REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 APEX1 DNA-(apurinic or apyrimidinic site) lyase [1] 0.10[2] -0.35[3] 0.26[4] -0.92[5] -1.25[6] -0.82[7]
2 PARP1 Poly [ADP-ribose] polymerase 1 [8] 0.13[9] -0.22[10] 0.21[11] 0.42[12] -0.04[13] 0.44[14]
3 PCNA Proliferating cell nuclear antigen [15] 0.89[16] 0.78[17] -0.94[18] -0.33[19] -0.02[20] -2.22[21]
4 POLD2 DNA polymerase delta subunit 2 [22] -0.59[23] -0.52[24] -0.32[25] -0.98[26] -0.58[27] 0.73[28]
5 POLD4 DNA polymerase delta subunit 4 [29] -2.13[30] -2.57[31] -0.80[32] 1.33[33] -2.23[34] 0.38[35]
6 POLE3 DNA polymerase epsilon subunit 3 [36] -0.78[37] -1.02[38] -1.04[39] -1.16[40] -0.11[41] -0.72[42]
7 POLE4 DNA polymerase epsilon subunit 4 [43] -1.04[44] -0.41[45] -4.17[46] -1.74[47] -2.18[48] -0.95[49]
8 RPA2 Replication protein A 32 kDa subunit [50] -1.45[51] -1.48[52] -1.23[53] -0.85[54] -0.75[55] -1.54[56]
9 RFC4 Replication factor C subunit 4 [57] -0.96[58] -0.44[59] -0.17[60] -1.08[61] 0.28[62] -1.90[63]
10 POLB DNA polymerase beta [64] -0.93[65] -0.99[66] -1.24[67] -2.40[68] -2.18[69] -0.65[70]
11 PARP2 Poly [ADP-ribose] polymerase 2 [71] -0.07[72] -0.54[73] -0.10[74] -0.39[75] 0.41[76] -0.62[77]
12 RFC1 Replication factor C subunit 1 [78] 0.15[79] 1.33[80] 1.41[81] 0.21[82] 1.08[83] 1.63[84]
13 RFC2 Replication factor C subunit 2 [85] -0.26[86] -0.50[87] -0.77[88] 0.07[89] 0.55[90] 0.08[91]
14 FEN1 Flap endonuclease 1 [92] 1.03[93] 0.72[94] 1.27[95] 0.57[96] 1.49[97] -0.24[98]
15 RPA1 Replication protein A 70 kDa DNA-binding subunit [99] 1.32[100] 0.95[101] 0.92[102] 1.74[103] 1.78[104] 0.86[105]
16 RPA3 Replication protein A 14 kDa subunit [106] -0.36[107] 0.34[108] 0.75[109] -1.01[110] -0.71[111] 0.16[112]
17 RFC5 Replication factor C subunit 5 [113] 0.13[114] 0.49[115] 0.38[116] 0.16[117] 0.71[118] -0.02[119]
18 PARG Poly(ADP-ribose) glycohydrolase [120] -0.08[121] 0.85[122] -0.38[123] 0.65[124] 0.31[125] 1.31[126]
19 RFC3 Replication factor C subunit 3 [127] 1.18[128] 1.94[129] 1.77[130] 1.14[131] 1.76[132] -0.01[133]
20 LIG1 DNA ligase 1 [134] 1.64[135] 1.55[136] 1.88[137] 0.40[138] 1.16[139] 0.49[140]
21 POLD1 DNA polymerase delta catalytic subunit [141] 1.86[142] 1.99[143] 2.50[144] 1.71[145] 2.50[146] 1.52[147]
22 POLD3 DNA polymerase delta subunit 3 [148] 1.18[149] 0.95[150] 1.61[151] 2.00[152] 2.51[153] 1.84[154]
23 POLE DNA polymerase epsilon catalytic subunit A [155] 3.05[156] 3.57[157] 3.31[158] 2.63[159] 3.66[160] 3.79[161]
24 POLE2 DNA polymerase epsilon subunit 2 [162] 0.71[163] 1.40[164] 2.08[165] 1.04[166] 1.61[167] -0.30[168]
25 ADPRS [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte APEX1
Mean 47.5
Standard deviation 8.3
Values 54 48 56 42 37
[2]
HepG2 APEX1
Mean 112
Standard deviation 14
Values 1.2e+02 1e+02
[3]
HepG2.C3A APEX1
Mean 78.4
Standard deviation 5.9
Values 83 74
[4]
HuH.7 APEX1
Mean 142
Standard deviation 16
Values 1.4e+02 1.3e+02 1.6e+02
[5]
SNU475 APEX1
Mean 49.7
Standard deviation 2
Values 48 51
[6]
THLE APEX1
Mean 43.8
Standard deviation 9.3
Values 37 50
[7]
liver APEX1
Mean 21.1
Standard deviation 12
Values 32 12 31 9.4
[8]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 26 91 33 17 16
[9]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 84 93
[10]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 56 76
[11]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[12]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 1e+02 93
