REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.58[2] -0.69[3] -0.87[4] -0.59[5] -0.16[6] -0.37[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.13[16] 0.06[17] -0.50[18] 0.26[19] 0.22[20] 0.08[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.30[23] 2.29[24] 3.01[25] 1.66[26] 2.45[27] 0.85[28]
5 LRP5 Low-density lipoprotein receptor-related protein 5 [29] 3.73[30] 3.53[31] 3.83[32] 3.93[33] 2.44[34] 3.66[35]
6 LGR4 Leucine-rich repeat-containing G-protein coupled receptor 4 [36] 1.94[37] 3.30[38] 4.07[39] 2.93[40] 0.98[41] 3.34[42]
7 USP8 Ubiquitin carboxyl-terminal hydrolase 8 [43] 1.45[44] 2.65[45] 2.32[46] 3.32[47] 3.04[48] 2.94[49]
8 FZD5 Frizzled-5 [50] 2.59[51] 3.54[52] 4.21[53] 1.05[54] -0.28[55] 4.09[56]
9 RNF43 E3 ubiquitin-protein ligase RNF43 [57] 4.70[58] 3.90[59] 2.56[60] 0.66[61] 1.80[62] 1.66[63]
10 FZD4 Frizzled-4 [64] 5.71[65] 4.73[66] 3.44[67] 2.88[68] 2.19[69] 4.45[70]
11 ZNRF3 E3 ubiquitin-protein ligase ZNRF3 [71] 4.86[72] 3.81[73] 3.94[74] 2.44[75] 2.35[76] 2.54[77]
12 LRP6 Low-density lipoprotein receptor-related protein 6 [78] 3.44[79] 4.19[80] 5.22[81] 4.05[82] 4.57[83] 6.29[84]
13 FZD6 Frizzled-6 [85] 3.41[86] 4.31[87] 1.48[88] 6.92[89] 5.66[90] 2.62[91]
14 FZD8 Frizzled-8 [92] -1.50[93] -6.76[94] 0.29[95] -0.78[96] 0.41[97] 1.31[98]
15 RSPO3 R-spondin-3 [99] -3.67[100] [101] -1.98[102] 8.11[103] -0.03[104] 4.68[105]
16 LGR5 Leucine-rich repeat-containing G-protein coupled receptor 5 [106] 7.94[107] 8.23[108] 4.14[109] 1.66[110] -0.45[111] 2.91[112]
17 RSPO4 R-spondin-4 [113] 0.62[114] [115] 0.05[116] 4.89[117] 5.96[118] 2.21[119]
18 LGR6 Leucine-rich repeat-containing G-protein coupled receptor 6 [120] 4.95[121] 6.65[122] [123] 4.33[124] 1.94[125] 8.11[126]
19 WNT3A Protein Wnt-3a [127] [128] [129] [130] [131] [132] [133]
20 RSPO1 R-spondin-1 [134] [135] [136] [137] [138] [139] [140]
21 RSPO2 R-spondin-2 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte LRP5
Mean 11.4
Standard deviation 3.9
Values 8.8 10 7.3 17 13
[30]
HepG2 LRP5
Mean 108
Standard deviation 24
Values 1.3e+02 91
[31]
HepG2.C3A LRP5
Mean 79.2
Standard deviation 20
Values 93 65
[32]
HuH.7 LRP5
Mean 117
Standard deviation 36
Values 1.5e+02 81 1.2e+02
[33]
SNU475 LRP5
Mean 69.8
Standard deviation 26
Values 88 52
[34]
THLE LRP5
Mean 28.3
Standard deviation 7.2
Values 23 33
[35]
liver LRP5
Mean 71.8
Standard deviation 33
Values 39 93 50 1.1e+02
[36]
ref_hepatocyte LGR4
Mean 9.13
Standard deviation 4.2
Values 10 7.5 6.2 5.6 16
[37]
HepG2 LGR4
Mean 25.2
Standard deviation 13
Values 16 34
[38]
HepG2.C3A LGR4
Mean 54.2
Standard deviation 4.8
Values 51 58
[39]
HuH.7 LGR4
Mean 111
Standard deviation 34
Values 1e+02 1.5e+02 83
[40]
SNU475 LGR4
Mean 28
Standard deviation 12
Values 37 19
[41]
THLE LGR4
Mean 8.28
Standard deviation 1.8
Values 7 9.5
[42]
liver LGR4
Mean 46.3
Standard deviation 18
Values 49 55 21 61
[43]
ref_hepatocyte USP8
Mean 6.73
Standard deviation 4.3
Values 12 10 3.2 3.5 4.3
[44]
HepG2 USP8
Mean 13.2
Standard deviation 5.6
Values 9.2 17
[45]
HepG2.C3A USP8
Mean 25.5
Standard deviation 2.2
Values 24 27
[46]
HuH.7 USP8
Mean 24.3
Standard deviation 2.7
Values 26 26 21
[47]
SNU475 USP8
Mean 27.1
Standard deviation 1.4
Values 26 28
[48]
THLE USP8
Mean 25.4
Standard deviation 6.5
Values 30 21
[49]
liver USP8
Mean 25.8
Standard deviation 2.7
Values 29 26 25 23
[50]
ref_hepatocyte FZD5
Mean 6.07
Standard deviation 3.7
