REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TXN Thioredoxin [1] -0.91[2] -0.95[3] -1.55[4] -0.97[5] -1.38[6] -1.81[7]
2 TXNIP Thioredoxin-interacting protein [8] 2.87[9] 3.49[10] 3.97[11] 3.84[12] 3.89[13] 4.00[14]
3 SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial [15] 1.36[16] 1.79[17] 1.70[18] 0.41[19] -0.46[20] 1.49[21]
4 KAT2B Histone acetyltransferase KAT2B [22] -0.03[23] -1.26[24] 0.98[25] 1.43[26] 1.90[27] 3.25[28]
5 FOXO3 Forkhead box protein O3 [29] 2.47[30] 2.45[31] 2.96[32] 1.89[33] 3.18[34] 3.79[35]
6 EP300 Histone acetyltransferase p300 [36] 4.74[37] 4.23[38] 4.99[39] 4.06[40] 4.16[41] 4.21[42]
7 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [43] 2.51[44] 3.51[45] 2.93[46] 3.06[47] 3.35[48] 2.80[49]
8 CREBBP CREB-binding protein [50] 4.91[51] 4.03[52] 4.50[53] 4.25[54] 4.30[55] 4.69[56]
9 FOXO1 Forkhead box protein O1 [57] 3.71[58] 3.27[59] 3.28[60] 2.67[61] 4.73[62] 4.55[63]
10 FOXO4 Forkhead box protein O4 [64] 2.74[65] 3.04[66] 2.74[67] 1.66[68] 1.92[69] 0.77[70]
[1]
ref_hepatocyte TXN
Mean 524
Standard deviation 4.3e+02
Values 6.9e+02 1.2e+03 2.7e+02 2.4e+02 2e+02
[2]
HepG2 TXN
Mean 153
Standard deviation 27
Values 1.7e+02 1.3e+02
[3]
HepG2.C3A TXN
Mean 142
Standard deviation 55
Values 1e+02 1.8e+02
[4]
HuH.7 TXN
Mean 98.2
Standard deviation 36
Values 91 67 1.4e+02
[5]
SNU475 TXN
Mean 174
Standard deviation 25
Values 1.9e+02 1.6e+02
[6]
THLE TXN
Mean 143
Standard deviation 0.49
Values 1.4e+02 1.4e+02
[7]
liver TXN
Mean 77.5
Standard deviation 77
Values 1.5e+02 16 1.3e+02 7.5
[8]
ref_hepatocyte TXNIP
Mean 11
Standard deviation 11
Values 6.2 1.1 4.9 29 13
[9]
HepG2 TXNIP
Mean 44
Standard deviation 36
Values 69 19
[10]
HepG2.C3A TXNIP
Mean 64.3
Standard deviation 30
Values 85 43
[11]
HuH.7 TXNIP
Mean 94.3
Standard deviation 8.4
Values 86 1e+02 94
[12]
SNU475 TXNIP
Mean 102
Standard deviation 25
Values 84 1.2e+02
[13]
THLE TXNIP
Mean 115
Standard deviation 45
Values 1.5e+02 83
[14]
liver TXNIP
Mean 90.5
Standard deviation 29
Values 1.2e+02 66 65 1.1e+02
[15]
ref_hepatocyte SIRT3
Mean 5.6
Standard deviation 2.3
Values 5.2 4 3.2 6.5 9.1
[16]
HepG2 SIRT3
Mean 7.83
Standard deviation 0.8
Values 7.3 8.4
[17]
HepG2.C3A SIRT3
Mean 10.1
Standard deviation 1.9
Values 11 8.7
[18]
HuH.7 SIRT3
Mean 9.98
Standard deviation 2.5
Values 10 7.4 12
[19]
SNU475 SIRT3
Mean 4.84
Standard deviation 1.7
Values 6 3.7
[20]
THLE SIRT3
Mean 2.87
Standard deviation 0.022
Values 2.9 2.9
[21]
liver SIRT3
Mean 8.11
Standard deviation 5.1
Values 14 3.7 11 4.1
[22]
ref_hepatocyte KAT2B
Mean 3.02
Standard deviation 2.4
Values 0.53 4.6 0.74 3.2 6.1
[23]
HepG2 KAT2B
Mean 1.62
Standard deviation 1.1
Values 0.84 2.4
[24]
HepG2.C3A KAT2B
Mean 0.662
Standard deviation 0.012
Values 0.67 0.65
[25]
HuH.7 KAT2B
Mean 3.28
Standard deviation 0.41
Values 2.8 3.6 3.4
[26]
SNU475 KAT2B
Mean 5.31
Standard deviation 1.3
Values 6.2 4.4
[27]
THLE KAT2B
Mean 7.98
Standard deviation 1.1
Values 7.2 8.8
[28]
liver KAT2B
Mean 14.8
Standard deviation 5
Values 19 17 7.6 16
[29]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[30]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[31]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[32]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[33]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[34]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[35]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[36]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[37]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[38]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[39]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[40]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[41]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[42]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[43]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 2.9 1.6 1.2 1.4 2
[44]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 4.7 6.7
[45]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 10 12
[46]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 7.5 9.3 6.3
[47]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 8.8 11
[48]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[49]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.9 6.2 4.4 7.7
[50]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[51]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[52]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[53]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[54]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[55]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[56]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[57]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 0.71 1.7 2 1.9 2.6
[58]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 11 14
[59]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 10 7.9
[60]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 10 10 7.6
[61]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 8.6 6
[62]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[63]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 25 19 13 29
[64]
ref_hepatocyte FOXO4
Mean 1.56
Standard deviation 0.85
Values 2.8 1.6 0.42 1.7 1.3
[65]
HepG2 FOXO4
Mean 5.71
Standard deviation 1.3
Values 6.6 4.8
[66]
HepG2.C3A FOXO4
Mean 6.69
Standard deviation 3.6
Values 9.2 4.2
[67]
HuH.7 FOXO4
Mean 5.72
Standard deviation 1.5
Values 5.1 7.5 4.6
[68]
SNU475 FOXO4
Mean 3.21
Standard deviation 1.1
Values 4 2.4
[69]
THLE FOXO4
Mean 4.17
Standard deviation 0.02
Values 4.2 4.2
[70]
liver FOXO4
Mean 1.37
Standard deviation 1.1
Values 0.54 2 0.33 2.6