REACTOME_REGULATION_OF_INSULIN_SECRETION |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
GNAS |
Guanine nucleotide-binding protein
G(s) subunit alpha isoforms XLas |
-0.22[1] |
-0.14[2] |
-0.48[3] |
0.26[4] |
-0.40[5] |
-1.64[6] |
2 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-1.85[7] |
-1.63[8] |
-2.49[9] |
-2.40[10] |
-2.55[11] |
-1.89[12] |
3 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[13] |
-0.57[14] |
-0.40[15] |
-0.25[16] |
-0.68[17] |
-0.68[18] |
0.29[19] |
4 |
SLC2A2 |
Solute carrier family 2, facilitated glucose transporter member 2 |
[20] |
-3.85[21] |
-3.03[22] |
-2.36[23] |
-7.37[24] |
-11.62[25] |
1.54[26] |
5 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[27] |
0.37[28] |
0.43[29] |
-0.04[30] |
0.69[31] |
0.60[32] |
-1.53[33] |
6 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[34] |
-1.25[35] |
-1.45[36] |
-1.11[37] |
-0.96[38] |
-0.79[39] |
-1.90[40] |
7 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-5.35[41] |
-5.01[42] |
-5.31[43] |
-4.40[44] |
-3.47[45] |
-4.64[46] |
8 |
GNAI2 |
Guanine nucleotide-binding protein G(i) subunit alpha-2 |
[47] |
-0.58[48] |
-1.60[49] |
-1.42[50] |
-0.76[51] |
0.42[52] |
-0.49[53] |
9 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[54] |
-0.41[55] |
-0.27[56] |
0.31[57] |
0.42[58] |
0.40[59] |
0.00[60] |
10 |
MARCKS |
Myristoylated alanine-rich C-kinase substrate |
[61] |
-0.27[62] |
0.57[63] |
1.03[64] |
1.15[65] |
-0.03[66] |
-1.76[67] |
11 |
ACSL3 |
Long-chain-fatty-acid--CoA ligase 3 |
[68] |
-0.55[69] |
1.64[70] |
0.83[71] |
-0.38[72] |
-0.78[73] |
0.42[74] |
12 |
RAP1A |
Ras-related protein Rap-1A |
[75] |
-1.70[76] |
-1.71[77] |
-0.87[78] |
-0.80[79] |
-0.93[80] |
-1.59[81] |
13 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-5.40[82] |
-8.28[83] |
-0.33[84] |
1.29[85] |
1.50[86] |
0.18[87] |
14 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[88] |
-0.81[89] |
-0.94[90] |
-0.93[91] |
-1.06[92] |
-0.36[93] |
-1.08[94] |
15 |
GNA11 |
Guanine nucleotide-binding protein subunit alpha-11 |
[95] |
-1.32[96] |
-1.35[97] |
-1.39[98] |
-1.77[99] |
-0.87[100] |
-1.56[101] |
16 |
ACSL4 |
Long-chain-fatty-acid--CoA ligase 4 |
[102] |
2.07[103] |
3.85[104] |
4.15[105] |
0.96[106] |
1.90[107] |
0.66[108] |
17 |
VAMP2 |
Vesicle-associated membrane protein 2 |
[109] |
-2.00[110] |
-1.59[111] |
-1.23[112] |
-1.06[113] |
-1.14[114] |
-0.49[115] |
18 |
PRKAR2A |
cAMP-dependent protein kinase type II-alpha regulatory subunit |
[116] |
-0.60[117] |
-0.86[118] |
0.25[119] |
-0.88[120] |
-0.91[121] |
-0.15[122] |
19 |
GNAI1 |
Guanine nucleotide-binding protein G(i) subunit alpha-1 |
[123] |
-2.30[124] |
-3.19[125] |
-1.04[126] |
0.63[127] |
0.11[128] |
0.53[129] |
20 |
PRKAR1B |
cAMP-dependent protein kinase type I-beta regulatory subunit |
[130] |
0.33[131] |
-0.18[132] |
-1.96[133] |
-4.69[134] |
-1.78[135] |
-0.47[136] |
21 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[137] |
0.27[138] |
1.77[139] |
0.23[140] |
-0.58[141] |
-0.34[142] |
3.57[143] |
22 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[144] |
-0.55[145] |
-0.46[146] |
0.56[147] |
0.20[148] |
0.43[149] |
0.59[150] |
23 |
IQGAP1 |
Ras GTPase-activating-like protein IQGAP1 |
[151] |
1.21[152] |
0.80[153] |
1.22[154] |
3.38[155] |
3.33[156] |
1.73[157] |
24 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[158] |
-1.48[159] |
-0.66[160] |
0.63[161] |
1.64[162] |
0.61[163] |
1.41[164] |
25 |
PRKCA |
Protein kinase C alpha type |
[165] |
2.19[166] |
2.28[167] |
2.64[168] |
