REACTOME_ARACHIDONIC_ACID_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PTGR1 | Prostaglandin reductase 1 | [1] | -2.54[2] | -8.02[3] | -2.18[4] | -0.55[5] | -1.44[6] | -1.18[7] |
2 | CYP2C8 | Cytochrome P450 2C8 | [8] | -14.19[9] | -9.34[10] | -7.08[11] | -11.45[12] | [13] | 0.63[14] |
3 | CYP2C9 | Cytochrome P450 2C9 | [15] | [16] | -14.26[17] | -7.29[18] | -14.13[19] | -12.55[20] | 1.13[21] |
4 | AKR1C3 | Aldo-keto reductase family 1 member C3 | [22] | 0.03[23] | 0.77[24] | -5.81[25] | 2.45[26] | -3.83[27] | -2.08[28] |
5 | GPX2 | Glutathione peroxidase 2 | [29] | 1.45[30] | 0.89[31] | -1.20[32] | -9.09[33] | -8.49[34] | -0.44[35] |
6 | GPX4 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | [36] | 0.50[37] | 1.00[38] | 0.76[39] | -0.59[40] | -0.21[41] | -1.68[42] |
7 | GPX1 | Glutathione peroxidase 1 | [43] | 0.78[44] | 0.57[45] | 1.00[46] | -0.21[47] | 1.55[48] | -1.43[49] |
8 | PTGES3 | Prostaglandin E synthase 3 | [50] | 1.53[51] | 1.98[52] | 2.39[53] | 1.39[54] | 2.12[55] | -1.96[56] |
9 | CYP4A11 | Cytochrome P450 4A11 | [57] | -12.36[58] | -9.62[59] | -11.43[60] | -10.26[61] | -10.50[62] | 0.99[63] |
10 | PON1 | Serum paraoxonase/arylesterase 1 | [64] | -6.22[65] | -3.35[66] | -1.35[67] | -10.16[68] | -9.73[69] | 0.62[70] |
11 | CBR1 | Carbonyl reductase [NADPH] 1 | [71] | -1.54[72] | -1.82[73] | -1.47[74] | -0.43[75] | -0.05[76] | -1.37[77] |
12 | PON3 | Serum paraoxonase/lactonase 3 | [78] | -1.86[79] | -1.52[80] | -2.61[81] | -6.40[82] | -10.98[83] | -0.14[84] |
13 | CYP1A2 | Cytochrome P450 1A2 | [85] | -8.62[86] | -7.21[87] | -7.80[88] | -8.02[89] | -7.65[90] | -1.54[91] |
14 | PON2 | Serum paraoxonase/arylesterase 2 | [92] | 1.89[93] | 2.09[94] | 1.86[95] | 0.27[96] | 0.89[97] | -0.12[98] |
15 | CYP1A1 | Cytochrome P450 1A1 | [99] | -2.16[100] | -3.64[101] | 0.09[102] | -3.42[103] | -3.18[104] | -5.69[105] |
16 | CYP8B1 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase | [106] | -5.92[107] | -3.26[108] | -7.12[109] | -7.91[110] | -8.96[111] | 2.56[112] |
17 | EPHX2 | Bifunctional epoxide hydrolase 2 | [113] | -0.98[114] | 0.94[115] | 2.44[116] | -3.79[117] | -2.78[118] | 1.05[119] |
18 | CYP4F2 | Phylloquinone omega-hydroxylase CYP4F2 | [120] | -4.32[121] | -0.59[122] | -12.22[123] | -11.48[124] | -8.81[125] | 0.93[126] |
19 | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | [127] | -5.85[128] | -5.98[129] | 3.22[130] | -4.73[131] | -4.49[132] | 0.73[133] |
20 | CYP2J2 | Cytochrome P450 2J2 | [134] | -3.10[135] | -2.99[136] | 0.19[137] | -6.11[138] | -3.86[139] | 0.38[140] |
21 | LTA4H | Leukotriene A-4 hydrolase | [141] | 2.33[142] | 3.07[143] | 2.92[144] | 1.45[145] | 2.72[146] | -1.41[147] |
22 | CYP2C19 | Cytochrome P450 2C19 | [148] | [149] | [150] | -4.44[151] | -11.82[152] | -10.85[153] | 1.69[154] |
23 | GGT1 | Glutathione hydrolase 1 proenzyme | [155] | 1.63[156] | 1.47[157] | 1.31[158] | -0.12[159] | -3.87[160] | 0.83[161] |
24 | CYP4F11 | Phylloquinone omega-hydroxylase CYP4F11 | [162] | -0.23[163] | -0.54[164] | -7.77[165] | 0.96[166] | -8.31[167] | 0.86[168] |
25 | CYP4F3 | Docosahexaenoic acid omega-hydroxylase CYP4F3 | [169] | -1.16[170] | -0.13[171] | 1.20[172] | -2.44[173] | -7.81[174] | 2.29[175] |
26 | PTGES2 | Prostaglandin E synthase 2 | [176] | 2.75[177] | 2.98[178] | 2.29[179] | 1.58[180] | 2.23[181] | -0.41[182] |
27 | MAPKAPK | MAP kinase-activated protein kinase 2 | [183] | 2.76[184] | 1.91[185] | 2.39[186] | 3.46[187] | 3.46[188] | -0.83[189] |
28 | FAAH | Fatty-acid amide hydrolase 1 | [190] | 0.01[191] | 1.30[192] | -1.15[193] | -1.14[194] | -3.53[195] | 0.57[196] |
