REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.19[2] | -1.57[3] | -1.57[4] | -1.70[5] | -1.40[6] | -0.75[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.74[16] | -0.82[17] | -1.21[18] | -0.85[19] | -1.02[20] | -0.30[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 1.69[23] | 1.41[24] | 2.30[25] | 0.55[26] | 1.21[27] | 0.47[28] |
5 | CSNK2B | Casein kinase II subunit beta | [29] | 0.67[30] | 0.32[31] | -0.46[32] | 0.08[33] | -0.33[34] | -0.38[35] |
6 | TAF9 | Transcription initiation factor TFIID subunit 9 | [36] | -0.10[37] | 0.48[38] | -0.15[39] | -0.17[40] | -0.07[41] | -0.03[42] |
7 | CSNK2A1 | Casein kinase II subunit alpha | [43] | 1.13[44] | 0.82[45] | 0.59[46] | 0.72[47] | 0.20[48] | -0.61[49] |
8 | TAF10 | Transcription initiation factor TFIID subunit 10 | [50] | -0.75[51] | -1.19[52] | -0.79[53] | -0.69[54] | -1.49[55] | -1.50[56] |
9 | SSRP1 | FACT complex subunit SSRP1 | [57] | 1.66[58] | 1.05[59] | 1.19[60] | 1.26[61] | 1.60[62] | -0.42[63] |
10 | TAF7 | Transcription initiation factor TFIID subunit 7 | [64] | 0.89[65] | 0.96[66] | 0.56[67] | 0.96[68] | 0.85[69] | 0.34[70] |
11 | NOC2L | Nucleolar complex protein 2 homolog | [71] | 1.33[72] | 1.07[73] | 0.69[74] | 0.87[75] | 0.89[76] | -0.10[77] |
12 | TAF13 | Transcription initiation factor TFIID subunit 13 | [78] | -2.25[79] | -2.56[80] | -3.63[81] | -1.66[82] | -1.91[83] | -3.10[84] |
13 | RPA2 | Replication protein A 32 kDa subunit | [85] | -0.45[86] | -0.56[87] | -0.15[88] | 0.33[89] | 0.26[90] | -1.27[91] |
14 | TAF15 | TATA-binding protein-associated factor 2N | [92] | 1.15[93] | 0.35[94] | 1.07[95] | 1.23[96] | 1.50[97] | -1.00[98] |
15 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [99] | -0.40[100] | -0.06[101] | -0.09[102] | 0.73[103] | 0.29[104] | -0.52[105] |
16 | PIN1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | [106] | -0.02[107] | -0.15[108] | -0.06[109] | -0.58[110] | 0.40[111] | -0.23[112] |
17 | SUPT16H | FACT complex subunit SPT16 | [113] | 2.62[114] | 1.73[115] | 2.33[116] | 2.56[117] | 2.60[118] | 1.08[119] |
18 | TAF11 | Transcription initiation factor TFIID subunit 11 | [120] | 0.42[121] | 0.51[122] | -0.36[123] | 0.81[124] | 0.08[125] | -0.80[126] |
19 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [127] | -3.04[128] | -8.33[129] | -2.05[130] | -0.66[131] | -0.68[132] | 0.65[133] |
20 | TAF12 | Transcription initiation factor TFIID subunit 12 | [134] | -0.63[135] | -0.96[136] | -0.09[137] | -0.18[138] | -0.62[139] | -0.55[140] |
21 | STK11 | Serine/threonine-protein kinase STK11 | [141] | 0.93[142] | 0.69[143] | 0.78[144] | 0.37[145] | 0.57[146] | 0.27[147] |
22 | CDK2 | Cyclin-dependent kinase 2 | [148] | 0.60[149] | 0.58[150] | 0.80[151] | 1.06[152] | 1.49[153] | -1.06[154] |
23 | RFC4 | Replication factor C subunit 4 | [155] | 0.04[156] | 0.48[157] | 0.91[158] | 0.11[159] | 1.29[160] | -1.63[161] |
