REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.64[2] | -1.91[3] | -1.78[4] | -2.33[5] | -1.74[6] | -0.74[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.20[16] | -1.15[17] | -1.42[18] | -1.47[19] | -1.36[20] | -0.29[21] |
4 | HSP90AA1 | Heat shock protein HSP 90-alpha | [22] | -0.09[23] | 0.82[24] | 0.02[25] | 0.54[26] | 0.36[27] | -0.12[28] |
5 | YWHAE | 14-3-3 protein epsilon | [29] | -0.68[30] | -0.64[31] | -0.31[32] | -0.41[33] | -0.24[34] | -0.42[35] |
6 | TUBB4B | Tubulin beta-4B chain | [36] | -0.23[37] | -0.40[38] | -0.45[39] | -1.19[40] | -0.17[41] | -0.32[42] |
7 | TUBB | Tubulin beta chain | [43] | 2.34[44] | 1.54[45] | 1.91[46] | 2.02[47] | 1.47[48] | 0.37[49] |
8 | DYNLL1 | Dynein light chain 1, cytoplasmic | [50] | -0.83[51] | -0.85[52] | -1.10[53] | -1.17[54] | -1.31[55] | -0.96[56] |
9 | SKP1 | S-phase kinase-associated protein 1 | [57] | -0.43[58] | -0.09[59] | -0.99[60] | -0.05[61] | 0.30[62] | 0.45[63] |
10 | TUBA4A | Tubulin alpha-4A chain | [64] | -3.49[65] | -3.72[66] | -4.52[67] | -1.35[68] | -1.39[69] | -1.48[70] |
11 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [71] | 1.23[72] | 1.08[73] | 2.09[74] | -0.08[75] | 0.87[76] | 0.48[77] |
12 | CETN2 | Centrin-2 | [78] | -2.05[79] | -1.73[80] | -2.93[81] | -2.21[82] | -2.50[83] | -2.35[84] |
13 | YWHAG | 14-3-3 protein gamma | [85] | 0.76[86] | 0.16[87] | 0.19[88] | 1.17[89] | 0.61[90] | -0.20[91] |
14 | OPTN | Optineurin | [92] | -1.01[93] | -0.21[94] | -0.96[95] | 0.68[96] | -0.05[97] | -0.07[98] |
15 | DCTN2 | Dynactin subunit 2 | [99] | 0.17[100] | 0.57[101] | 0.32[102] | 0.31[103] | 0.26[104] | -0.31[105] |
16 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [106] | 0.32[107] | 0.82[108] | 0.88[109] | 1.21[110] | 1.16[111] | 1.64[112] |
17 | RAB8A | Ras-related protein Rab-8A | [113] | -0.86[114] | -0.96[115] | -0.23[116] | -1.58[117] | -0.59[118] | 0.65[119] |
18 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 1.35[120] | 1.12[121] | 1.02[122] | 1.66[123] | 1.12[124] | 1.28[125] | |
19 | SSNA1 | Sjoegren syndrome nuclear autoantigen 1 | [126] | -0.89[127] | -1.01[128] | -1.03[129] | -1.20[130] | -1.14[131] | -0.79[132] |
20 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 | [133] | 2.23[134] | 1.76[135] | 1.07[136] | 2.15[137] | 1.50[138] | -0.41[139] |
21 | HAUS4 | HAUS augmin-like complex subunit 4 | [140] | 0.30[141] | -1.00[142] | 1.15[143] | -1.50[144] | -0.96[145] | -2.26[146] |
22 | DCTN3 | Dynactin subunit 3 | [147] | -1.40[148] | -1.26[149] | -1.14[150] | -1.60[151] | -0.38[152] | -0.41[153] |
23 | CSNK1D | Casein kinase I isoform delta | [154] | 1.73[155] | 1.43[156] | 1.32[157] | 1.48[158] | 1.14[159] | 0.55[160] |
