REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FGG Fibrinogen gamma chain [1] -2.14[2] -1.92[3] -1.43[4] -6.38[5] -7.87[6] -0.93[7]
2 FGA Fibrinogen alpha chain [8] -1.80[9] -2.17[10] -1.32[11] -5.59[12] -7.88[13] -0.26[14]
3 FGB Fibrinogen beta chain [15] -3.01[16] -2.94[17] -0.33[18] -3.71[19] -6.52[20] 0.52[21]
4 LBP Lipopolysaccharide-binding protein [22] -7.20[23] -10.98[24] -3.16[25] -6.23[26] -11.02[27] -0.31[28]
5 APOB Apolipoprotein B-100 [29] 6.40[30] 6.41[31] 5.83[32] -0.53[33] -0.08[34] 4.49[35]
6 CD14 Monocyte differentiation antigen CD14 [36] -3.88[37] -4.71[38] -1.66[39] 2.10[40] 1.32[41] -0.88[42]
7 HMGB1 High mobility group protein B1 [43] 4.16[44] 4.14[45] 4.12[46] 7.37[47] 7.25[48] -0.93[49]
8 S100A1 Protein S100-A1 [50] 2.51[51] 3.01[52] -2.65[53] -1.35[54] -2.13[55] -10.64[56]
9 S100A9 Protein S100-A9 [57] -1.72[58] -4.95[59] -2.75[60] -1.81[61] -1.94[62] -2.32[63]
10 GSDMD Gasdermin-D [64] 2.54[65] 2.60[66] 2.17[67] 5.64[68] 4.97[69] -1.03[70]
11 S100A8 Protein S100-A8 [71] [72] [73] [74] -2.57[75] [76] -0.32[77]
12 LY96 Lymphocyte antigen 96 [78] 1.81[79] 0.66[80] -5.52[81] 5.54[82] 2.32[83] -1.73[84]
13 CD36 Platelet glycoprotein 4 [85] 5.79[86] 4.36[87] -0.49[88] 10.09[89] 1.49[90] 2.71[91]
14 TLR2 Toll-like receptor 2 [92] 0.91[93] 1.57[94] -5.19[95] 1.94[96] 9.09[97] 0.87[98]
15 TLR4 Toll-like receptor 4 [99] 4.73[100] -1.18[101] -1.83[102] 1.81[103] 12.63[104] 4.09[105]
16 TLR1 Toll-like receptor 1 [106] 1.09[107] [108] -3.08[109] 6.51[110] 8.09[111] 1.69[112]
17 SFTPD Pulmonary surfactant-associated protein D [113] -2.43[114] [115] [116] 2.63[117] 3.39[118] -1.04[119]
18 TLR6 Toll-like receptor 6 [120] 5.24[121] 4.60[122] 4.07[123] 9.21[124] 9.69[125] 2.37[126]
19 GSDME Gasdermin-E [127] [128] [129] [130] [131] [132] [133]
20 SFTPA1 Pulmonary surfactant-associated protein A1 [134] [135] [136] [137] [138] [139] [140]
21 SFTPA2 Pulmonary surfactant-associated protein A2 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte FGG
Mean 8.49e+03
Standard deviation 1.1e+04
Values 1.5e+03 1.1e+02 9e+02 2.5e+04 1.5e+04
[2]
HepG2 FGG
Mean 194
Standard deviation 1.5e+02
Values 91 3e+02
[3]
HepG2.C3A FGG
Mean 338
Standard deviation 15
Values 3.3e+02 3.5e+02
[4]
HuH.7 FGG
Mean 389
Standard deviation 3e+02
Values 2.1e+02 7.3e+02 2.3e+02
[5]
SNU475 FGG
Mean 1.56
Standard deviation 0.22
Values 1.4 1.7
[6]
THLE FGG
Mean 0.473
Standard deviation 0.016
Values 0.46 0.48
[7]
liver FGG
Mean 8.17e+03
Standard deviation 4.2e+03
Values 5.8e+03 7.5e+03 1.4e+04 5.1e+03
[8]
ref_hepatocyte FGA
Mean 6.91e+03
Standard deviation 9.4e+03
Values 4.5e+02 63 4.3e+02 2.1e+04 1.3e+04
[9]
HepG2 FGA
Mean 200
Standard deviation 1.3e+02
Values 1.1e+02 2.9e+02
[10]
HepG2.C3A FGA
Mean 232
Standard deviation 52
Values 2.7e+02 2e+02
[11]
HuH.7 FGA
Mean 342
Standard deviation 2.4e+02
Values 2e+02 6.2e+02 2e+02
[12]
SNU475 FGA
Mean 2.2
Standard deviation 0.085
Values 2.3 2.1
[13]
THLE FGA
Mean 0.381
Standard deviation 0.064
Values 0.43 0.34
[14]
liver FGA
Mean 1.06e+04
Standard deviation 2.8e+03
