REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SLC2A2 Solute carrier family 2, facilitated glucose transporter member 2 [1] -3.14[2] -2.70[3] -2.07[4] -5.90[5] -10.18[6] 0.60[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] 0.14[9] -0.43[10] -1.53[11] 0.83[12] 0.94[13] -1.49[14]
3 HNF4A Hepatocyte nuclear factor 4-alpha [15] 1.14[16] 1.28[17] 1.16[18] -6.14[19] -6.68[20] 0.59[21]
4 FOXA3 Hepatocyte nuclear factor 3-gamma [22] -1.02[23] -0.18[24] 0.29[25] -6.62[26] -7.52[27] -2.28[28]
5 AKT2 RAC-beta serine/threonine-protein kinase [29] 1.02[30] 0.96[31] 1.06[32] 1.74[33] 1.62[34] -0.12[35]
6 FOXA2 Hepatocyte nuclear factor 3-beta [36] 0.57[37] 0.54[38] 0.93[39] -6.67[40] -7.20[41] -1.73[42]
7 PKLR Pyruvate kinase PKLR [43] -1.81[44] -0.27[45] -2.01[46] -9.30[47] -9.11[48] -0.29[49]
8 HNF1A Hepatocyte nuclear factor 1-alpha [50] 0.97[51] 0.96[52] 1.63[53] -2.49[54] -3.25[55] -1.05[56]
9 HNF4G Hepatocyte nuclear factor 4-gamma [57] -0.90[58] 1.38[59] 1.54[60] 0.12[61] -5.12[62] 0.50[63]
10 FOXO1 Forkhead box protein O1 [64] 1.75[65] 1.08[66] 1.19[67] 2.05[68] 4.16[69] 1.84[70]
11 GCK Glucokinase [71] -7.89[72] -6.23[73] -9.45[74] -6.05[75] -4.01[76] 0.68[77]
12 AKT3 RAC-gamma serine/threonine-protein kinase [78] -1.78[79] -4.68[80] -4.01[81] 6.72[82] 5.76[83] 2.36[84]
13 IAPP Islet amyloid polypeptide [85] -1.82[86] -1.45[87] -1.30[88] -1.03[89] -0.87[90] -2.71[91]
14 MAFA Transcription factor MafA [92] 0.47[93] -1.51[94] -0.81[95] -2.56[96] -0.45[97] [98]
15 PAX6 Paired box protein Pax-6 [99] 5.73[100] 3.72[101] 5.37[102] 5.63[103] 2.56[104] 1.12[105]
16 PDX1 Pancreas/duodenum homeobox protein 1 [106] 0.45[107] -2.56[108] 5.32[109] -1.39[110] [111] 1.20[112]
17 NKX6-1 Homeobox protein Nkx-6.1 [113] [114] [115] [116] [117] [118] [119]
18 NEUROD1 Neurogenic differentiation factor 1 [120] [121] [122] [123] [124] [125] [126]
19 RFX6 DNA-binding protein RFX6 [127] [128] [129] [130] [131] [132] [133]
20 INS Insulin [134] [135] [136] [137] [138] [139] [140]
21 NKX2-2 Homeobox protein Nkx-2.2 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte SLC2A2
Mean 50.4
Standard deviation 77
Values 3.6 23 0.5 39 1.9e+02
[2]
HepG2 SLC2A2
Mean 12.1
Standard deviation 6.3
Values 7.6 17
[3]
HepG2.C3A SLC2A2
Mean 18.4
Standard deviation 9.8
Values 11 25
[4]
HuH.7 SLC2A2
Mean 27.9
Standard deviation 5.4
Values 29 32 22
[5]
SNU475 SLC2A2
Mean 0.843
Standard deviation 0.21
Values 0.99 0.69
[6]
THLE SLC2A2
Mean 0.0458
Standard deviation 0.027
Values 0.065 0.027
[7]
liver SLC2A2
Mean 257
Standard deviation 32
Values 2.5e+02 2.6e+02 2.2e+02 2.9e+02
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[15]
ref_hepatocyte HNF4A
Mean 22.2
Standard deviation 11
Values 30 11 9.6 30 30
[16]
HepG2 HNF4A
Mean 104
Standard deviation 5.9
Values 1e+02 1.1e+02
[17]
HepG2.C3A HNF4A
Mean 128
Standard deviation 15
Values 1.4e+02 1.2e+02
[18]
HuH.7 HNF4A
Mean 115
Standard deviation 13
Values 1.2e+02 1.2e+02 1e+02
[19]
SNU475 HNF4A
Mean 0.314
Standard deviation 0.14
Values 0.21 0.42
[20]
THLE HNF4A
Mean 0.228
Standard deviation 0.1
Values 0.3 0.15
[21]
liver HNF4A
Mean 113
Standard deviation 8.7
Values 1.2e+02 1.1e+02 1e+02 1.2e+02
[22]
ref_hepatocyte FOXA3
Mean 12.4
Standard deviation 15
Values 0.59 1.2 5.3 18 37
[23]
HepG2 FOXA3
Mean 13
Standard deviation 1.4
Values 12 14
[24]
HepG2.C3A FOXA3
Mean 26.1
Standard deviation 5.7
Values 30 22
[25]
HuH.7 FOXA3
Mean 35.3
Standard deviation 3
Values 33 38 35
[26]
SNU475 FOXA3
Mean 0.126
Standard deviation 0.087
Values 0.065 0.19
[27]
THLE FOXA3
Mean 0.0713
Standard deviation 0.033
Values 0.095 0.048
[28]
liver FOXA3
Mean 8.61
Standard deviation 3.6
Values 10 6.9 13 4.6
