standard deviation 16
Values 35 11 40
[96]
SNU475 RAD51AP1
Mean 9.27
Standard deviation 0.72
Values 8.8 9.8
[97]
THLE RAD51AP1
Mean 18.2
Standard deviation 0.39
Values 18 19
[98]
liver RAD51AP1
Mean 0.601
Standard deviation 0.46
Values 0.49 0.71 1.2 0.04
[99]
ref_hepatocyte RMI1
Mean 1.11
Standard deviation 0.61
Values 2.1 1.1 0.59 0.72 1
[100]
HepG2 RMI1
Mean 3.68
Standard deviation 1.6
Values 2.5 4.8
[101]
HepG2.C3A RMI1
Mean 7.72
Standard deviation 4.6
Values 4.4 11
[102]
HuH.7 RMI1
Mean 10.1
Standard deviation 1.9
Values 12 8.1 11
[103]
SNU475 RMI1
Mean 8.62
Standard deviation 0.62
Values 8.2 9.1
[104]
THLE RMI1
Mean 17.4
Standard deviation 1
Values 17 18
[105]
liver RMI1
Mean 3.13
Standard deviation 0.48
Values 3.2 3.1 3.7 2.5
[106]
ref_hepatocyte XRCC2
Mean 1.11
Standard deviation 0.61
Values 1 2.2 0.72 0.7 0.93
[107]
HepG2 XRCC2
Mean 2.77
Standard deviation 0.98
Values 2.1 3.5
[108]
HepG2.C3A XRCC2
Mean 4.26
Standard deviation 3.6
Values 1.7 6.8
[109]
HuH.7 XRCC2
Mean 5.22
Standard deviation 2.5
Values 7.6 2.6 5.5
[110]
SNU475 XRCC2
Mean 3.55
Standard deviation 1
Values 2.8 4.3
[111]
THLE XRCC2
Mean 4.73
Standard deviation 0.54
Values 4.3 5.1
[112]
liver XRCC2
Mean 0.328
Standard deviation 0.18
Values 0.14 0.53 0.21 0.44
[113]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 2.1 0.69 0.27 0.7 1.1
[114]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 12 23
[115]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 44 51
[116]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 41 44 27
[117]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 38 26
[118]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[119]
liver ATM
Mean 43.7
Standard deviation 31
Values 17 76 17 64
[120]
ref_hepatocyte RAD51B
Mean 0.964
Standard deviation 0.83
Values 0.38 2.3 1.2 0.56 0.39
[121]
HepG2 RAD51B
Mean 1.92
Standard deviation 0.11
Values 2 1.8
[122]
HepG2.C3A RAD51B
Mean 1.86
Standard deviation 0.24
Values 1.7 2
[123]
HuH.7 RAD51B
Mean 1.81
Standard deviation 0.039
Values 1.8 1.8 1.8
[124]
SNU475 RAD51B
Mean 1.85
Standard deviation 0.075
Values 1.9 1.8
[125]
THLE RAD51B
Mean 1.83
Standard deviation 0.49
Values 1.5 2.2
[126]
liver RAD51B
Mean 0.938
Standard deviation 0.46
Values 0.54 1.6 0.92 0.7
[127]
ref_hepatocyte DNA2
Mean 0.686
Standard deviation 0.42
Values 1.2 1.1 0.52 0.36 0.28
[128]
HepG2 DNA2
Mean 5.13
Standard deviation 3.4
Values 2.7 7.6
[129]
HepG2.C3A DNA2
Mean 15.6
Standard deviation 12
Values 7.4 24
[130]
HuH.7 DNA2
Mean 8.62
Standard deviation 3.7
Values 11 4.3 11
[131]
SNU475 DNA2
Mean 7.89
Standard deviation 1.4
Values 6.9 8.9
[132]
THLE DNA2
Mean 7
Standard deviation 0.46
Values 6.7 7.3
[133]
liver DNA2
Mean 2.88
Standard deviation 1.1
Values 2.8 3.6 1.3 3.8
[134]
ref_hepatocyte EXO1
Mean 0.669
Standard deviation 0.56
Values 1.1 1.4 0.19 0.53 0.12
[135]
HepG2 EXO1
Mean 5.53
Standard deviation 3.6
Values 3 8
[136]
HepG2.C3A EXO1
Mean 6
Standard deviation 4.2
Values 3.1 8.9
