REACTOME_REGULATED_NECROSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.94[2] | -1.40[3] | -1.11[4] | -1.63[5] | -1.10[6] | -0.46[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.50[16] | -0.65[17] | -0.75[18] | -0.78[19] | -0.73[20] | -0.01[21] |
4 | HSP90AA1 | Heat shock protein HSP 90-alpha | [22] | 0.61[23] | 1.32[24] | 0.69[25] | 1.24[26] | 0.99[27] | 0.16[28] |
5 | HMGB1 | High mobility group protein B1 | [29] | 0.96[30] | 1.44[31] | 1.32[32] | 1.61[33] | 1.16[34] | 0.86[35] |
6 | CDC37 | Hsp90 co-chaperone Cdc37 | [36] | 0.50[37] | -0.41[38] | 0.10[39] | -0.66[40] | -0.01[41] | -0.57[42] |
7 | CHMP2A | Charged multivesicular body protein 2a | [43] | -1.84[44] | -2.59[45] | -2.63[46] | -1.08[47] | -1.77[48] | -0.73[49] |
8 | CHMP4B | Charged multivesicular body protein 4b | [50] | 0.53[51] | -0.33[52] | -0.76[53] | 0.47[54] | -0.35[55] | -3.15[56] |
9 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [57] | 1.94[58] | 1.58[59] | 2.77[60] | 0.62[61] | 1.50[62] | 0.76[63] |
10 | FLOT1 | Flotillin-1 | [64] | 0.63[65] | 0.88[66] | 0.39[67] | 1.35[68] | 0.58[69] | 0.16[70] |
11 | STUB1 | E3 ubiquitin-protein ligase CHIP | [71] | -0.73[72] | -0.96[73] | -1.48[74] | -1.52[75] | -1.12[76] | -0.84[77] |
12 | CASP4 | Caspase-4 | [78] | -0.04[79] | -0.66[80] | 0.08[81] | -0.20[82] | -0.15[83] | -0.86[84] |
13 | SDCBP | Syntenin-1 | [85] | 0.24[86] | -0.33[87] | -0.83[88] | 2.18[89] | 1.87[90] | 1.40[91] |
14 | CHMP4A | Charged multivesicular body protein 4a | [92] | 1.10[93] | -1.22[94] | -0.72[95] | -0.81[96] | -1.28[97] | -0.77[98] |
15 | FLOT2 | Flotillin-2 | [99] | 0.74[100] | 0.41[101] | 0.93[102] | 0.79[103] | 0.56[104] | 1.96[105] |
16 | BAX | Apoptosis regulator BAX | [106] | 1.59[107] | 0.53[108] | 0.21[109] | -0.46[110] | 0.00[111] | -2.54[112] |
17 | GSDMD | Gasdermin-D | [113] | -0.67[114] | -0.11[115] | -0.63[116] | -0.12[117] | -1.11[118] | 0.76[119] |
18 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | [120] | -3.22[121] | -1.87[122] | 0.89[123] | -1.33[124] | -4.50[125] | 0.02[126] |
19 | CFLAR | CASP8 and FADD-like apoptosis regulator | [127] | 0.87[128] | 1.36[129] | 1.05[130] | 0.60[131] | 0.83[132] | 2.98[133] |
20 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [134] | -1.86[135] | -1.10[136] | -3.35[137] | -1.97[138] | 1.86[139] | -0.67[140] |
21 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [141] | 3.24[142] | 2.86[143] | 2.80[144] | 0.81[145] | 2.50[146] | 1.45[147] |
22 | CYCS | Cytochrome c | [148] | 2.59[149] | 2.53[150] | 2.74[151] | 2.48[152] | 2.95[153] | 2.73[154] |
23 | IL18 | Interleukin-18 | [155] | 0.39[156] | -3.70[157] | 0.57[158] | -0.03[159] | -0.62[160] | -2.75[161] |
24 | PDCD6IP | Programmed cell death 6-interacting protein | [162] | 1.77[163] | 1.50[164] | 2.91[165] | 2.03[166] | 2.52[167] | 2.49[168] |
25 | CASP3 | Caspase-3 | [169] | 1.39[170] | 1.81[171] | -0.60[172] | 0.25[173] | 1.32[174] | 0.61[175] |
26 | CHMP2B | Charged multivesicular body protein 2b | [176] | 0.23[177] | 0.83[178] | 1.71[179] | 0.40[180] | 1.10[181] | 1.37[182] |
27 | FAS | Tumor necrosis factor receptor superfamily member 6 | [183] | -0.34[184] | 0.17[185] | -7.69[186] | -0.60[187] | -0.01[188] | -0.31[189] |
28 | CHMP3 | Charged multivesicular body protein 3 | [190] | -1.07[191] | -1.42[192] | -1.97[193] | -1.92[194] | -2.29[195] | -3.38[196] |
