REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_U | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ALB | Serum albumin | [1] | -0.88[2] | 0.38[3] | -0.28[4] | -8.03[5] | -7.94[6] | -0.02[7] |
2 | FGG | Fibrinogen gamma chain | [8] | -4.19[9] | -4.58[10] | -3.05[11] | -9.26[12] | -11.23[13] | -0.46[14] |
3 | APOA2 | Apolipoprotein A-II | [15] | -1.85[16] | -2.17[17] | -1.92[18] | -9.53[19] | -9.38[20] | -2.02[21] |
4 | SERPINA1 | Alpha-1-antitrypsin | [22] | -0.37[23] | -1.07[24] | -1.35[25] | -8.59[26] | -7.24[27] | 0.32[28] |
5 | FGA | Fibrinogen alpha chain | [29] | -3.85[30] | -4.83[31] | -2.95[32] | -8.47[33] | -11.25[34] | 0.21[35] |
6 | APOA1 | Apolipoprotein A-I | [36] | -1.83[37] | -1.91[38] | -3.28[39] | -10.04[40] | -10.28[41] | -1.04[42] |
7 | APOE | Apolipoprotein E | [43] | -1.25[44] | -2.24[45] | -0.99[46] | -6.75[47] | -6.07[48] | -1.73[49] |
8 | TF | Serotransferrin | [50] | 1.12[51] | 1.05[52] | 1.03[53] | -6.52[54] | -6.56[55] | -0.03[56] |
9 | C3 | Complement C3 | [57] | 1.03[58] | 0.33[59] | -0.92[60] | -3.36[61] | 0.55[62] | 1.45[63] |
10 | SERPINC1 | Antithrombin-III | [64] | -4.20[65] | -3.76[66] | -2.27[67] | -9.76[68] | -9.89[69] | 0.01[70] |
11 | AHSG | Alpha-2-HS-glycoprotein | [71] | 1.71[72] | 2.86[73] | 1.03[74] | -6.09[75] | -6.11[76] | 0.04[77] |
12 | P4HB | Protein disulfide-isomerase | [78] | 2.44[79] | 0.90[80] | 1.50[81] | 2.46[82] | 2.50[83] | 0.65[84] |
13 | F2 | Prothrombin | [85] | 0.15[86] | -0.72[87] | 0.93[88] | -6.53[89] | -6.96[90] | 0.43[91] |
14 | PLG | Plasminogen | [92] | -9.35[93] | -8.60[94] | 0.19[95] | -8.16[96] | -6.57[97] | 0.80[98] |
15 | KNG1 | Kininogen-1 | [99] | -5.20[100] | -7.10[101] | -0.20[102] | -8.86[103] | -8.12[104] | 0.02[105] |
16 | HSP90B1 | Endoplasmin | [106] | 1.12[107] | 1.40[108] | 1.61[109] | 3.15[110] | 3.00[111] | 0.08[112] |
17 | CP | Ceruloplasmin | [113] | -1.15[114] | 0.58[115] | 0.34[116] | -1.30[117] | -7.12[118] | 1.84[119] |
18 | C4A | Complement C4-A | [120] | [121] | [122] | [123] | [124] | [125] | [126] |
19 | ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2 | [127] | 2.30[128] | 2.39[129] | 1.37[130] | -4.71[131] | -5.66[132] | 0.50[133] |
20 | IGFBP4 | Insulin-like growth factor-binding protein 4 | [134] | 0.68[135] | -5.08[136] | -3.85[137] | 1.74[138] | 3.59[139] | -1.08[140] |
21 | CST3 | Cystatin-C | [141] | 1.68[142] | 0.10[143] | -0.19[144] | 0.68[145] | 1.22[146] | -0.19[147] |
22 | PDIA6 | Protein disulfide-isomerase A6 | [148] | 1.86[149] | 0.42[150] | 0.86[151] | 2.86[152] | 2.02[153] | -0.54[154] |
23 | APOB | Apolipoprotein B-100 | [155] | 4.35[156] | 3.75[157] | 4.20[158] | -3.42[159] | -3.44[160] | 4.97[161] |
24 | FN1 | Fibronectin | [162] | 5.90[163] | 4.01[164] | 5.17[165] | 6.94[166] | 7.06[167] | 2.40[168] |
25 | GPC3 | Glypican-3 | [169] | 4.59[170] | 3.65[171] | 3.55[172] | -3.88[173] | -3.75[174] | -8.13[175] |