[13]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[14]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 51 31
[15]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[16]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[17]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[18]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[19]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[20]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[21]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[22]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[23]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[24]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[25]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[26]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[27]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[28]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[29]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[30]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[31]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[32]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[33]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[34]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[35]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[36]
ref_hepatocyte POLE3
Mean 29.6
Standard deviation 21
Values 23 62 36 15 11
[37]
HepG2 POLE3
Mean 37.9
Standard deviation 13
Values 29 47
[38]
HepG2.C3A POLE3
Mean 30.6
Standard deviation 16
Values 19 42
[39]
HuH.7 POLE3
Mean 36
Standard deviation 15
Values 40 20 48
[40]
SNU475 POLE3
Mean 26.1
Standard deviation 0.99
Values 25 27
[41]
THLE POLE3
Mean 60
Standard deviation 7.2
Values 55 65
[42]
liver POLE3
Mean 14.1
Standard deviation 6.6
Values 15 11 23 7.8
[43]
ref_hepatocyte POLE4
Mean 27.1
Standard deviation 15
Values 28 15 9.6 45 38
[44]
HepG2 POLE4
Mean 28.9
Standard deviation 4.6
Values 26 32
[45]
HepG2.C3A POLE4
Mean 43
Standard deviation 18
Values 30 56
[46]
HuH.7 POLE4
Mean 3.76
Standard deviation 1.5
Values 3.8 2.3 5.3
[47]
SNU475 POLE4
Mean 16.1
Standard deviation 1
Values 17 15
[48]
THLE POLE4
Mean 13
Standard deviation 1.2
Values 12 14
[49]
liver POLE4
Mean 11
Standard deviation 11
Values 24 1.7 18 1.1
[50]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[51]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[52]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[53]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[54]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[55]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[56]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[57]
ref_hepatocyte RFC4
Mean 11
Standard deviation 7.9
Values 17 21 9.8 4.7 2.4
[58]
HepG2 RFC4
Mean 12.4
Standard deviation 2.7
Values 10 14
[59]
HepG2.C3A RFC4
Mean 17
Standard deviation 7.7
Values 12 22
[60]
HuH.7 RFC4
Mean 24.4
Standard deviation 12
Values 26 12 35
[61]
SNU475 RFC4
Mean 10.3
Standard deviation 3.5
Values 7.8 13
[62]
THLE RFC4
Mean 29.1
Standard deviation 0.079
Values 29 29
[63]
liver RFC4
Mean 2.31
Standard deviation 1.2
Values 2.3 1.9 4 1
[64]
ref_hepatocyte POLB
Mean 10.8
Standard deviation 1.8
Values 9.3 13 12 8.8 11
[65]
HepG2 POLB
Mean 12.5
Standard deviation 2.5
Values 11 14
[66]
HepG2.C3A POLB
Mean 11.5
Standard deviation 2.8
Values 9.5 13
[67]
HuH.7 POLB