[137]
HuH.7 EXO1
Mean 13
Standard deviation 8
Values 18 3.7 17
[138]
SNU475 EXO1
Mean 16.8
Standard deviation 6.9
Values 12 22
[139]
THLE EXO1
Mean 11.5
Standard deviation 1.2
Values 11 12
[140]
liver EXO1
Mean 0.343
Standard deviation 0.28
Values 0.28 0.73 0.31 0.053
[141]
ref_hepatocyte XRCC3
Mean 0.648
Standard deviation 0.33
Values 0.18 0.69 1 0.84 0.5
[142]
HepG2 XRCC3
Mean 11.8
Standard deviation 1.1
Values 11 13
[143]
HepG2.C3A XRCC3
Mean 11.9
Standard deviation 2.5
Values 10 14
[144]
HuH.7 XRCC3
Mean 9.29
Standard deviation 4.1
Values 12 4.5 11
[145]
SNU475 XRCC3
Mean 10.8
Standard deviation 0.81
Values 10 11
[146]
THLE XRCC3
Mean 16.5
Standard deviation 0.61
Values 16 17
[147]
liver XRCC3
Mean 3.01
Standard deviation 2
Values 1.1 4.7 1.6 4.7
[148]
ref_hepatocyte BRIP1
Mean 0.512
Standard deviation 0.37
Values 1.1 0.59 0.29 0.2 0.37
[149]
HepG2 BRIP1
Mean 5
Standard deviation 2.9
Values 3 7
[150]
HepG2.C3A BRIP1
Mean 11.8
Standard deviation 7.8
Values 6.3 17
[151]
HuH.7 BRIP1
Mean 11.4
Standard deviation 5.9
Values 17 5.2 12
[152]
SNU475 BRIP1
Mean 8.68
Standard deviation 2.1
Values 7.2 10
[153]
THLE BRIP1
Mean 10
Standard deviation 0.62
Values 10 9.6
[154]
liver BRIP1
Mean 2.83
Standard deviation 1.3
Values 1.7 4.3 1.7 3.5
[155]
ref_hepatocyte BLM
Mean 0.47
Standard deviation 0.48
Values 1.3 0.54 0.16 0.18 0.18
[156]
HepG2 BLM
Mean 3.02
Standard deviation 1.6
Values 1.9 4.1
[157]
HepG2.C3A BLM
Mean 6.88
Standard deviation 4.6
Values 3.6 10
[158]
HuH.7 BLM
Mean 11.6
Standard deviation 6.1
Values 16 4.6 14
[159]
SNU475 BLM
Mean 6.41
Standard deviation 2.4
Values 4.7 8.1
[160]
THLE BLM
Mean 7.59
Standard deviation 0.46
Values 7.3 7.9
[161]
liver BLM
Mean 0.512
Standard deviation 0.32
Values 0.38 0.87 0.67 0.13
[162]
ref_hepatocyte BARD1
Mean 0.427
Standard deviation 0.62
Values 0.59 1.4 0 0.1 0
[163]
HepG2 BARD1
Mean 2.35
Standard deviation 1.5
Values 1.3 3.4
[164]
HepG2.C3A BARD1
Mean 4.15
Standard deviation 3.3
Values 1.8 6.4
[165]
HuH.7 BARD1
Mean 4.04
Standard deviation 1.6
Values 5.9 3 3.3
[166]
SNU475 BARD1
Mean 5.09
Standard deviation 0.31
Values 4.9 5.3
[167]
THLE BARD1
Mean 6.04
Standard deviation 1.7
Values 4.8 7.3
[168]
liver BARD1
Mean 2.22
Standard deviation 0.7
Values 1.4 3 1.9 2.5
[169]
ref_hepatocyte BRCA2
Mean 0.134
Standard deviation 0.16
Values 0.26 0.35 0 0.026 0.041
[170]
HepG2 BRCA2
Mean 2.06
Standard deviation 0.93
Values 1.4 2.7
[171]
HepG2.C3A BRCA2
Mean 10.4
Standard deviation 8.9
Values 4.1 17
[172]
HuH.7 BRCA2
Mean 11.2
Standard deviation 6.2
Values 18 5.9 9.6
[173]
SNU475 BRCA2
Mean 5.48
Standard deviation 3.4
Values 3.1 7.9
[174]
THLE BRCA2
Mean 6.84
Standard deviation 2
Values 8.2 5.4
[175]
liver BRCA2
Mean 2.07
Standard deviation 0.83
Values 1.6 3.3 1.7 1.6
[176]
ref_hepatocyte MRE11
Missing
[177]
HepG2 MRE11
Missing
[178]
HepG2.C3A MRE11
Missing
[179]
HuH.7 MRE11
Missing
[180]
SNU475 MRE11
Missing
[181]
THLE MRE11
Missing
[182]
liver MRE11
Missing