REACTOME_REGULATION_OF_RAS_BY_GAPS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.09[2] | -1.15[3] | -1.03[4] | -1.38[5] | -1.00[6] | -0.45[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.65[16] | -0.40[17] | -0.66[18] | -0.53[19] | -0.63[20] | 0.00[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.42[23] | -1.99[24] | -1.63[25] | -1.25[26] | -1.85[27] | -0.95[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.24[30] | -1.61[31] | -1.72[32] | -1.03[33] | -1.39[34] | -0.57[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.72[37] | 0.85[38] | -0.47[39] | 0.59[40] | 0.09[41] | 0.45[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.27[44] | 0.41[45] | -0.67[46] | -0.65[47] | 0.05[48] | 0.29[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.22[51] | -0.98[52] | 0.06[53] | -0.67[54] | -0.85[55] | -0.01[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | 0.03[58] | 0.22[59] | 0.35[60] | 0.76[61] | 0.69[62] | -0.34[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.91[65] | -0.88[66] | -0.74[67] | -1.02[68] | -0.64[69] | -0.78[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.48[72] | 0.08[73] | 0.01[74] | -0.30[75] | -0.08[76] | -0.30[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.61[79] | 0.36[80] | 0.30[81] | 0.23[82] | 0.19[83] | -0.22[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.32[86] | 0.38[87] | 0.17[88] | 0.53[89] | 0.30[90] | -0.30[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.35[93] | -0.38[94] | 0.24[95] | -0.66[96] | -0.52[97] | 0.17[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -0.94[100] | 0.10[101] | -0.58[102] | 0.08[103] | -0.42[104] | -0.05[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.39[107] | -0.21[108] | -0.06[109] | -0.46[110] | -0.79[111] | 0.11[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.47[114] | 0.52[115] | 0.85[116] | 0.03[117] | 0.35[118] | 0.33[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | 0.04[121] | 0.09[122] | 0.29[123] | 0.73[124] | 0.14[125] | 0.01[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.04[128] | 0.37[129] | 0.23[130] | -0.35[131] | 0.07[132] | -0.17[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | 0.13[135] | 0.40[136] | 0.54[137] | -0.08[138] | 0.63[139] | -0.14[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.66[142] | 0.87[143] | 0.95[144] | 1.03[145] | 2.27[146] | 0.89[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.02[149] | 0.08[150] | -0.57[151] | 1.22[152] | 0.69[153] | 0.05[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | 0.17[156] | 0.59[157] | 0.65[158] | 0.79[159] | 0.24[160] | 0.54[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.79[163] | 1.83[164] | 2.85[165] | 0.87[166] | 1.60[167] | 0.77[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | 0.48[170] | 0.41[171] | 0.49[172] | 0.20[173] | 0.56[174] | 0.31[175] |
26 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [176] | -0.95[177] | -0.38[178] | -0.52[179] | -1.31[180] | -0.96[181] | -0.67[182] |
27 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [183] | 0.88[184] | 0.41[185] | 1.00[186] | 0.73[187] | 0.90[188] | 0.02[189] |
28 | PSMB8 | Proteasome subunit beta type-8 | [190] | -1.52[191] | -2.07[192] | -9.29[193] | 0.71[194] | -0.66[195] | -0.66[196] |
29 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [197] | 0.06[198] | 0.70[199] | 0.96[200] | 0.60[201] | 0.57[202] | -0.12[203] |
30 | PSMC4 | 26S proteasome regulatory subunit 6B | [204] | 0.48[205] | 0.55[206] | 0.49[207] | 0.23[208] | 0.28[209] | 0.36[210] |
31 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [211] | -0.67[212] | -0.15[213] | -1.24[214] | -0.40[215] | 0.36[216] | -0.23[217] |
32 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [218] | 0.53[219] | 0.68[220] | 1.18[221] | 0.66[222] | 0.11[223] | -0.05[224] |
33 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [225] | -0.29[226] | -0.18[227] | -0.48[228] | 0.28[229] | 0.29[230] | -0.12[231] |
34 | PSMC6 | 26S proteasome regulatory subunit 10B | [232] | 0.00[233] | 1.61[234] | 0.44[235] | 0.64[236] | 0.51[237] | 0.53[238] |
35 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [239] | 0.89[240] | 0.54[241] | 1.13[242] | 1.04[243] | 1.15[244] | 1.35[245] |
