REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.94[2] -1.41[3] -1.22[4] -1.35[5] -1.11[6] -0.71[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.49[16] -0.65[17] -0.85[18] -0.50[19] -0.74[20] -0.26[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 1.94[23] 1.58[24] 2.66[25] 0.90[26] 1.49[27] 0.51[28]
5 AKT1 RAC-alpha serine/threonine-protein kinase [29] 1.34[30] 0.84[31] -0.20[32] 1.38[33] 1.18[34] 0.92[35]
6 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 2.06[36] 1.62[37] 1.58[38] 2.64[39] 1.74[40] 1.31[41]
7 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.54[42] 1.36[43] 0.76[44] 2.17[45] 2.06[46] 1.06[47]
8 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.87[48] 0.26[49] 0.37[50] 0.97[51] 0.65[52] 0.18[53]
9 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 [54] 1.25[55] 0.73[56] 0.99[57] 1.51[58] 1.47[59] 0.98[60]
10 CCNG1 Cyclin-G1 [61] 2.06[62] 3.07[63] 3.16[64] 1.18[65] 1.34[66] 1.67[67]
11 DAXX Death domain-associated protein 6 [68] 1.43[69] 1.02[70] 0.65[71] 1.58[72] 1.23[73] 0.21[74]
12 PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 0.96[75] 1.56[76] 1.30[77] 2.37[78] 1.95[79] 0.97[80]
13 USP7 Ubiquitin carboxyl-terminal hydrolase 7 [81] 2.82[82] 2.35[83] 1.77[84] 1.52[85] 1.68[86] 1.70[87]
14 CDK2 Cyclin-dependent kinase 2 [88] 0.85[89] 0.75[90] 1.16[91] 1.41[92] 1.78[93] -1.02[94]
15 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1.71[95] 0.92[96] 1.37[97] 1.70[98] 1.26[99] 4.10[100]
16 AKT2 RAC-beta serine/threonine-protein kinase [101] 2.22[102] 2.23[103] 2.39[104] 2.29[105] 1.86[106] 2.30[107]
17 MLST8 Target of rapamycin complex subunit LST8 [108] 1.09[109] 1.15[110] 1.55[111] 0.45[112] 0.58[113] 0.60[114]
18 SGK1 Serine/threonine-protein kinase Sgk1 [115] 0.21[116] -1.02[117] 3.08[118] 1.05[119] 2.47[120] 2.26[121]
19 RFFL E3 ubiquitin-protein ligase rififylin [122] -0.55[123] -0.54[124] 0.20[125] -0.98[126] -2.16[127] -0.30[128]
20 RNF34 E3 ubiquitin-protein ligase RNF34 [129] 1.23[130] 0.81[131] 0.30[132] 0.83[133] 0.99[134] 0.67[135]
21 PRR5 Proline-rich protein 5 [136] 0.67[137] 0.46[138] -0.42[139] -0.86[140] -3.87[141] 0.39[142]
22 MDM2 E3 ubiquitin-protein ligase Mdm2 [143] 3.37[144] 4.52[145] 1.79[146] 1.94[147] 2.59[148] 3.33[149]
23 CDK1 Cyclin-dependent kinase 1 [150] 2.52[151] 4.31[152] 3.08[153] 3.70[154] 4.29[155] -1.30[156]
24 CHEK2 Serine/threonine-protein kinase Chk2 [157] 1.36[158] 1.54[159] 1.97[160] 1.18[161] 0.59[162] -2.11[163]
25 TP53 Cellular tumor antigen p53 [164] 2.90[165] 2.19[166] 2.99[167] 2.72[168] 2.16[169] 1.12[170]
26 PDPK1 3-phosphoinositide-dependent protein kinase 1 [171] 3.60[172] 4.52[173] 3.26[174] 2.87[175] 3.04[176] 3.67[177]
27 MTOR Serine/threonine-protein kinase mTOR [178] 3.80[179] 4.54[180] 4.14[181] 4.11[182] 3.97[183] 4.62[184]
28 CCNA2 Cyclin-A2 [185] 3.47[186] 4.21[187] 3.59[188] 3.43[189] 4.60[190] -0.06[191]
29 PHF20 PHD finger protein 20 [192] 3.40[193] 2.91[194] 3.50[195] 4.63[196] 3.43[197] 2.92[198]
30 RICTOR Rapamycin-insensitive companion of mTOR [199] 1.99[200] 3.80[201] 4.51[202] 3.78[203] 3.76[204] 4.68[205]
31 USP2 Ubiquitin carboxyl-terminal hydrolase 2 [206] 2.48[207] 1.87[208] 0.94[209] 1.14[210] -0.58[211] 1.30[212]
32 ATM Serine-protein kinase ATM [213] 4.29[214] 5.63[215] 5.39[216] 5.58[217] 4.85[218] 6.15[219]
33 MDM4 Protein Mdm4 [220] 2.90[221] 3.65[222] 4.12[223] 3.72[224] 3.38[225] 5.72[226]
34 AKT3 RAC-gamma serine/threonine-protein kinase [227] -0.58[228] -3.41[229] -2.68[230] 7.27[231] 6.00[232] 4.77[233]
35 CDKN2A Cyclin-dependent kinase inhibitor 2A [234] 5.35[235] 2.84[236] 6.28[237] 6.64[238] 8.20[239] -0.99[240]
36 PRDM1 PR domain zinc finger protein 1 [241] -2.55[242] -4.65[243] 2.47[244] 4.79[245] 2.25[246] 4.53[247]
