REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HIGD1A HIG1 domain family member 1A, mitochondrial [1] -1.35[2] -0.84[3] -1.03[4] -2.58[5] -2.04[6] -0.18[7]
2 HIF1A Hypoxia-inducible factor 1-alpha [8] -0.88[9] -1.25[10] -0.15[11] 1.72[12] 1.51[13] -1.44[14]
3 CITED2 Cbp/p300-interacting transactivator 2 [15] -1.75[16] -1.97[17] -0.29[18] -0.66[19] -2.03[20] -2.11[21]
4 VEGFA Vascular endothelial growth factor A [22] 0.49[23] 1.79[24] 0.69[25] -0.13[26] 0.00[27] 0.15[28]
5 EPAS1 Endothelial PAS domain-containing protein 1 [29] 1.98[30] 1.16[31] 1.11[32] -1.13[33] 1.29[34] 1.30[35]
6 ARNT Aryl hydrocarbon receptor nuclear translocator [36] -0.31[37] -0.56[38] 0.62[39] 0.80[40] -0.02[41] 0.90[42]
7 EPO Erythropoietin [43] -1.86[44] 0.26[45] -3.28[46] -10.23[47] -12.70[48] -0.65[49]
8 EP300 Histone acetyltransferase p300 [50] 2.00[51] 1.55[52] 2.75[53] 2.01[54] 1.47[55] 2.12[56]
9 CREBBP CREB-binding protein [57] 2.18[58] 1.35[59] 2.26[60] 2.19[61] 1.61[62] 2.60[63]
10 HIF3A Hypoxia-inducible factor 3-alpha [64] -1.66[65] -1.16[66] -3.52[67] -2.50[68] -3.17[69] 2.96[70]
11 CA9 Carbonic anhydrase 9 [71] 8.18[72] 6.08[73] -1.26[74] 5.36[75] 4.33[76] 1.86[77]
[1]
ref_hepatocyte HIGD1A
Mean 73.2
Standard deviation 47
Values 44 1.6e+02 49 56 61
[2]
HepG2 HIGD1A
Mean 105
Standard deviation 11
Values 97 1.1e+02
[3]
HepG2.C3A HIGD1A
Mean 137
Standard deviation 44
Values 1.1e+02 1.7e+02
[4]
HuH.7 HIGD1A
Mean 93.2
Standard deviation 14
Values 95 78 1.1e+02
[5]
SNU475 HIGD1A
Mean 33.2
Standard deviation 2.8
Values 35 31
[6]
THLE HIGD1A
Mean 81.4
Standard deviation 6.9
Values 77 86
[7]
liver HIGD1A
Mean 142
Standard deviation 89
Values 1.8e+02 87 2.5e+02 53
[8]
ref_hepatocyte HIF1A
Mean 26.5
Standard deviation 22
Values 27 61 30 8.1 5.8
[9]
HepG2 HIF1A
Mean 52.5
Standard deviation 22
Values 37 68
[10]
HepG2.C3A HIF1A
Mean 37.2
Standard deviation 10
Values 30 44
[11]
HuH.7 HIF1A
Mean 62
Standard deviation 17
Values 81 55 49
[12]
SNU475 HIF1A
Mean 237
Standard deviation 65
Values 2.8e+02 1.9e+02
[13]
THLE HIF1A
Mean 346
Standard deviation 60
Values 3.9e+02 3e+02
[14]
liver HIF1A
Mean 21.5
Standard deviation 8.5
Values 12 25 18 31
[15]
ref_hepatocyte CITED2
Mean 22.2
Standard deviation 7.4
Values 12 17 22 30 29
[16]
HepG2 CITED2
Mean 24
Standard deviation 6.9
Values 29 19
[17]
HepG2.C3A CITED2
Mean 18.8
Standard deviation 1.9
Values 20 17
[18]
HuH.7 CITED2
Mean 47.1
Standard deviation 14
Values 40 63 39
[19]
SNU475 CITED2
Mean 38.2
Standard deviation 1.3
Values 37 39
[20]
THLE CITED2
Mean 24.9
Standard deviation 4
Values 22 28
[21]
liver CITED2
Mean 11.3
Standard deviation 4.5
Values 12 17 10 6.3
[22]
ref_hepatocyte VEGFA
Mean 15.4
Standard deviation 8.3
Values 12 5.2 12 22 25
[23]
HepG2 VEGFA
Mean 78.9
Standard deviation 39
Values 1.1e+02 51
[24]
HepG2.C3A VEGFA
Mean 178
Standard deviation 91
Values 2.4e+02 1.1e+02
[25]
HuH.7 VEGFA
Mean 64.6
Standard deviation 7.4
Values 59 62 73
[26]
SNU475 VEGFA
Mean 38.2
Standard deviation 17
Values 26 50
[27]
THLE VEGFA
Mean 70.1
Standard deviation 17
Values 82 58
[28]
liver VEGFA
Mean 37.5
Standard deviation 27
Values 18 70 14 48
[29]
ref_hepatocyte EPAS1
Mean 12.6
Standard deviation 4.8
Values 9.5 8.7 9.1 18 18
