REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | APOA2 | Apolipoprotein A-II | [1] | -1.24[2] | -0.87[3] | -1.50[4] | -9.97[5] | -9.64[6] | -1.35[7] |
2 | APOA1 | Apolipoprotein A-I | [8] | -1.23[9] | -0.62[10] | -2.86[11] | -10.48[12] | -10.54[13] | -0.37[14] |
3 | FABP1 | Fatty acid-binding protein, liver | [15] | -6.63[16] | -1.14[17] | -0.56[18] | -9.82[19] | -9.66[20] | -1.46[21] |
4 | AGT | Angiotensinogen | [22] | 1.18[23] | 1.47[24] | 0.27[25] | -3.03[26] | -8.00[27] | 2.63[28] |
5 | SULT2A1 | Bile salt sulfotransferase | [29] | -0.26[30] | 0.00[31] | -0.87[32] | -9.03[33] | -8.73[34] | 1.07[35] |
6 | ANKRD1 | Ankyrin repeat domain-containing protein 1 | [36] | 0.62[37] | -2.01[38] | -8.03[39] | -2.32[40] | 1.39[41] | -10.07[42] |
7 | HMGCS2 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | [43] | -10.42[44] | -8.75[45] | -1.43[46] | -7.01[47] | -11.33[48] | 1.61[49] |
8 | G0S2 | G0/G1 switch protein 2 | [50] | -7.10[51] | -10.92[52] | -3.23[53] | -0.76[54] | -0.65[55] | -1.25[56] |
9 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | [57] | 0.98[58] | -2.15[59] | -1.13[60] | -1.37[61] | 1.89[62] | 3.04[63] |
10 | TXNRD1 | Thioredoxin reductase 1, cytoplasmic | [64] | 2.42[65] | 0.93[66] | 1.18[67] | 5.05[68] | 3.85[69] | -1.29[70] |
11 | HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | [71] | -0.79[72] | 1.77[73] | 3.55[74] | -0.71[75] | -0.85[76] | 0.53[77] |
12 | CYP4A11 | Cytochrome P450 4A11 | [78] | -11.65[79] | -9.70[80] | -11.17[81] | -8.75[82] | -9.67[83] | 1.65[84] |
13 | FDFT1 | Squalene synthase | [85] | 1.25[86] | 2.53[87] | 2.48[88] | -0.19[89] | 0.96[90] | -0.18[91] |
14 | PLIN2 | Perilipin-2 | [92] | 4.27[93] | 3.43[94] | 2.38[95] | 0.72[96] | 4.76[97] | 2.10[98] |
15 | APOA5 | Apolipoprotein A-V | [99] | 0.37[100] | 1.40[101] | -0.35[102] | -8.68[103] | -7.30[104] | 2.95[105] |
16 | GPS2 | G protein pathway suppressor 2 | [106] | 0.98[107] | -0.20[108] | -0.20[109] | 1.10[110] | 1.02[111] | -2.04[112] |
17 | ALAS1 | 5-aminolevulinate synthase, nonspecific, mitochondrial | [113] | 1.32[114] | 0.27[115] | 1.37[116] | 1.69[117] | 2.06[118] | 1.86[119] |
18 | CYP1A1 | Cytochrome P450 1A1 | [120] | -1.45[121] | -3.71[122] | 0.34[123] | -1.91[124] | -2.35[125] | -5.02[126] |
19 | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | [127] | 1.04[128] | 1.80[129] | 1.47[130] | 2.20[131] | 1.38[132] | 1.60[133] |
20 | TRIB3 | Tribbles homolog 3 | [134] | 3.92[135] | 3.54[136] | 2.82[137] | 1.56[138] | 2.17[139] | 0.35[140] |
21 | SREBF1 | Sterol regulatory element-binding protein 1 | [141] | 2.24[142] | 1.85[143] | 2.79[144] | 2.04[145] | 2.32[146] | 1.27[147] |
22 | CCNC | Cyclin-C | [148] | 2.09[149] | 2.80[150] | 2.70[151] | 2.49[152] | 2.83[153] | 0.67[154] |