29 | PTGR2 | Prostaglandin reductase 2 | [197] | 0.95[198] | 2.64[199] | 4.58[200] | 1.69[201] | 2.44[202] | 0.73[203] |
30 | CYP4A22 | Cytochrome P450 4A22 | [204] | [205] | [206] | [207] | [208] | [209] | 2.37[210] |
31 | CYP4F22 | Cytochrome P450 4F22 | [211] | -3.57[212] | [213] | -8.41[214] | -7.89[215] | -5.30[216] | -0.86[217] |
32 | FAAH2 | Fatty-acid amide hydrolase 2 | [218] | -0.10[219] | 0.40[220] | [221] | -4.85[222] | -5.52[223] | 0.46[224] |
33 | CYP1B1 | Cytochrome P450 1B1 | [225] | -4.75[226] | -4.07[227] | 0.10[228] | 3.57[229] | 6.96[230] | 1.12[231] |
34 | ABCC1 | Multidrug resistance-associated protein 1 | [232] | 7.55[233] | 4.85[234] | 4.00[235] | 6.48[236] | 5.71[237] | 0.88[238] |
35 | DPEP1 | Dipeptidase 1 | [239] | 4.18[240] | 2.58[241] | -4.06[242] | -4.99[243] | -6.40[244] | -4.02[245] |
36 | CYP2U1 | Cytochrome P450 2U1 | [246] | 2.48[247] | -1.21[248] | -0.95[249] | 3.30[250] | 4.87[251] | 2.18[252] |
37 | ALOX5AP | Arachidonate 5-lipoxygenase-activating protein | [253] | 0.29[254] | -1.44[255] | 0.02[256] | 1.92[257] | 2.16[258] | -0.22[259] |
38 | TBXAS1 | Thromboxane-A synthase | [260] | -0.67[261] | 1.51[262] | -1.62[263] | 2.71[264] | 2.04[265] | 1.76[266] |
39 | ALOXE3 | Hydroperoxide isomerase ALOXE3 | [267] | 0.13[268] | -2.05[269] | -2.16[270] | -3.92[271] | 1.42[272] | [273] |
40 | PTGDS | Prostaglandin-H2 D-isomerase | [274] | 2.79[275] | 3.09[276] | -5.72[277] | 1.88[278] | 2.79[279] | 1.00[280] |
41 | ALOX5 | Arachidonate 5-lipoxygenase | [281] | 1.43[282] | -3.80[283] | -3.66[284] | -5.06[285] | -3.02[286] | 2.93[287] |
42 | LTC4S | Leukotriene C4 synthase | [288] | -0.62[289] | 0.99[290] | -0.32[291] | -3.75[292] | 0.37[293] | 0.65[294] |
43 | PTGIS | Prostacyclin synthase | [295] | 0.74[296] | 1.98[297] | 6.02[298] | 3.19[299] | 9.92[300] | 4.95[301] |
44 | DPEP2 | Dipeptidase 2 | [302] | -0.89[303] | 0.33[304] | -1.62[305] | [306] | [307] | 1.14[308] |
45 | PTGES | Prostaglandin E synthase | [309] | 3.59[310] | -0.14[311] | 0.03[312] | 5.39[313] | 8.68[314] | -1.26[315] |
46 | ALOX15B | Arachidonate 15-lipoxygenase B | [316] | -3.18[317] | [318] | 3.46[319] | -5.04[320] | 3.59[321] | 0.07[322] |
47 | GGT5 | Glutathione hydrolase 5 proenzyme | [323] | 6.88[324] | 4.37[325] | -0.44[326] | 5.98[327] | 6.90[328] | 5.74[329] |
48 | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | [330] | 2.93[331] | 2.98[332] | 2.01[333] | 2.90[334] | 3.09[335] | 0.93[336] |
49 | PTGS1 | Prostaglandin G/H synthase 1 | [337] | 3.65[338] | -3.15[339] | -1.34[340] | 4.75[341] | 8.37[342] | 3.09[343] |
50 | DPEP3 | Dipeptidase 3 | [344] | [345] | [346] | -3.73[347] | -3.86[348] | [349] | -0.75[350] |
51 | HPGDS | Hematopoietic prostaglandin D synthase | [351] | [352] | [353] | [354] | -3.97[355] | -1.03[356] | 0.07[357] |
52 | AWAT1 | Acyl-CoA wax alcohol acyltransferase 1 | [358] | -1.11[359] | -0.58[360] | -1.71[361] | [362] | [363] | -0.69[364] |
53 | PTGS2 | Prostaglandin G/H synthase 2 | [365] | [366] | -0.20[367] | 0.11[368] | 4.93[369] | 11.53[370] | 2.95[371] |
54 | ALOX15 | Arachidonate 15-lipoxygenase | [372] | 3.91[373] | -0.04[374] | 4.60[375] | 0.31[376] | 1.54[377] | -0.83[378] |
55 | PLA2G4A | Cytosolic phospholipase A2 | [379] | 2.57[380] | 0.13[381] | 8.30[382] | 5.57[383] | 10.12[384] | 4.46[385] |
56 | CYP4B1 | Cytochrome P450 4B1 | [386] | [387] | [388] | [389] | [390] | [391] | [392] |
57 | CYP4F8 | Cytochrome P450 4F8 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | ALOX12B | Arachidonate 12-lipoxygenase, 12R-type | [400] | [401] | [402] | [403] | [404] | [405] | [406] |
59 | PRXL2B | [407] | [408] | [409] | [410] | [411] | [412] | [413] |