REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALB Serum albumin [1] -0.03[2] 0.02[3] -0.04[4] -4.00[5] -3.19[6] -0.06[7]
2 SLC27A5 Bile acyl-CoA synthetase [8] -2.19[9] -3.51[10] -3.24[11] 0.57[12] -1.30[13] 0.70[14]
3 BAAT Bile acid-CoA:amino acid N-acyltransferase [15] -2.26[16] -4.22[17] -4.70[18] -0.20[19] -0.87[20] 1.82[21]
4 SLC10A1 Sodium/bile acid cotransporter [22] -6.56[23] -9.51[24] -9.11[25] -3.92[26] -4.65[27] -0.33[28]
5 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [29] -11.92[30] -10.71[31] -3.61[32] -4.29[33] [34] 1.65[35]
6 NR1H4 Bile acid receptor [36] 1.66[37] -0.33[38] 3.33[39] 0.01[40] 0.61[41] 0.59[42]
7 SLCO1B3 Solute carrier organic anion transporter family member 1B3 [43] -4.45[44] -5.61[45] 1.11[46] -2.54[47] -2.04[48] 2.01[49]
8 RXRA Retinoic acid receptor RXR-alpha [50] 3.20[51] 0.43[52] 3.14[53] 8.07[54] 8.37[55] 2.22[56]
9 ABCC3 Canalicular multispecific organic anion transporter 2 [57] 4.34[58] 1.08[59] 1.32[60] 8.32[61] 8.37[62] 2.71[63]
10 STARD5 StAR-related lipid transfer protein 5 [64] -2.74[65] -4.33[66] -5.40[67] 2.95[68] 3.24[69] -0.22[70]
11 NCOA1 Nuclear receptor coactivator 1 [71] 3.72[72] 1.72[73] 3.78[74] 9.85[75] 9.94[76] 2.73[77]
12 ABCB11 Bile salt export pump [78] -3.54[79] [80] -2.94[81] 2.53[82] [83] 4.86[84]
13 NCOA2 Nuclear receptor coactivator 2 [85] 4.83[86] 3.08[87] 6.77[88] 11.26[89] 10.18[90] 4.68[91]
14 SLCO1A2 Solute carrier organic anion transporter family member 1A2 [92] 1.79[93] -0.43[94] 9.36[95] 11.48[96] 6.80[97] 4.57[98]
15 SLC10A2 Ileal sodium/bile acid cotransporter [99] [100] [101] [102] [103] [104] [105]
16 SLC51B Organic solute transporter subunit beta [106] [107] [108] [109] [110] [111] [112]
17 FABP6 Gastrotropin [113] [114] [115] [116] [117] [118] [119]
18 SLC51A Organic solute transporter subunit alpha [120] [121] [122] [123] [124] [125] [126]
[1]
ref_hepatocyte ALB
Mean 1.45e+04
Standard deviation 2e+04
Values 3e+03 3.5e+02 7.4e+02 2.1e+04 4.8e+04
[2]
HepG2 ALB
Mean 3.29e+03
Standard deviation 9.9e+02
Values 2.6e+03 4e+03
[3]
HepG2.C3A ALB
Mean 1.8e+04
Standard deviation 4.3e+03
Values 2.1e+04 1.5e+04
[4]
HuH.7 ALB
Mean 4.54e+03
Standard deviation 1.4e+03
Values 3.4e+03 6.1e+03 4.1e+03
[5]
SNU475 ALB
Mean 6.25
Standard deviation 1.4
Values 5.3 7.2
[6]
THLE ALB
Mean 7.91
Standard deviation 4.5
Values 11 4.7
[7]
liver ALB
Mean 1.88e+04
Standard deviation 4.8e+03
Values 2.2e+04 2.3e+04 1.8e+04 1.3e+04
[8]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 0.8 1.2 6 1.4e+02 2.7e+02
[9]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 4.7 3.8
[10]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 9.7 8.2
[11]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 2.3 2.7 3.5
[12]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.83 0.89
[13]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[14]
liver SLC27A5
Mean 184
Standard deviation 60
Values 2.2e+02 1.1e+02 2.5e+02 1.6e+02
[15]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 1.6 59 17 89 84
[16]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 1.9 3
[17]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.5 3.1
[18]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.098 1.6 0.18
[19]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.49 0.11
[20]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[21]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 4.1e+02 1.7e+02 2.7e+02 1.1e+02
[22]
ref_hepatocyte SLC10A1
Mean 41.6
Standard deviation 64
Values 0 0 1.5 60 1.5e+02
[23]
HepG2 SLC10A1
Mean 0.102
Standard deviation 0.08
Values 0.046 0.16
[24]
HepG2.C3A SLC10A1
Mean 0.0701
Standard deviation 0.038
Values 0.097 0.043
[25]
HuH.7 SLC10A1
Mean 0.0242
Standard deviation 0.015
Values 0.041 0.013 0.019
[26]
SNU475 SLC10A1
Mean 0.019
Standard deviation 0.013
Values 0.028 0.01
[27]
THLE SLC10A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[28]
liver SLC10A1
Mean 44.8
Standard deviation 22
Values 64 22 63 29
[29]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 0 40 1.4 37 1e+02
[30]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[31]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[32]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.074 2.6 0.22
