REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [1] -1.06[2] -0.56[3] -1.66[4] -1.66[5] -1.31[6] -1.43[7]
2 GSTZ1 Maleylacetoacetate isomerase [8] -3.19[9] -2.74[10] -3.31[11] -3.81[12] -3.95[13] -2.25[14]
3 DLD Dihydrolipoyl dehydrogenase, mitochondrial [15] -0.36[16] 0.02[17] -0.32[18] 0.28[19] -0.43[20] -0.35[21]
4 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial -0.01[22] -0.35[23] 0.49[24] 0.01[25] -0.62[26] -0.29[27]
5 RXRA Retinoic acid receptor RXR-alpha [28] 0.72[29] 0.19[30] 0.85[31] 0.57[32] 0.06[33] 1.71[34]
6 PDHX Pyruvate dehydrogenase protein X component, mitochondrial [35] 0.22[36] 0.89[37] 0.66[38] 0.30[39] -0.50[40] -0.29[41]
7 PPARD Peroxisome proliferator-activated receptor delta [42] 0.41[43] -0.47[44] -0.91[45] 0.64[46] 0.87[47] -2.07[48]
8 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 1.59[49] 1.08[50] 1.36[51] 1.56[52] 0.91[53] -0.09[54]
9 PDK4 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial -5.48[55] -8.08[56] -5.29[57] -1.77[58] 2.84[59] 2.17[60]
10 PDK2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 1.00[61] 0.76[62] -0.52[63] -3.59[64] 0.46[65] 1.00[66]
11 PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 3.14[67] 3.53[68] 2.96[69] 3.17[70] 1.22[71] 1.62[72]
12 PDP2 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial 2.68[73] 2.73[74] 3.13[75] 2.35[76] 1.85[77] 1.97[78]
13 PDPR Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial 3.96[79] 3.70[80] 4.17[81] 2.87[82] 3.20[83] 2.20[84]
14 PDP1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial 1.88[85] -0.23[86] 0.03[87] 3.68[88] 3.58[89] 1.29[90]
15 PDK3 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.74[91] 2.93[92] 3.88[93] 3.55[94] 3.28[95] 4.17[96]
16 PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [97] [98] [99] [100] [101]
[1]
ref_hepatocyte PDHB
Mean 48.5
Standard deviation 30
Values 75 85 15 35 33
[2]
HepG2 PDHB
Mean 30
Standard deviation 6.5
Values 25 35
[3]
HepG2.C3A PDHB
Mean 47.6
Standard deviation 2.1
Values 49 46
[4]
HuH.7 PDHB
Mean 24.2
Standard deviation 4.2
Values 24 20 28
[5]
SNU475 PDHB
Mean 19.1
Standard deviation 2.2
Values 21 18
[6]
THLE PDHB
Mean 30.9
Standard deviation 4.1
Values 28 34
[7]
liver PDHB
Mean 34.7
Standard deviation 25
Values 62 15 50 12
[8]
ref_hepatocyte GSTZ1
Mean 46.1
Standard deviation 60
Values 4.8 6.8 9 66 1.4e+02
[9]
HepG2 GSTZ1
Mean 6.52
Standard deviation 0.28
Values 6.7 6.3
[10]
HepG2.C3A GSTZ1
Mean 9.98
Standard deviation 2.1
Values 11 8.5
[11]
HuH.7 GSTZ1
Mean 7.32
Standard deviation 1
Values 6.6 6.9 8.5
[12]
SNU475 GSTZ1
Mean 4.11
Standard deviation 1.9
Values 5.4 2.8
[13]
THLE GSTZ1
Mean 4.72
Standard deviation 0.55
Values 4.3 5.1
[14]
liver GSTZ1
Mean 18.6
Standard deviation 9.1
Values 28 7.5 16 23
[15]
ref_hepatocyte DLD
Mean 31.7
Standard deviation 25
Values 39 73 13 16 19
[16]
HepG2 DLD
Mean 31.9
Standard deviation 11
Values 24 39
[17]
HepG2.C3A DLD
Mean 46.4
Standard deviation 13
Values 37 56
[18]
HuH.7 DLD
Mean 39.8
Standard deviation 5.6
Values 44 33 43
[19]
SNU475 DLD