36 | PSMC2 | 26S proteasome regulatory subunit 7 | [246] | 0.64[247] | 1.08[248] | 0.86[249] | 1.44[250] | 1.21[251] | 1.41[252] |
37 | PSME3 | Proteasome activator complex subunit 3 | [253] | 1.87[254] | 1.62[255] | 1.31[256] | 1.46[257] | 1.68[258] | 0.97[259] |
38 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [260] | 1.63[261] | 1.98[262] | 1.86[263] | 2.27[264] | 2.22[265] | 2.16[266] |
39 | PSMB10 | Proteasome subunit beta type-10 | [267] | -1.10[268] | -0.46[269] | -2.35[270] | 0.06[271] | -1.16[272] | 0.01[273] |
40 | PSMA5 | Proteasome subunit alpha type-5 | [274] | 1.96[275] | 2.42[276] | 1.98[277] | 2.32[278] | 1.83[279] | 2.00[280] |
41 | PSMF1 | Proteasome inhibitor PI31 subunit | [281] | 2.34[282] | 2.42[283] | 1.22[284] | 1.33[285] | 1.03[286] | 1.94[287] |
42 | PSMB2 | Proteasome subunit beta type-2 | [288] | 2.12[289] | 1.89[290] | 2.27[291] | 2.63[292] | 2.55[293] | 2.49[294] |
43 | PSMB9 | Proteasome subunit beta type-9 | [295] | -1.89[296] | -4.48[297] | -6.78[298] | 1.88[299] | -0.45[300] | -0.41[301] |
44 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [302] | 0.49[303] | 1.02[304] | 0.03[305] | 0.50[306] | 0.89[307] | 0.82[308] |
45 | NRAS | GTPase NRas | [309] | 1.74[310] | 2.31[311] | 2.70[312] | 2.39[313] | 1.89[314] | 1.18[315] |
46 | HRAS | GTPase HRas | [316] | 0.10[317] | -0.47[318] | -1.28[319] | 0.45[320] | 0.15[321] | -1.23[322] |
47 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [323] | 1.05[324] | 1.41[325] | 1.43[326] | 2.17[327] | 1.44[328] | 0.80[329] |
48 | KRAS | GTPase KRas | [330] | 0.59[331] | 0.71[332] | 2.29[333] | 2.20[334] | 1.78[335] | 2.10[336] |
49 | PSME4 | Proteasome activator complex subunit 4 | [337] | 2.58[338] | 3.52[339] | 3.52[340] | 2.73[341] | 2.64[342] | 3.07[343] |
50 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [344] | 1.47[345] | 1.05[346] | 2.62[347] | 2.56[348] | 2.58[349] | 2.25[350] |
51 | CUL3 | Cullin-3 | [351] | 1.72[352] | 2.77[353] | 2.47[354] | 2.86[355] | 2.87[356] | 2.37[357] |
52 | DAB2IP | Disabled homolog 2-interacting protein | [358] | 2.94[359] | 3.47[360] | 0.32[361] | 0.31[362] | 1.85[363] | 1.66[364] |
53 | SPRED2 | Sprouty-related, EVH1 domain-containing protein 2 | [365] | 3.19[366] | 3.58[367] | 3.32[368] | 2.54[369] | 2.87[370] | 2.34[371] |
54 | RASA1 | Ras GTPase-activating protein 1 | [372] | 1.48[373] | 2.54[374] | 2.62[375] | 3.31[376] | 2.29[377] | 2.64[378] |
55 | NF1 | Neurofibromin | [379] | 3.57[380] | 4.04[381] | 4.83[382] | 5.37[383] | 4.73[384] | 5.54[385] |
56 | KBTBD7 | Kelch repeat and BTB domain-containing protein 7 | [386] | 0.21[387] | 0.91[388] | 2.24[389] | 0.78[390] | -0.42[391] | 2.98[392] |
57 | RASA2 | Ras GTPase-activating protein 2 | [393] | -0.19[394] | 0.98[395] | 0.83[396] | 1.38[397] | 1.26[398] | 2.16[399] |
58 | RASAL2 | Ras GTPase-activating protein nGAP | [400] | 3.10[401] | 3.38[402] | 3.40[403] | 4.84[404] | 4.09[405] | 4.35[406] |
59 | RASA4 | Ras GTPase-activating protein 4 | [407] | 1.24[408] | 2.96[409] | 3.99[410] | 1.59[411] | 1.88[412] | 2.10[413] |
60 | SPRED1 | Sprouty-related, EVH1 domain-containing protein 1 | [414] | 3.52[415] | 4.17[416] | 4.06[417] | 5.37[418] | 5.78[419] | 4.22[420] |
61 | RASA3 | Ras GTPase-activating protein 3 | [421] | 1.29[422] | -5.58[423] | -4.86[424] | 5.06[425] | 4.53[426] | 3.02[427] |
62 | RASAL3 | RAS protein activator like-3 | [428] | -2.88[429] | [430] | -2.79[431] | -1.63[432] | -1.87[433] | 3.17[434] |
63 | SYNGAP1 | Ras/Rap GTPase-activating protein SynGAP | [435] | 4.30[436] | 4.40[437] | 4.43[438] | 6.28[439] | 6.63[440] | 3.30[441] |
64 | SPRED3 | Sprouty-related, EVH1 domain-containing protein 3 | [442] | 4.79[443] | 3.33[444] | 3.77[445] | 3.98[446] | 5.81[447] | 1.00[448] |
65 | RASAL1 | RasGAP-activating-like protein 1 | [449] | 6.83[450] | 6.57[451] | [452] | 3.93[453] | 1.71[454] | 5.13[455] |
66 | PSMB11 | Proteasome subunit beta type-11 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |
67 | PSMA8 | Proteasome subunit alpha type-7-like | [463] | [464] | [465] | [466] | [467] | [468] | [469] |
68 | SEM1 | Putative protein SEM1, isoform 2 | [470] | [471] | [472] | [473] | [474] | [475] | [476] |