24 | TUBG1 | Tubulin gamma-1 chain | [161] | 0.80[162] | 1.62[163] | 0.56[164] | -0.03[165] | 0.14[166] | -0.32[167] |
25 | DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 | [168] | 0.98[169] | 1.38[170] | 1.15[171] | 1.25[172] | 1.04[173] | 0.56[174] |
26 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [175] | 0.39[176] | 0.15[177] | 0.13[178] | -0.02[179] | 0.70[180] | 0.36[181] |
27 | ACTR1A | Alpha-centractin | [182] | 1.52[183] | 1.63[184] | 1.73[185] | 0.95[186] | 1.88[187] | 1.51[188] |
28 | DCTN1 | Dynactin subunit 1 | [189] | 2.42[190] | 1.51[191] | 0.84[192] | 1.88[193] | 2.02[194] | 1.70[195] |
29 | CUL1 | Cullin-1 | [196] | 0.17[197] | 0.79[198] | 0.31[199] | 1.04[200] | 0.82[201] | 1.89[202] |
30 | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha | [203] | 1.34[204] | 1.39[205] | 1.31[206] | 2.59[207] | 2.58[208] | 1.98[209] |
31 | AJUBA | LIM domain-containing protein ajuba | [210] | 3.09[211] | 1.51[212] | 3.44[213] | 1.69[214] | 0.88[215] | 1.70[216] |
32 | DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 | [217] | 4.12[218] | 2.65[219] | 3.43[220] | 4.11[221] | 4.25[222] | 4.33[223] |
33 | CCNB1 | G2/mitotic-specific cyclin-B1 | [224] | 2.40[225] | 2.58[226] | 2.73[227] | 2.06[228] | 3.17[229] | -1.20[230] |
34 | AURKA | Aurora kinase A | [231] | 2.26[232] | 2.46[233] | 1.93[234] | 2.07[235] | 2.11[236] | -1.66[237] |
35 | CEP57 | Centrosomal protein of 57 kDa | [238] | 0.41[239] | 1.99[240] | 2.34[241] | 1.01[242] | 0.84[243] | 2.14[244] |
36 | CSNK1E | Casein kinase I isoform epsilon | [245] | 1.92[246] | 1.49[247] | 2.12[248] | 0.92[249] | 2.12[250] | 0.32[251] |
37 | HAUS1 | HAUS augmin-like complex subunit 1 | [252] | 0.05[253] | 1.09[254] | 0.55[255] | 0.36[256] | 0.87[257] | -0.75[258] |
38 | FBXW11 | F-box/WD repeat-containing protein 11 | [259] | 1.93[260] | 1.78[261] | 2.51[262] | 1.98[263] | 2.02[264] | 2.09[265] |
39 | CDK5RAP2 | CDK5 regulatory subunit-associated protein 2 | [266] | 1.93[267] | 2.12[268] | 2.07[269] | 2.35[270] | 2.03[271] | 2.08[272] |
40 | CDK1 | Cyclin-dependent kinase 1 | [273] | 1.81[274] | 3.81[275] | 2.52[276] | 2.72[277] | 3.67[278] | -1.33[279] |
41 | CEP63 | Centrosomal protein of 63 kDa | [280] | -1.22[281] | 0.25[282] | 0.15[283] | -0.83[284] | -0.35[285] | 0.70[286] |
42 | CKAP5 | Cytoskeleton-associated protein 5 | [287] | 3.02[288] | 3.12[289] | 3.80[290] | 2.94[291] | 3.39[292] | 2.63[293] |
43 | ODF2 | Outer dense fiber protein 2 | [294] | 1.25[295] | 1.58[296] | 2.05[297] | 1.29[298] | 1.72[299] | 1.56[300] |
44 | PCM1 | Pericentriolar material 1 protein | [301] | 1.43[302] | 3.30[303] | 3.29[304] | 1.89[305] | 2.10[306] | 4.30[307] |
