REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.55[2] -0.74[3] -0.69[4] -0.59[5] -0.31[6] -0.18[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.11[16] 0.01[17] -0.32[18] 0.26[19] 0.07[20] 0.27[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.33[23] 2.25[24] 3.19[25] 1.66[26] 2.29[27] 1.04[28]
5 PRMT5 Protein arginine N-methyltransferase 5 [29] 3.03[30] 1.01[31] 1.53[32] 1.84[33] 1.99[34] 0.37[35]
6 SMYD2 N-lysine methyltransferase SMYD2 [36] 2.09[37] 2.10[38] 0.94[39] 1.35[40] 0.39[41] 0.71[42]
7 MDM2 E3 ubiquitin-protein ligase Mdm2 [43] 3.76[44] 5.19[45] 2.33[46] 2.70[47] 3.39[48] 3.86[49]
8 CHEK2 Serine/threonine-protein kinase Chk2 [50] 1.75[51] 2.20[52] 2.51[53] 1.94[54] 1.39[55] -1.58[56]
9 TP53 Cellular tumor antigen p53 [57] 3.29[58] 2.86[59] 3.52[60] 3.48[61] 2.96[62] 1.66[63]
10 EHMT2 Histone-lysine N-methyltransferase EHMT2 [64] 4.12[65] 3.75[66] 3.72[67] 4.85[68] 3.39[69] 1.96[70]
11 EHMT1 Histone-lysine N-methyltransferase EHMT1 [71] 3.29[72] 3.10[73] 3.33[74] 3.88[75] 3.31[76] 3.60[77]
12 SETD9 SET domain-containing protein 9 [78] 0.10[79] 1.23[80] -0.12[81] 1.01[82] 0.25[83] 1.25[84]
13 EP300 Histone acetyltransferase p300 [85] 4.37[86] 3.98[87] 4.77[88] 4.76[89] 4.63[90] 4.45[91]
14 TTC5 Tetratricopeptide repeat protein 5 [92] 2.93[93] 1.98[94] 1.70[95] 2.72[96] 2.59[97] 1.98[98]
15 JMY Junction-mediating and -regulatory protein [99] 2.90[100] 3.98[101] 4.67[102] 4.32[103] 4.48[104] 5.11[105]
16 ATM Serine-protein kinase ATM [106] 4.68[107] 6.30[108] 5.92[109] 6.34[110] 5.65[111] 6.69[112]
17 MDM4 Protein Mdm4 [113] 3.29[114] 4.31[115] 4.65[116] 4.48[117] 4.18[118] 6.26[119]
18 L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 [120] 3.68[121] 5.64[122] 3.19[123] 3.77[124] 3.14[125] 3.89[126]
19 KMT5A N-lysine methyltransferase KMT5A [127] [128] [129] [130] [131] [132] [133]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte PRMT5
Mean 23.1
Standard deviation 9.7
Values 29 32 28 17 9.3
[30]
HepG2 PRMT5
Mean 133
Standard deviation 12
Values 1.4e+02 1.2e+02
[31]
HepG2.C3A PRMT5
Mean 29
Standard deviation 4.9
Values 25 32
[32]
HuH.7 PRMT5
Mean 42.6
Standard deviation 10
Values 49 31 48
[33]
SNU475 PRMT5
Mean 33.4
Standard deviation 11
Values 26 41
[34]
THLE PRMT5
Mean 46.9
Standard deviation 8.4
Values 41 53
[35]
liver PRMT5
Mean 13
Standard deviation 5.3
Values 10 13 21 8.3
[36]
ref_hepatocyte SMYD2
Mean 13.7
Standard deviation 5.8
Values 18 21 12 8.8 8.7
[37]
HepG2 SMYD2
Mean 41.2
Standard deviation 0.45
Values 42 41
[38]
HepG2.C3A SMYD2
Mean 36.7
Standard deviation 2.3
Values 35 38
[39]
HuH.7 SMYD2
Mean 16.9
Standard deviation 1.9
Values 16 16 19
[40]
SNU475 SMYD2
Mean 14.2
Standard deviation 3
Values 16 12
[41]
THLE SMYD2
Mean 9.22
Standard deviation 0.54
Values 9.6 8.8
[42]
liver SMYD2
Mean 9.84
Standard deviation 4
Values 11 8 15 5.4
[43]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 11 7.6 5 3.6 4.8