Mean 11.5
Standard deviation 2.4
Values 10 10 14
[68]
SNU475 POLB
Mean 4.06
Standard deviation 0.015
Values 4.1 4.1
[69]
THLE POLB
Mean 5.21
Standard deviation 0.74
Values 5.7 4.7
[70]
liver POLB
Mean 5.42
Standard deviation 4
Values 7.1 2.8 10 1.5
[71]
ref_hepatocyte PARP2
Mean 9.38
Standard deviation 6.1
Values 15 17 5.5 4.8 4.6
[72]
HepG2 PARP2
Mean 19.7
Standard deviation 5.2
Values 16 23
[73]
HepG2.C3A PARP2
Mean 13.6
Standard deviation 4
Values 11 16
[74]
HuH.7 PARP2
Mean 22
Standard deviation 9.2
Values 24 12 30
[75]
SNU475 PARP2
Mean 14.2
Standard deviation 3.8
Values 12 17
[76]
THLE PARP2
Mean 27.3
Standard deviation 2.1
Values 29 26
[77]
liver PARP2
Mean 4.8
Standard deviation 3.1
Values 8 2.1 6.9 2.2
[78]
ref_hepatocyte RFC1
Mean 9.26
Standard deviation 5.4
Values 15 15 7.1 4.1 5
[79]
HepG2 RFC1
Mean 22.5
Standard deviation 11
Values 15 30
[80]
HepG2.C3A RFC1
Mean 49.1
Standard deviation 4.6
Values 46 52
[81]
HuH.7 RFC1
Mean 61.4
Standard deviation 8.8
Values 66 67 51
[82]
SNU475 RFC1
Mean 21.2
Standard deviation 2
Values 20 23
[83]
THLE RFC1
Mean 42.7
Standard deviation 3.9
Values 45 40
[84]
liver RFC1
Mean 22.6
Standard deviation 3.4
Values 24 26 18 23
[85]
ref_hepatocyte RFC2
Mean 8.95
Standard deviation 3.2
Values 7.3 13 6.2 11 6.5
[86]
HepG2 RFC2
Mean 16.5
Standard deviation 2.8
Values 14 18
[87]
HepG2.C3A RFC2
Mean 13.3
Standard deviation 5.7
Values 9.3 17
[88]
HuH.7 RFC2
Mean 13.1
Standard deviation 6.2
Values 15 6.1 18
[89]
SNU475 RFC2
Mean 18.6
Standard deviation 4.4
Values 16 22
[90]
THLE RFC2
Mean 28.7
Standard deviation 3.4
Values 26 31
[91]
liver RFC2
Mean 7.44
Standard deviation 4.1
Values 10 4.9 11 3.1
[92]
ref_hepatocyte FEN1
Mean 8.88
Standard deviation 4.9
Values 17 9.6 7.8 7 3.4
[93]
HepG2 FEN1
Mean 40
Standard deviation 13
Values 31 49
[94]
HepG2.C3A FEN1
Mean 30.8
Standard deviation 20
Values 17 45
[95]
HuH.7 FEN1
Mean 53.6
Standard deviation 31
Values 63 19 79
[96]
SNU475 FEN1
Mean 26.1
Standard deviation 5.2
Values 22 30
[97]
THLE FEN1
Mean 54.6
Standard deviation 11
Values 47 62
[98]
liver FEN1
Mean 5.91
Standard deviation 2.9
Values 3.7 5.8 10 4.1
[99]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[100]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[101]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[102]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[103]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[104]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[105]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[106]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[107]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[108]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[109]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[110]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[111]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[112]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[113]
ref_hepatocyte RFC5
Mean 5.54
Standard deviation 4.9
Values 13 7.4 0.42 3.6 3.2
[114]
HepG2 RFC5
Mean 13.4
Standard deviation 5.4
Values 9.6 17
[115]
HepG2.C3A RFC5
Mean 16.4
Standard deviation 10
Values 9 24
[116]
HuH.7 RFC5
Mean 18.1
Standard deviation 6.8
Values 23 10 21
[117]
SNU475 RFC5
Mean 12.2
Standard deviation 2.4
Values 11 14
[118]
THLE RFC5
Mean 19.8
Standard deviation 2.4
Values 18 22
[119]
liver RFC5
Mean 4.29
