REACTOME_REGULATION_OF_SIGNALING_BY_CBL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.48[2] -0.70[3] -0.81[4] -0.76[5] -0.48[6] -0.32[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.04[16] 0.06[17] -0.45[18] 0.09[19] -0.10[20] 0.13[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.40[23] 2.29[24] 3.07[25] 1.49[26] 2.13[27] 0.90[28]
5 GRB2 Growth factor receptor-bound protein 2 [29] 2.91[30] 2.74[31] 2.59[32] 2.57[33] 2.31[34] 1.86[35]
6 YES1 Tyrosine-protein kinase Yes [36] 0.86[37] 2.33[38] 2.29[39] 2.47[40] 1.76[41] 1.68[42]
7 CRK Adapter molecule crk [43] 1.51[44] 1.43[45] 1.23[46] 1.78[47] 2.00[48] 2.40[49]
8 CRKL Crk-like protein [50] 3.42[51] 3.50[52] 3.85[53] 3.14[54] 3.17[55] 3.01[56]
9 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [57] 1.24[58] 1.35[59] 2.18[60] 4.08[61] 3.41[62] 4.56[63]
10 BLNK B-cell linker protein [64] -7.88[65] -8.04[66] -5.97[67] -8.28[68] -7.01[69] 1.48[70]
11 LYN Tyrosine-protein kinase Lyn [71] 0.85[72] 0.66[73] 0.93[74] 3.07[75] 1.66[76] 1.57[77]
12 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [78] 3.59[79] 3.80[80] 4.14[81] 2.72[82] 3.11[83] 1.27[84]
13 RAPGEF1 Rap guanine nucleotide exchange factor 1 [85] 3.80[86] 3.62[87] 3.07[88] 3.27[89] 2.77[90] 2.73[91]
14 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2.93[92] 3.42[93] 3.32[94] 3.07[95] 3.05[96] 2.71[97]
15 FYN Tyrosine-protein kinase Fyn [98] 2.66[99] -5.96[100] 2.35[101] 3.49[102] 4.84[103] 2.53[104]
16 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.34[105] 2.96[106] 2.88[107] 3.15[108] 3.18[109] 3.47[110]
17 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 3.60[111] 4.68[112] 0.60[113] 2.30[114] 2.89[115] 1.86[116]
18 HCK Tyrosine-protein kinase HCK [117] -4.13[118] -4.32[119] [120] -3.25[121] -4.36[122] 2.26[123]
19 CBL E3 ubiquitin-protein ligase CBL [124] 6.16[125] 5.10[126] 5.05[127] 7.15[128] 6.46[129] 5.31[130]
20 VAV1 Proto-oncogene vav [131] -6.78[132] -1.97[133] -3.94[134] -4.07[135] -5.51[136] 2.74[137]
21 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma [138] 3.44[139] 3.43[140] 4.02[141] 5.18[142] 4.03[143] 4.23[144]
22 SYK Tyrosine-protein kinase SYK [145] -6.45[146] -0.59[147] -3.87[148] 2.12[149] -1.57[150] 4.92[151]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[30]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[31]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[32]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[33]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[34]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[35]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[36]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[37]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[38]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[39]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[40]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[41]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[42]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[43]
ref_hepatocyte CRK
Mean 18.5
Standard deviation 12
Values 16 38 19 11 8.5
[44]
HepG2 CRK
Mean 35.5
Standard deviation 2.8
Values 34 38
[45]
HepG2.C3A CRK
Mean 30.2
Standard deviation 5.3
Values 27 34
[46]
HuH.7 CRK
Mean 30.3
Standard deviation 2.4
Values 32 32 28
[47]
SNU475 CRK
Mean 28.8
Standard deviation 1.2
Values 30 28
[48]
THLE CRK
Mean 42.5
Standard deviation 6.6
Values 38 47
[49]
liver CRK
Mean 47.1
Standard deviation 5.8
Values 41 55 45 47
[50]
ref_hepatocyte CRKL
Mean 7.86
Standard deviation 3.2
Values 13 7.5 7.1 6.1 5.2
[51]
HepG2 CRKL
Mean 56.6
Standard deviation 7.1
Values 52 62
[52]
HepG2.C3A CRKL
Mean 53.9
Standard deviation 8
Values 60 48
[53]
HuH.7 CRKL
Mean 78.7
Standard deviation 6.8
Values 86 76 74
[54]
SNU475 CRKL
Mean 31.5
Standard deviation 0.52
Values 32 31
[55]
THLE CRKL
Mean 40.6
Standard deviation 0.46
Values 41 40
[56]
liver CRKL
Mean 30.6
Standard deviation 3.9
Values 25 32 32 33
[57]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[58]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[59]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[60]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[61]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[62]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[63]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[64]
ref_hepatocyte BLNK
Mean 6.78
Standard deviation 7.3
Values 0 1.1 3.4 14 15
[65]
HepG2 BLNK
Mean 0.0193
Standard deviation 0.003
Values 0.017 0.021
[66]
HepG2.C3A BLNK
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[67]
HuH.7 BLNK
Mean 0.0755
Standard deviation 0.044
Values 0.11 0.083 0.028
[68]
SNU475 BLNK
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[69]
THLE BLNK
Mean 0.0302
Standard deviation 0.018
Values 0.018 0.043
[70]
liver BLNK
Mean 9.11
Standard deviation 8.1
Values 20 2.2 9.8 4.1