37 CCNA1 Cyclin-A1 [248] [249] -2.40[250] [251] 0.64[252] 7.82[253] [254]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[30]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[31]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[32]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[33]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[34]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[35]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[36]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[37]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[38]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[39]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[40]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[41]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[42]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[43]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[44]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[45]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[46]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[47]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[48]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[49]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[50]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[51]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[52]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[53]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[54]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[55]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[56]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[57]
ref_hepatocyte MAPKAP1
Mean 18.9
Standard deviation 8.4
Values 14 33 18 16 13
[58]
HepG2 MAPKAP1
Mean 41.3
Standard deviation 6.5
Values 37 46
[59]
HepG2.C3A MAPKAP1
Mean 31
Standard deviation 5.4
Values 27 35
[60]
HuH.7 MAPKAP1
Mean 34.6
Standard deviation 7.1
Values 38 26 40
[61]
SNU475 MAPKAP1
Mean 36.6
Standard deviation 8.3
Values 43 31
[62]
THLE MAPKAP1
Mean 46.7
Standard deviation 15
Values 36 57
[63]
liver MAPKAP1
Mean 23.6
Standard deviation 2.7
Values 23 26 20 25
[64]
ref_hepatocyte CCNG1
Mean 17.9
Standard deviation 7.2
Values 25 14 7.2 21 22
[65]
HepG2 CCNG1
Mean 68.7
Standard deviation 14
Values 59 78
[66]
HepG2.C3A CCNG1
Mean 148
Standard deviation 22
Values 1.6e+02 1.3e+02
[67]
HuH.7 CCNG1
Mean 148
Standard deviation 22
Values 1.5e+02 1.7e+02 1.3e+02
[68]
SNU475 CCNG1
Mean 27.6
Standard deviation 13
Values 37 19
[69]
THLE CCNG1
Mean 40.2
Standard deviation 2.8
Values 42 38
[70]
liver CCNG1
Mean 36.1
Standard deviation 12
Values 53 26 32 33
[71]
ref_hepatocyte DAXX
Mean 15.6
Standard deviation 11
Values 9.6 22 31 9.5 5.8
[72]
HepG2 DAXX
Mean 38.8
Standard deviation 3.2
Values 36 41
[73]
HepG2.C3A DAXX
Mean 31.3
Standard deviation 3.1
Values 29 33
[74]
HuH.7 DAXX
Mean 22.7
Standard deviation 6
Values 23 16 28
[75]
SNU475 DAXX
Mean 31.9
Standard deviation 3.2
Values 30 34
[76]
THLE DAXX
Mean 32.7
Standard deviation 1.7
Values 32 34
[77]
liver DAXX
Mean 11.4
Standard deviation 6
Values 15 6 18 6.5
[78]
ref_hepatocyte PPP2R5C
Mean 14.1
Standard deviation 2.7
Values 15 17 10 13 15
[79]
HepG2 PPP2R5C
Mean 25.2
Standard deviation 5.7
Values 21 29
[80]
HepG2.C3A PPP2R5C
Mean 41.3
Standard deviation 0.87
Values 41 42
[81]
HuH.7 PPP2R5C
Mean 32.2
Standard deviation 4.1
Values 31 37 29
[82]
SNU475 PPP2R5C
Mean 49.7
Standard deviation 5.7
Values 54 46
[83]
THLE PPP2R5C
Mean 48.8
Standard deviation 6.3
Values 44 53
[84]
liver PPP2R5C
Mean 17.5
Standard deviation 1.8
Values 18 20 16 16
[85]
ref_hepatocyte USP7
Mean 13.8
Standard deviation 9.3
Values 30 11 13 8.6 6.8
[86]
HepG2 USP7
Mean 90
Standard deviation 14
Values 80 1e+02
[87]
HepG2.C3A USP7
Mean 69.8
Standard deviation 2.3
Values 68 71
[88]
HuH.7 USP7
Mean 43.7
Standard deviation 8.8
