REACTOME_REGULATION_OF_IFNA_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] 0.34[2] 0.69[3] 0.58[4] -0.27[5] 0.82[6] 0.03[7]
2 STAT1 Signal transducer and activator of transcription 1-alpha/beta [8] -0.18[9] -1.18[10] -0.14[11] 1.37[12] -0.44[13] -0.28[14]
3 JAK1 Tyrosine-protein kinase JAK1 [15] 0.41[16] -0.19[17] -0.07[18] -0.53[19] 0.56[20] 0.30[21]
4 IFNAR2 Interferon alpha/beta receptor 2 [22] -1.32[23] -1.74[24] -1.12[25] -2.55[26] -2.10[27] -2.00[28]
5 SOCS3 Suppressor of cytokine signaling 3 [29] -4.25[30] -4.74[31] -3.08[32] -1.96[33] -2.58[34] -1.09[35]
6 PTPN1 Tyrosine-protein phosphatase non-receptor type 1 [36] 1.01[37] 0.59[38] 0.06[39] 0.66[40] 0.42[41] -1.53[42]
7 IFNAR1 Interferon alpha/beta receptor 1 [43] -0.05[44] 0.34[45] -0.01[46] -0.17[47] 0.27[48] 1.21[49]
8 STAT2 Signal transducer and activator of transcription 2 [50] -0.08[51] 1.20[52] 0.30[53] 0.37[54] 0.28[55] 1.80[56]
9 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [57] -0.57[58] -0.46[59] 0.05[60] -8.30[61] -2.83[62] -1.41[63]
10 TYK2 Non-receptor tyrosine-protein kinase TYK2 [64] 1.03[65] 1.30[66] 1.38[67] -0.41[68] 0.97[69] 0.76[70]
11 USP18 Ubl carboxyl-terminal hydrolase 18 [71] -0.17[72] 0.21[73] -0.21[74] -1.65[75] -3.65[76] -1.21[77]
12 SOCS1 Suppressor of cytokine signaling 1 [78] -1.56[79] -0.77[80] -0.56[81] -2.95[82] -3.88[83] -2.69[84]
13 IFNA7 Interferon alpha-7 [85] [86] [87] [88] [89] [90] [91]
14 IFNA6 Interferon alpha-6 [92] [93] [94] [95] [96] [97] [98]
15 IFNB1 Interferon beta [99] [100] [101] [102] [103] [104] [105]
16 IFNA4 Interferon alpha-4 [106] [107] [108] [109] [110] [111] [112]
17 IFNA8 Interferon alpha-8 [113] [114] [115] [116] [117] [118] [119]
18 IFNA13 [120] [121] [122] [123] [124] [125] [126]
19 IFNA2 Interferon alpha-2 [127] [128] [129] [130] [131] [132] [133]
20 IFNA1 Interferon alpha-1/13 [134] [135] [136] [137] [138] [139] [140]
21 IFNA10 Interferon alpha-10 [141] [142] [143] [144] [145] [146] [147]
22 IFNA21 Interferon alpha-21 [148] [149] [150] [151] [152] [153] [154]
23 IFNA17 Interferon alpha-17 [155] [156] [157] [158] [159] [160] [161]
24 IFNA16 Interferon alpha-16 [162] [163] [164] [165] [166] [167] [168]
25 IFNA14 Interferon alpha-14 [169] [170] [171] [172] [173] [174] [175]
26 IFNA5 Interferon alpha-5 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[9]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[10]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[11]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[12]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[13]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[14]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[15]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[16]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[17]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[18]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[19]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[20]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[21]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[22]
ref_hepatocyte IFNAR2
Mean 12.8
Standard deviation 6.4
Values 8 18 22 9.2 7.5
[23]
HepG2 IFNAR2
Mean 12.2
Standard deviation 0.31
Values 12 12
[24]
HepG2.C3A IFNAR2
Mean 8.58
Standard deviation 1.2
Values 9.4 7.7
[25]
HuH.7 IFNAR2
Mean 13.2
Standard deviation 0.52
Values 13 14 13
[26]
SNU475 IFNAR2
Mean 8.96
Standard deviation 1.9
Values 10 7.6
[27]
THLE IFNAR2
Mean 9.98
Standard deviation 0.57
Values 9.6 10
[28]
liver IFNAR2
Mean 10.6
Standard deviation 1.7
Values 9 11 13 9.4
[29]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 1 1.5 19 24 10
[30]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.7 1.1
