REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SCD | Acyl-CoA desaturase | [1] | -0.27[2] | 0.61[3] | 1.02[4] | -2.15[5] | -2.93[6] | -0.14[7] |
2 | FDPS | Farnesyl pyrophosphate synthase | [8] | -2.61[9] | -1.94[10] | -2.01[11] | -2.11[12] | -2.10[13] | -2.24[14] |
3 | RAN | GTP-binding nuclear protein Ran | [15] | -0.01[16] | -0.83[17] | -1.85[18] | -0.32[19] | 0.04[20] | -2.58[21] |
4 | HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | [22] | -3.45[23] | -1.16[24] | -0.14[25] | -3.45[26] | -3.56[27] | -0.88[28] |
5 | FDFT1 | Squalene synthase | [29] | -1.41[30] | -0.40[31] | -1.21[32] | -2.93[33] | -1.75[34] | -1.60[35] |
6 | INSIG1 | Insulin-induced gene 1 protein | [36] | -10.52[37] | -11.26[38] | -1.86[39] | -3.28[40] | -4.04[41] | 0.48[42] |
7 | CYP51A1 | Lanosterol 14-alpha demethylase | [43] | -2.35[44] | -0.90[45] | -1.33[46] | -1.59[47] | -1.80[48] | 0.16[49] |
8 | IDI1 | Isopentenyl-diphosphate Delta-isomerase 1 | [50] | -2.50[51] | 0.04[52] | -1.73[53] | -0.73[54] | -1.81[55] | -0.32[56] |
9 | KPNB1 | Importin subunit beta-1 | [57] | 1.27[58] | 0.48[59] | 0.41[60] | 2.03[61] | 1.77[62] | -1.19[63] |
10 | SQLE | Squalene monooxygenase | [64] | -1.52[65] | 0.12[66] | -0.51[67] | -1.32[68] | -1.76[69] | -0.95[70] |
11 | DHCR7 | 7-dehydrocholesterol reductase | [71] | -0.66[72] | 0.12[73] | 0.02[74] | -1.80[75] | -1.43[76] | 0.48[77] |
12 | SEC23A | Protein transport protein Sec23A | [78] | 2.29[79] | 0.13[80] | 0.82[81] | 1.75[82] | 1.15[83] | 0.41[84] |
13 | SREBF1 | Sterol regulatory element-binding protein 1 | [85] | -0.42[86] | -1.08[87] | -0.90[88] | -0.71[89] | -0.39[90] | -0.15[91] |
14 | TM7SF2 | Delta(14)-sterol reductase | [92] | -1.06[93] | -1.09[94] | -1.79[95] | -1.72[96] | -3.38[97] | -0.60[98] |
15 | PMVK | Phosphomevalonate kinase | [99] | -2.19[100] | -3.06[101] | -2.19[102] | -1.22[103] | -1.34[104] | -2.81[105] |
16 | MVD | Diphosphomevalonate decarboxylase | [106] | -0.89[107] | 0.64[108] | -0.54[109] | -1.57[110] | -1.41[111] | -1.08[112] |
17 | INSIG2 | Insulin-induced gene 2 protein | [113] | 0.48[114] | 0.56[115] | -1.68[116] | -1.49[117] | -0.71[118] | -1.71[119] |
18 | FASN | Fatty acid synthase | [120] | 2.76[121] | 2.45[122] | 2.65[123] | 1.57[124] | 1.73[125] | 1.86[126] |
19 | LSS | Lanosterol synthase | [127] | -0.28[128] | 0.87[129] | -0.55[130] | -0.06[131] | -0.33[132] | 0.42[133] |
20 | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial | [134] | 1.27[135] | 1.79[136] | 0.18[137] | -2.48[138] | 1.80[139] | 2.03[140] |
21 | HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | [141] | -0.20[142] | 1.60[143] | 1.51[144] | 0.52[145] | 0.35[146] | 0.73[147] |
22 | MVK | Mevalonate kinase | [148] | -1.96[149] | -0.54[150] | -1.46[151] | -2.39[152] | -2.47[153] | -0.40[154] |
23 | RXRA | Retinoic acid receptor RXR-alpha | [155] | 0.30[156] | -0.85[157] | -0.37[158] | 0.85[159] | 0.65[160] | 1.51[161] |
24 | ELOVL6 | Elongation of very long chain fatty acids protein 6 | [162] | -2.41[163] | -0.29[164] | -0.57[165] | -0.27[166] | 0.58[167] | -0.28[168] |
25 | MBTPS1 | Membrane-bound transcription factor site-1 protease | [169] | 1.94[170] | 0.81[171] | 0.44[172] | 2.22[173] | 2.41[174] | 0.68[175] |
26 | SEC24C | Protein transport protein Sec24C | [176] | 1.87[177] | 1.32[178] | 0.26[179] | 2.46[180] | 2.08[181] | 0.66[182] |
27 | SAR1B | GTP-binding protein SAR1b | [183] | 0.09[184] | 0.36[185] | -0.15[186] | 0.84[187] | 1.39[188] | 2.22[189] |
28 | NFYC | Nuclear transcription factor Y subunit gamma | [190] | 0.06[191] | -1.03[192] | -1.31[193] | 0.58[194] | 0.01[195] | -1.07[196] |
