REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHEB | GTP-binding protein Rheb | [1] | -2.38[2] | -1.91[3] | -2.04[4] | -1.57[5] | -1.57[6] | -1.15[7] |
2 | LAMTOR2 | Ragulator complex protein LAMTOR2 | [8] | -3.85[9] | -3.93[10] | -4.20[11] | -4.00[12] | -3.91[13] | -2.24[14] |
3 | JUN | Transcription factor AP-1 | [15] | -0.93[16] | -2.57[17] | -2.36[18] | -2.17[19] | -1.71[20] | -1.87[21] |
4 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [22] | -1.06[23] | -1.91[24] | -2.06[25] | -1.54[26] | -1.69[27] | -1.37[28] |
5 | RRAGA | Ras-related GTP-binding protein A | [29] | -0.13[30] | -0.99[31] | -2.32[32] | -1.50[33] | -1.01[34] | -0.90[35] |
6 | RBBP7 | Histone-binding protein RBBP7 | [36] | -0.57[37] | -0.49[38] | -0.87[39] | 0.18[40] | 0.82[41] | -0.73[42] |
7 | PHC2 | Polyhomeotic-like protein 2 | [43] | 0.02[44] | -0.24[45] | -0.69[46] | -0.70[47] | 0.38[48] | -0.74[49] |
8 | HDAC1 | Histone deacetylase 1 | [50] | 0.07[51] | -0.02[52] | 0.61[53] | 0.18[54] | -0.14[55] | -0.53[56] |
9 | MAF1 | Repressor of RNA polymerase III transcription MAF1 homolog | [57] | -0.26[58] | 0.14[59] | -0.56[60] | -0.08[61] | -0.89[62] | -0.78[63] |
10 | KDM1A | Lysine-specific histone demethylase 1A | [64] | 0.64[65] | 1.13[66] | 0.58[67] | 0.41[68] | -0.17[69] | -0.89[70] |
11 | CHD4 | Chromodomain-helicase-DNA-binding protein 4 | [71] | 1.60[72] | 1.03[73] | 1.02[74] | 1.52[75] | 1.28[76] | 1.50[77] |
12 | EGR1 | Early growth response protein 1 | [78] | -2.24[79] | -1.86[80] | -4.04[81] | -2.79[82] | -1.24[83] | 1.08[84] |
13 | MTA1 | Metastasis-associated protein MTA1 | [85] | -0.15[86] | -0.32[87] | -0.24[88] | -0.56[89] | -0.81[90] | -2.08[91] |
14 | HDAC3 | Histone deacetylase 3 | [92] | 0.04[93] | -0.01[94] | -0.26[95] | -0.51[96] | -0.47[97] | -0.47[98] |
15 | MTA2 | Metastasis-associated protein MTA2 | [99] | 0.58[100] | -0.36[101] | -0.07[102] | 0.16[103] | 0.28[104] | -0.49[105] |
16 | MBD3 | Methyl-CpG-binding domain protein 3 | [106] | 0.03[107] | 0.50[108] | -0.39[109] | -0.77[110] | 0.11[111] | -0.15[112] |
17 | MAPK1 | Mitogen-activated protein kinase 1 | [113] | 1.27[114] | 1.31[115] | 1.08[116] | 1.38[117] | 0.92[118] | 1.71[119] |
18 | RING1 | E3 ubiquitin-protein ligase RING1 | [120] | -0.37[121] | -0.76[122] | -1.57[123] | -0.15[124] | -0.84[125] | -2.24[126] |
19 | MLST8 | Target of rapamycin complex subunit LST8 | [127] | -0.61[128] | -0.39[129] | -0.07[130] | -1.44[131] | -1.20[132] | -0.63[133] |
20 | GATAD2A | Transcriptional repressor p66-alpha | [134] | 0.72[135] | -0.18[136] | 1.12[137] | -0.18[138] | 0.58[139] | -0.01[140] |