45 | PLK1 | Serine/threonine-protein kinase PLK1 | [308] | 3.05[309] | 2.73[310] | 2.56[311] | 1.70[312] | 2.86[313] | -1.49[314] |
46 | CEP70 | Centrosomal protein of 70 kDa | [315] | -1.35[316] | 0.50[317] | 0.99[318] | -0.06[319] | 0.23[320] | 1.67[321] |
47 | PPP1R12A | Protein phosphatase 1 regulatory subunit 12A | [322] | 0.71[323] | 2.38[324] | 2.08[325] | 3.18[326] | 2.23[327] | 2.88[328] |
48 | TUBA1A | Tubulin alpha-1A chain | [329] | 2.72[330] | -0.72[331] | -3.94[332] | 4.54[333] | 2.19[334] | 1.14[335] |
49 | HAUS2 | HAUS augmin-like complex subunit 2 | [336] | 1.59[337] | 1.62[338] | 1.54[339] | 2.26[340] | 2.31[341] | 0.76[342] |
50 | NINL | Ninein-like protein | [343] | 2.61[344] | 2.99[345] | 2.47[346] | 1.43[347] | 0.18[348] | 1.09[349] |
51 | HAUS8 | HAUS augmin-like complex subunit 8 | [350] | 0.43[351] | 0.63[352] | 1.56[353] | 0.36[354] | 0.99[355] | -0.12[356] |
52 | HAUS7 | HAUS augmin-like complex subunit 7 | [357] | 0.94[358] | 0.78[359] | 0.70[360] | 0.23[361] | 0.52[362] | 1.07[363] |
53 | CLASP1 | CLIP-associating protein 1 | [364] | 3.09[365] | 3.02[366] | 2.69[367] | 2.97[368] | 3.15[369] | 4.05[370] |
54 | HAUS6 | HAUS augmin-like complex subunit 6 | [371] | 1.87[372] | 3.08[373] | 2.81[374] | 2.26[375] | 3.11[376] | 2.19[377] |
55 | SDCCAG8 | Serologically defined colon cancer antigen 8 | [378] | -0.18[379] | 0.60[380] | 0.71[381] | 0.88[382] | 0.18[383] | 2.23[384] |
56 | OFD1 | Oral-facial-digital syndrome 1 protein | [385] | 0.09[386] | 1.77[387] | 1.67[388] | 1.25[389] | 1.09[390] | 2.44[391] |
57 | NEDD1 | Protein NEDD1 | [392] | 0.97[393] | 2.24[394] | 1.74[395] | 2.72[396] | 2.88[397] | 1.75[398] |
58 | AKAP9 | A-kinase anchor protein 9 | [399] | 0.58[400] | 3.23[401] | 3.38[402] | 2.25[403] | 2.50[404] | 6.21[405] |
59 | BTRC | F-box/WD repeat-containing protein 1A | [406] | 1.97[407] | 2.70[408] | 2.28[409] | 1.21[410] | 1.88[411] | 2.49[412] |
60 | CCNB2 | G2/mitotic-specific cyclin-B2 | [413] | 2.65[414] | 3.34[415] | 3.70[416] | 2.98[417] | 4.09[418] | -0.46[419] |
61 | NEK2 | Serine/threonine-protein kinase Nek2 | [420] | 1.58[421] | 2.58[422] | 3.17[423] | 2.59[424] | 3.18[425] | -1.13[426] |
62 | CEP250 | Centrosome-associated protein CEP250 | [427] | 4.04[428] | 3.61[429] | 3.57[430] | 3.76[431] | 3.22[432] | 2.49[433] |
63 | NDE1 | Nuclear distribution protein nudE homolog 1 | [434] | 3.22[435] | 2.42[436] | 1.40[437] | 1.21[438] | 2.31[439] | 1.08[440] |
64 | CEP164 | Centrosomal protein of 164 kDa | [441] | 2.68[442] | 2.66[443] | 2.41[444] | 2.89[445] | 2.70[446] | 2.50[447] |
65 | CCP110 | Centriolar coiled-coil protein of 110 kDa | [448] | 1.51[449] | 2.29[450] | 1.09[451] | 1.41[452] | 2.55[453] | 2.48[454] |