Standard deviation 1.7
Values 4.9 3.5 6.3 2.5
[120]
ref_hepatocyte PARG
Mean 4.42
Standard deviation 2.1
Values 7 5.8 4.5 2.1 2.7
[121]
HepG2 PARG
Mean 9.22
Standard deviation 1.7
Values 8 10
[122]
HepG2.C3A PARG
Mean 16.8
Standard deviation 2.6
Values 15 19
[123]
HuH.7 PARG
Mean 8.52
Standard deviation 1
Values 9 7.3 9.2
[124]
SNU475 PARG
Mean 13.8
Standard deviation 1.1
Values 15 13
[125]
THLE PARG
Mean 12
Standard deviation 0.045
Values 12 12
[126]
liver PARG
Mean 8.64
Standard deviation 2.8
Values 6.1 12 7.2 8.9
[127]
ref_hepatocyte RFC3
Mean 3.17
Standard deviation 3.1
Values 6.3 6.7 1.4 0.35 1.1
[128]
HepG2 RFC3
Mean 15.8
Standard deviation 7.8
Values 10 21
[129]
HepG2.C3A RFC3
Mean 25.6
Standard deviation 17
Values 14 37
[130]
HuH.7 RFC3
Mean 27.1
Standard deviation 12
Values 35 14 33
[131]
SNU475 RFC3
Mean 13.8
Standard deviation 3.5
Values 11 16
[132]
THLE RFC3
Mean 23.5
Standard deviation 5.4
Values 20 27
[133]
liver RFC3
Mean 2.46
Standard deviation 0.85
Values 2 2.9 3.4 1.5
[134]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[135]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[136]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[137]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[138]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[139]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[140]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[141]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[142]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[143]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[144]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[145]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[146]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[147]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[148]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[149]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[150]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[151]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[152]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[153]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[154]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[155]
ref_hepatocyte POLE
Mean 1.41
Standard deviation 0.61
Values 1.7 0.95 0.68 1.5 2.2
[156]
HepG2 POLE
Mean 25.6
Standard deviation 5.9
Values 22 30
[157]
HepG2.C3A POLE
Mean 35.2
Standard deviation 15
Values 24 46
[158]
HuH.7 POLE
Mean 35.1
Standard deviation 18
Values 50 15 40
[159]
SNU475 POLE
Mean 17.2
Standard deviation 0.14
Values 17 17
[160]
THLE POLE
Mean 39
Standard deviation 5
Values 35 43
[161]
liver POLE
Mean 15.3
Standard deviation 8.7
Values 11 19 6 25
[162]
ref_hepatocyte POLE2
Mean 1.24
Standard deviation 0.85
Values 1.7 2.2 0.24 1.6 0.46
[163]
HepG2 POLE2
Mean 4.44
Standard deviation 2.1
Values 3 5.9
[164]
HepG2.C3A POLE2
Mean 6.88
Standard deviation 5.4
Values 3.1 11
[165]
HuH.7 POLE2
Mean 13.1
Standard deviation 7.8
Values 15 4.4 20
[166]
SNU475 POLE2
Mean 5.05
Standard deviation 2
Values 3.6 6.4
[167]
THLE POLE2
Mean 8.23
Standard deviation 0.9
Values 7.6 8.9
[168]
liver POLE2
Mean 0.788
Standard deviation 0.23
Values 0.68 1 0.9 0.53
[169]
ref_hepatocyte ADPRS
Missing
[170]
HepG2 ADPRS
Missing
[171]
HepG2.C3A ADPRS
Missing
[172]
HuH.7 ADPRS
Missing
[173]
SNU475 ADPRS
Missing
[174]
THLE ADPRS
Missing
[175]
liver ADPRS
Missing