REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 APH1A Gamma-secretase subunit APH-1A [1] -0.38[2] 0.21[3] 0.26[4] -0.50[5] -0.39[6] -0.78[7]
2 PSENEN Gamma-secretase subunit PEN-2 [8] -2.38[9] -2.05[10] -1.75[11] -2.12[12] -2.33[13] -1.83[14]
3 NCSTN Nicastrin [15] 1.03[16] 0.51[17] 0.49[18] 0.85[19] 0.94[20] 0.62[21]
4 RELA Transcription factor p65 [22] -0.18[23] -0.37[24] -0.40[25] -0.29[26] -0.17[27] -0.65[28]
5 PSEN1 Presenilin-1 [29] 0.74[30] 1.28[31] 0.68[32] 1.02[33] 1.11[34] 1.23[35]
6 NFKB1 Nuclear factor NF-kappa-B p105 subunit [36] 0.35[37] 0.35[38] -0.03[39] -0.48[40] 0.64[41] 0.68[42]
7 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 [43] 0.36[44] 0.56[45] 0.13[46] 1.51[47] 0.85[48] 0.31[49]
8 PSEN2 Presenilin-2 [50] -1.00[51] -1.55[52] -5.53[53] -0.16[54] -1.32[55] 0.14[56]
9 TRAF6 TNF receptor-associated factor 6 [57] 0.78[58] 0.98[59] 1.38[60] 1.43[61] 1.09[62] 3.14[63]
10 APH1B Gamma-secretase subunit APH-1B [64] -0.55[65] 0.57[66] 3.53[67] 2.86[68] 2.11[69] 1.46[70]
11 NGFR Tumor necrosis factor receptor superfamily member 16 [71] 8.15[72] 1.62[73] -2.55[74] 1.52[75] 2.67[76] 7.84[77]
[1]
ref_hepatocyte APH1A
Mean 33
Standard deviation 14
Values 23 24 22 47 49
[2]
HepG2 APH1A
Mean 69.5
Standard deviation 1.3
Values 69 70
[3]
HepG2.C3A APH1A
Mean 75
Standard deviation 1.3
Values 76 74
[4]
HuH.7 APH1A
Mean 83.8
Standard deviation 7.5
Values 79 80 92
[5]
SNU475 APH1A
Mean 50.3
Standard deviation 16
Values 61 39
[6]
THLE APH1A
Mean 52.6
Standard deviation 11
Values 45 60
[7]
liver APH1A
Mean 23.2
Standard deviation 0.44
Values 23 24 23 24
[8]
ref_hepatocyte PSENEN
Mean 26.8
Standard deviation 21
Values 8.7 7.6 23 58 37
[9]
HepG2 PSENEN
Mean 14.1
Standard deviation 1.6
Values 13 15
[10]
HepG2.C3A PSENEN
Mean 12.7
Standard deviation 0.49
Values 12 13
[11]
HuH.7 PSENEN
Mean 16.9
Standard deviation 4
Values 17 13 21
[12]
SNU475 PSENEN
Mean 13.3
Standard deviation 0.61
Values 13 14
[13]
THLE PSENEN
Mean 11.1
Standard deviation 0.49
Values 11 11
[14]
liver PSENEN
Mean 9.09
Standard deviation 9.1
Values 17 1.1 17 1.3
[15]
ref_hepatocyte NCSTN
Mean 16.1
Standard deviation 1.3
Values 18 15 16 16 15
[16]
HepG2 NCSTN
Mean 90.9
Standard deviation 5.4
Values 95 87
[17]
HepG2.C3A NCSTN
Mean 45.1
Standard deviation 8.2
Values 51 39
[18]
HuH.7 NCSTN
Mean 48.2
Standard deviation 2.5
Values 47 46 51
[19]
SNU475 NCSTN
Mean 63.1
Standard deviation 12
Values 72 55
[20]
THLE NCSTN
Mean 65
Standard deviation 14
Values 55 75
[21]
liver NCSTN
Mean 30.1
Standard deviation 12
Values 32 22 46 20
[22]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 9.8 12 35 15 8.1
[23]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 42 35
[24]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 29 20
[25]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 29 25 23
[26]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[27]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[28]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 19 4.1 20 5.7
[29]
ref_hepatocyte PSEN1
Mean 6.64
Standard deviation 2.1
Values 8.7 7.5 8.3 4.7 4.1
[30]
HepG2 PSEN1
Mean 30.5
Standard deviation 2.4