23 | MED8 | Mediator of RNA polymerase II transcription subunit 8 | [155] | 2.30[156] | 1.36[157] | 1.88[158] | 2.36[159] | 2.12[160] | -0.14[161] |
24 | ANGPTL4 | Angiopoietin-related protein 4 | [162] | 1.30[163] | -0.34[164] | 0.51[165] | 0.62[166] | 4.69[167] | 1.25[168] |
25 | MED10 | Mediator of RNA polymerase II transcription subunit 10 | [169] | 1.01[170] | 0.34[171] | -0.11[172] | 2.23[173] | 2.65[174] | -1.27[175] |
26 | NR1H4 | Bile acid receptor | [176] | 1.42[177] | 1.33[178] | 3.51[179] | -4.47[180] | -4.40[181] | 1.30[182] |
27 | THRAP3 | Thyroid hormone receptor-associated protein 3 | [183] | 3.79[184] | 3.04[185] | 3.90[186] | 4.17[187] | 4.48[188] | 1.95[189] |
28 | FADS1 | Fatty acid desaturase 1 | [190] | 3.38[191] | 3.81[192] | 5.54[193] | 4.09[194] | 3.94[195] | 1.93[196] |
29 | MED28 | Mediator of RNA polymerase II transcription subunit 28 | [197] | 2.40[198] | 2.03[199] | 2.82[200] | 2.08[201] | 1.80[202] | -1.55[203] |
30 | UGT1A9 | UDP-glucuronosyltransferase 1-9 | [204] | -4.70[205] | -10.24[206] | -6.04[207] | -3.10[208] | -8.26[209] | 0.14[210] |
31 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [211] | 2.45[212] | 4.54[213] | 5.20[214] | 3.27[215] | 3.06[216] | 2.15[217] |
32 | NR1H3 | Oxysterols receptor LXR-alpha | [218] | 1.34[219] | 1.70[220] | 3.01[221] | 0.85[222] | -0.40[223] | 0.47[224] |
33 | RXRA | Retinoic acid receptor RXR-alpha | [225] | 2.96[226] | 2.09[227] | 3.32[228] | 3.59[229] | 3.36[230] | 2.92[231] |
34 | ESRRA | Steroid hormone receptor ERR1 | [232] | 2.80[233] | 2.95[234] | 2.78[235] | 2.75[236] | 2.81[237] | 0.81[238] |
35 | MED11 | Mediator of RNA polymerase II transcription subunit 11 | [239] | 0.94[240] | 0.89[241] | 1.45[242] | 1.32[243] | 0.90[244] | -1.03[245] |
36 | GLIPR1 | Glioma pathogenesis-related protein 1 | [246] | 0.58[247] | -2.61[248] | -3.96[249] | 3.13[250] | 3.77[251] | -1.84[252] |
37 | NR1H2 | Oxysterols receptor LXR-beta | [253] | 2.33[254] | 1.54[255] | 2.30[256] | 3.33[257] | 3.78[258] | 0.79[259] |
38 | TNFRSF21 | Tumor necrosis factor receptor superfamily member 21 | [260] | 4.94[261] | 1.86[262] | 2.48[263] | 4.73[264] | 4.76[265] | -1.91[266] |
39 | HDAC3 | Histone deacetylase 3 | [267] | 3.49[268] | 2.88[269] | 3.07[270] | 3.53[271] | 3.79[272] | 0.37[273] |
40 | CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial | [274] | 1.50[275] | 1.69[276] | 2.68[277] | 2.13[278] | 2.49[279] | 2.67[280] |
41 | MED6 | Mediator of RNA polymerase II transcription subunit 6 | [281] | 2.37[282] | 1.41[283] | 1.41[284] | 2.86[285] | 2.78[286] | -0.99[287] |
42 | ACOX1 | Peroxisomal acyl-coenzyme A oxidase 1 | [288] | 3.94[289] | 3.70[290] | 3.59[291] | 3.15[292] | 2.90[293] | 3.85[294] |