[44]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 51 70
[45]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.1e+02 1.8e+02
[46]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 21 20 20
[47]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 18 15
[48]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[49]
liver MDM2
Mean 40.5
Standard deviation 11
Values 29 54 35 45
[50]
ref_hepatocyte CHEK2
Mean 5.74
Standard deviation 6.1
Values 16 5.5 4.2 1.7 1.1
[51]
HepG2 CHEK2
Mean 13.6
Standard deviation 0.16
Values 13 14
[52]
HepG2.C3A CHEK2
Mean 16.4
Standard deviation 6.4
Values 12 21
[53]
HuH.7 CHEK2
Mean 20.8
Standard deviation 7.6
Values 22 13 28
[54]
SNU475 CHEK2
Mean 8.87
Standard deviation 0.55
Values 8.5 9.3
[55]
THLE CHEK2
Mean 7.68
Standard deviation 1.3
Values 6.8 8.6
[56]
liver CHEK2
Mean 0.84
Standard deviation 0.33
Values 0.87 0.88 1.2 0.4
[57]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[58]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[59]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[60]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[61]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[62]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[63]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[64]
ref_hepatocyte EHMT2
Mean 3.9
Standard deviation 2.8
Values 8.9 2.8 2.2 2.7 2.9
[65]
HepG2 EHMT2
Mean 47.9
Standard deviation 1.4
Values 49 47
[66]
HepG2.C3A EHMT2
Mean 32.7
Standard deviation 3.5
Values 35 30
[67]
HuH.7 EHMT2
Mean 32.9
Standard deviation 6.7
Values 39 26 34
[68]
SNU475 EHMT2
Mean 45.3
Standard deviation 4.2
Values 48 42
[69]
THLE EHMT2
Mean 20.9
Standard deviation 2.3
Values 19 23
[70]
liver EHMT2
Mean 6.65
Standard deviation 1.5
Values 8.4 5 7.1 6.1
[71]
ref_hepatocyte EHMT1
Mean 3.27
Standard deviation 0.31
Values 2.9 3.1 3.7 3.1 3.5
[72]
HepG2 EHMT1
Mean 22.5
Standard deviation 1.6
Values 24 21
[73]
HepG2.C3A EHMT1
Mean 17.5
Standard deviation 2.6
Values 19 16
[74]
HuH.7 EHMT1
Mean 20.9
Standard deviation 4.1
Values 24 16 23
[75]
SNU475 EHMT1
Mean 19.4
Standard deviation 3.5
Values 22 17
[76]
THLE EHMT1
Mean 16.6
Standard deviation 5
Values 13 20
[77]
liver EHMT1
Mean 17.4
Standard deviation 6.4
Values 13 21 11 24
[78]
ref_hepatocyte SETD9
Mean 2.64
Standard deviation 1.4
Values 4.5 2.7 0.68 2.2 3.1
[79]
HepG2 SETD9
Mean 1.99
Standard deviation 0.72
Values 1.5 2.5
[80]
HepG2.C3A SETD9
Mean 3.84
Standard deviation 1.8
Values 2.6 5.1
[81]
HuH.7 SETD9
Mean 1.55
Standard deviation 0.24
Values 1.6 1.3 1.8
[82]
SNU475 SETD9
Mean 2.14
Standard deviation 0.31
Values 2.4 1.9
[83]
THLE SETD9
Mean 1.61
Standard deviation 0.27
Values 1.4 1.8
[84]
liver SETD9
Mean 2.75
Standard deviation 1.8
Values 5.2 1.4 3 1.5