26 | TIMP1 | Metalloproteinase inhibitor 1 | [176] | 0.18[177] | -2.81[178] | -8.72[179] | 2.06[180] | 3.56[181] | 0.06[182] |
27 | SERPIND1 | Heparin cofactor 2 | [183] | 1.14[184] | 0.74[185] | 1.14[186] | -5.48[187] | -4.77[188] | -0.37[189] |
28 | SERPINA1 | Protein Z-dependent protease inhibitor | [190] | -2.08[191] | -2.25[192] | -1.76[193] | -10.02[194] | -6.27[195] | 0.52[196] |
29 | IGFBP2 | Insulin-like growth factor-binding protein 2 | [197] | -0.91[198] | -6.02[199] | -8.54[200] | -4.10[201] | 1.86[202] | -0.33[203] |
30 | AFP | Alpha-fetoprotein | [204] | 3.14[205] | 6.68[206] | 6.91[207] | -0.90[208] | -0.98[209] | -7.38[210] |
31 | IGF2 | Insulin-like growth factor II | [211] | -0.56[212] | 0.18[213] | -1.33[214] | -9.40[215] | -7.59[216] | -6.91[217] |
32 | APLP2 | Amyloid-like protein 2 | [218] | 3.87[219] | 1.65[220] | 3.09[221] | 4.13[222] | 4.28[223] | 0.50[224] |
33 | LGALS1 | Galectin-1 | [225] | 1.84[226] | -1.45[227] | -5.95[228] | 3.47[229] | 4.02[230] | -3.06[231] |
34 | NUCB1 | Nucleobindin-1 | [232] | 0.92[233] | -0.62[234] | 1.37[235] | 2.48[236] | 2.80[237] | 0.40[238] |
35 | PROC | Vitamin K-dependent protein C | [239] | 0.35[240] | 0.40[241] | -0.36[242] | -2.97[243] | -7.25[244] | -0.05[245] |
36 | RCN1 | Reticulocalbin-1 | [246] | 0.97[247] | 0.24[248] | 0.57[249] | 3.19[250] | 3.44[251] | -0.99[252] |
37 | IGFBP1 | Insulin-like growth factor-binding protein 1 | [253] | 2.25[254] | 3.96[255] | -2.58[256] | -5.76[257] | -5.34[258] | -0.44[259] |
38 | APOA5 | Apolipoprotein A-V | [260] | -0.24[261] | 0.10[262] | -0.78[263] | -8.23[264] | -7.04[265] | 2.28[266] |
39 | APP | Amyloid-beta A4 protein | [267] | 2.79[268] | 0.87[269] | 2.79[270] | 4.80[271] | 5.13[272] | 0.24[273] |
40 | SPP2 | Secreted phosphoprotein 24 | [274] | -11.77[275] | [276] | [277] | -11.23[278] | [279] | 0.28[280] |
41 | APOL1 | Apolipoprotein L1 | [281] | 1.67[282] | -0.23[283] | -5.82[284] | 2.34[285] | 1.99[286] | -0.59[287] |
42 | PRKCSH | Glucosidase 2 subunit beta | [288] | 2.47[289] | 0.60[290] | 3.62[291] | 3.43[292] | 3.88[293] | -1.27[294] |
43 | SDC2 | Syndecan-2 | [295] | 2.82[296] | 2.40[297] | 3.30[298] | 3.83[299] | 0.54[300] | 0.73[301] |
44 | FUCA2 | Plasma alpha-L-fucosidase | [302] | 2.87[303] | 1.28[304] | 2.10[305] | 3.95[306] | 3.54[307] | -0.70[308] |
45 | IGFALS | Insulin-like growth factor-binding protein complex acid labile subunit | -2.47[309] | -4.60[310] | -5.82[311] | -6.01[312] | -7.65[313] | 0.25[314] | |
46 | SHISA5 | Protein shisa-5 | [315] | 2.65[316] | 0.55[317] | 3.05[318] | 3.97[319] | 3.47[320] | 0.21[321] |
47 | SPP1 | Osteopontin | [322] | 5.58[323] | 2.99[324] | -4.25[325] | 5.92[326] | -2.23[327] | -0.97[328] |
48 | CALU | Calumenin | [329] | 3.86[330] | 2.45[331] | 4.12[332] | 6.02[333] | 6.46[334] | 0.64[335] |
49 | CKAP4 | Cytoskeleton-associated protein 4 | [336] | 3.60[337] | 2.01[338] | 3.15[339] | 4.08[340] | 4.88[341] | -0.95[342] |