43 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform | [295] | 4.47[296] | 2.23[297] | 3.40[298] | 5.81[299] | 4.61[300] | 3.71[301] |
44 | NFYC | Nuclear transcription factor Y subunit gamma | [302] | 2.71[303] | 1.90[304] | 2.38[305] | 3.32[306] | 2.72[307] | 0.35[308] |
45 | SREBF2 | Sterol regulatory element-binding protein 2 | [309] | 4.28[310] | 4.45[311] | 6.03[312] | 3.25[313] | 3.63[314] | 2.25[315] |
46 | MED4 | Mediator of RNA polymerase II transcription subunit 4 | [316] | 2.26[317] | 1.99[318] | 2.81[319] | 2.29[320] | 3.08[321] | 0.22[322] |
47 | MED15 | Mediator of RNA polymerase II transcription subunit 15 | [323] | 4.15[324] | 2.67[325] | 2.88[326] | 4.84[327] | 4.74[328] | 0.30[329] |
48 | PEX11A | Peroxisomal membrane protein 11A | [330] | 0.56[331] | 0.74[332] | 0.72[333] | 1.83[334] | 1.13[335] | 1.23[336] |
49 | FHL2 | Four and a half LIM domains protein 2 | [337] | 3.54[338] | 2.13[339] | -4.22[340] | 4.29[341] | 4.40[342] | -1.26[343] |
50 | MED29 | Mediator of RNA polymerase II transcription subunit 29 | [344] | 3.25[345] | 2.51[346] | 3.17[347] | 4.08[348] | 3.98[349] | 1.15[350] |
51 | ABCB4 | Phosphatidylcholine translocator ABCB4 | [351] | 1.15[352] | 1.33[353] | 2.49[354] | -1.78[355] | -5.50[356] | 4.36[357] |
52 | CARM1 | Histone-arginine methyltransferase CARM1 | [358] | 4.47[359] | 3.24[360] | 3.96[361] | 3.33[362] | 4.22[363] | -0.24[364] |
53 | NCOR1 | Nuclear receptor corepressor 1 | [365] | 4.09[366] | 3.92[367] | 4.96[368] | 5.15[369] | 5.29[370] | 3.57[371] |
54 | NR1D1 | Nuclear receptor subfamily 1 group D member 1 | [372] | 1.74[373] | 0.74[374] | 1.64[375] | 2.46[376] | 1.96[377] | -0.18[378] |
55 | MED16 | Mediator of RNA polymerase II transcription subunit 16 | [379] | 3.40[380] | 2.63[381] | 2.75[382] | 3.73[383] | 3.66[384] | 2.00[385] |
56 | MED24 | Mediator of RNA polymerase II transcription subunit 24 | [386] | 4.87[387] | 3.38[388] | 4.72[389] | 4.46[390] | 4.86[391] | 1.39[392] |
57 | MED9 | Mediator of RNA polymerase II transcription subunit 9 | [393] | 2.89[394] | 1.66[395] | 2.32[396] | 2.39[397] | 3.04[398] | 0.00[399] |
58 | ARNT | Aryl hydrocarbon receptor nuclear translocator | [400] | 3.43[401] | 2.55[402] | 3.81[403] | 4.95[404] | 4.81[405] | 2.31[406] |
59 | MED30 | Mediator of RNA polymerase II transcription subunit 30 | [407] | 1.28[408] | 1.13[409] | -0.13[410] | 2.33[411] | 1.36[412] | -0.89[413] |
60 | MED21 | Mediator of RNA polymerase II transcription subunit 21 | [414] | 2.52[415] | 2.64[416] | 3.14[417] | 3.20[418] | 4.47[419] | 0.75[420] |