66 | CEP78 | Centrosomal protein of 78 kDa | [455] | 1.19[456] | 2.02[457] | 2.61[458] | 1.83[459] | 2.81[460] | 2.02[461] |
67 | HAUS3 | HAUS augmin-like complex subunit 3 | [462] | 0.97[463] | 2.08[464] | 2.47[465] | 2.59[466] | 2.59[467] | 2.46[468] |
68 | HAUS5 | HAUS augmin-like complex subunit 5 | [469] | 2.05[470] | 2.67[471] | 3.94[472] | 2.10[473] | 2.73[474] | 1.74[475] |
69 | CEP76 | Centrosomal protein of 76 kDa | [476] | 1.71[477] | 2.66[478] | 3.21[479] | 2.10[480] | 2.02[481] | 1.87[482] |
70 | SFI1 | Protein SFI1 homolog | [483] | 2.32[484] | 4.14[485] | 2.93[486] | 1.66[487] | 1.93[488] | 2.31[489] |
71 | PCNT | Pericentrin | [490] | 3.23[491] | 3.62[492] | 3.02[493] | 3.91[494] | 3.86[495] | 4.99[496] |
72 | CEP290 | Centrosomal protein of 290 kDa | [497] | 0.82[498] | 3.82[499] | 2.71[500] | 2.60[501] | 2.68[502] | 2.99[503] |
73 | BORA | Protein aurora borealis | [504] | 1.73[505] | 3.02[506] | 3.46[507] | 2.13[508] | 2.35[509] | 0.67[510] |
74 | CENPJ | Centromere protein J | [511] | 1.03[512] | 2.74[513] | 2.87[514] | 3.27[515] | 2.74[516] | 1.94[517] |
75 | CEP192 | Centrosomal protein of 192 kDa | [518] | 2.78[519] | 4.18[520] | 5.26[521] | 4.21[522] | 4.15[523] | 4.85[524] |
76 | PLK4 | Serine/threonine-protein kinase PLK4 | [525] | 2.38[526] | 3.95[527] | 3.00[528] | 3.03[529] | 4.03[530] | 0.00[531] |
77 | CNTRL | Centriolin | [532] | 1.56[533] | 3.74[534] | 4.56[535] | 3.21[536] | 3.04[537] | 3.72[538] |
78 | CEP72 | Centrosomal protein of 72 kDa | [539] | 1.74[540] | 1.66[541] | 2.66[542] | 1.32[543] | 1.93[544] | 2.24[545] |
79 | CEP135 | Centrosomal protein of 135 kDa | [546] | 1.01[547] | 2.24[548] | 1.87[549] | 2.54[550] | 2.63[551] | 2.48[552] |
80 | PPP1R12B | Protein phosphatase 1 regulatory subunit 12B | [553] | 2.64[554] | 3.43[555] | 3.80[556] | 4.47[557] | 3.49[558] | 5.72[559] |
81 | CEP41 | Centrosomal protein of 41 kDa | [560] | 2.67[561] | 2.46[562] | 3.24[563] | 3.69[564] | 3.61[565] | 2.89[566] |
82 | ALMS1 | Alstrom syndrome protein 1 | [567] | 3.21[568] | 4.72[569] | 4.53[570] | 4.44[571] | 4.40[572] | 5.78[573] |
83 | CEP152 | Centrosomal protein of 152 kDa | [574] | 2.19[575] | 4.12[576] | 4.27[577] | 4.30[578] | 4.48[579] | 4.05[580] |
84 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [581] | -1.78[582] | -0.02[583] | 4.23[584] | 5.54[585] | 4.18[586] | 4.45[587] |
85 | TUBB4A | Tubulin beta-4A chain | [588] | 2.38[589] | -1.80[590] | 4.70[591] | 4.09[592] | 2.78[593] | 2.99[594] |
86 | CEP131 | Centrosomal protein of 131 kDa | [595] | [596] | [597] | [598] | [599] | [600] | [601] |
87 | CEP43 | [602] | [603] | [604] | [605] | [606] | [607] | [608] |