REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.15[2] -0.32[3] -0.48[4] -0.30[5] -0.12[6] 0.09[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.29[16] 0.44[17] -0.12[18] 0.56[19] 0.26[20] 0.54[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.72[23] 2.67[24] 3.39[25] 1.95[26] 2.49[27] 1.31[28]
5 DDX41 Probable ATP-dependent RNA helicase DDX41 [29] 2.06[30] 1.95[31] 2.35[32] 2.13[33] 1.72[34] 1.01[35]
6 TRIM21 E3 ubiquitin-protein ligase TRIM21 [36] -0.05[37] -1.84[38] -2.71[39] 0.64[40] -0.61[41] 0.52[42]
7 IRF3 Interferon regulatory factor 3 [43] 2.34[44] 2.55[45] 2.96[46] 2.84[47] 2.15[48] 0.78[49]
8 TBK1 Serine/threonine-protein kinase TBK1 [50] 1.41[51] 3.12[52] 1.95[53] 2.98[54] 2.78[55] 2.44[56]
9 DTX4 E3 ubiquitin-protein ligase DTX4 [57] 2.93[58] 2.99[59] 3.89[60] 3.26[61] -0.49[62] 4.35[63]
10 TREX1 Three-prime repair exonuclease 1 [64] -1.51[65] -0.18[66] 0.45[67] 0.75[68] 2.91[69] 1.14[70]
11 TRIM56 E3 ubiquitin-protein ligase TRIM56 [71] 2.70[72] 2.04[73] 3.00[74] 3.83[75] 3.73[76] 3.48[77]
12 TRIM32 E3 ubiquitin-protein ligase TRIM32 [78] 3.99[79] 3.09[80] 3.85[81] 4.42[82] 5.22[83] 3.49[84]
13 ZBP1 Z-DNA-binding protein 1 [85] -2.26[86] -1.41[87] -2.64[88] -0.22[89] -0.77[90] 1.46[91]
14 STING1 [92] [93] [94] [95] [96] [97] [98]
15 NLRP4 NACHT, LRR and PYD domains-containing protein 4 [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte DDX41
Mean 15.7
Standard deviation 5.8
Values 13 26 15 15 10
[30]
HepG2 DDX41
Mean 35.1
Standard deviation 6.6
Values 30 40
[31]
HepG2.C3A DDX41
Mean 28.2
Standard deviation 3.5
Values 26 31
[32]
HuH.7 DDX41
Mean 44.4
Standard deviation 14
Values 51 28 54
[33]
SNU475 DDX41
Mean 22.5
Standard deviation 3.1
Values 25 20
[34]
THLE DDX41
Mean 23.1
Standard deviation 1.2
Values 22 24
[35]
liver DDX41
Mean 11.5
Standard deviation 2.3
Values 12 9.7 14 9.6
[36]
ref_hepatocyte TRIM21
Mean 12
Standard deviation 9.3
Values 1.2 24 19 8.5 7.5
[37]
HepG2 TRIM21
Mean 6.22
Standard deviation 0.36
Values 6.5 6
[38]
HepG2.C3A TRIM21
Mean 1.56
Standard deviation 0.47
Values 1.2 1.9
[39]
HuH.7 TRIM21
Mean 1.02
Standard deviation 0.14
Values 0.88 1 1.2
[40]
SNU475 TRIM21
Mean 6.15
Standard deviation 1.6
Values 7.3 5
[41]
THLE TRIM21
Mean 3.51
Standard deviation 0.59
Values 3.1 3.9
[42]
liver TRIM21
Mean 6.26
Standard deviation 2.6
Values 9.5 4.4 7.1 3.9
[43]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[44]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[45]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[46]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[47]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[48]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[49]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[50]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[51]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[52]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[53]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[54]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[55]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[56]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[57]