29 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [197] | 1.50[198] | 2.19[199] | 1.29[200] | 1.56[201] | 2.42[202] | 2.14[203] |
30 | CHMP6 | Charged multivesicular body protein 6 | [204] | 0.89[205] | 0.73[206] | -1.10[207] | 0.32[208] | -0.37[209] | 1.07[210] |
31 | FADD | FAS-associated death domain protein | [211] | 1.29[212] | 0.33[213] | 1.19[214] | 3.08[215] | 0.96[216] | -0.36[217] |
32 | IRF2 | Interferon regulatory factor 2 | [218] | 0.16[219] | 0.29[220] | -0.73[221] | 0.05[222] | 0.18[223] | 1.07[224] |
33 | CASP8 | Caspase-8 | [225] | 1.28[226] | 1.59[227] | 0.90[228] | 1.06[229] | 0.39[230] | -0.01[231] |
34 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10A | [232] | -0.19[233] | -0.91[234] | -0.75[235] | -1.88[236] | -2.06[237] | -0.30[238] |
35 | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subu | 2.47[239] | 3.07[240] | 3.25[241] | 2.67[242] | 2.71[243] | 3.77[244] | |
36 | IRF1 | Interferon regulatory factor 1 | [245] | 0.75[246] | 0.02[247] | 0.30[248] | 2.40[249] | 1.47[250] | 2.25[251] |
37 | BAK1 | Bcl-2 homologous antagonist/killer | [252] | 2.15[253] | 1.43[254] | 1.54[255] | 2.33[256] | 1.89[257] | -0.38[258] |
38 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | 1.00[259] | 0.57[260] | -0.45[261] | 0.16[262] | 0.08[263] | 0.82[264] | |
39 | TP53 | Cellular tumor antigen p53 | [265] | 2.89[266] | 2.20[267] | 3.10[268] | 2.44[269] | 2.17[270] | 1.37[271] |
40 | TRAF2 | TNF receptor-associated factor 2 | [272] | 1.48[273] | 1.29[274] | 1.16[275] | 1.27[276] | 1.35[277] | 0.62[278] |
41 | CHMP7 | Charged multivesicular body protein 7 | [279] | 2.43[280] | 1.79[281] | 2.41[282] | 1.85[283] | 2.06[284] | 2.25[285] |
42 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [286] | 1.54[287] | 1.45[288] | 1.27[289] | 2.22[290] | 1.82[291] | 2.90[292] |
43 | CHMP4C | Charged multivesicular body protein 4c | [293] | 1.70[294] | 1.46[295] | -0.40[296] | 0.76[297] | -1.13[298] | -0.10[299] |
44 | CASP1 | Caspase-1 | [300] | -1.78[301] | -5.44[302] | -3.76[303] | 1.23[304] | 1.45[305] | 0.68[306] |
45 | IL1B | Interleukin-1 beta | [307] | -7.44[308] | -7.57[309] | -3.10[310] | -2.45[311] | 3.22[312] | -3.79[313] |
46 | XIAP | E3 ubiquitin-protein ligase XIAP | [314] | 2.77[315] | 3.10[316] | 3.70[317] | 3.74[318] | 3.23[319] | 4.10[320] |
47 | PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | [321] | 1.40[322] | 2.06[323] | 2.71[324] | 0.89[325] | 1.05[326] | 2.82[327] |
48 | MLKL | Mixed lineage kinase domain-like protein | [328] | 1.10[329] | 0.72[330] | -0.80[331] | 0.63[332] | 1.09[333] | 1.20[334] |
49 | GZMB | Granzyme B | [335] | -3.36[336] | [337] | [338] | [339] | [340] | 0.70[341] |
50 | RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | [342] | -5.39[343] | [344] | -4.19[345] | [346] | -4.16[347] | 1.97[348] |
51 | TP63 | Tumor protein 63 | [349] | [350] | [351] | -0.93[352] | -0.23[353] | -3.74[354] | -0.07[355] |
52 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [356] | -2.56[357] | -0.94[358] | -4.77[359] | [360] | [361] | 2.00[362] |
53 | IL1A | Interleukin-1 alpha | [363] | 0.83[364] | 0.17[365] | -0.87[366] | 0.50[367] | 7.33[368] | -0.17[369] |
54 | ELANE | Neutrophil elastase | [370] | [371] | [372] | -1.30[373] | -0.51[374] | -3.03[375] | 3.46[376] |
55 | CASP5 | Caspase-5 | [377] | -2.66[378] | [379] | 1.77[380] | -2.50[381] | -1.36[382] | 1.93[383] |
56 | GSDME | Gasdermin-E | [384] | [385] | [386] | [387] | [388] | [389] | [390] |