Values 52 35 44
[89]
SNU475 USP7
Mean 27.1
Standard deviation 1.8
Values 26 28
[90]
THLE USP7
Mean 39.6
Standard deviation 7.8
Values 34 45
[91]
liver USP7
Mean 28.4
Standard deviation 9.3
Values 24 38 18 34
[92]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 19 28 3.3 5.7 4.6
[93]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 18 22
[94]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 14 26
[95]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 30 11 33
[96]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 20 24
[97]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[98]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 4.4 2.3 5.2 3.2
[99]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[100]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[101]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[102]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[103]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[104]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[105]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[106]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[107]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[108]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[109]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[110]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[111]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[112]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[113]
ref_hepatocyte MLST8
Mean 10
Standard deviation 3.8
Values 7 5.5 14 14 10
[114]
HepG2 MLST8
Mean 19.6
Standard deviation 1.4
Values 21 19
[115]
HepG2.C3A MLST8
Mean 22
Standard deviation 3.6
Values 24 19
[116]
HuH.7 MLST8
Mean 27.2
Standard deviation 3.6
Values 28 23 30
[117]
SNU475 MLST8
Mean 9.36
Standard deviation 0.84
Values 9.9 8.8
[118]
THLE MLST8
Mean 13.3
Standard deviation 1.9
Values 12 15
[119]
liver MLST8
Mean 9.64
Standard deviation 7.6
Values 17 2.5 15 3.8
[120]
ref_hepatocyte SGK1
Mean 9.78
Standard deviation 9
Values 10 0.53 6.9 25 6.8
[121]
HepG2 SGK1
Mean 10.4
Standard deviation 8
Values 4.7 16
[122]
HepG2.C3A SGK1
Mean 4.78
Standard deviation 1.7
Values 6 3.6
[123]
HuH.7 SGK1
Mean 76.3
Standard deviation 7.9
Values 75 85 69
[124]
SNU475 SGK1
Mean 13.8
Standard deviation 1.6
Values 15 13
[125]
THLE SGK1
Mean 48.3
Standard deviation 15
Values 37 59
[126]
liver SGK1
Mean 29.6
Standard deviation 5.6
Values 30 22 32 34
[127]
ref_hepatocyte RFFL
Mean 8.95
Standard deviation 3.9
Values 3.7 7.7 14 9.8 9.1
[128]
HepG2 RFFL
Mean 5.61
Standard deviation 0.65
Values 6.1 5.2
[129]
HepG2.C3A RFFL
Mean 6.1
Standard deviation 0.19
Values 6 6.2
[130]
HuH.7 RFFL
Mean 9.52
Standard deviation 2.3
Values 11 11 6.9
[131]
SNU475 RFFL
Mean 3.1
Standard deviation 0.02
Values 3.1 3.1
[132]
THLE RFFL
Mean 1.79
Standard deviation 0.5
Values 1.4 2.1
[133]
liver RFFL
Mean 4.62
Standard deviation 1
Values 3.2 5.2 4.4 5.6
[134]
ref_hepatocyte RNF34
Mean 8.7
Standard deviation 5
Values 14 13 8 4.1 3.6
[135]
HepG2 RNF34
Mean 18.8
Standard deviation 2.1
Values 17 20
[136]
HepG2.C3A RNF34
Mean 15
Standard deviation 5.5
Values 11 19
[137]
HuH.7 RNF34
Mean 9.91
Standard deviation 2.4
Values 10 7.2 12
[138]
SNU475 RNF34
Mean 10.6
Standard deviation 0.6
Values 11 10
[139]
THLE RNF34
Mean 15.4
Standard deviation 2.8
Values 13 17
[140]
liver RNF34
Mean 8.74
Standard deviation 2.3
Values 9.3 7.8 12 6.2
[141]
ref_hepatocyte PRR5
Mean 7.43
Standard deviation 4.5
Values 11 2 3.1 10 11
[142]
HepG2 PRR5
Mean 10.9
Standard deviation 2.6
Values 13 9.1
[143]
HepG2.C3A PRR5
Mean 10.1
Standard deviation 0.29
Values 10 9.9
[144]
HuH.7 PRR5
Mean 5.13
Standard deviation 0.59
Values 4.7 4.9 5.8
[145]
SNU475 PRR5
Mean 2.8
Standard deviation 0.093
Values 2.7 2.9
[146]
THLE PRR5
Mean 0.452