Mean 48.2
Standard deviation 1.7
Values 49 47
[20]
THLE DLD
Mean 37.3
Standard deviation 2.8
Values 35 39
[21]
liver DLD
Mean 47.9
Standard deviation 25
Values 56 37 79 20
[22]
ref_hepatocyte PDHA1
Mean 24.9
Standard deviation 8.4
Values 25 38 16 25 20
[23]
HepG2 PDHA1
Mean 32
Standard deviation 3.7
Values 29 35
[24]
HepG2.C3A PDHA1
Mean 28.2
Standard deviation 0.42
Values 28 28
[25]
HuH.7 PDHA1
Mean 55
Standard deviation 18
Values 64 34 67
[26]
SNU475 PDHA1
Mean 31.4
Standard deviation 0.34
Values 32 31
[27]
THLE PDHA1
Mean 25.6
Standard deviation 3
Values 24 28
[28]
liver PDHA1
Mean 39.1
Standard deviation 23
Values 54 22 63 17
[29]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[30]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[31]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[32]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[33]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[34]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[35]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[36]
ref_hepatocyte PDHX
Mean 11.4
Standard deviation 4.3
Values 15 17 6.9 8.2 10
[37]
HepG2 PDHX
Mean 17.1
Standard deviation 5.7
Values 13 21
[38]
HepG2.C3A PDHX
Mean 30.4
Standard deviation 1.9
Values 29 32
[39]
HuH.7 PDHX
Mean 28.3
Standard deviation 3.1
Values 30 25 30
[40]
SNU475 PDHX
Mean 17.6
Standard deviation 1.9
Values 16 19
[41]
THLE PDHX
Mean 12.8
Standard deviation 1.1
Values 12 14
[42]
liver PDHX
Mean 18
Standard deviation 6.9
Values 24 14 24 10
[43]
ref_hepatocyte PPARD
Mean 10.1
Standard deviation 15
Values 1.4 2.3 37 7.9 2.2
[44]
HepG2 PPARD
Mean 17.4
Standard deviation 8.1
Values 23 12
[45]
HepG2.C3A PPARD
Mean 10.6
Standard deviation 2.3
Values 12 8.9
[46]
HuH.7 PPARD
Mean 8.45
Standard deviation 0.13
Values 8.5 8.5 8.3
[47]
SNU475 PPARD
Mean 19.7
Standard deviation 2.2
Values 21 18
[48]
THLE PPARD
Mean 29.3
Standard deviation 0.077
Values 29 29
[49]
liver PPARD
Mean 4.66
Standard deviation 1.3
Values 4.8 2.7 5.8 5.3
[50]
ref_hepatocyte DLAT
Mean 7.51
Standard deviation 3.3
Values 6.6 12 9.3 4.2 5.2
[51]
HepG2 DLAT
Mean 29.3
Standard deviation 8.9
Values 23 36
[52]
HepG2.C3A DLAT
Mean 22.9
Standard deviation 4.1
Values 20 26
[53]
HuH.7 DLAT
Mean 30.4
Standard deviation 4
Values 35 26 30
[54]
SNU475 DLAT
Mean 27.6
Standard deviation 0.023
Values 28 28
[55]
THLE DLAT
Mean 22.4
Standard deviation 2.8
Values 20 24
[56]
liver DLAT
Mean 13.6
Standard deviation 1.8
Values 13 13 16 12
[57]
ref_hepatocyte PDK4
Mean 6.64
Standard deviation 8
Values 0.25 3.9 0.83 8.4 20
[58]
HepG2 PDK4
Mean 0.192
Standard deviation 0.14
Values 0.092 0.29
[59]
HepG2.C3A PDK4
Mean 0.0355
Standard deviation 0.0047
Values 0.039 0.032
[60]
HuH.7 PDK4
Mean 0.267
Standard deviation 0.054
Values 0.31 0.28 0.21
[61]
SNU475 PDK4
Mean 2.44
Standard deviation 0.53
Values 2.8 2.1
[62]
THLE PDK4
Mean 75.1
Standard deviation 8.3
Values 81 69
[63]
liver PDK4
Mean 57.6
Standard deviation 22
Values 82 35 42 72
[64]
ref_hepatocyte PDK2
Mean 4.96
Standard deviation 3.1