[29]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[30]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[31]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[32]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[33]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[34]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[35]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[36]
ref_hepatocyte FOXA2
Mean 7.53
Standard deviation 2.5
Values 7.1 4.1 8.6 11 6.8
[37]
HepG2 FOXA2
Mean 23.7
Standard deviation 12
Values 32 15
[38]
HepG2.C3A FOXA2
Mean 26.1
Standard deviation 10
Values 33 19
[39]
HuH.7 FOXA2
Mean 33.3
Standard deviation 2.6
Values 31 36 33
[40]
SNU475 FOXA2
Mean 0.074
Standard deviation 0.033
Values 0.097 0.051
[41]
THLE FOXA2
Mean 0.0538
Standard deviation 0.016
Values 0.065 0.043
[42]
liver FOXA2
Mean 7.66
Standard deviation 5
Values 15 3.8 6.3 5.6
[43]
ref_hepatocyte PKLR
Mean 7.45
Standard deviation 8
Values 8.4 0.078 0.38 8.7 20
[44]
HepG2 PKLR
Mean 4.51
Standard deviation 1.3
Values 3.6 5.4
[45]
HepG2.C3A PKLR
Mean 14.7
Standard deviation 7.4
Values 20 9.5
[46]
HuH.7 PKLR
Mean 4.29
Standard deviation 1.9
Values 3.3 6.5 3.1
[47]
SNU475 PKLR
Mean 0.0118
Standard deviation 0.0095
Values 0.019 0.0051
[48]
THLE PKLR
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[49]
liver PKLR
Mean 20.6
Standard deviation 18
Values 46 5 9.8 22
[50]
ref_hepatocyte HNF1A
Mean 5.57
Standard deviation 2.4
Values 3.4 2.6 7.8 6.4 7.6
[51]
HepG2 HNF1A
Mean 23.2
Standard deviation 1.9
Values 24 22
[52]
HepG2.C3A HNF1A
Mean 25.8
Standard deviation 0.61
Values 26 25
[53]
HuH.7 HNF1A
Mean 40
Standard deviation 1.9
Values 38 41 41
[54]
SNU475 HNF1A
Mean 0.99
Standard deviation 0.31
Values 1.2 0.77
[55]
THLE HNF1A
Mean 0.614
Standard deviation 0.01
Values 0.62 0.61
[56]
liver HNF1A
Mean 9.06
Standard deviation 1.3
Values 9.8 7.4 10 8.6
[57]
ref_hepatocyte HNF4G
Mean 2.02
Standard deviation 1.6
Values 1.8 1.1 4.8 1.4 1
[58]
HepG2 HNF4G
Mean 2.3
Standard deviation 0.24
Values 2.1 2.5
[59]
HepG2.C3A HNF4G
Mean 12.6
Standard deviation 0.36
Values 12 13
[60]
HuH.7 HNF4G
Mean 13.7
Standard deviation 4.6
Values 12 19 9.9
[61]
SNU475 HNF4G
Mean 2.21
Standard deviation 1.1
Values 3 1.4
[62]
THLE HNF4G
Mean 0.0612
Standard deviation 0.011
Values 0.053 0.069
[63]
liver HNF4G
Mean 9.62
Standard deviation 3.1
Values 7.3 13 7 11
[64]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 0.71 1.7 2 1.9 2.6
[65]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 11 14
[66]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 10 7.9
[67]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 10 10 7.6
[68]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 8.6 6
[69]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[70]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 25 19 13 29
[71]
ref_hepatocyte GCK
Mean 0.642
Standard deviation 1.1
Values 0 0 0 0.7 2.5
[72]
HepG2 GCK
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[73]
HepG2.C3A GCK
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[74]
HuH.7 GCK
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[75]
SNU475 GCK
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[76]
THLE GCK
Mean 0.042
Standard deviation 0.00081
Values 0.041 0.043
[77]
liver GCK
Mean 3.47
Standard deviation 6.5
Values 13 0.17 0.13 0.38
[78]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[79]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[80]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[81]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[82]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[83]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[84]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[85]