Values 7.3e+03 1.4e+04 1e+04 1.1e+04
[15]
ref_hepatocyte FGB
Mean 4.4e+03
Standard deviation 5.7e+03
Values 3.6e+02 3.3e+02 3.9e+02 1.2e+04 8.4e+03
[16]
HepG2 FGB
Mean 55
Standard deviation 32
Values 33 77
[17]
HepG2.C3A FGB
Mean 86.5
Standard deviation 3.3
Values 84 89
[18]
HuH.7 FGB
Mean 431
Standard deviation 3.8e+02
Values 1.9e+02 8.7e+02 2.3e+02
[19]
SNU475 FGB
Mean 5.14
Standard deviation 3.4
Values 2.7 7.6
[20]
THLE FGB
Mean 0.624
Standard deviation 0.0046
Values 0.62 0.63
[21]
liver FGB
Mean 1.16e+04
Standard deviation 4.8e+03
Values 9.6e+03 1.1e+04 1.8e+04 7.3e+03
[22]
ref_hepatocyte LBP
Mean 424
Standard deviation 5.3e+02
Values 0.39 1e+02 86 1.2e+03 7.2e+02
[23]
HepG2 LBP
Mean 0.29
Standard deviation 0.045
Values 0.26 0.32
[24]
HepG2.C3A LBP
Mean 0.0317
Standard deviation 0.031
Values 0.0097 0.054
[25]
HuH.7 LBP
Mean 5.83
Standard deviation 7.8
Values 1.3 15 1.3
[26]
SNU475 LBP
Mean 0.0865
Standard deviation 0.057
Values 0.046 0.13
[27]
THLE LBP
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[28]
liver LBP
Mean 630
Standard deviation 2.6e+02
Values 5e+02 4.9e+02 1e+03 5e+02
[29]
ref_hepatocyte APOB
Mean 165
Standard deviation 1.5e+02
Values 2.4e+02 15 8.3 2.2e+02 3.4e+02
[30]
HepG2 APOB
Mean 1.41e+03
Standard deviation 6.5e+02
Values 9.5e+02 1.9e+03
[31]
HepG2.C3A APOB
Mean 2.13e+03
Standard deviation 5.8e+02
Values 1.7e+03 2.5e+03
[32]
HuH.7 APOB
Mean 1.16e+03
Standard deviation 4.8e+02
Values 1.4e+03 1.5e+03 6.1e+02
[33]
SNU475 APOB
Mean 1.75
Standard deviation 0.12
Values 1.7 1.8
[34]
THLE APOB
Mean 2.04
Standard deviation 0.96
Values 2.7 1.4
[35]
liver APOB
Mean 6.85e+03
Standard deviation 4.5e+03
Values 2.9e+03 1.2e+04 3.6e+03 8.5e+03
[36]
ref_hepatocyte CD14
Mean 148
Standard deviation 1.9e+02
Values 0.7 1.6 16 3.4e+02 3.8e+02
[37]
HepG2 CD14
Mean 1.01
Standard deviation 0.084
Values 1.1 0.95
[38]
HepG2.C3A CD14
Mean 0.856
Standard deviation 0.32
Values 1.1 0.63
[39]
HuH.7 CD14
Mean 5.78
Standard deviation 1.1
Values 5.8 4.7 6.9
[40]
SNU475 CD14
Mean 9.74
Standard deviation 1.9
Values 8.4 11
[41]
THLE CD14
Mean 4.8
Standard deviation 0.97
Values 5.5 4.1
[42]
liver CD14
Mean 148
Standard deviation 88
Values 2.1e+02 68 2.4e+02 77
[43]
ref_hepatocyte HMGB1
Mean 96.9
Standard deviation 78
Values 1.5e+02 2.1e+02 24 42 63
[44]
HepG2 HMGB1
Mean 174
Standard deviation 48
Values 1.4e+02 2.1e+02
[45]
HepG2.C3A HMGB1
Mean 259
Standard deviation 1.5e+02
Values 1.5e+02 3.7e+02
[46]
HuH.7 HMGB1
Mean 207
Standard deviation 1.1e+02
Values 2.5e+02 85 2.9e+02
[47]
SNU475 HMGB1
Mean 245
Standard deviation 23
Values 2.6e+02 2.3e+02
[48]
THLE HMGB1
Mean 191
Standard deviation 52
Values 1.5e+02 2.3e+02
[49]
liver HMGB1
Mean 93.7
Standard deviation 62
Values 1.7e+02 50 1.3e+02 34
[50]
ref_hepatocyte S100A1
Mean 52.6
Standard deviation 1.2e+02
Values 2.6e+02 0 0.83 0.49 0.99
[51]
HepG2 S100A1
Mean 30.2
Standard deviation 8.9
Values 24 36
[52]
HepG2.C3A S100A1
Mean 63.9
Standard deviation 1.9
Values 65 63
[53]
HuH.7 S100A1
Mean 1.03
Standard deviation 0.38
Values 0.71 1.4 0.95
[54]
SNU475 S100A1
Mean 0.315