Values 3.2 2.9 2 8.6 8.1
[65]
HepG2 PDK2
Mean 12.8
Standard deviation 0.77
Values 12 13
[66]
HepG2.C3A PDK2
Mean 12.2
Standard deviation 2.8
Values 14 10
[67]
HuH.7 PDK2
Mean 5.43
Standard deviation 1.1
Values 6.2 4.1 5.9
[68]
SNU475 PDK2
Mean 0.514
Standard deviation 0.33
Values 0.28 0.75
[69]
THLE PDK2
Mean 10.8
Standard deviation 1.9
Values 9.4 12
[70]
liver PDK2
Mean 19.1
Standard deviation 13
Values 31 6.6 30 8.9
[71]
ref_hepatocyte PDK1
Mean 1.82
Standard deviation 1.1
Values 3.7 1.3 0.89 1.1 2.1
[72]
HepG2 PDK1
Mean 20.7
Standard deviation 5.2
Values 17 24
[73]
HepG2.C3A PDK1
Mean 30.3
Standard deviation 3.9
Values 28 33
[74]
HuH.7 PDK1
Mean 22.3
Standard deviation 0.9
Values 23 22 21
[75]
SNU475 PDK1
Mean 20.4
Standard deviation 4.6
Values 24 17
[76]
THLE PDK1
Mean 6.71
Standard deviation 0.29
Values 6.5 6.9
[77]
liver PDK1
Mean 10.8
Standard deviation 3
Values 10 12 14 7.1
[78]
ref_hepatocyte PDP2
Mean 1.33
Standard deviation 0.54
Values 1.9 0.85 1 0.93 1.9
[79]
HepG2 PDP2
Mean 11
Standard deviation 1.3
Values 12 10
[80]
HepG2.C3A PDP2
Mean 12.8
Standard deviation 1.3
Values 14 12
[81]
HuH.7 PDP2
Mean 18.3
Standard deviation 2.6
Values 18 21 16
[82]
SNU475 PDP2
Mean 8.5
Standard deviation 0.56
Values 8.9 8.1
[83]
THLE PDP2
Mean 7.59
Standard deviation 1.4
Values 6.6 8.6
[84]
liver PDP2
Mean 10.1
Standard deviation 3.5
Values 6.2 15 11 8.7
[85]
ref_hepatocyte PDPR
Mean 1.11
Standard deviation 0.68
Values 2.3 1 0.85 0.53 0.87
[86]
HepG2 PDPR
Mean 22.3
Standard deviation 3.7
Values 20 25
[87]
HepG2.C3A PDPR
Mean 20.8
Standard deviation 0.99
Values 20 22
[88]
HuH.7 PDPR
Mean 31.5
Standard deviation 9
Values 39 34 22
[89]
SNU475 PDPR
Mean 10.2
Standard deviation 1
Values 11 9.5
[90]
THLE PDPR
Mean 16.2
Standard deviation 1.1
Values 15 17
[91]
liver PDPR
Mean 9.88
Standard deviation 3.8
Values 10 9.2 5.4 15
[92]
ref_hepatocyte PDP1
Mean 1.02
Standard deviation 0.64
Values 1.3 1.7 1.4 0.21 0.49
[93]
HepG2 PDP1
Mean 4.87
Standard deviation 1.8
Values 6.2 3.6
[94]
HepG2.C3A PDP1
Mean 1.26
Standard deviation 0.064
Values 1.3 1.2
[95]
HuH.7 PDP1
Mean 1.64
Standard deviation 0.16
Values 1.8 1.6 1.5
[96]
SNU475 PDP1
Mean 16.4
Standard deviation 5
Values 13 20
[97]
THLE PDP1
Mean 19.3
Standard deviation 2.9
Values 17 21
[98]
liver PDP1
Mean 4.83
Standard deviation 0.92
Values 3.7 5.7 5.4 4.5
[99]
ref_hepatocyte PDK3
Mean 0.851
Standard deviation 0.55
Values 0.39 1.1 0.17 1.5 1.1
[100]
HepG2 PDK3
Mean 7.32
Standard deviation 2.4
Values 5.6 9
[101]
HepG2.C3A PDK3
Mean 9.37
Standard deviation 1.6
Values 8.3 10
[102]
HuH.7 PDK3
Mean 19.7
Standard deviation 3.8
Values 24 17 19
[103]
SNU475 PDK3
Mean 12.5
Standard deviation 1.3
Values 13 12
[104]
THLE PDK3
Mean 13
Standard deviation 2.9
Values 15 11
[105]
liver PDK3
Mean 29.5
Standard deviation 3.5
Values 26 34 29 29
[106]
ref_hepatocyte PDHA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 PDHA2
Missing
[108]
HepG2.C3A PDHA2
Missing
[109]
HuH.7 PDHA2
Missing
[110]
SNU475 PDHA2
Missing
[111]
THLE PDHA2
Missing
[112]
liver PDHA2
Missing