[30]
HepG2 EPAS1
Mean 182
Standard deviation 60
Values 2.2e+02 1.4e+02
[31]
HepG2.C3A EPAS1
Mean 93.9
Standard deviation 18
Values 1.1e+02 81
[32]
HuH.7 EPAS1
Mean 71
Standard deviation 9.1
Values 75 77 61
[33]
SNU475 EPAS1
Mean 15.6
Standard deviation 8.9
Values 9.3 22
[34]
THLE EPAS1
Mean 142
Standard deviation 5.8
Values 1.4e+02 1.5e+02
[35]
liver EPAS1
Mean 68.1
Standard deviation 34
Values 49 69 38 1.2e+02
[36]
ref_hepatocyte ARNT
Mean 5.93
Standard deviation 1.4
Values 7.7 6.5 4.1 4.8 6.5
[37]
HepG2 ARNT
Mean 17.5
Standard deviation 1.2
Values 17 18
[38]
HepG2.C3A ARNT
Mean 13.5
Standard deviation 3
Values 16 11
[39]
HuH.7 ARNT
Mean 23.6
Standard deviation 6.3
Values 22 31 19
[40]
SNU475 ARNT
Mean 28.1
Standard deviation 0.55
Values 28 28
[41]
THLE ARNT
Mean 26.8
Standard deviation 1.6
Values 26 28
[42]
liver ARNT
Mean 24.4
Standard deviation 4.2
Values 29 19 26 23
[43]
ref_hepatocyte EPO
Mean 4.3
Standard deviation 5.9
Values 1.1 0 0.32 14 6.2
[44]
HepG2 EPO
Mean 4.34
Standard deviation 2.9
Values 2.3 6.4
[45]
HepG2.C3A EPO
Mean 17.3
Standard deviation 2.6
Values 15 19
[46]
HuH.7 EPO
Mean 1.15
Standard deviation 0.76
Values 0.71 2 0.72
[47]
SNU475 EPO
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[48]
THLE EPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[49]
liver EPO
Mean 6.05
Standard deviation 8
Values 3.1 2.9 18 0.3
[50]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[51]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[52]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[53]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[54]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[55]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[56]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[57]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[58]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[59]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[60]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[61]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[62]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[63]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[64]
ref_hepatocyte HIF3A
Mean 0.183
Standard deviation 0.16
Values 0.11 0.039 0.13 0.45 0.19
[65]
HepG2 HIF3A
Mean 0.212
Standard deviation 0.081
Values 0.27 0.15
[66]
HepG2.C3A HIF3A
Mean 0.274
Standard deviation 0.053
Values 0.31 0.24
[67]
HuH.7 HIF3A
Mean 0.0415
Standard deviation 0.0076
Values 0.033 0.045 0.047
[68]
SNU475 HIF3A
Mean 0.0882
Standard deviation 0.033
Values 0.065 0.11
[69]
THLE HIF3A
Mean 0.0929
Standard deviation 0.086
Values 0.15 0.032
[70]
liver HIF3A
Mean 3.13
Standard deviation 2.6
Values 7 1.4 2.3 1.9
[71]
ref_hepatocyte CA9
Mean 0.0671
Standard deviation 0.092
Values 0 0 0 0.18 0.15
[72]
HepG2 CA9
Mean 70.9
Standard deviation 69
Values 1.2e+02 22
[73]
HepG2.C3A CA9
Mean 15.1
Standard deviation 4
Values 12 18
[74]
HuH.7 CA9
Mean 0.0731
Standard deviation 0.065
Values 0.12 0.096 0
[75]
SNU475 CA9
Mean 7.48
Standard deviation 1.3
Values 6.6 8.4
[76]
THLE CA9
Mean 6.18
Standard deviation 3.4
Values 8.6 3.8
[77]
liver CA9
Mean 0.538
Standard deviation 0.57
Values 1.3 0.057 0.72 0.11