Standard deviation 0.15
Values 0.42 0.21
[55]
THLE S100A1
Mean 0.157
Standard deviation 0.0041
Values 0.15 0.16
[56]
liver S100A1
Mean 0.0607
Standard deviation 0.044
Values 0.024 0.11 0.026 0.079
[57]
ref_hepatocyte S100A9
Mean 27.8
Standard deviation 27
Values 0 0.21 61 46 32
[58]
HepG2 S100A9
Mean 0.849
Standard deviation 0.92
Values 1.5 0.2
[59]
HepG2.C3A S100A9
Mean 0.136
Standard deviation 0.11
Values 0.058 0.21
[60]
HuH.7 S100A9
Mean 0.51
Standard deviation 0.36
Values 0.57 0.12 0.84
[61]
SNU475 S100A9
Mean 0.121
Standard deviation 0.15
Values 0.014 0.23
[62]
THLE S100A9
Mean 0.0943
Standard deviation 0.051
Values 0.13 0.059
[63]
liver S100A9
Mean 10.3
Standard deviation 5.8
Values 7.9 4.3 18 11
[64]
ref_hepatocyte GSDMD
Mean 24
Standard deviation 21
Values 5.5 9.4 14 55 36
[65]
HepG2 GSDMD
Mean 14
Standard deviation 2.3
Values 12 16
[66]
HepG2.C3A GSDMD
Mean 22
Standard deviation 2.9
Values 24 20
[67]
HuH.7 GSDMD
Mean 13.3
Standard deviation 4.2
Values 14 8.8 17
[68]
SNU475 GSDMD
Mean 18.4
Standard deviation 3.2
Values 21 16
[69]
THLE GSDMD
Mean 9.83
Standard deviation 1.7
Values 11 8.6
[70]
liver GSDMD
Mean 21.7
Standard deviation 5.3
Values 29 16 19 23
[71]
ref_hepatocyte S100A8
Mean 3.94
Standard deviation 5.3
Values 0 0 0.42 8.5 11
[72]
HepG2 S100A8
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A S100A8
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 S100A8
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 S100A8
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[76]
THLE S100A8
Mean 0
Standard deviation 0
Values 0 0
[77]
liver S100A8
Mean 5.79
Standard deviation 5.5
Values 9.2 0.63 12 1.6
[78]
ref_hepatocyte LY96
Mean 2.98
Standard deviation 1.7
Values 3 4.2 0 4 3.7
[79]
HepG2 LY96
Mean 1.05
Standard deviation 0.03
Values 1 1.1
[80]
HepG2.C3A LY96
Mean 0.711
Standard deviation 0.08
Values 0.77 0.65
[81]
HuH.7 LY96
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[82]
SNU475 LY96
Mean 2.13
Standard deviation 0.56
Values 2.5 1.7
[83]
THLE LY96
Mean 0.194
Standard deviation 0.13
Values 0.1 0.29
[84]
liver LY96
Mean 1.65
Standard deviation 1.4
Values 2.6 0.6 3 0.34
[85]
ref_hepatocyte CD36
Mean 1.74
Standard deviation 1.4
Values 3.5 0.39 0.28 1.9 2.6
[86]
HepG2 CD36
Mean 9.69
Standard deviation 5.6
Values 5.8 14
[87]
HepG2.C3A CD36
Mean 5.39
Standard deviation 3.6
Values 2.8 8
[88]
HuH.7 CD36
Mean 0.152
Standard deviation 0.061
Values 0.098 0.22 0.14
[89]
SNU475 CD36
Mean 28.9
Standard deviation 5.9
Values 25 33
[90]
THLE CD36
Mean 0.0633
Standard deviation 0.044
Values 0.095 0.032
[91]
liver CD36
Mean 20.9
Standard deviation 5.9
Values 22 24 25 12
[92]
ref_hepatocyte TLR2
Mean 1.56
Standard deviation 1.2
Values 0 0.96 2.3 3.1 1.4
[93]
HepG2 TLR2
Mean 0.296
Standard deviation 0.084
Values 0.36 0.24
[94]
HepG2.C3A TLR2
Mean 0.704
Standard deviation 0.0056
Values 0.7 0.71
[95]
HuH.7 TLR2
Mean 0.00526
Standard deviation 0.0048
Values 0 0.0064 0.0094
[96]
SNU475 TLR2
Mean 0.0914
Standard deviation 0.057
Values 0.051 0.13
[97]
THLE TLR2
Mean 11.1
Standard deviation 4.3
Values 14 8.1