21 | RRAGC | Ras-related GTP-binding protein C | [141] | -0.99[142] | -1.93[143] | -1.59[144] | -0.09[145] | -0.51[146] | -1.03[147] |
22 | MTA3 | Metastasis-associated protein MTA3 | [148] | 0.09[149] | -0.32[150] | -1.25[151] | -0.39[152] | -0.86[153] | -1.72[154] |
23 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [155] | 0.20[156] | 1.15[157] | 1.32[158] | 0.32[159] | -0.02[160] | 0.96[161] |
24 | RBBP4 | Histone-binding protein RBBP4 | [162] | 1.50[163] | 1.52[164] | 1.27[165] | 1.21[166] | 1.49[167] | 1.44[168] |
25 | SLC38A9 | Sodium-coupled neutral amino acid transporter 9 | [169] | -1.12[170] | -0.98[171] | -1.92[172] | -1.38[173] | -1.58[174] | -0.29[175] |
26 | HDAC2 | Histone deacetylase 2 | [176] | 1.29[177] | 2.51[178] | 1.82[179] | 1.70[180] | 1.73[181] | 0.14[182] |
27 | CBX4 | E3 SUMO-protein ligase CBX4 | [183] | 0.70[184] | 0.45[185] | 0.25[186] | -0.14[187] | -0.96[188] | -1.47[189] |
28 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.98[190] | 0.31[191] | 0.45[192] | -1.03[193] | 0.11[194] | 2.41[195] | |
29 | TP53 | Cellular tumor antigen p53 | [196] | 1.20[197] | 0.66[198] | 1.36[199] | 0.83[200] | 0.38[201] | -0.11[202] |
30 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [203] | 0.55[204] | 1.03[205] | 0.08[206] | 0.01[207] | 0.41[208] | 0.83[209] |
31 | MAPK3 | Mitogen-activated protein kinase 3 | [210] | 1.41[211] | 1.35[212] | 1.34[213] | -0.04[214] | -0.13[215] | -1.10[216] |
32 | SUZ12 | Polycomb protein SUZ12 | [217] | 0.07[218] | 1.15[219] | 2.15[220] | 1.56[221] | 1.50[222] | 1.08[223] |
33 | PPARG | Peroxisome proliferator-activated receptor gamma | [224] | -0.52[225] | 0.99[226] | 1.44[227] | 0.38[228] | 0.24[229] | -0.44[230] |
34 | MTOR | Serine/threonine-protein kinase mTOR | [231] | 2.10[232] | 3.01[233] | 2.51[234] | 2.22[235] | 2.19[236] | 3.39[237] |
35 | EZH2 | Histone-lysine N-methyltransferase EZH2 | [238] | 0.43[239] | 1.02[240] | 0.64[241] | 1.03[242] | 0.72[243] | -0.88[244] |
36 | ATN1 | Atrophin-1 | [245] | 1.90[246] | 1.28[247] | 1.40[248] | 2.05[249] | 2.81[250] | 0.26[251] |
37 | CBX6 | Chromobox protein homolog 6 | [252] | 0.44[253] | -0.19[254] | -0.04[255] | 1.05[256] | 1.42[257] | 0.91[258] |
38 | SNAI2 | Zinc finger protein SNAI2 | [259] | -5.65[260] | -6.72[261] | -8.49[262] | -0.37[263] | 2.54[264] | -0.67[265] |
39 | RCOR1 | REST corepressor 1 | [266] | 1.35[267] | 1.05[268] | 1.04[269] | 2.37[270] | 1.44[271] | 1.03[272] |
40 | CBX8 | Chromobox protein homolog 8 | [273] | -0.20[274] | 0.28[275] | 0.02[276] | -0.41[277] | -1.65[278] | -2.15[279] |
