REACTOME_REGULATION_OF_PTEN_STABILITY_AND_ACTIVITY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.16[2] | -1.24[3] | -1.08[4] | -1.42[5] | -1.03[6] | -0.54[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.72[16] | -0.49[17] | -0.72[18] | -0.57[19] | -0.65[20] | -0.08[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.49[23] | -2.08[24] | -1.69[25] | -1.29[26] | -1.87[27] | -1.04[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.30[30] | -1.70[31] | -1.78[32] | -1.07[33] | -1.41[34] | -0.66[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.65[37] | 0.77[38] | -0.53[39] | 0.56[40] | 0.06[41] | 0.36[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.20[44] | 0.32[45] | -0.73[46] | -0.69[47] | 0.02[48] | 0.20[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.29[51] | -1.06[52] | 0.00[53] | -0.71[54] | -0.88[55] | -0.10[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.04[58] | 0.14[59] | 0.30[60] | 0.72[61] | 0.66[62] | -0.42[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.98[65] | -0.96[66] | -0.80[67] | -1.06[68] | -0.67[69] | -0.86[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.42[72] | 0.00[73] | -0.05[74] | -0.33[75] | -0.10[76] | -0.39[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.54[79] | 0.28[80] | 0.24[81] | 0.19[82] | 0.16[83] | -0.31[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.39[86] | 0.29[87] | 0.12[88] | 0.50[89] | 0.28[90] | -0.39[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.42[93] | -0.47[94] | 0.18[95] | -0.70[96] | -0.55[97] | 0.08[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -1.01[100] | 0.01[101] | -0.63[102] | 0.04[103] | -0.45[104] | -0.14[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.46[107] | -0.29[108] | -0.12[109] | -0.50[110] | -0.82[111] | 0.02[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.54[114] | 0.43[115] | 0.80[116] | -0.01[117] | 0.32[118] | 0.24[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | -0.03[121] | 0.01[122] | 0.24[123] | 0.70[124] | 0.12[125] | -0.08[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.11[128] | 0.28[129] | 0.17[130] | -0.39[131] | 0.04[132] | -0.26[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | 0.06[135] | 0.32[136] | 0.49[137] | -0.11[138] | 0.60[139] | -0.23[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.59[142] | 0.79[143] | 0.89[144] | 0.99[145] | 2.25[146] | 0.81[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.09[149] | 0.00[150] | -0.62[151] | 1.18[152] | 0.66[153] | -0.03[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | 0.10[156] | 0.51[157] | 0.60[158] | 0.75[159] | 0.21[160] | 0.45[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.72[163] | 1.75[164] | 2.80[165] | 0.83[166] | 1.58[167] | 0.68[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | 0.42[170] | 0.33[171] | 0.44[172] | 0.16[173] | 0.53[174] | 0.22[175] |
26 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [176] | 0.81[177] | 0.32[178] | 0.95[179] | 0.69[180] | 0.87[181] | -0.06[182] |
27 | PSMB8 | Proteasome subunit beta type-8 | [183] | -1.58[184] | -2.16[185] | -9.34[186] | 0.67[187] | -0.68[188] | -0.75[189] |
28 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [190] | -0.01[191] | 0.61[192] | 0.90[193] | 0.56[194] | 0.55[195] | -0.21[196] |
29 | PSMC4 | 26S proteasome regulatory subunit 6B | [197] | 0.42[198] | 0.46[199] | 0.43[200] | 0.19[201] | 0.26[202] | 0.27[203] |
30 | CSNK2B | Casein kinase II subunit beta | [204] | 0.69[205] | 0.65[206] | 0.04[207] | 0.36[208] | 0.03[209] | -0.17[210] |
31 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [211] | -0.74[212] | -0.24[213] | -1.30[214] | -0.44[215] | 0.33[216] | -0.32[217] |
32 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [218] | 0.46[219] | 0.59[220] | 1.12[221] | 0.62[222] | 0.09[223] | -0.13[224] |
33 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [225] | -0.36[226] | -0.26[227] | -0.54[228] | 0.24[229] | 0.26[230] | -0.21[231] |
34 | AKT1 | RAC-alpha serine/threonine-protein kinase | [232] | 1.12[233] | 1.01[234] | -0.06[235] | 1.31[236] | 1.26[237] | 1.10[238] |
35 | STUB1 | E3 ubiquitin-protein ligase CHIP | [239] | -0.94[240] | -0.80[241] | -1.45[242] | -1.30[243] | -1.05[244] | -0.91[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.06[247] | 1.53[248] | 0.38[249] | 0.60[250] | 0.49[251] | 0.44[252] |