61 | ARNTL | Aryl hydrocarbon receptor nuclear translocator-like protein 1 | [421] | 0.94[422] | 0.78[423] | 0.20[424] | 2.53[425] | 2.82[426] | 1.56[427] |
62 | MED18 | Mediator of RNA polymerase II transcription subunit 18 | [428] | 3.21[429] | 2.10[430] | 2.65[431] | 3.60[432] | 2.83[433] | 0.22[434] |
63 | CDK8 | Cyclin-dependent kinase 8 | [435] | 2.17[436] | 2.04[437] | 1.50[438] | 3.08[439] | 2.79[440] | -0.98[441] |
64 | RXRB | Retinoic acid receptor RXR-beta | [442] | 4.03[443] | 3.68[444] | 3.00[445] | 5.16[446] | 4.14[447] | 0.89[448] |
65 | ABCA1 | ATP-binding cassette sub-family A member 1 | [449] | 4.68[450] | 4.92[451] | 5.08[452] | 4.80[453] | 5.46[454] | 5.99[455] |
66 | AHR | Aryl hydrocarbon receptor | [456] | 4.14[457] | 3.76[458] | 5.17[459] | 4.13[460] | 5.13[461] | 3.37[462] |
67 | NFYB | Nuclear transcription factor Y subunit beta | [463] | 2.38[464] | 3.31[465] | 3.07[466] | 3.97[467] | 4.41[468] | 0.77[469] |
68 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [470] | 4.09[471] | 3.96[472] | 5.00[473] | 5.99[474] | 5.65[475] | 3.65[476] |
69 | MED27 | Mediator of RNA polymerase II transcription subunit 27 | [477] | 2.57[478] | 1.76[479] | 2.21[480] | 3.45[481] | 3.65[482] | -0.38[483] |
70 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [484] | 4.35[485] | 4.09[486] | 6.04[487] | -0.82[488] | 4.77[489] | 2.52[490] |
71 | MED7 | Mediator of RNA polymerase II transcription subunit 7 | [491] | 1.41[492] | 1.55[493] | 1.73[494] | 2.59[495] | 2.66[496] | -0.08[497] |
72 | ME1 | NADP-dependent malic enzyme | [498] | -3.33[499] | -3.37[500] | 5.16[501] | 6.47[502] | 5.06[503] | 1.30[504] |
73 | CYP7A1 | Cholesterol 7-alpha-monooxygenase | [505] | -1.33[506] | -4.33[507] | -7.48[508] | -6.39[509] | [510] | -2.18[511] |
74 | PPARA | Peroxisome proliferator-activated receptor alpha | [512] | 3.69[513] | 3.99[514] | 5.24[515] | 3.61[516] | 2.88[517] | 4.92[518] |
75 | NFYA | Nuclear transcription factor Y subunit alpha | [519] | 4.56[520] | 4.11[521] | 4.38[522] | 5.02[523] | 4.57[524] | 1.24[525] |
76 | SIN3A | Paired amphipathic helix protein Sin3a | [526] | 4.39[527] | 3.81[528] | 5.40[529] | 5.57[530] | 5.42[531] | 2.06[532] |
77 | MED1 | Mediator of RNA polymerase II transcription subunit 1 | [533] | 5.56[534] | 4.21[535] | 5.51[536] | 5.78[537] | 6.03[538] | 2.05[539] |
78 | MED19 | Mediator of RNA polymerase II transcription subunit 19 | [540] | 2.19[541] | 1.38[542] | 2.98[543] | 3.76[544] | 3.33[545] | -0.26[546] |
79 | PPARG | Peroxisome proliferator-activated receptor gamma | [547] | 2.93[548] | 3.87[549] | 4.77[550] | 4.42[551] | 4.49[552] | 0.40[553] |
80 | MED20 | Mediator of RNA polymerase II transcription subunit 20 | [554] | 4.17[555] | 3.51[556] | 3.15[557] | 5.12[558] | 3.98[559] | 0.82[560] |