1.56[169] |
2.03[170] |
1.62[171] |
26 |
SLC2A1 |
Solute carrier family 2, facilitated glucose transporter member 1 |
[172] |
6.00[173] |
3.06[174] |
2.13[175] |
2.86[176] |
2.10[177] |
-1.65[178] |
27 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[179] |
4.64[180] |
3.54[181] |
2.03[182] |
1.76[183] |
4.04[184] |
-0.07[185] |
28 |
GNAQ |
Guanine nucleotide-binding protein G(q) subunit alpha |
[186] |
-0.57[187] |
0.25[188] |
0.77[189] |
1.00[190] |
1.33[191] |
1.14[192] |
29 |
ADCY6 |
Adenylate cyclase type 6 |
[193] |
1.40[194] |
1.91[195] |
1.88[196] |
1.92[197] |
2.70[198] |
2.34[199] |
30 |
CD36 |
Platelet glycoprotein 4 |
[200] |
0.69[201] |
0.06[202] |
-5.02[203] |
2.59[204] |
-6.30[205] |
2.79[206] |
31 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[207] |
1.36[208] |
0.89[209] |
1.36[210] |
2.12[211] |
1.87[212] |
0.43[213] |
32 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-8.83[214] |
-8.78[215] |
-8.08[216] |
1.68[217] |
3.10[218] |
1.93[219] |
33 |
RAPGEF4 |
Rap guanine nucleotide exchange factor 4 |
[220] |
-4.67[221] |
-2.82[222] |
-1.90[223] |
-2.25[224] |
0.26[225] |
2.60[226] |
34 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[227] |
2.14[228] |
3.82[229] |
3.25[230] |
0.19[231] |
0.79[232] |
2.19[233] |
35 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
0.91[234] |
0.61[235] |
1.42[236] |
-2.83[237] |
-2.09[238] |
-0.28[239] |
36 |
CHRM3 |
Muscarinic acetylcholine receptor M3 |
[240] |
-4.16[241] |
-2.93[242] |
0.00[243] |
-0.99[244] |
-3.65[245] |
2.45[246] |
37 |
ADRA2C |
Alpha-2C adrenergic receptor |
[247] |
3.37[248] |
-2.99[249] |
-1.33[250] |
-3.83[251] |
-5.44[252] |
-3.53[253] |
38 |
KCNS3 |
Potassium voltage-gated channel subfamily S member 3 |
[254] |
-5.13[255] |
[256] |
-6.47[257] |
-2.94[258] |
-1.70[259] |
0.26[260] |
39 |
STX1A |
Syntaxin-1A |
[261] |
0.29[262] |
0.31[263] |
-1.18[264] |
2.00[265] |
1.12[266] |
-1.46[267] |
40 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
2.82[268] |
0.63[269] |
4.44[270] |
0.67[271] |
-1.34[272] |
-2.85[273] |
41 |
STXBP1 |
Syntaxin-binding protein 1 |
[274] |
1.08[275] |
1.54[276] |
1.97[277] |
3.61[278] |
3.57[279] |
0.54[280] |
42 |
PLCB2 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
[281] |
-2.27[282] |
-7.00[283] |
-8.84[284] |
-2.52[285] |
-3.13[286] |
1.94[287] |
43 |
KCNJ11 |
ATP-sensitive inward rectifier potassium channel 11 |
[288] |
-0.34[289] |
-0.80[290] |
-1.36[291] |
-1.80[292] |
-2.42[293] |
-0.75[294] |
44 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[295] |
2.49[296] |
2.42[297] |
3.58[298] |
2.26[299] |
3.24[300] |
4.35[301] |
45 |
GNB4 |
Guanine nucleotide-binding protein subunit beta-4 |
[302] |
-1.02[303] |
-0.48[304] |
0.53[305] |
2.09[306] |
4.94[307] |
3.79[308] |
46 |
GNG2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-2 |
-6.93[309] |
-7.76[310] |
[311] |
2.53[312] |
2.11[313] |
2.48[314] |
47 |
GNA15 |
Guanine nucleotide-binding protein subunit alpha-15 |
[315] |
-4.03[316] |
-5.69[317] |
[318] |
-6.62[319] |
-2.95[320] |
-0.20[321] |
48 |
GNA14 |
Guanine nucleotide-binding protein subunit alpha-14 |
[322] |
-6.71[323] |
-7.05[324] |
-5.89[325] |
-6.88[326] |
-3.68[327] |
2.93[328] |
49 |
AKAP5 |
A-kinase anchor protein 5 |
[329] |
0.43[330] |
0.93[331] |
1.21[332] |
3.53[333] |
2.00[334] |
1.90[335] |
50 |
CACNB3 |
Voltage-dependent L-type calcium channel subunit beta-3 |
[336] |
1.66[337] |
-1.39[338] |
3.32[339] |
4.51[340] |
3.78[341] |
0.16[342] |
51 |
CACNA1D |