24 | MAPKAPK | MAP kinase-activated protein kinase 5 | [162] | 0.18[163] | 0.84[164] | 0.63[165] | -0.13[166] | -0.04[167] | 0.17[168] |
25 | RFC2 | Replication factor C subunit 2 | [169] | 0.75[170] | 0.42[171] | 0.31[172] | 1.26[173] | 1.56[174] | 0.35[175] |
26 | MAPK14 | Mitogen-activated protein kinase 14 | [176] | 2.49[177] | 2.37[178] | 1.79[179] | 2.76[180] | 2.08[181] | 2.41[182] |
27 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [183] | 2.33[184] | 1.87[185] | 2.00[186] | 2.93[187] | 2.79[188] | 1.13[189] |
28 | RPA3 | Replication protein A 14 kDa subunit | [190] | 0.64[191] | 1.26[192] | 1.83[193] | 0.17[194] | 0.30[195] | 0.44[196] |
29 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [197] | 0.93[198] | 2.03[199] | 3.39[200] | 2.54[201] | 2.66[202] | 3.19[203] |
30 | TP53INP1 | Tumor protein p53-inducible nuclear protein 1 | [204] | 1.37[205] | 1.42[206] | 0.52[207] | 1.28[208] | 0.21[209] | 4.15[210] |
31 | CSNK2A2 | Casein kinase II subunit alpha' | [211] | 1.21[212] | 1.09[213] | 0.93[214] | 0.67[215] | 0.71[216] | -1.08[217] |
32 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [218] | 1.90[219] | 2.90[220] | 2.86[221] | 2.10[222] | 0.92[223] | 2.54[224] |
33 | AURKA | Aurora kinase A | [225] | 2.72[226] | 2.79[227] | 2.14[228] | 2.69[229] | 2.45[230] | -1.68[231] |
34 | RAD17 | Cell cycle checkpoint protein RAD17 | [232] | 0.16[233] | 1.07[234] | 0.96[235] | 0.73[236] | 0.93[237] | 0.69[238] |
35 | KAT5 | Histone acetyltransferase KAT5 | [239] | 0.23[240] | 0.46[241] | -0.72[242] | 0.24[243] | 0.00[244] | 0.06[245] |
36 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [246] | 3.12[247] | 4.36[248] | 1.44[249] | 1.59[250] | 2.31[251] | 3.29[252] |
37 | NBN | Nibrin | [253] | 0.60[254] | 1.59[255] | 1.19[256] | 2.58[257] | 1.55[258] | 2.40[259] |
38 | TBP | TATA-box-binding protein | [260] | 0.79[261] | 0.90[262] | -0.44[263] | -0.01[264] | 0.64[265] | 0.05[266] |
39 | CHEK2 | Serine/threonine-protein kinase Chk2 | [267] | 1.11[268] | 1.37[269] | 1.62[270] | 0.83[271] | 0.30[272] | -2.15[273] |
40 | TAF6 | Transcription initiation factor TFIID subunit 6 | [274] | 1.96[275] | 1.33[276] | 1.70[277] | 1.89[278] | 2.11[279] | 0.97[280] |
41 | RFC5 | Replication factor C subunit 5 | [281] | 1.14[282] | 1.42[283] | 1.46[284] | 1.34[285] | 1.72[286] | 0.25[287] |
42 | AURKB | Aurora kinase B | [288] | 1.60[289] | 1.77[290] | 2.65[291] | 1.42[292] | 1.80[293] | -2.22[294] |
43 | TP53 | Cellular tumor antigen p53 | [295] | 2.65[296] | 2.03[297] | 2.63[298] | 2.37[299] | 1.88[300] | 1.09[301] |
44 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [302] | 1.72[303] | 2.07[304] | 1.07[305] | 1.01[306] | 0.96[307] | 1.13[308] |
45 | TP53RK | TP53-regulating kinase | [309] | 2.24[310] | 2.04[311] | -0.12[312] | 1.54[313] | 1.15[314] | 1.05[315] |
46 | CDK5 | Cyclin-dependent-like kinase 5 | [316] | 1.25[317] | 0.37[318] | 0.27[319] | 1.71[320] | 0.34[321] | 0.25[322] |