81 | MED31 | Mediator of RNA polymerase II transcription subunit 31 | [561] | 1.64[562] | 1.58[563] | 2.01[564] | 2.48[565] | 2.98[566] | -0.42[567] |
82 | NPAS2 | Neuronal PAS domain-containing protein 2 | [568] | 4.59[569] | 4.60[570] | 4.57[571] | 1.20[572] | 3.52[573] | 0.59[574] |
83 | SP1 | Transcription factor Sp1 | [575] | 4.83[576] | 4.40[577] | 5.86[578] | 6.25[579] | 6.03[580] | 2.93[581] |
84 | MED17 | Mediator of RNA polymerase II transcription subunit 17 | [582] | 4.33[583] | 3.46[584] | 3.15[585] | 4.65[586] | 4.76[587] | 0.62[588] |
85 | MED25 | Mediator of RNA polymerase II transcription subunit 25 | [589] | 4.06[590] | 2.92[591] | 3.67[592] | 4.89[593] | 4.70[594] | -0.29[595] |
86 | FAM120B | Constitutive coactivator of peroxisome proliferator-activated receptor gamma | 4.14[596] | 3.14[597] | 2.91[598] | 4.08[599] | 5.01[600] | 2.03[601] | |
87 | MED22 | Mediator of RNA polymerase II transcription subunit 22 | [602] | 4.49[603] | 3.80[604] | 4.06[605] | 5.34[606] | 5.15[607] | 1.07[608] |
88 | NCOA6 | Nuclear receptor coactivator 6 | [609] | 5.22[610] | 4.40[611] | 4.99[612] | 6.14[613] | 5.49[614] | 2.18[615] |
89 | NCOA3 | Nuclear receptor coactivator 3 | [616] | 5.73[617] | 4.47[618] | 5.16[619] | 6.68[620] | 5.73[621] | 3.43[622] |
90 | NCOR2 | Nuclear receptor corepressor 2 | [623] | 6.36[624] | 4.08[625] | 4.58[626] | 7.73[627] | 7.32[628] | 2.66[629] |
91 | MED13 | Mediator of RNA polymerase II transcription subunit 13 | [630] | 4.93[631] | 4.66[632] | 6.03[633] | 6.31[634] | 6.36[635] | 4.72[636] |
92 | EP300 | Histone acetyltransferase p300 | [637] | 5.74[638] | 4.66[639] | 5.94[640] | 6.15[641] | 6.30[642] | 3.53[643] |
93 | MED14 | Mediator of RNA polymerase II transcription subunit 14 | [644] | 4.57[645] | 4.08[646] | 5.37[647] | 6.71[648] | 6.63[649] | 2.74[650] |
94 | TGS1 | Trimethylguanosine synthase | [651] | 3.61[652] | 3.38[653] | 4.30[654] | 5.29[655] | 5.22[656] | 1.75[657] |
95 | MED23 | Mediator of RNA polymerase II transcription subunit 23 | [658] | 4.61[659] | 4.64[660] | 4.82[661] | 5.74[662] | 5.53[663] | 3.05[664] |
96 | NCOA1 | Nuclear receptor coactivator 1 | [665] | 3.48[666] | 3.37[667] | 3.96[668] | 5.37[669] | 4.92[670] | 3.43[671] |
97 | SIN3B | Paired amphipathic helix protein Sin3b | [672] | 4.90[673] | 4.29[674] | 4.98[675] | 5.56[676] | 6.17[677] | 2.21[678] |
98 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | 1.92[679] | 4.14[680] | -6.24[681] | 4.34[682] | 1.14[683] | 4.21[684] | |
99 | CREBBP | CREB-binding protein | [685] | 5.91[686] | 4.46[687] | 5.46[688] | 6.33[689] | 6.44[690] | 4.01[691] |
100 | CLOCK | Circadian locomoter output cycles protein kaput | [692] | 3.80[693] | 4.34[694] | 4.48[695] | 5.92[696] | 6.64[697] | 4.20[698] |