ref_hepatocyte IAPP
Mean 0.301
Standard deviation 0.42
Values 0.52 0.94 0.03 0 0.0081
[86]
HepG2 IAPP
Mean 0.18
Standard deviation 0.012
Values 0.19 0.17
[87]
HepG2.C3A IAPP
Mean 0.263
Standard deviation 0.068
Values 0.31 0.21
[88]
HuH.7 IAPP
Mean 0.285
Standard deviation 0.091
Values 0.26 0.39 0.21
[89]
SNU475 IAPP
Mean 0.147
Standard deviation 0.015
Values 0.16 0.14
[90]
THLE IAPP
Mean 0.174
Standard deviation 0.0028
Values 0.17 0.18
[91]
liver IAPP
Mean 0.155
Standard deviation 0.059
Values 0.21 0.19 0.077 0.15
[92]
ref_hepatocyte MAFA
Mean 0.0832
Standard deviation 0.19
Values 0 0 0.42 0 0
[93]
HepG2 MAFA
Mean 0.245
Standard deviation 0.16
Values 0.36 0.13
[94]
HepG2.C3A MAFA
Mean 0.0696
Standard deviation 0.053
Values 0.11 0.032
[95]
HuH.7 MAFA
Mean 0.11
Standard deviation 0.033
Values 0.11 0.14 0.075
[96]
SNU475 MAFA
Mean 0.0141
Standard deviation 0.013
Values 0.023 0.0051
[97]
THLE MAFA
Mean 0.0639
Standard deviation 0.015
Values 0.053 0.074
[98]
liver MAFA
Mean 0
Standard deviation 0
Values 0 0 0 0
[99]
ref_hepatocyte PAX6
Mean 0.0716
Standard deviation 0.088
Values 0 0 0.052 0.095 0.21
[100]
HepG2 PAX6
Mean 8.03
Standard deviation 2.9
Values 10 6
[101]
HepG2.C3A PAX6
Mean 2.25
Standard deviation 0.65
Values 2.7 1.8
[102]
HuH.7 PAX6
Mean 6.86
Standard deviation 0.41
Values 7.3 6.8 6.5
[103]
SNU475 PAX6
Mean 3.54
Standard deviation 0.9
Values 2.9 4.2
[104]
THLE PAX6
Mean 0.444
Standard deviation 0.12
Values 0.53 0.36
[105]
liver PAX6
Mean 0.523
Standard deviation 0.14
Values 0.73 0.4 0.46 0.5
[106]
ref_hepatocyte PDX1
Mean 0.0133
Standard deviation 0.02
Values 0.045 0 0.022 0 0
[107]
HepG2 PDX1
Mean 0.0386
Standard deviation 0.006
Values 0.034 0.043
[108]
HepG2.C3A PDX1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[109]
HuH.7 PDX1
Mean 1.24
Standard deviation 0.28
Values 1.3 0.93 1.5
[110]
SNU475 PDX1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[111]
THLE PDX1
Mean 0
Standard deviation 0
Values 0 0
[112]
liver PDX1
Mean 0.103
Standard deviation 0.045
Values 0.12 0.057 0.077 0.16
[113]
ref_hepatocyte NKX6-1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 NKX6-1
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[115]
HepG2.C3A NKX6-1
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 NKX6-1
Mean 0.143
Standard deviation 0.079
Values 0.057 0.21 0.16
[117]
SNU475 NKX6-1
Mean 0.61
Standard deviation 0.29
Values 0.4 0.82
[118]
THLE NKX6-1
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[119]
liver NKX6-1
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte NEUROD1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 NEUROD1
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[124]
SNU475 NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE NEUROD1
Mean 0
Standard deviation 0
Values 0 0
[126]
liver NEUROD1
Mean 0.185
Standard deviation 0.02
Values 0.16 0.2 0.21 0.17
[127]
ref_hepatocyte RFX6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 RFX6
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A RFX6
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[130]
HuH.7 RFX6
Mean 0.504
Standard deviation 0.4
Values 0.26 0.97 0.28
[131]
SNU475 RFX6
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[132]
THLE RFX6
Mean 0
Standard deviation 0
Values 0 0
[133]
liver RFX6
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[140]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0 0.057 0 0.28
[141]
ref_hepatocyte NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 NKX2-2
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[146]
THLE NKX2-2
Mean 0
Standard deviation 0
Values 0 0
[147]
liver NKX2-2
Mean 0
Standard deviation 0
Values 0 0 0 0