50 | KTN1 | Kinectin | [343] | 1.69[344] | 2.51[345] | 3.41[346] | 5.93[347] | 4.40[348] | 1.02[349] |
51 | CDH2 | Cadherin-2 | [350] | 2.55[351] | -0.75[352] | 1.33[353] | 5.81[354] | 4.11[355] | 0.07[356] |
52 | TGOLN2 | Trans-Golgi network integral membrane protein 2 | [357] | 4.87[358] | 2.98[359] | 3.73[360] | 5.14[361] | 5.53[362] | 2.28[363] |
53 | IGF1 | Insulin-like growth factor I | [364] | -6.01[365] | -8.32[366] | -5.26[367] | 2.48[368] | -5.43[369] | 1.02[370] |
54 | FAM20C | Extracellular serine/threonine protein kinase FAM20C | [371] | 0.17[372] | -0.31[373] | 0.04[374] | 1.67[375] | 3.00[376] | -0.46[377] |
55 | PRSS23 | Serine protease 23 | [378] | -0.71[379] | -7.50[380] | -2.95[381] | 6.15[382] | 3.56[383] | -1.08[384] |
56 | F5 | Coagulation factor V | [385] | 3.15[386] | 2.45[387] | 4.62[388] | -2.04[389] | -1.98[390] | 3.57[391] |
57 | DNAJC3 | DnaJ homolog subfamily C member 3 | [392] | 1.70[393] | 1.29[394] | 1.28[395] | 4.09[396] | 3.67[397] | 2.84[398] |
58 | VWA1 | von Willebrand factor A domain-containing protein 1 | [399] | 3.83[400] | 2.49[401] | 3.02[402] | 5.03[403] | 0.02[404] | 0.69[405] |
59 | LAMB2 | Laminin subunit beta-2 | [406] | 4.54[407] | 2.86[408] | 3.07[409] | 4.92[410] | 5.73[411] | 2.20[412] |
60 | MBTPS1 | Membrane-bound transcription factor site-1 protease | [413] | 3.99[414] | 2.44[415] | 3.70[416] | 5.41[417] | 5.38[418] | 1.42[419] |
61 | PNPLA2 | Patatin-like phospholipase domain-containing protein 2 | [420] | 2.99[421] | 1.71[422] | 2.04[423] | 4.34[424] | 4.12[425] | 0.08[426] |
62 | MMP1 | Interstitial collagenase | [427] | -2.76[428] | -7.89[429] | [430] | 2.27[431] | 1.74[432] | -12.02[433] |
63 | PCSK9 | Proprotein convertase subtilisin/kexin type 9 | [434] | -0.54[435] | 3.18[436] | 5.79[437] | -1.96[438] | -2.47[439] | 1.37[440] |
64 | LAMC1 | Laminin subunit gamma-1 | [441] | 5.76[442] | 2.65[443] | 4.65[444] | 7.79[445] | 7.35[446] | 1.33[447] |
65 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [448] | 3.39[449] | 2.51[450] | 3.80[451] | 5.30[452] | 5.63[453] | 0.90[454] |
66 | FSTL1 | Follistatin-related protein 1 | [455] | -3.91[456] | -5.49[457] | -2.80[458] | 7.67[459] | 7.53[460] | 1.66[461] |
67 | QSOX1 | Sulfhydryl oxidase 1 | [462] | 4.20[463] | 1.68[464] | 2.79[465] | 6.43[466] | 7.43[467] | 1.05[468] |
68 | MIA3 | Transport and Golgi organization protein 1 homolog | [469] | 1.89[470] | 1.33[471] | 3.99[472] | 5.34[473] | 4.52[474] | 2.31[475] |
69 | GOLM1 | Golgi membrane protein 1 | [476] | 0.83[477] | -1.74[478] | 5.44[479] | 5.60[480] | 6.28[481] | 0.23[482] |
70 | FAM20A | Pseudokinase FAM20A | [483] | -0.72[484] | -4.82[485] | 0.95[486] | 2.14[487] | -4.48[488] | 1.55[489] |
71 | FSTL3 | Follistatin-related protein 3 | [490] | 5.29[491] | 0.60[492] | 1.93[493] | 4.56[494] | 5.78[495] | -1.75[496] |
72 | MEN1 | Menin | [497] | 3.23[498] | 1.76[499] | 3.11[500] | 3.90[501] | 4.21[502] | -0.30[503] |