Values 29 32
[31]
HepG2.C3A PSEN1
Mean 31.6
Standard deviation 3.9
Values 34 29
[32]
HuH.7 PSEN1
Mean 22.5
Standard deviation 3.1
Values 23 25 19
[33]
SNU475 PSEN1
Mean 29.1
Standard deviation 1.1
Values 30 28
[34]
THLE PSEN1
Mean 30
Standard deviation 4
Values 27 33
[35]
liver PSEN1
Mean 18.8
Standard deviation 3
Values 15 22 19 19
[36]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[37]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[38]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[39]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[40]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[41]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[42]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[43]
ref_hepatocyte ADAM17
Mean 5.04
Standard deviation 4.3
Values 10 8.5 4.3 1 1.1
[44]
HepG2 ADAM17
Mean 17.8
Standard deviation 0.96
Values 18 17
[45]
HepG2.C3A ADAM17
Mean 14.6
Standard deviation 0.94
Values 14 15
[46]
HuH.7 ADAM17
Mean 11.7
Standard deviation 1.5
Values 13 12 10
[47]
SNU475 ADAM17
Mean 31
Standard deviation 2.8
Values 33 29
[48]
THLE ADAM17
Mean 19
Standard deviation 2.3
Values 17 21
[49]
liver ADAM17
Mean 7.57
Standard deviation 0.72
Values 7.2 8.6 7 7.4
[50]
ref_hepatocyte PSEN2
Mean 4.44
Standard deviation 2.5
Values 2.3 4.3 8.7 3.4 3.5
[51]
HepG2 PSEN2
Mean 6.08
Standard deviation 0.97
Values 6.8 5.4
[52]
HepG2.C3A PSEN2
Mean 2.99
Standard deviation 0.53
Values 3.4 2.6
[53]
HuH.7 PSEN2
Mean 0.204
Standard deviation 0.067
Values 0.13 0.22 0.26
[54]
SNU475 PSEN2
Mean 8.62
Standard deviation 2.2
Values 10 7.1
[55]
THLE PSEN2
Mean 3.74
Standard deviation 0.46
Values 3.4 4.1
[56]
liver PSEN2
Mean 5.9
Standard deviation 0.87
Values 7.1 5.8 5.8 5
[57]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[58]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[59]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[60]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[61]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[62]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[63]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[64]
ref_hepatocyte APH1B
Mean 0.759
Standard deviation 0.26
Values 0.86 1.2 0.64 0.63 0.5
[65]
HepG2 APH1B
Mean 1.42
Standard deviation 0.39
Values 1.7 1.1
[66]
HepG2.C3A APH1B
Mean 2.22
Standard deviation 0.15
Values 2.3 2.1
[67]
HuH.7 APH1B
Mean 18.6
Standard deviation 5.3
Values 23 13 20
[68]
SNU475 APH1B
Mean 11.9
Standard deviation 2.9
Values 14 9.9
[69]
THLE APH1B
Mean 6.86
Standard deviation 0.17
Values 7 6.7
[70]
liver APH1B
Mean 2.52
Standard deviation 0.52
Values 3 2.6 2.7 1.8
[71]
ref_hepatocyte NGFR
Mean 0.0296
Standard deviation 0.032
Values 0 0 0.03 0.078 0.041
[72]
HepG2 NGFR
Mean 23.1
Standard deviation 11
Values 15 31
[73]
HepG2.C3A NGFR
Mean 0.179
Standard deviation 0.0052
Values 0.17 0.18
[74]
HuH.7 NGFR
Mean 0.0107
Standard deviation 0.0051
Values 0.016 0.0064 0.0094
[75]
SNU475 NGFR
Mean 0.183
Standard deviation 0.21
Values 0.037 0.33
[76]
THLE NGFR
Mean 0.394
Standard deviation 0.045
Values 0.43 0.36
[77]
liver NGFR
Mean 8.18
Standard deviation 5.6
Values 16 3.2 5.7 7.7