Voltage-dependent L-type calcium channel subunit alpha-1D |
[343] |
-4.37[344] |
-1.31[345] |
1.00[346] |
-2.06[347] |
-4.59[348] |
4.21[349] |
52 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[350] |
[351] |
[352] |
-2.66[353] |
-7.22[354] |
-0.19[355] |
53 |
SNAP25 |
Synaptosomal-associated protein 25 |
[356] |
-4.15[357] |
-3.90[358] |
1.78[359] |
1.87[360] |
4.02[361] |
0.74[362] |
54 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-1.50[363] |
0.38[364] |
-1.84[365] |
-1.29[366] |
-1.50[367] |
-0.38[368] |
55 |
PRKAR2B |
cAMP-dependent protein kinase type II-beta regulatory subunit |
[369] |
-2.99[370] |
-1.11[371] |
3.17[372] |
4.50[373] |
3.12[374] |
3.01[375] |
56 |
CACNB2 |
Voltage-dependent L-type calcium channel subunit beta-2 |
[376] |
-0.64[377] |
1.36[378] |
1.39[379] |
2.98[380] |
1.50[381] |
4.74[382] |
57 |
RAPGEF3 |
Rap guanine nucleotide exchange factor 3 |
[383] |
1.17[384] |
0.90[385] |
0.34[386] |
1.29[387] |
0.05[388] |
3.51[389] |
58 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[390] |
0.94[391] |
3.24[392] |
2.55[393] |
0.42[394] |
3.24[395] |
-1.98[396] |
59 |
KCNB1 |
Potassium voltage-gated channel subfamily B member 1 |
[397] |
[398] |
[399] |
-1.34[400] |
-3.80[401] |
-1.64[402] |
5.91[403] |
60 |
ADCY5 |
Adenylate cyclase type 5 |
[404] |
-0.50[405] |
0.55[406] |
1.59[407] |
0.06[408] |
1.29[409] |
6.07[410] |
61 |
CACNA2D2 |
Voltage-dependent calcium channel subunit alpha-2/delta-2 |
[411] |
-1.95[412] |
0.29[413] |
0.87[414] |
-0.35[415] |
1.52[416] |
1.53[417] |
62 |
SYT5 |
Synaptotagmin-5 |
[418] |
3.14[419] |
2.35[420] |
[421] |
1.16[422] |
0.32[423] |
-2.03[424] |
63 |
ABCC8 |
ATP-binding cassette sub-family C member 8 |
[425] |
-1.54[426] |
[427] |
-2.42[428] |
[429] |
[430] |
1.19[431] |
64 |
ADRA2A |
Alpha-2A adrenergic receptor |
[432] |
-3.80[433] |
-2.26[434] |
[435] |
0.75[436] |
3.56[437] |
3.69[438] |
65 |
CACNA1A |
Voltage-dependent P/Q-type calcium channel subunit alpha-1A |
[439] |
-2.75[440] |
-1.35[441] |
1.54[442] |
4.34[443] |
2.52[444] |
3.99[445] |
66 |
CACNA1C |
Voltage-dependent L-type calcium channel subunit alpha-1C |
[446] |
4.07[447] |
1.62[448] |
4.49[449] |
5.13[450] |
7.47[451] |
8.01[452] |
67 |
KCNC2 |
Potassium voltage-gated channel subfamily C member 2 |
[453] |
[454] |
[455] |
[456] |
[457] |
[458] |
[459] |
68 |
INS |
Insulin |
[460] |
[461] |
[462] |
[463] |
[464] |
[465] |
[466] |
69 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[467] |
[468] |
[469] |
[470] |
[471] |
[472] |
[473] |
70 |
CACNA1E |
Voltage-dependent R-type calcium channel subunit alpha-1E |
[474] |
[475] |
[476] |
[477] |
[478] |
[479] |
[480] |
71 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[481] |
[482] |
[483] |
[484] |
[485] |
[486] |
72 |
GLP1R |
Glucagon-like peptide 1 receptor |
[487] |
[488] |
[489] |
[490] |
[491] |
[492] |
[493] |
73 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[494] |
[495] |
[496] |
[497] |
[498] |
[499] |
74 |
ADCY8 |
Adenylate cyclase type 8 |
[500] |
[501] |
[502] |
[503] |
[504] |
[505] |
[506] |
75 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[507] |
[508] |
[509] |
[510] |
[511] |
[512] |
[513] |
76 |
FFAR1 |
Free fatty acid receptor 1 |
[514] |
[515] |
[516] |
[517] |
[518] |
[519] |
[520] |
77 |
KCNG2 |
Potassium voltage-gated channel subfamily G member 2 |
[521] |
[522] |
[523] |
[524] |
[525] |
[526] |
[527] |
78 |
GCG |
Glucagon |
[528] |
[529] |
[530] |
[531] |
[532] |
[533] |
[534] |
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