[85]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[86]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[87]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[88]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[89]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[90]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[91]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[92]
ref_hepatocyte TTC5
Mean 1.83
Standard deviation 0.66
Values 2.3 2.8 1.4 1.2 1.5
[93]
HepG2 TTC5
Mean 9.81
Standard deviation 0.88
Values 9.2 10
[94]
HepG2.C3A TTC5
Mean 4.51
Standard deviation 2.6
Values 2.7 6.3
[95]
HuH.7 TTC5
Mean 3.82
Standard deviation 0.96
Values 4.6 2.7 4.1
[96]
SNU475 TTC5
Mean 4.86
Standard deviation 0.94
Values 5.5 4.2
[97]
THLE TTC5
Mean 5.63
Standard deviation 0.7
Values 5.1 6.1
[98]
liver TTC5
Mean 3.16
Standard deviation 0.92
Values 2.4 3.4 4.4 2.5
[99]
ref_hepatocyte JMY
Mean 1.09
Standard deviation 0.51
Values 1.7 1.6 0.64 0.95 0.6
[100]
HepG2 JMY
Mean 5.74
Standard deviation 0.19
Values 5.9 5.6
[101]
HepG2.C3A JMY
Mean 10.7
Standard deviation 4.9
Values 14 7.2
[102]
HuH.7 JMY
Mean 17.7
Standard deviation 7.8
Values 16 26 11
[103]
SNU475 JMY
Mean 8.78
Standard deviation 2.5
Values 11 7
[104]
THLE JMY
Mean 12.4
Standard deviation 1.7
Values 14 11
[105]
liver JMY
Mean 16.5
Standard deviation 5.7
Values 17 22 8.5 19
[106]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 2.1 0.69 0.27 0.7 1.1
[107]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 12 23
[108]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 44 51
[109]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 41 44 27
[110]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 38 26
[111]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[112]
liver ATM
Mean 43.7
Standard deviation 31
Values 17 76 17 64
[113]
ref_hepatocyte MDM4
Mean 0.953
Standard deviation 0.42
Values 1.6 0.7 0.53 0.84 1.1
[114]
HepG2 MDM4
Mean 6.55
Standard deviation 0.35
Values 6.8 6.3
[115]
HepG2.C3A MDM4
Mean 11.8
Standard deviation 4.8
Values 15 8.4
[116]
HuH.7 MDM4
Mean 15.3
Standard deviation 0.63
Values 15 16 15
[117]
SNU475 MDM4
Mean 8.57
Standard deviation 2.6
Values 10 6.7
[118]
THLE MDM4
Mean 8.85
Standard deviation 2.2
Values 10 7.3
[119]
liver MDM4
Mean 31.9
Standard deviation 8.3
Values 25 40 24 38
[120]
ref_hepatocyte L3MBTL1
Mean 0.177
Standard deviation 0.2
Values 0.51 0.036 0.033 0.21 0.098
[121]
HepG2 L3MBTL1
Mean 1.59
Standard deviation 0.14
Values 1.7 1.5
[122]
HepG2.C3A L3MBTL1
Mean 5.48
Standard deviation 1.1
Values 6.3 4.7
[123]
HuH.7 L3MBTL1
Mean 1.04
Standard deviation 0.21
Values 0.83 1.2 1
[124]
SNU475 L3MBTL1
Mean 0.976
Standard deviation 0.069
Values 1 0.93
[125]
THLE L3MBTL1
Mean 0.798
Standard deviation 0.15
Values 0.91 0.69
[126]
liver L3MBTL1
Mean 1.15
Standard deviation 0.29
Values 0.96 1.5 0.85 1.3
[127]
ref_hepatocyte KMT5A
Missing
[128]
HepG2 KMT5A
Missing
[129]
HepG2.C3A KMT5A
Missing
[130]
HuH.7 KMT5A
Missing
[131]
SNU475 KMT5A
Missing
[132]
THLE KMT5A
Missing
[133]
liver KMT5A
Missing