73 | NOTUM | Palmitoleoyl-protein carboxylesterase NOTUM | [504] | 6.53[505] | 3.66[506] | 0.32[507] | -2.27[508] | -2.85[509] | -2.61[510] |
74 | CSF1 | Macrophage colony-stimulating factor 1 | [511] | 3.45[512] | -2.62[513] | 2.82[514] | 7.02[515] | 6.41[516] | 0.52[517] |
75 | WFS1 | Wolframin | [518] | 4.55[519] | 2.44[520] | 3.42[521] | 6.54[522] | 4.09[523] | 0.83[524] |
76 | IGFBP7 | Insulin-like growth factor-binding protein 7 | [525] | 2.72[526] | -1.72[527] | -0.48[528] | 7.09[529] | 8.18[530] | 4.09[531] |
77 | IGFBP3 | Insulin-like growth factor-binding protein 3 | [532] | 5.45[533] | -0.80[534] | -0.06[535] | 4.47[536] | 3.40[537] | 4.33[538] |
78 | MFGE8 | Lactadherin | [539] | 3.83[540] | -0.72[541] | 1.96[542] | 7.86[543] | 7.17[544] | 0.29[545] |
79 | LAMB1 | Laminin subunit beta-1 | [546] | 6.32[547] | 4.52[548] | 7.13[549] | 9.41[550] | 8.51[551] | 2.44[552] |
80 | GAS6 | Growth arrest-specific protein 6 | [553] | 0.12[554] | -3.83[555] | -6.17[556] | 2.70[557] | 6.16[558] | 0.61[559] |
81 | TMEM132 | Transmembrane protein 132A | [560] | 5.18[561] | 1.68[562] | 5.54[563] | 4.76[564] | 7.90[565] | -3.15[566] |
82 | TNC | Tenascin | [567] | -4.41[568] | -5.42[569] | -3.26[570] | 8.40[571] | 7.56[572] | 0.15[573] |
83 | MGAT4A | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | 4.23[574] | 4.71[575] | 6.86[576] | 2.18[577] | 2.34[578] | 1.65[579] | |
84 | LTBP1 | Latent-transforming growth factor beta-binding protein 1 | [580] | 1.65[581] | -5.77[582] | 1.54[583] | 6.28[584] | 6.42[585] | 2.49[586] |
85 | BMP4 | Bone morphogenetic protein 4 | [587] | 6.89[588] | 4.76[589] | 2.95[590] | 6.02[591] | 3.80[592] | -1.08[593] |
86 | IGFBP6 | Insulin-like growth factor-binding protein 6 | [594] | 4.79[595] | -0.34[596] | 0.91[597] | 5.83[598] | 6.00[599] | 0.74[600] |
87 | IL6 | Interleukin-6 | [601] | -6.04[602] | [603] | -2.53[604] | 3.17[605] | 5.60[606] | [607] |
88 | MXRA8 | Matrix remodeling-associated protein 8 | [608] | 6.20[609] | 5.72[610] | 0.96[611] | 3.96[612] | 4.23[613] | 0.15[614] |
89 | STC2 | Stanniocalcin-2 | [615] | 8.16[616] | 6.07[617] | 7.80[618] | 8.71[619] | 9.08[620] | -4.19[621] |
90 | ANO8 | Anoctamin-8 | [622] | 3.35[623] | 2.10[624] | 4.63[625] | 4.73[626] | 4.91[627] | 0.95[628] |
91 | BPIFB2 | BPI fold-containing family B member 2 | [629] | 6.53[630] | 8.38[631] | -3.42[632] | -1.32[633] | -1.36[634] | -1.32[635] |
92 | CTSG | Cathepsin G | [636] | [637] | [638] | [639] | [640] | [641] | -2.06[642] |
93 | HRC | Sarcoplasmic reticulum histidine-rich calcium-binding protein | [643] | 4.08[644] | 3.80[645] | -5.27[646] | -2.46[647] | -3.12[648] | -1.68[649] |
94 | SPARCL1 | SPARC-like protein 1 | [650] | -3.32[651] | -1.98[652] | 0.74[653] | 6.72[654] | -0.63[655] | 4.12[656] |
95 | MATN3 | Matrilin-3 | [657] | 7.61[658] | 9.83[659] | 5.39[660] | 5.58[661] | 5.34[662] | -3.09[663] |