Standard deviation 0.2
Values 0.31 0.59
[147]
liver PRR5
Mean 6.15
Standard deviation 3.4
Values 7.7 2.9 10 3.9
[148]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 11 7.6 5 3.6 4.8
[149]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 51 70
[150]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.1e+02 1.8e+02
[151]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 21 20 20
[152]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 18 15
[153]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[154]
liver MDM2
Mean 40.5
Standard deviation 11
Values 29 54 35 45
[155]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[156]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[157]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[158]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[159]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[160]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[161]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[162]
ref_hepatocyte CHEK2
Mean 5.74
Standard deviation 6.1
Values 16 5.5 4.2 1.7 1.1
[163]
HepG2 CHEK2
Mean 13.6
Standard deviation 0.16
Values 13 14
[164]
HepG2.C3A CHEK2
Mean 16.4
Standard deviation 6.4
Values 12 21
[165]
HuH.7 CHEK2
Mean 20.8
Standard deviation 7.6
Values 22 13 28
[166]
SNU475 CHEK2
Mean 8.87
Standard deviation 0.55
Values 8.5 9.3
[167]
THLE CHEK2
Mean 7.68
Standard deviation 1.3
Values 6.8 8.6
[168]
liver CHEK2
Mean 0.84
Standard deviation 0.33
Values 0.87 0.88 1.2 0.4
[169]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[170]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[171]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[172]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[173]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[174]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[175]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[176]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[177]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[178]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[179]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[180]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[181]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[182]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[183]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 2.6 3.1 4.3 3.5 3.2
[184]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 38 47
[185]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 89 65
[186]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 73 50 41
[187]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 39 40
[188]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[189]
liver MTOR
Mean 51.8
Standard deviation 18
Values 34 72 39 62
[190]
ref_hepatocyte CCNA2
Mean 3.28
Standard deviation 3.7
Values 7 7.5 0.2 1.1 0.57
[191]
HepG2 CCNA2
Mean 33.4
Standard deviation 16
Values 22 44
[192]
HepG2.C3A CCNA2
Mean 60.1
Standard deviation 42
Values 30 90
[193]
HuH.7 CCNA2
Mean 36.5
Standard deviation 15
Values 47 20 43
[194]
SNU475 CCNA2
Mean 24.1
Standard deviation 0.4
Values 24 24
[195]
THLE CCNA2
Mean 71
Standard deviation 9.4
Values 64 78
[196]
liver CCNA2
Mean 1.99
Standard deviation 1.7
Values 0.85 3.4 3.5 0.21
[197]
ref_hepatocyte PHF20
Mean 2.01
Standard deviation 1
Values 3.4 2.8 1.4 1.2 1.3
[198]
HepG2 PHF20
Mean 19.5
Standard deviation 1.2
Values 19 20
[199]
HepG2.C3A PHF20
Mean 15
Standard deviation 0.61
Values 15 15
[200]
HuH.7 PHF20
Mean 21.1
Standard deviation 3.1
Values 24 21 18
[201]
SNU475 PHF20
Mean 34.1
Standard deviation 4.1
Values 37 31
[202]
THLE PHF20
Mean 19.4
Standard deviation 2.6
Values 18 21
[203]
liver PHF20
Mean 9.65
Standard deviation 1.1
Values 11 9 9.3 8.9
[204]
ref_hepatocyte RICTOR
Mean 1.67
Standard deviation 0.88