Values 12 4.4 2.3 5.6 5.8
[51]
HepG2 FZD5
Mean 26.3
Standard deviation 2.4
Values 28 25
[52]
HepG2.C3A FZD5
Mean 42.7
Standard deviation 15
Values 53 32
[53]
HuH.7 FZD5
Mean 81.4
Standard deviation 28
Values 76 1.1e+02 56
[54]
SNU475 FZD5
Mean 5.07
Standard deviation 1.9
Values 6.5 3.7
[55]
THLE FZD5
Mean 2.29
Standard deviation 0.46
Values 2 2.6
[56]
liver FZD5
Mean 51.7
Standard deviation 15
Values 73 42 47 44
[57]
ref_hepatocyte RNF43
Mean 3.83
Standard deviation 6
Values 15 1.1 0.59 1.1 1.9
[58]
HepG2 RNF43
Mean 71.6
Standard deviation 11
Values 79 64
[59]
HepG2.C3A RNF43
Mean 34.4
Standard deviation 9.6
Values 28 41
[60]
HuH.7 RNF43
Mean 16.4
Standard deviation 1.2
Values 18 16 16
[61]
SNU475 RNF43
Mean 2.44
Standard deviation 0.81
Values 3 1.9
[62]
THLE RNF43
Mean 6.13
Standard deviation 1.6
Values 7.3 5
[63]
liver RNF43
Mean 6.06
Standard deviation 1.1
Values 7.3 6.5 4.6 5.8
[64]
ref_hepatocyte FZD4
Mean 2.69
Standard deviation 3.7
Values 9.2 0.68 0.82 1.2 1.5
[65]
HepG2 FZD4
Mean 101
Standard deviation 33
Values 78 1.2e+02
[66]
HepG2.C3A FZD4
Mean 43.1
Standard deviation 1.2
Values 42 44
[67]
HuH.7 FZD4
Mean 21.2
Standard deviation 1.5
Values 22 22 20
[68]
SNU475 FZD4
Mean 7.99
Standard deviation 1.3
Values 8.9 7
[69]
THLE FZD4
Mean 5.63
Standard deviation 0.2
Values 5.5 5.8
[70]
liver FZD4
Mean 29.5
Standard deviation 13
Values 17 44 19 38
[71]
ref_hepatocyte ZNRF3
Mean 2.4
Standard deviation 2.2
Values 6.3 0.88 2 1.2 1.6
[72]
HepG2 ZNRF3
Mean 49.8
Standard deviation 3.7
Values 52 47
[73]
HepG2.C3A ZNRF3
Mean 20.3
Standard deviation 2.3
Values 19 22
[74]
HuH.7 ZNRF3
Mean 26.7
Standard deviation 7
Values 34 20 25
[75]
SNU475 ZNRF3
Mean 5.24
Standard deviation 0.076
Values 5.2 5.3
[76]
THLE ZNRF3
Mean 5.6
Standard deviation 1.9
Values 4.2 7
[77]
liver ZNRF3
Mean 6.98
Standard deviation 2
Values 7 7.5 4.3 9.1
[78]
ref_hepatocyte LRP6
Mean 1.95
Standard deviation 0.83
Values 2.8 2.6 0.7 1.7 1.9
[79]
HepG2 LRP6
Mean 15.2
Standard deviation 4.8
Values 12 19
[80]
HepG2.C3A LRP6
Mean 21.5
Standard deviation 0.56
Values 21 22
[81]
HuH.7 LRP6
Mean 52.6
Standard deviation 14
Values 58 64 37
[82]
SNU475 LRP6
Mean 13
Standard deviation 2
Values 14 12
[83]
THLE LRP6
Mean 21.2
Standard deviation 0.26
Values 21 21
[84]
liver LRP6
Mean 76.1
Standard deviation 40
Values 42 1.1e+02 40 1.1e+02
[85]
ref_hepatocyte FZD6
Mean 1.28
Standard deviation 0.91
Values 2.4 1.3 1.9 0.49 0.28
[86]
HepG2 FZD6
Mean 9.74
Standard deviation 0.56
Values 9.3 10
[87]
HepG2.C3A FZD6
Mean 15.4
Standard deviation 0.43
Values 15 16
[88]
HuH.7 FZD6
Mean 2.59
Standard deviation 0.88
Values 2.1 3.6 2.1
[89]
SNU475 FZD6
Mean 62.6
Standard deviation 37
Values 89 36
[90]
THLE FZD6
Mean 29.7
Standard deviation 3.7
Values 27 32
[91]
liver FZD6
Mean 3.95
Standard deviation 1.6
Values 3 5.8 2.3 4.7
[92]
ref_hepatocyte FZD8
Mean 0.963
Standard deviation 1
Values 0 0.036 2.3 0.92 1.5
[93]
HepG2 FZD8
Mean 0.243
Standard deviation 0.2
Values 0.38 0.1
[94]
HepG2.C3A FZD8
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[95]
HuH.7 FZD8
Mean 0.853
Standard deviation 0.068
Values 0.81 0.93 0.82
[96]
SNU475 FZD8
Mean 0.227
Standard deviation 0.034
Values 0.25 0.2
[97]
THLE FZD8
Mean 0.588
Standard deviation 0.15
Values 0.48 0.7
[98]
liver FZD8
Mean 1.19
Standard deviation 0.79
Values 0.54 1.3 0.64 2.3
[99]
ref_hepatocyte RSPO3
Mean 0.127
Standard deviation 0.12