47 | TPX2 | Targeting protein for Xklp2 | [323] | 4.28[324] | 4.02[325] | 4.85[326] | 4.47[327] | 4.40[328] | -0.10[329] |
48 | HIPK2 | Homeodomain-interacting protein kinase 2 | [330] | 3.01[331] | 3.14[332] | 2.33[333] | 3.80[334] | 3.76[335] | 5.57[336] |
49 | RAD50 | DNA repair protein RAD50 | [337] | 1.16[338] | 3.11[339] | 2.11[340] | 2.34[341] | 2.68[342] | 3.33[343] |
50 | RMI2 | RecQ-mediated genome instability protein 2 | [344] | 2.26[345] | 1.36[346] | 1.16[347] | -0.12[348] | 0.03[349] | -3.30[350] |
51 | RBBP8 | DNA endonuclease RBBP8 | [351] | 1.21[352] | 2.43[353] | 0.91[354] | 2.51[355] | 2.56[356] | 1.37[357] |
52 | HIPK1 | Homeodomain-interacting protein kinase 1 | [358] | 2.58[359] | 2.43[360] | 3.21[361] | 3.28[362] | 2.98[363] | 3.38[364] |
53 | TAF9B | Transcription initiation factor TFIID subunit 9B | [365] | 0.97[366] | 1.77[367] | 1.62[368] | 2.29[369] | 2.16[370] | 1.80[371] |
54 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [372] | 2.04[373] | 2.88[374] | 2.89[375] | 3.21[376] | 3.46[377] | 2.01[378] |
55 | CCNA2 | Cyclin-A2 | [379] | 3.22[380] | 4.04[381] | 3.23[382] | 3.08[383] | 4.32[384] | -0.10[385] |
56 | RFC3 | Replication factor C subunit 3 | [386] | 2.19[387] | 2.86[388] | 2.85[389] | 2.33[390] | 2.77[391] | 0.26[392] |
57 | HUS1 | Checkpoint protein HUS1 | [393] | 0.29[394] | 0.38[395] | 0.77[396] | 0.97[397] | 0.62[398] | 2.50[399] |
58 | TAF4 | Transcription initiation factor TFIID subunit 4 | [400] | 2.42[401] | 1.84[402] | 1.46[403] | 1.84[404] | 0.73[405] | 0.76[406] |
59 | TAF2 | Transcription initiation factor TFIID subunit 2 | [407] | 1.61[408] | 2.11[409] | 2.43[410] | 3.05[411] | 2.75[412] | 3.04[413] |
60 | CHEK1 | Serine/threonine-protein kinase Chk1 | [414] | 2.55[415] | 2.72[416] | 2.14[417] | 3.23[418] | 3.30[419] | -0.90[420] |
61 | PLK3 | Serine/threonine-protein kinase PLK3 | [421] | 1.71[422] | 1.40[423] | -1.80[424] | 0.15[425] | 1.22[426] | -0.18[427] |
62 | TAF3 | Transcription initiation factor TFIID subunit 3 | [428] | 1.14[429] | 0.69[430] | 0.92[431] | 1.75[432] | 1.47[433] | 1.51[434] |
63 | TOP3A | DNA topoisomerase 3-alpha | [435] | 2.98[436] | 2.46[437] | 2.61[438] | 2.92[439] | 3.16[440] | 2.92[441] |
64 | RAD1 | Cell cycle checkpoint protein RAD1 | [442] | 2.38[443] | 2.87[444] | 3.25[445] | 2.88[446] | 3.62[447] | 2.03[448] |
65 | RAD9A | Cell cycle checkpoint control protein RAD9A | [449] | 1.08[450] | 1.18[451] | 2.84[452] | 3.41[453] | 1.08[454] | 0.95[455] |
66 | BRCA1 | Breast cancer type 1 susceptibility protein | [456] | 2.68[457] | 3.74[458] | 3.98[459] | 3.22[460] | 3.59[461] | 2.80[462] |
67 | ATRIP | ATR-interacting protein | [463] | 1.26[464] | 1.31[465] | 2.04[466] | 0.73[467] | 1.66[468] | 0.96[469] |
68 | ATR | Serine/threonine-protein kinase ATR | [470] | 2.11[471] | 2.92[472] | 2.85[473] | 3.61[474] | 3.41[475] | 4.68[476] |
69 | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | [477] | 2.18[478] | 2.34[479] | 3.70[480] | 3.83[481] | 2.65[482] | 3.18[483] |