Values 2.2 2.1 2.6 0.49 1
[205]
HepG2 RICTOR
Mean 6.11
Standard deviation 1
Values 5.4 6.8
[206]
HepG2.C3A RICTOR
Mean 23
Standard deviation 1
Values 22 24
[207]
HuH.7 RICTOR
Mean 35.2
Standard deviation 17
Values 31 54 21
[208]
SNU475 RICTOR
Mean 15.7
Standard deviation 0.97
Values 16 15
[209]
THLE RICTOR
Mean 20.3
Standard deviation 7.9
Values 26 15
[210]
liver RICTOR
Mean 27.1
Standard deviation 8.5
Values 24 35 17 33
[211]
ref_hepatocyte USP2
Mean 1.28
Standard deviation 0.47
Values 1.7 1.4 1.2 1.6 0.52
[212]
HepG2 USP2
Mean 6.54
Standard deviation 0.021
Values 6.5 6.6
[213]
HepG2.C3A USP2
Mean 4.63
Standard deviation 0.13
Values 4.7 4.5
[214]
HuH.7 USP2
Mean 2.26
Standard deviation 0.065
Values 2.2 2.2 2.3
[215]
SNU475 USP2
Mean 1.92
Standard deviation 0.082
Values 2 1.9
[216]
THLE USP2
Mean 0.761
Standard deviation 0.26
Values 0.58 0.94
[217]
liver USP2
Mean 1.98
Standard deviation 0.74
Values 2.7 0.96 2.3 2
[218]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 2.1 0.69 0.27 0.7 1.1
[219]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 12 23
[220]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 44 51
[221]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 41 44 27
[222]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 38 26
[223]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[224]
liver ATM
Mean 43.7
Standard deviation 31
Values 17 76 17 64
[225]
ref_hepatocyte MDM4
Mean 0.953
Standard deviation 0.42
Values 1.6 0.7 0.53 0.84 1.1
[226]
HepG2 MDM4
Mean 6.55
Standard deviation 0.35
Values 6.8 6.3
[227]
HepG2.C3A MDM4
Mean 11.8
Standard deviation 4.8
Values 15 8.4
[228]
HuH.7 MDM4
Mean 15.3
Standard deviation 0.63
Values 15 16 15
[229]
SNU475 MDM4
Mean 8.57
Standard deviation 2.6
Values 10 6.7
[230]
THLE MDM4
Mean 8.85
Standard deviation 2.2
Values 10 7.3
[231]
liver MDM4
Mean 31.9
Standard deviation 8.3
Values 25 40 24 38
[232]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[233]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[234]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[235]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[236]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[237]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[238]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[239]
ref_hepatocyte CDKN2A
Mean 0.323
Standard deviation 0.62
Values 1.4 0 0 0.13 0.065
[240]
HepG2 CDKN2A
Mean 12.1
Standard deviation 5.5
Values 16 8.2
[241]
HepG2.C3A CDKN2A
Mean 2.29
Standard deviation 0.19
Values 2.1 2.4
[242]
HuH.7 CDKN2A
Mean 23.3
Standard deviation 9
Values 24 14 32
[243]
SNU475 CDKN2A
Mean 21.9
Standard deviation 6.8
Values 27 17
[244]
THLE CDKN2A
Mean 84.5
Standard deviation 8.9
Values 78 91
[245]
liver CDKN2A
Mean 0.103
Standard deviation 0.079
Values 0.21 0.071 0.1 0.026
[246]
ref_hepatocyte PRDM1
Mean 0.123
Standard deviation 0.21
Values 0 0 0 0.12 0.5
[247]
HepG2 PRDM1
Mean 0.0193
Standard deviation 0.021
Values 0.034 0.0043
[248]
HepG2.C3A PRDM1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[249]
HuH.7 PRDM1
Mean 0.63
Standard deviation 0.2
Values 0.55 0.85 0.49
[250]
SNU475 PRDM1
Mean 2.32
Standard deviation 0.44
Values 2 2.6
[251]
THLE PRDM1
Mean 0.522
Standard deviation 0.015
Values 0.53 0.51
[252]
liver PRDM1
Mean 1.81
Standard deviation 1.3
Values 3.6 0.87 1.9 0.9
[253]
ref_hepatocyte CCNA1
Mean 0.0259
Standard deviation 0.058
Values 0.13 0 0 0 0
[254]
HepG2 CCNA1
Mean 0
Standard deviation 0
Values 0 0
[255]
HepG2.C3A CCNA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[256]
HuH.7 CCNA1
Mean 0
Standard deviation 0
Values 0 0 0
[257]
SNU475 CCNA1
Mean 0.0274
Standard deviation 0.026
Values 0.0093 0.046
[258]
THLE CCNA1
Mean 5.22
Standard deviation 2.3
Values 3.6 6.9
[259]
liver CCNA1
Mean 0
Standard deviation 0
Values 0 0 0 0