[31]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 1.6 0.32
[32]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[33]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 12 11
[34]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[35]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 15 14 15 26
[36]
ref_hepatocyte PTPN1
Mean 8.72
Standard deviation 6.8
Values 20 10 6.8 4.1 2.6
[37]
HepG2 PTPN1
Mean 41.8
Standard deviation 5
Values 38 45
[38]
HepG2.C3A PTPN1
Mean 29.5
Standard deviation 3
Values 27 32
[39]
HuH.7 PTPN1
Mean 20.4
Standard deviation 3.4
Values 24 18 19
[40]
SNU475 PTPN1
Mean 56.7
Standard deviation 1.9
Values 55 58
[41]
THLE PTPN1
Mean 39.1
Standard deviation 7.5
Values 34 44
[42]
liver PTPN1
Mean 10
Standard deviation 0.98
Values 11 10 11 8.6
[43]
ref_hepatocyte IFNAR1
Mean 7.46
Standard deviation 3.8
Values 3.7 6.8 3.9 11 12
[44]
HepG2 IFNAR1
Mean 17.2
Standard deviation 4.5
Values 14 20
[45]
HepG2.C3A IFNAR1
Mean 21.2
Standard deviation 0.44
Values 21 22
[46]
HuH.7 IFNAR1
Mean 16.6
Standard deviation 2.6
Values 17 19 14
[47]
SNU475 IFNAR1
Mean 27.1
Standard deviation 2
Values 29 26
[48]
THLE IFNAR1
Mean 30.2
Standard deviation 1.7
Values 29 31
[49]
liver IFNAR1
Mean 57.2
Standard deviation 9.6
Values 50 70 60 49
[50]
ref_hepatocyte STAT2
Mean 5.97
Standard deviation 4.9
Values 2.5 2.7 2.3 9.4 13
[51]
HepG2 STAT2
Mean 13.4
Standard deviation 4
Values 11 16
[52]
HepG2.C3A STAT2
Mean 30.9
Standard deviation 3.5
Values 33 28
[53]
HuH.7 STAT2
Mean 16.5
Standard deviation 0.99
Values 16 16 17
[54]
SNU475 STAT2
Mean 31.7
Standard deviation 16
Values 43 20
[55]
THLE STAT2
Mean 24.3
Standard deviation 2
Values 26 23
[56]
liver STAT2
Mean 69
Standard deviation 4.2
Values 70 74 64 68
[57]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[58]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[59]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[60]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[61]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[62]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[63]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[64]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[65]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[66]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[67]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[68]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[69]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[70]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[71]
ref_hepatocyte USP18
Mean 3.69
Standard deviation 0.82
Values 4.8 4.1 2.8 3 3.8
[72]
HepG2 USP18
Mean 7.81
Standard deviation 2
Values 6.4 9.2
[73]
HepG2.C3A USP18
Mean 9.61
Standard deviation 0.58
Values 10 9.2
[74]
HuH.7 USP18
Mean 7.19
Standard deviation 1
Values 7.9 6 7.6
[75]
SNU475 USP18
Mean 4.83
Standard deviation 0.0086
Values 4.8 4.8
[76]
THLE USP18
Mean 0.985
Standard deviation 0.11
Values 1.1 0.9
[77]
liver USP18
Mean 5.32
Standard deviation 2.6
Values 8.3 4.4 6.3 2.2
[78]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.1 0 1.3 4.7 3.4
[79]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.8 1.6
[80]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 3.7 1.9
[81]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 3.3 1 5.3
[82]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 1.3 0.95
[83]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[84]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 1.1 0.27 0.8 2.2
[85]
ref_hepatocyte IFNA7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 IFNA7
Missing
[87]
HepG2.C3A IFNA7
Missing
[88]
HuH.7 IFNA7
Missing
[89]
SNU475 IFNA7