ref_hepatocyte DTX4
Mean 2.52
Standard deviation 1.8
Values 0.67 1.7 1.6 4.9 3.8
[58]
HepG2 DTX4
Mean 10.3
Standard deviation 1.7
Values 9.1 12
[59]
HepG2.C3A DTX4
Mean 9.29
Standard deviation 0.13
Values 9.2 9.4
[60]
HuH.7 DTX4
Mean 20.7
Standard deviation 3.3
Values 23 22 17
[61]
SNU475 DTX4
Mean 7.93
Standard deviation 2.6
Values 9.8 6.1
[62]
THLE DTX4
Mean 0.804
Standard deviation 0.22
Values 0.64 0.96
[63]
liver DTX4
Mean 18.7
Standard deviation 4.9
Values 17 25 14 19
[64]
ref_hepatocyte TREX1
Mean 2.46
Standard deviation 2.5
Values 0 0.24 6.1 3.3 2.6
[65]
HepG2 TREX1
Mean 0.463
Standard deviation 0.066
Values 0.51 0.42
[66]
HepG2.C3A TREX1
Mean 1.01
Standard deviation 0.32
Values 1.2 0.78
[67]
HuH.7 TREX1
Mean 1.86
Standard deviation 0.62
Values 1.9 1.2 2.5
[68]
SNU475 TREX1
Mean 1.36
Standard deviation 0.25
Values 1.2 1.5
[69]
THLE TREX1
Mean 8.25
Standard deviation 0.64
Values 8.7 7.8
[70]
liver TREX1
Mean 1.98
Standard deviation 1.2
Values 2.6 0.88 3.3 1.1
[71]
ref_hepatocyte TRIM56
Mean 2.25
Standard deviation 1.6
Values 2 4.4 3.3 0.99 0.58
[72]
HepG2 TRIM56
Mean 7.81
Standard deviation 0.4
Values 8.1 7.5
[73]
HepG2.C3A TRIM56
Mean 4.29
Standard deviation 0.65
Values 4.7 3.8
[74]
HuH.7 TRIM56
Mean 10
Standard deviation 4
Values 13 11 5.5
[75]
SNU475 TRIM56
Mean 10.5
Standard deviation 0.96
Values 11 9.8
[76]
THLE TRIM56
Mean 13.3
Standard deviation 4.2
Values 10 16
[77]
liver TRIM56
Mean 9.17
Standard deviation 7.2
Values 4 12 2.5 18
[78]
ref_hepatocyte TRIM32
Mean 1.33
Standard deviation 0.74
Values 2.2 2 0.92 0.6 0.88
[79]
HepG2 TRIM32
Mean 11.3
Standard deviation 0.007
Values 11 11
[80]
HepG2.C3A TRIM32
Mean 5.26
Standard deviation 1.4
Values 4.2 6.3
[81]
HuH.7 TRIM32
Mean 10.6
Standard deviation 0.7
Values 11 10 10
[82]
SNU475 TRIM32
Mean 9.35
Standard deviation 0.59
Values 9.8 8.9
[83]
THLE TRIM32
Mean 22.1
Standard deviation 0.88
Values 23 21
[84]
liver TRIM32
Mean 5.44
Standard deviation 1
Values 5.4 5 6.9 4.5
[85]
ref_hepatocyte ZBP1
Mean 0.153
Standard deviation 0.17
Values 0.13 0.065 0 0.12 0.45
[86]
HepG2 ZBP1
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[87]
HepG2.C3A ZBP1
Mean 0.0268
Standard deviation 0.038
Values 0 0.054
[88]
HuH.7 ZBP1
Mean 0.0137
Standard deviation 0.014
Values 0 0.013 0.028
[89]
SNU475 ZBP1
Mean 0.0432
Standard deviation 0.011
Values 0.051 0.035
[90]
THLE ZBP1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[91]
liver ZBP1
Mean 0.154
Standard deviation 0.026
Values 0.12 0.17 0.15 0.17
[92]
ref_hepatocyte STING1
Missing
[93]
HepG2 STING1
Missing
[94]
HepG2.C3A STING1
Missing
[95]
HuH.7 STING1
Missing
[96]
SNU475 STING1
Missing
[97]
THLE STING1
Missing
[98]
liver STING1
Missing
[99]
ref_hepatocyte NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 NLRP4
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A NLRP4
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 NLRP4
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[103]
SNU475 NLRP4
Mean 0.0327
Standard deviation 0.04
Values 0.0046 0.061
[104]
THLE NLRP4
Mean 0
Standard deviation 0
Values 0 0
[105]
liver NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0