70 | WRN | Werner syndrome ATP-dependent helicase | [484] | 1.62[485] | 2.90[486] | 4.68[487] | 2.78[488] | 2.44[489] | 3.10[490] |
71 | TAF1 | Transcription initiation factor TFIID subunit 1 | [491] | 2.97[492] | 3.29[493] | 2.50[494] | 4.19[495] | 3.33[496] | 4.27[497] |
72 | RMI1 | RecQ-mediated genome instability protein 1 | [498] | 1.59[499] | 2.64[500] | 2.94[501] | 3.15[502] | 3.85[503] | 2.11[504] |
73 | TAF5 | Transcription initiation factor TFIID subunit 5 | [505] | 1.24[506] | 2.08[507] | 3.33[508] | 0.97[509] | 2.12[510] | 1.53[511] |
74 | ATM | Serine-protein kinase ATM | [512] | 4.04[513] | 5.46[514] | 5.03[515] | 5.23[516] | 4.56[517] | 6.11[518] |
75 | MDM4 | Protein Mdm4 | [519] | 2.65[520] | 3.48[521] | 3.76[522] | 3.37[523] | 3.10[524] | 5.69[525] |
76 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [526] | 4.05[527] | 4.31[528] | 4.18[529] | 4.12[530] | 2.01[531] | 2.98[532] |
77 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [533] | 2.77[534] | 4.36[535] | 3.41[536] | 3.72[537] | 3.23[538] | 2.69[539] |
78 | EXO1 | Exonuclease 1 | [540] | 2.92[541] | 3.02[542] | 4.03[543] | 4.85[544] | 3.98[545] | -0.34[546] |
79 | NUAK1 | NUAK family SNF1-like kinase 1 | [547] | 3.66[548] | -0.58[549] | 3.38[550] | 4.30[551] | 3.31[552] | 4.59[553] |
80 | BRIP1 | Fanconi anemia group J protein | [554] | 3.16[555] | 4.37[556] | 4.23[557] | 4.28[558] | 4.17[559] | 3.09[560] |
81 | BLM | Bloom syndrome protein | [561] | 2.56[562] | 3.72[563] | 4.38[564] | 3.97[565] | 3.90[566] | 0.74[567] |
82 | BARD1 | BRCA1-associated RING domain protein 1 | [568] | 2.33[569] | 3.13[570] | 3.00[571] | 3.77[572] | 3.70[573] | 3.00[574] |
83 | MAPK11 | Mitogen-activated protein kinase 11 | [575] | 0.84[576] | 0.55[577] | -0.49[578] | 1.43[579] | 3.27[580] | 1.29[581] |
84 | CDK5R1 | Cyclin-dependent kinase 5 activator 1 | [582] | 3.10[583] | 2.69[584] | 2.70[585] | 3.05[586] | 2.26[587] | 0.76[588] |
85 | TAF4B | Transcription initiation factor TFIID subunit 4B | [589] | 3.04[590] | 3.24[591] | [592] | 4.08[593] | 4.29[594] | 2.03[595] |
86 | RAD9B | Cell cycle checkpoint control protein RAD9B | [596] | -2.32[597] | 0.70[598] | -0.15[599] | 1.51[600] | 0.69[601] | 0.34[602] |
87 | TAF7L | Transcription initiation factor TFIID subunit 7-like | [603] | -4.91[604] | -3.75[605] | -1.23[606] | -1.07[607] | -0.72[608] | 2.87[609] |
88 | TAF1L | Transcription initiation factor TFIID subunit 1-like | [610] | -0.71[611] | -0.07[612] | -1.90[613] | 0.30[614] | -1.07[615] | -0.07[616] |
89 | CCNA1 | Cyclin-A1 | [617] | [618] | -2.56[619] | [620] | 0.29[621] | 7.54[622] | [623] |
90 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [624] | -0.73[625] | [626] | -1.39[627] | 0.06[628] | [629] | 4.25[630] |
91 | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | MRE11 | Double-strand break repair protein MRE11 | [638] | [639] | [640] | [641] | [642] | [643] | [644] |