Missing
[90]
THLE IFNA7
Missing
[91]
liver IFNA7
Missing
[92]
ref_hepatocyte IFNA6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 IFNA6
Missing
[94]
HepG2.C3A IFNA6
Missing
[95]
HuH.7 IFNA6
Missing
[96]
SNU475 IFNA6
Missing
[97]
THLE IFNA6
Missing
[98]
liver IFNA6
Missing
[99]
ref_hepatocyte IFNB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 IFNB1
Missing
[101]
HepG2.C3A IFNB1
Missing
[102]
HuH.7 IFNB1
Missing
[103]
SNU475 IFNB1
Missing
[104]
THLE IFNB1
Missing
[105]
liver IFNB1
Missing
[106]
ref_hepatocyte IFNA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 IFNA4
Missing
[108]
HepG2.C3A IFNA4
Missing
[109]
HuH.7 IFNA4
Missing
[110]
SNU475 IFNA4
Missing
[111]
THLE IFNA4
Missing
[112]
liver IFNA4
Missing
[113]
ref_hepatocyte IFNA8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 IFNA8
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A IFNA8
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 IFNA8
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 IFNA8
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[118]
THLE IFNA8
Mean 0
Standard deviation 0
Values 0 0
[119]
liver IFNA8
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte IFNA13
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 IFNA13
Missing
[122]
HepG2.C3A IFNA13
Missing
[123]
HuH.7 IFNA13
Missing
[124]
SNU475 IFNA13
Missing
[125]
THLE IFNA13
Missing
[126]
liver IFNA13
Missing
[127]
ref_hepatocyte IFNA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 IFNA2
Missing
[129]
HepG2.C3A IFNA2
Missing
[130]
HuH.7 IFNA2
Missing
[131]
SNU475 IFNA2
Missing
[132]
THLE IFNA2
Missing
[133]
liver IFNA2
Missing
[134]
ref_hepatocyte IFNA1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 IFNA1
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A IFNA1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 IFNA1
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 IFNA1
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[139]
THLE IFNA1
Mean 0
Standard deviation 0
Values 0 0
[140]
liver IFNA1
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte IFNA10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 IFNA10
Missing
[143]
HepG2.C3A IFNA10
Missing
[144]
HuH.7 IFNA10
Missing
[145]
SNU475 IFNA10
Missing
[146]
THLE IFNA10
Missing
[147]
liver IFNA10
Missing
[148]
ref_hepatocyte IFNA21
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 IFNA21
Missing
[150]
HepG2.C3A IFNA21
Missing
[151]
HuH.7 IFNA21
Missing
[152]
SNU475 IFNA21
Missing
[153]
THLE IFNA21
Missing
[154]
liver IFNA21
Missing
[155]
ref_hepatocyte IFNA17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 IFNA17
Missing
[157]
HepG2.C3A IFNA17
Missing
[158]
HuH.7 IFNA17
Missing
[159]
SNU475 IFNA17
Missing
[160]
THLE IFNA17
Missing
[161]
liver IFNA17
Missing
[162]
ref_hepatocyte IFNA16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 IFNA16
Missing
[164]
HepG2.C3A IFNA16
Missing
[165]
HuH.7 IFNA16
Missing
[166]
SNU475 IFNA16
Missing
[167]
THLE IFNA16
Missing
[168]
liver IFNA16
Missing
[169]
ref_hepatocyte IFNA14
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 IFNA14
Missing
[171]
HepG2.C3A IFNA14
Missing
[172]
HuH.7 IFNA14
Missing
[173]
SNU475 IFNA14
Missing
[174]
THLE IFNA14
Missing
[175]
liver IFNA14
Missing
[176]
ref_hepatocyte IFNA5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 IFNA5
Mean 0
Standard deviation 0
Values 0 0
[178]
HepG2.C3A IFNA5
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 IFNA5
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 IFNA5
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[181]
THLE IFNA5
Mean 0
Standard deviation 0
Values 0 0
[182]
liver IFNA5
Mean 0.00688
Standard deviation 0.008
Values 0 0.014 0 0.013