37 | CSNK2A1 | Casein kinase II subunit alpha | [253] | 1.16[254] | 1.15[255] | 1.09[256] | 1.00[257] | 0.57[258] | -0.39[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 0.82[261] | 0.45[262] | 1.07[263] | 1.00[264] | 1.12[265] | 1.27[266] |
39 | PSMC2 | 26S proteasome regulatory subunit 7 | [267] | 0.57[268] | 0.99[269] | 0.80[270] | 1.40[271] | 1.18[272] | 1.32[273] |
40 | PSME3 | Proteasome activator complex subunit 3 | [274] | 1.80[275] | 1.54[276] | 1.25[277] | 1.43[278] | 1.65[279] | 0.89[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.56[282] | 1.90[283] | 1.81[284] | 2.23[285] | 2.20[286] | 2.07[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.16[289] | -0.55[290] | -2.41[291] | 0.02[292] | -1.19[293] | -0.08[294] |
43 | PSMA5 | Proteasome subunit alpha type-5 | [295] | 1.89[296] | 2.33[297] | 1.93[298] | 2.28[299] | 1.80[300] | 1.91[301] |
44 | PSMF1 | Proteasome inhibitor PI31 subunit | [302] | 2.27[303] | 2.33[304] | 1.17[305] | 1.29[306] | 1.01[307] | 1.86[308] |
45 | TRIM27 | Zinc finger protein RFP | [309] | 1.76[310] | 1.83[311] | 0.98[312] | 1.25[313] | 0.76[314] | 1.63[315] |
46 | PSMB2 | Proteasome subunit beta type-2 | [316] | 2.05[317] | 1.80[318] | 2.22[319] | 2.59[320] | 2.53[321] | 2.40[322] |
47 | PSMB9 | Proteasome subunit beta type-9 | [323] | -1.96[324] | -4.56[325] | -6.84[326] | 1.84[327] | -0.47[328] | -0.49[329] |
48 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [330] | 0.42[331] | 0.93[332] | -0.02[333] | 0.46[334] | 0.86[335] | 0.73[336] |
49 | MKRN1 | E3 ubiquitin-protein ligase makorin-1 | [337] | 1.26[338] | 1.09[339] | 1.86[340] | 1.76[341] | 1.18[342] | 1.45[343] |
50 | AKT2 | RAC-beta serine/threonine-protein kinase | [344] | 2.00[345] | 2.39[346] | 2.53[347] | 2.22[348] | 1.94[349] | 2.47[350] |
51 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [351] | 0.98[352] | 1.32[353] | 1.37[354] | 2.14[355] | 1.41[356] | 0.71[357] |
52 | PSME4 | Proteasome activator complex subunit 4 | [358] | 2.51[359] | 3.44[360] | 3.47[361] | 2.69[362] | 2.61[363] | 2.98[364] |
53 | CSNK2A2 | Casein kinase II subunit alpha' | [365] | 1.24[366] | 1.42[367] | 1.42[368] | 0.95[369] | 1.08[370] | -0.86[371] |
54 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | 0.50[372] | 2.01[373] | 2.22[374] | 0.79[375] | 1.98[376] | 3.82[377] | |
55 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [378] | 1.40[379] | 0.97[380] | 2.56[381] | 2.52[382] | 2.56[383] | 2.16[384] |
56 | RNF146 | E3 ubiquitin-protein ligase RNF146 | [385] | 0.99[386] | 1.58[387] | 0.82[388] | 1.97[389] | 1.60[390] | 1.80[391] |
57 | WWP2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | [392] | 2.78[393] | 2.91[394] | 2.67[395] | 2.10[396] | 2.04[397] | 2.42[398] |
58 | NEDD4 | E3 ubiquitin-protein ligase NEDD4 | [399] | 0.58[400] | 2.77[401] | 2.92[402] | 2.36[403] | 2.56[404] | 3.54[405] |
59 | TNKS2 | Tankyrase-2 | [406] | 2.75[407] | 3.95[408] | 4.42[409] | 3.49[410] | 3.60[411] | 3.76[412] |
60 | XIAP | E3 ubiquitin-protein ligase XIAP | [413] | 2.56[414] | 3.27[415] | 3.73[416] | 3.95[417] | 3.30[418] | 4.02[419] |
61 | USP13 | Ubiquitin carboxyl-terminal hydrolase 13 | [420] | 3.19[421] | 4.96[422] | 3.77[423] | 3.33[424] | 3.40[425] | 3.45[426] |
62 | TNKS | Tankyrase-1 | [427] | 3.77[428] | 4.22[429] | 5.20[430] | 2.97[431] | 3.93[432] | 4.54[433] |
63 | FRK | Tyrosine-protein kinase FRK | [434] | 1.47[435] | 2.25[436] | 2.71[437] | 2.46[438] | -0.06[439] | 4.32[440] |
64 | OTUD3 | OTU domain-containing protein 3 | [441] | 3.01[442] | 4.04[443] | 2.98[444] | 3.79[445] | 3.29[446] | 2.22[447] |
65 | AKT3 | RAC-gamma serine/threonine-protein kinase | [448] | -0.80[449] | -3.24[450] | -2.55[451] | 7.20[452] | 6.09[453] | 4.95[454] |
66 | PREX2 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein | -2.37[455] | -2.18[456] | 4.94[457] | 3.96[458] | [459] | 8.25[460] | |
67 | SEM1 | Putative protein SEM1, isoform 2 | [461] | [462] | [463] | [464] | [465] | [466] | [467] |
68 | PSMA8 | Proteasome subunit alpha type-7-like | [468] | [469] | [470] | [471] | [472] | [473] | [474] |
69 | PSMB11 | Proteasome subunit beta type-11 | [475] | [476] | [477] | [478] | [479] | [480] | [481] |