96 | VCAN | Versican core protein | [664] | 7.15[665] | 0.62[666] | 6.01[667] | 5.51[668] | 9.72[669] | 3.93[670] |
97 | ENAM | Enamelin | [671] | -5.12[672] | [673] | 0.19[674] | 2.90[675] | -1.85[676] | 0.54[677] |
98 | MSLN | Mesothelin | [678] | 7.18[679] | 4.25[680] | -3.10[681] | 2.43[682] | 4.09[683] | -3.69[684] |
99 | GZMH | Granzyme H | [685] | [686] | [687] | [688] | [689] | [690] | -0.29[691] |
100 | MMP2 | 72 kDa type IV collagenase | [692] | 5.84[693] | -2.51[694] | 0.04[695] | 11.46[696] | 10.93[697] | 4.04[698] |
101 | SCG3 | Secretogranin-3 | [699] | -2.10[700] | -1.05[701] | -0.52[702] | 2.86[703] | 0.06[704] | 0.18[705] |
102 | IGFBP5 | Insulin-like growth factor-binding protein 5 | [706] | 4.05[707] | -0.97[708] | 3.32[709] | 15.33[710] | 7.53[711] | 7.85[712] |
103 | FBN1 | Fibrillin-1 | [713] | 5.46[714] | 2.17[715] | 5.98[716] | 10.36[717] | 13.24[718] | 7.50[719] |
104 | PAPPA2 | Pappalysin-2 | [720] | 2.41[721] | -2.34[722] | 2.40[723] | -0.34[724] | 7.81[725] | 8.02[726] |
105 | KLK13 | Kallikrein-13 | [727] | 0.48[728] | [729] | [730] | 0.33[731] | [732] | [733] |
106 | CHGB | Secretogranin-1 | [734] | 5.66[735] | 3.28[736] | 6.66[737] | 3.08[738] | 5.49[739] | [740] |
107 | VGF | Neurosecretory protein VGF | [741] | 7.80[742] | 2.14[743] | 3.37[744] | 7.80[745] | 6.76[746] | -2.00[747] |
108 | PAPPA | Pappalysin-1 | [748] | 5.92[749] | 3.59[750] | 5.22[751] | 12.06[752] | 15.76[753] | 5.49[754] |
109 | CHRDL1 | Chordin-like protein 1 | [755] | 1.95[756] | 2.17[757] | [758] | 12.78[759] | 4.71[760] | 6.18[761] |
110 | MEPE | Matrix extracellular phosphoglycoprotein | [762] | [763] | [764] | [765] | [766] | [767] | [768] |
111 | BMP15 | Bone morphogenetic protein 15 | [769] | [770] | [771] | [772] | [773] | [774] | [775] |
112 | KLK3 | Prostate-specific antigen | [776] | [777] | [778] | [779] | [780] | [781] | [782] |
113 | EVA1A | Protein eva-1 homolog A | [783] | [784] | [785] | [786] | [787] | [788] | [789] |
114 | FGF23 | Fibroblast growth factor 23 | [790] | [791] | [792] | [793] | [794] | [795] | [796] |
115 | KLK2 | Kallikrein-2 | [797] | [798] | [799] | [800] | [801] | [802] | [803] |
116 | PENK | Proenkephalin-A | [804] | [805] | [806] | [807] | [808] | [809] | [810] |
117 | AMBN | Ameloblastin | [811] | [812] | [813] | [814] | [815] | [816] | [817] |
118 | SCG2 | Secretogranin-2 | [818] | [819] | [820] | [821] | [822] | [823] | [824] |
119 | KLK1 | Kallikrein-1 | [825] | [826] | [827] | [828] | [829] | [830] | [831] |
120 | MELTF | Melanotransferrin | [832] | [833] | [834] | [835] | [836] | [837] | [838] |
121 | AMTN | Amelotin | [839] | [840] | [841] | [842] | [843] | [844] | [845] |
122 | DMP1 | Dentin matrix acidic phosphoprotein 1 | [846] | [847] | [848] | [849] | [850] | [851] | [852] |
123 | AMELX | Amelogenin, X isoform | [853] | [854] | [855] | [856] | [857] | [858] | [859] |
124 | CCN1 | [860] | [861] | [862] | [863] | [864] | [865] | [866] |