41 | EED | Polycomb protein EED | [280] | 0.72[281] | 0.22[282] | 0.41[283] | 0.99[284] | 0.91[285] | 0.13[286] |
42 | HDAC5 | Histone deacetylase 5 | [287] | 2.24[288] | 2.97[289] | 2.27[290] | 1.19[291] | 0.47[292] | 1.13[293] |
43 | RNF2 | E3 ubiquitin-protein ligase RING2 | [294] | 0.33[295] | 1.12[296] | 0.50[297] | 1.63[298] | -0.01[299] | 0.28[300] |
44 | BMI1 | Polycomb complex protein BMI-1 | [301] | -3.14[302] | -1.48[303] | -2.50[304] | -1.43[305] | -1.73[306] | -1.55[307] |
45 | SCMH1 | Polycomb protein SCMH1 | [308] | 1.16[309] | -1.52[310] | 0.40[311] | 0.77[312] | 0.81[313] | 1.03[314] |
46 | RPTOR | Regulatory-associated protein of mTOR | [315] | 2.65[316] | 1.78[317] | 1.82[318] | 1.38[319] | 1.51[320] | 2.27[321] |
47 | RRAGD | Ras-related GTP-binding protein D | [322] | -1.45[323] | -5.26[324] | 2.58[325] | 0.65[326] | -1.18[327] | 1.12[328] |
48 | REST | RE1-silencing transcription factor | [329] | 0.86[330] | 1.46[331] | 1.56[332] | 1.71[333] | 1.88[334] | 3.07[335] |
49 | PHC1 | Polyhomeotic-like protein 1 | [336] | 1.09[337] | 0.10[338] | 0.20[339] | 0.29[340] | 1.18[341] | 0.12[342] |
50 | RRAGB | Ras-related GTP-binding protein B | [343] | -0.71[344] | -0.25[345] | -9.78[346] | -0.02[347] | -0.31[348] | 0.53[349] |
51 | HDAC7 | Histone deacetylase 7 | [350] | 1.95[351] | 1.20[352] | 0.83[353] | 2.64[354] | 2.85[355] | 0.91[356] |
52 | GATAD2B | Transcriptional repressor p66-beta | [357] | 1.20[358] | 0.71[359] | 2.08[360] | 2.31[361] | 2.01[362] | 2.06[363] |
53 | PHC3 | Polyhomeotic-like protein 3 | [364] | 1.28[365] | 2.39[366] | 3.52[367] | 2.16[368] | 2.55[369] | 4.20[370] |
54 | CBX2 | Chromobox protein homolog 2 | [371] | 2.90[372] | 2.73[373] | 3.63[374] | 2.24[375] | 1.11[376] | -0.93[377] |
55 | CHD3 | Chromodomain-helicase-DNA-binding protein 3 | [378] | 2.36[379] | 2.87[380] | 4.93[381] | 5.83[382] | 4.89[383] | 2.46[384] |
56 | MECOM | MDS1 and EVI1 complex locus protein EVI1 | [385] | -1.57[386] | -3.44[387] | 5.18[388] | 1.10[389] | 3.41[390] | 2.61[391] |
57 | SNAI1 | Zinc finger protein SNAI1 | [392] | 2.63[393] | 0.85[394] | 2.85[395] | 2.56[396] | 1.73[397] | 0.98[398] |
58 | SALL4 | Sal-like protein 4 | [399] | -0.43[400] | -2.31[401] | 3.22[402] | -1.19[403] | -0.90[404] | 1.12[405] |
59 | NR2E1 | Nuclear receptor subfamily 2 group E member 1 | [406] | -4.44[407] | [408] | -0.13[409] | 1.64[410] | -4.01[411] | 0.85[412] |
60 | LAMTOR4 | Ragulator complex protein LAMTOR4 | [413] | [414] | [415] | [416] | [417] | [418] | [419] |
61 | LAMTOR5 | Ragulator complex protein LAMTOR5 | [420] | [421] | [422] | [423] | [424] | [425] | [426] |