[98]
liver TLR2
Mean 5.26
Standard deviation 1.6
Values 3.2 6.8 5.1 5.9
[99]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0 1.1 0.33 0.64 0.66
[100]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 0.82 2.1
[101]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[102]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0 0.019 0.037
[103]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[104]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[105]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 13 19 11 25
[106]
ref_hepatocyte TLR1
Mean 0.481
Standard deviation 0.24
Values 0.12 0.52 0.38 0.69 0.7
[107]
HepG2 TLR1
Mean 0.103
Standard deviation 0.024
Values 0.12 0.086
[108]
HepG2.C3A TLR1
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 TLR1
Mean 0.00701
Standard deviation 0.0065
Values 0.0082 0.013 0
[110]
SNU475 TLR1
Mean 0.672
Standard deviation 0.026
Values 0.69 0.65
[111]
THLE TLR1
Mean 1.71
Standard deviation 0.1
Values 1.8 1.6
[112]
liver TLR1
Mean 2.86
Standard deviation 1.1
Values 2 4.4 2.1 3
[113]
ref_hepatocyte SFTPD
Mean 0.23
Standard deviation 0.35
Values 0 0 0 0.78 0.37
[114]
HepG2 SFTPD
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[115]
HepG2.C3A SFTPD
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 SFTPD
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 SFTPD
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[118]
THLE SFTPD
Mean 0.0313
Standard deviation 0.014
Values 0.041 0.021
[119]
liver SFTPD
Mean 0.206
Standard deviation 0.19
Values 0.16 0.16 0.026 0.48
[120]
ref_hepatocyte TLR6
Mean 0.179
Standard deviation 0.1
Values 0.23 0.34 0.082 0.12 0.13
[121]
HepG2 TLR6
Mean 0.681
Standard deviation 0.059
Values 0.72 0.64
[122]
HepG2.C3A TLR6
Mean 0.655
Standard deviation 0.06
Values 0.61 0.7
[123]
HuH.7 TLR6
Mean 0.369
Standard deviation 0.13
Values 0.46 0.42 0.22
[124]
SNU475 TLR6
Mean 1.62
Standard deviation 0.2
Values 1.5 1.8
[125]
THLE TLR6
Mean 1.93
Standard deviation 0.11
Values 2 1.9
[126]
liver TLR6
Mean 1.7
Standard deviation 1
Values 0.63 2.6 1.1 2.5
[127]
ref_hepatocyte GSDME
Missing
[128]
HepG2 GSDME
Missing
[129]
HepG2.C3A GSDME
Missing
[130]
HuH.7 GSDME
Missing
[131]
SNU475 GSDME
Missing
[132]
THLE GSDME
Missing
[133]
liver GSDME
Missing
[134]
ref_hepatocyte SFTPA1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 SFTPA1
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 SFTPA1
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[139]
THLE SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[140]
liver SFTPA1
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[141]
ref_hepatocyte SFTPA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 SFTPA2
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[143]
HepG2.C3A SFTPA2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 SFTPA2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[145]
SNU475 SFTPA2
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[146]
THLE SFTPA2
Mean 0
Standard deviation 0
Values 0 0
[147]
liver SFTPA2
Mean 0
Standard deviation 0
Values 0 0 0 0