101 | CD36 | Platelet glycoprotein 4 | [699] | 4.35[700] | 3.00[701] | -1.69[702] | 6.76[703] | -2.14[704] | 3.86[705] |
102 | RORA | Nuclear receptor ROR-alpha | [706] | 3.30[707] | 4.82[708] | 3.41[709] | 0.38[710] | 1.88[711] | 5.12[712] |
103 | GRHL1 | Grainyhead-like protein 1 homolog | [713] | 3.14[714] | 4.51[715] | 3.98[716] | 2.83[717] | 1.21[718] | 2.73[719] |
104 | NRF1 | Nuclear respiratory factor 1 | [720] | 4.02[721] | 3.58[722] | 3.95[723] | 4.58[724] | 4.65[725] | 1.25[726] |
105 | MED13L | Mediator of RNA polymerase II transcription subunit 13-like | [727] | 5.39[728] | 5.06[729] | 6.46[730] | 7.03[731] | 6.74[732] | 4.54[733] |
106 | SLC27A1 | Long-chain fatty acid transport protein 1 | [734] | 3.75[735] | 3.83[736] | 3.60[737] | 4.13[738] | 3.83[739] | 1.84[740] |
107 | MTF1 | Metal regulatory transcription factor 1 | [741] | 4.53[742] | 3.72[743] | 4.68[744] | 5.73[745] | 5.85[746] | 2.75[747] |
108 | MED26 | Mediator of RNA polymerase II transcription subunit 26 | [748] | 3.59[749] | 2.88[750] | 4.46[751] | 3.92[752] | 4.91[753] | 0.65[754] |
109 | RGL1 | Ral guanine nucleotide dissociation stimulator-like 1 | [755] | 6.23[756] | 3.40[757] | 2.69[758] | 6.71[759] | 6.24[760] | 3.51[761] |
110 | CHD9 | Chromodomain-helicase-DNA-binding protein 9 | [762] | 4.34[763] | 5.76[764] | 5.40[765] | 5.96[766] | 7.07[767] | 5.70[768] |
111 | NCOA2 | Nuclear receptor coactivator 2 | [769] | 4.59[770] | 4.74[771] | 6.95[772] | 6.78[773] | 5.17[774] | 5.38[775] |
112 | MED12 | Mediator of RNA polymerase II transcription subunit 12 | [776] | 6.02[777] | 4.65[778] | 5.44[779] | 7.11[780] | 6.43[781] | 3.52[782] |
113 | CDK19 | Cyclin-dependent kinase 19 | [783] | 5.37[784] | 5.90[785] | 4.56[786] | 6.45[787] | 6.44[788] | 2.58[789] |
114 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 4.49[790] | 2.14[791] | 4.59[792] | 6.84[793] | 7.13[794] | 2.14[795] | |
115 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-beta | 5.38[796] | 0.79[797] | 6.95[798] | 6.24[799] | 6.71[800] | 5.72[801] | |
116 | AHRR | Aryl hydrocarbon receptor repressor | [802] | 4.40[803] | 2.85[804] | 3.54[805] | 8.37[806] | 6.85[807] | 1.51[808] |
117 | TIAM2 | T-lymphoma invasion and metastasis-inducing protein 2 | [809] | 6.92[810] | 5.66[811] | 7.48[812] | 8.12[813] | 6.09[814] | 0.75[815] |
118 | ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2 | [816] | 8.39[817] | -0.28[818] | 1.44[819] | 10.00[820] | 11.87[821] | 5.72[822] |
119 | HELZ2 | Helicase with zinc finger domain 2 | [823] | [824] | [825] | [826] | [827] | [828] | [829] |
120 | PDCD6-AHRR | [830] | [831] | [832] | [833] | [834] | [835] | [836] |