29 | SREBF2 | Sterol regulatory element-binding protein 2 | [197] | 1.62[198] | 1.52[199] | 2.34[200] | 0.50[201] | 0.92[202] | 0.83[203] |
30 | SEC24D | Protein transport protein Sec24D | [204] | 0.69[205] | 0.57[206] | 0.18[207] | 1.82[208] | 1.64[209] | 1.18[210] |
31 | SCAP | Sterol regulatory element-binding protein cleavage-activating protein | 1.67[211] | 0.94[212] | 1.19[213] | 1.00[214] | 1.87[215] | 1.18[216] | |
32 | CARM1 | Histone-arginine methyltransferase CARM1 | [217] | 1.81[218] | 0.31[219] | 0.27[220] | 0.58[221] | 1.51[222] | -1.66[223] |
33 | SEC24A | Protein transport protein Sec24A | [224] | 1.55[225] | 1.12[226] | 1.38[227] | 2.42[228] | 1.80[229] | 1.77[230] |
34 | SEC24B | Protein transport protein Sec24B | [231] | 0.54[232] | -0.08[233] | -0.35[234] | 1.29[235] | 1.99[236] | 1.45[237] |
35 | ACACB | Acetyl-CoA carboxylase 2 | [238] | -0.51[239] | -0.49[240] | -0.73[241] | -0.93[242] | -0.51[243] | 3.54[244] |
36 | NFYB | Nuclear transcription factor Y subunit beta | [245] | -0.28[246] | 0.38[247] | -0.62[248] | 1.22[249] | 1.70[250] | -0.65[251] |
37 | TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 | [252] | 1.44[253] | 1.02[254] | 1.31[255] | 3.24[256] | 2.94[257] | 2.23[258] |
38 | TBL1X | F-box-like/WD repeat-containing protein TBL1X | [259] | 1.70[260] | 1.15[261] | 2.35[262] | -3.57[263] | 2.06[264] | 1.10[265] |
39 | PPARA | Peroxisome proliferator-activated receptor alpha | [266] | 1.03[267] | 1.06[268] | 1.55[269] | 0.87[270] | 0.17[271] | 3.51[272] |
40 | NFYA | Nuclear transcription factor Y subunit alpha | [273] | 1.91[274] | 1.17[275] | 0.69[276] | 2.27[277] | 1.86[278] | -0.17[279] |
41 | MED1 | Mediator of RNA polymerase II transcription subunit 1 | [280] | 2.90[281] | 1.28[282] | 1.82[283] | 3.03[284] | 3.32[285] | 0.64[286] |
42 | GGPS1 | Geranylgeranyl pyrophosphate synthase | [287] | 0.57[288] | 0.87[289] | 0.48[290] | 2.44[291] | 0.94[292] | -0.29[293] |
43 | SP1 | Transcription factor Sp1 | [294] | 2.18[295] | 1.47[296] | 2.17[297] | 3.50[298] | 3.32[299] | 1.51[300] |
44 | ACACA | Acetyl-CoA carboxylase 1 | [301] | 2.81[302] | 2.20[303] | 2.75[304] | 3.41[305] | 2.74[306] | 2.71[307] |
45 | MBTPS2 | Membrane-bound transcription factor site-2 protease | [308] | 1.30[309] | 0.71[310] | 1.13[311] | 2.93[312] | 2.97[313] | 0.91[314] |
46 | NCOA6 | Nuclear receptor coactivator 6 | [315] | 2.56[316] | 1.46[317] | 1.31[318] | 3.40[319] | 2.78[320] | 0.77[321] |
47 | TGS1 | Trimethylguanosine synthase | [322] | 0.95[323] | 0.44[324] | 0.62[325] | 2.55[326] | 2.51[327] | 0.34[328] |
48 | NCOA1 | Nuclear receptor coactivator 1 | [329] | 0.82[330] | 0.44[331] | 0.27[332] | 2.63[333] | 2.21[334] | 2.01[335] |
49 | CREBBP | CREB-binding protein | [336] | 3.26[337] | 1.52[338] | 1.77[339] | 3.59[340] | 3.73[341] | 2.60[342] |
50 | MTF1 | Metal regulatory transcription factor 1 | [343] | 1.87[344] | 0.78[345] | 1.00[346] | 2.98[347] | 3.13[348] | 1.34[349] |
51 | CHD9 | Chromodomain-helicase-DNA-binding protein 9 | [350] | 1.68[351] | 2.83[352] | 1.71[353] | 3.21[354] | 4.36[355] | 4.29[356] |
52 | NCOA2 | Nuclear receptor coactivator 2 | [357] | 1.93[358] | 1.80[359] | 3.27[360] | 4.03[361] | 2.46[362] | 3.96[363] |
53 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 1.83[364] | -0.79[365] | 0.90[366] | 4.10[367] | 4.42[368] | 0.72[369] | |
54 | SC5D | Lathosterol oxidase | [370] | [371] | [372] | [373] | [374] | [375] | [376] |
55 | HELZ2 | Helicase with zinc finger domain 2 | [377] | [378] | [379] | [380] | [381] | [382] | [383] |