Values 0 0.22 0 0.26 0.15
[100]
HepG2 RSPO3
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[101]
HepG2.C3A RSPO3
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 RSPO3
Mean 0.0232
Standard deviation 0.016
Values 0.041 0.019 0.0094
[103]
SNU475 RSPO3
Mean 14.1
Standard deviation 4.7
Values 17 11
[104]
THLE RSPO3
Mean 0.057
Standard deviation 0.047
Values 0.024 0.09
[105]
liver RSPO3
Mean 1.63
Standard deviation 1.4
Values 3.5 0.5 1.6 0.82
[106]
ref_hepatocyte LGR5
Mean 0.119
Standard deviation 0.19
Values 0.45 0 0.035 0 0.11
[107]
HepG2 LGR5
Mean 21.1
Standard deviation 5.5
Values 17 25
[108]
HepG2.C3A LGR5
Mean 21.5
Standard deviation 14
Values 12 31
[109]
HuH.7 LGR5
Mean 1.53
Standard deviation 0.8
Values 2.1 0.62 1.8
[110]
SNU475 LGR5
Mean 0.152
Standard deviation 0.014
Values 0.16 0.14
[111]
THLE LGR5
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[112]
liver LGR5
Mean 0.447
Standard deviation 0.48
Values 1.2 0.1 0.21 0.33
[113]
ref_hepatocyte RSPO4
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[114]
HepG2 RSPO4
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[115]
HepG2.C3A RSPO4
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 RSPO4
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[117]
SNU475 RSPO4
Mean 0.0779
Standard deviation 0.012
Values 0.07 0.086
[118]
THLE RSPO4
Mean 0.186
Standard deviation 0.03
Values 0.21 0.16
[119]
liver RSPO4
Mean 0.0151
Standard deviation 0.022
Values 0.047 0 0 0.013
[120]
ref_hepatocyte LGR6
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[121]
HepG2 LGR6
Mean 0.108
Standard deviation 0.0012
Values 0.11 0.11
[122]
HepG2.C3A LGR6
Mean 0.295
Standard deviation 0.023
Values 0.31 0.28
[123]
HuH.7 LGR6
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 LGR6
Mean 0.0395
Standard deviation 0.023
Values 0.023 0.056
[125]
THLE LGR6
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[126]
liver LGR6
Mean 0.672
Standard deviation 0.37
Values 1.1 0.19 0.8 0.65
[127]
ref_hepatocyte WNT3A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 WNT3A
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[129]
HepG2.C3A WNT3A
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 WNT3A
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 WNT3A
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[132]
THLE WNT3A
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[133]
liver WNT3A
Mean 0.0165
Standard deviation 0.033
Values 0 0 0 0.066
[134]
ref_hepatocyte RSPO1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 RSPO1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A RSPO1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 RSPO1
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 RSPO1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[139]
THLE RSPO1
Mean 0.0461
Standard deviation 0.035
Values 0.071 0.021
[140]
liver RSPO1
Mean 0.0135
Standard deviation 0.019
Values 0 0.014 0 0.04
[141]
ref_hepatocyte RSPO2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 RSPO2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A RSPO2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 RSPO2
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[145]
SNU475 RSPO2
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE RSPO2
Mean 0.0689
Standard deviation 0.045
Values 0.1 0.037
[147]
liver RSPO2
Mean 0.16
Standard deviation 0.1
Values 0.31 0.071 0.1 0.16