[71]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[72]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[73]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[74]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[75]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[76]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[77]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[78]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[79]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[80]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[81]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[82]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[83]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[84]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[85]
ref_hepatocyte RAPGEF1
Mean 4.9
Standard deviation 2.3
Values 6.6 5.4 7.5 2.5 2.6
[86]
HepG2 RAPGEF1
Mean 46
Standard deviation 2.9
Values 48 44
[87]
HepG2.C3A RAPGEF1
Mean 36.5
Standard deviation 6.8
Values 41 32
[88]
HuH.7 RAPGEF1
Mean 28.7
Standard deviation 4.9
Values 30 33 23
[89]
SNU475 RAPGEF1
Mean 21.5
Standard deviation 2.8
Values 23 20
[90]
THLE RAPGEF1
Mean 19.2
Standard deviation 5.1
Values 16 23
[91]
liver RAPGEF1
Mean 15.7
Standard deviation 4.8
Values 16 19 8.9 19
[92]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[93]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[94]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[95]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[96]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[97]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[98]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[99]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[100]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[101]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[102]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[103]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[104]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[105]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[106]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[107]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[108]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[109]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[110]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[111]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[112]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[113]
ref_hepatocyte PIK3CD
Mean 1.86
Standard deviation 1.7
Values 4.1 0.94 3.3 0.38 0.66
[114]
HepG2 PIK3CD
Mean 15.2
Standard deviation 3.8
Values 18 13
[115]
HepG2.C3A PIK3CD
Mean 28.8
Standard deviation 2.6
Values 31 27
[116]
HuH.7 PIK3CD
Mean 1.97
Standard deviation 0.32
Values 2 2.3 1.6
[117]
SNU475 PIK3CD
Mean 4.15
Standard deviation 0.57
Values 4.6 3.7
[118]
THLE PIK3CD
Mean 7.91
Standard deviation 1.1
Values 7.1 8.7
[119]
liver PIK3CD
Mean 3.25
Standard deviation 1.3
Values 2.4 3 2.6 5.1
[120]
ref_hepatocyte HCK
Mean 1.57
Standard deviation 1.7
Values 0 0 2.7 1.2 3.9
[121]
HepG2 HCK
Mean 0.0602
Standard deviation 0.085
Values 0.12 0
[122]
HepG2.C3A HCK
Mean 0.0473
Standard deviation 0.039
Values 0.019 0.075
[123]
HuH.7 HCK
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 HCK
Mean 0.0747
Standard deviation 0.066
Values 0.028 0.12
[125]
THLE HCK
Mean 0.0438
Standard deviation 0.047
Values 0.077 0.011
[126]
liver HCK
Mean 3.63
Standard deviation 1.3
Values 1.7 4.2 4 4.7
[127]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[128]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[129]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[130]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[131]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[132]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[133]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14
[134]
ref_hepatocyte VAV1
Mean 0.469
Standard deviation 0.4
Values 0 0.2 0.63 0.48 1
[135]
HepG2 VAV1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A VAV1
Mean 0.0726
Standard deviation 0.034
Values 0.049 0.097
[137]
HuH.7 VAV1
Mean 0.0213
Standard deviation 0.0061
Values 0.016 0.019 0.028
[138]
SNU475 VAV1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[139]
THLE VAV1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[140]
liver VAV1
Mean 1.51
Standard deviation 0.9
Values 0.75 1.8 0.82 2.6
[141]
ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.52 0.81 0.47 0.078 0.15
[142]
HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 1.2 4.7
[143]
HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 1.5 3.8
[144]
HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5.7 3.1 5
[145]
SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.5 6.8
[146]
THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4
[147]
liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 3.7 3.8 3.3 4
[148]
ref_hepatocyte SYK
Mean 0.279
Standard deviation 0.38
Values 0 0.17 0 0.31 0.92
[149]
HepG2 SYK
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[150]
HepG2.C3A SYK
Mean 0.112
Standard deviation 0.0066
Values 0.12 0.11
[151]
HuH.7 SYK
Mean 0.0133
Standard deviation 0.0053
Values 0.0082 0.013 0.019
[152]
SNU475 SYK
Mean 0.549
Standard deviation 0.36
Values 0.3 0.8
[153]
THLE SYK
Mean 0.0538
Standard deviation 0.016
Values 0.065 0.043
[154]
liver SYK
Mean 4.07
Standard deviation 1.3
Values 3.6 4.8 2.5 5.4