REACTOME_REGULATION_OF_KIT_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.20[2] -0.11[3] -0.10[4] -0.56[5] -0.41[6] -0.28[7]
2 YES1 Tyrosine-protein kinase Yes [8] -1.85[9] -0.52[10] -0.40[11] -0.66[12] -0.97[13] -0.46[14]
3 SOS1 Son of sevenless homolog 1 [15] -1.09[16] 0.29[17] -0.31[18] -0.27[19] -0.80[20] -0.04[21]
4 LYN Tyrosine-protein kinase Lyn [22] -1.86[23] -2.18[24] -1.76[25] -0.06[26] -1.07[27] -0.56[28]
5 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [29] -1.46[30] -1.41[31] -0.95[32] -8.25[33] -3.00[34] -0.76[35]
6 SOCS6 Suppressor of cytokine signaling 6 [36] -0.63[37] 0.07[38] -1.00[39] 0.22[40] 0.06[41] 1.25[42]
7 SRC Proto-oncogene tyrosine-protein kinase Src [43] 2.03[44] 1.86[45] 0.76[46] 1.29[47] 0.69[48] -1.43[49]
8 SH2B3 SH2B adapter protein 3 [50] 0.12[51] -0.44[52] -0.33[53] 0.44[54] 1.50[55] 0.82[56]
9 PRKCA Protein kinase C alpha type [57] 1.84[58] 1.73[59] 1.99[60] 1.04[61] 1.63[62] 1.34[63]
10 SOCS1 Suppressor of cytokine signaling 1 [64] -2.44[65] -1.73[66] -1.56[67] -2.90[68] -4.06[69] -2.04[70]
11 FYN Tyrosine-protein kinase Fyn [71] -0.05[72] -8.80[73] -0.34[74] 0.36[75] 2.12[76] 0.39[77]
12 CBL E3 ubiquitin-protein ligase CBL [78] 3.45[79] 2.25[80] 2.36[81] 4.02[82] 3.74[83] 3.18[84]
13 LCK Tyrosine-protein kinase Lck [85] 1.78[86] 1.71[87] -8.39[88] -6.19[89] -6.17[90] 0.65[91]
14 SH2B2 SH2B adapter protein 2 [92] -0.99[93] -1.79[94] -1.09[95] -0.57[96] -1.04[97] -1.69[98]
15 KITLG Kit ligand [99] 4.45[100] 0.52[101] 6.14[102] 5.62[103] 4.04[104] 2.46[105]
16 KIT Mast/stem cell growth factor receptor Kit [106] -3.98[107] -6.02[108] [109] 1.39[110] -3.91[111] 3.06[112]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[9]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[10]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[11]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[12]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[13]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[14]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[15]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[16]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[17]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[18]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[19]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[20]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[21]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[22]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[23]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[24]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[25]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[26]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[27]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[28]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[29]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[30]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[31]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[32]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[33]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[34]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[35]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[36]
ref_hepatocyte SOCS6
Mean 3.82
Standard deviation 2.2
Values 3.9 7.5 2.4 2.5 2.7
[37]
HepG2 SOCS6
Mean 10.8
Standard deviation 2.5
Values 9.1 13
[38]
HepG2.C3A SOCS6
Mean 17.4
Standard deviation 1.2
Values 18 17
[39]
HuH.7 SOCS6
Mean 8.58
Standard deviation 0.94
Values 8.8 9.4 7.6
[40]
SNU475 SOCS6
Mean 17.6
Standard deviation 0.84
Values 17 18
[41]
THLE SOCS6
Mean 15.1
Standard deviation 1.1
Values 14 16
[42]
liver SOCS6
Mean 19.3
Standard deviation 6.3
Values 15 24 13 26
[43]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[44]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[45]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[46]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[47]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[48]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[49]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[50]
ref_hepatocyte SH2B3
Mean 3.01
Standard deviation 1.8
Values 1.5 5.4 4.5 2.2 1.4
[51]
HepG2 SH2B3
Mean 14.4
Standard deviation 3.2
Values 17 12
[52]
HepG2.C3A SH2B3
Mean 9.65
Standard deviation 3.7
Values 12 7
[53]
HuH.7 SH2B3
Mean 10.8
Standard deviation 1.3
Values 12 9.4 11
[54]
SNU475 SH2B3
Mean 16.2
Standard deviation 14
Values 6.5 26
[55]
THLE SH2B3
Mean 32.3
Standard deviation 2
Values 34 31
[56]
liver SH2B3
Mean 11.3
Standard deviation 4.4
Values 11 13 5.4 16
[57]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 2.7 6 1.1 1.2 1.2
[58]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 35 43
[59]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 32 39
[60]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 54 44 33
[61]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 17 23
[62]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[63]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 11 17 4.7 21
[64]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.1 0 1.3 4.7 3.4
[65]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.8 1.6
[66]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 3.7 1.9
[67]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 3.3 1 5.3
[68]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 1.3 0.95
[69]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[70]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 1.1 0.27 0.8 2.2
[71]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[72]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[73]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[74]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[75]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[76]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[77]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[78]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[79]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[80]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[81]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[82]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[83]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[84]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14
[85]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[86]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[87]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[88]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[89]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[90]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[91]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[92]
ref_hepatocyte SH2B2
Mean 0.26
Standard deviation 0.25
Values 0 0.06 0.39 0.6 0.25
[93]
HepG2 SH2B2
Mean 0.577
Standard deviation 0.29
Values 0.79 0.37
[94]
HepG2.C3A SH2B2
Mean 0.326
Standard deviation 0.14
Values 0.43 0.23
[95]
HuH.7 SH2B2
Mean 0.55
Standard deviation 0.077
Values 0.6 0.46 0.59
[96]
SNU475 SH2B2
Mean 0.694
Standard deviation 0.34
Values 0.45 0.94
[97]
THLE SH2B2
Mean 0.48
Standard deviation 0.024
Values 0.5 0.46
[98]
liver SH2B2
Mean 0.171
Standard deviation 0.17
Values 0.024 0.34 0.026 0.29
[99]
ref_hepatocyte KITLG
Mean 0.0988
Standard deviation 0.16
Values 0.024 0.39 0 0.052 0.033
[100]
HepG2 KITLG
Mean 9.5
Standard deviation 3.6
Values 6.9 12
[101]
HepG2.C3A KITLG
Mean 0.616
Standard deviation 0.27
Values 0.43 0.8
[102]
HuH.7 KITLG
Mean 31.3
Standard deviation 8.5
Values 41 24 29
[103]
SNU475 KITLG
Mean 19.3
Standard deviation 0.86
Values 20 19
[104]
THLE KITLG
Mean 6.16
Standard deviation 2
Values 7.6 4.7
[105]
liver KITLG
Mean 1.15
Standard deviation 0.074
Values 1.2 1.2 1.1 1.1
[106]
ref_hepatocyte KIT
Mean 0.0798
Standard deviation 0.075
Values 0 0 0.15 0.1 0.15
[107]
HepG2 KIT
Mean 0.0222
Standard deviation 0.025
Values 0.04 0.0043
[108]
HepG2.C3A KIT
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[109]
HuH.7 KIT
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 KIT
Mean 0.83
Standard deviation 0.64
Values 1.3 0.38
[111]
THLE KIT
Mean 0.0201
Standard deviation 0.013
Values 0.03 0.011
[112]
liver KIT
Mean 1.41
Standard deviation 1.3
Values 0.21 3 1.9 0.54