[33]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[34]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[35]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 1.8e+02 1.8e+02 1.5e+02 95
[36]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 15 9.3 3.8 43 33
[37]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 11 20
[38]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 19 21
[39]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 62 82 58
[40]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.12 0.17
[41]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[42]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 59 37 35 39
[43]
ref_hepatocyte SLCO1B3
Mean 16.4
Standard deviation 25
Values 0 3.8 0.31 18 60
[44]
HepG2 SLCO1B3
Mean 0.173
Standard deviation 0.087
Values 0.23 0.11
[45]
HepG2.C3A SLCO1B3
Mean 0.409
Standard deviation 0.26
Values 0.59 0.23
[46]
HuH.7 SLCO1B3
Mean 11.4
Standard deviation 8.7
Values 5.7 21 7.1
[47]
SNU475 SLCO1B3
Mean 0.0194
Standard deviation 0.0012
Values 0.019 0.02
[48]
THLE SLCO1B3
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[49]
liver SLCO1B3
Mean 89.3
Standard deviation 67
Values 1.9e+02 52 44 75
[50]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[51]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[52]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[53]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[54]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[55]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[56]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[57]
ref_hepatocyte ABCC3
Mean 14.4
Standard deviation 9.9
Values 14 12 5 31 9.7
[58]
HepG2 ABCC3
Mean 67.6
Standard deviation 20
Values 81 54
[59]
HepG2.C3A ABCC3
Mean 37.4
Standard deviation 7.2
Values 42 32
[60]
HuH.7 ABCC3
Mean 11.6
Standard deviation 4.6
Values 7.9 17 10
[61]
SNU475 ABCC3
Mean 31.8
Standard deviation 16
Values 43 21
[62]
THLE ABCC3
Mean 23.7
Standard deviation 5.8
Values 28 20
[63]
liver ABCC3
Mean 128
Standard deviation 23
Values 93 1.4e+02 1.5e+02 1.3e+02
[64]
ref_hepatocyte STARD5
Mean 12.5
Standard deviation 16
Values 0.18 1.9 0.6 27 33
[65]
HepG2 STARD5
Mean 0.434
Standard deviation 0.03
Values 0.41 0.45
[66]
HepG2.C3A STARD5
Mean 0.76
Standard deviation 0.15
Values 0.87 0.65
[67]
HuH.7 STARD5
Mean 0.0956
Standard deviation 0.039
Values 0.12 0.051 0.11
[68]
SNU475 STARD5
Mean 0.667
Standard deviation 0.038
Values 0.64 0.69
[69]
THLE STARD5
Mean 0.587
Standard deviation 0.048
Values 0.62 0.55
[70]
liver STARD5
Mean 14.5
Standard deviation 8.7
Values 26 6.4 15 9.9
[71]
ref_hepatocyte NCOA1
Mean 2.09
Standard deviation 0.73
Values 1.8 2 1.1 2.8 2.8
[72]
HepG2 NCOA1
Mean 6.38
Standard deviation 1.4
Values 5.4 7.4
[73]
HepG2.C3A NCOA1
Mean 8.42
Standard deviation 0.79
Values 7.9 9
[74]
HuH.7 NCOA1
Mean 9.25
Standard deviation 2.7
Values 9.2 12 6.6
[75]
SNU475 NCOA1
Mean 13.3
Standard deviation 1
Values 14 13
[76]
THLE NCOA1
Mean 10.2
Standard deviation 0.47
Values 9.9 11
[77]
liver NCOA1
Mean 18.7
Standard deviation 4.8
Values 17 23 13 22
[78]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 0 1 1.8 3 4.1
[79]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.057 0.021
[80]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.11 0.096 0.037
[82]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.051 0.11
[83]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[84]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 17 1.9e+02 36 71
[85]
ref_hepatocyte NCOA2
Mean 1.14
Standard deviation 0.47
Values 1.5 1.7 1.2 0.47 0.91
[86]
HepG2 NCOA2
Mean 7.51
Standard deviation 4.4
Values 4.4 11
[87]
HepG2.C3A NCOA2
Mean 11.8
Standard deviation 4.3
Values 8.7 15
[88]
HuH.7 NCOA2
Mean 40.1
Standard deviation 18
Values 55 45 21
[89]
SNU475 NCOA2
Mean 19.2
Standard deviation 3.8
Values 22 17
[90]
THLE NCOA2
Mean 6.6
Standard deviation 1.4
Values 5.6 7.6
[91]
liver NCOA2
Mean 39.3
Standard deviation 20
Values 25 56 20 57
[92]
ref_hepatocyte SLCO1A2
Mean 0.102
Standard deviation 0.15
Values 0 0 0.09 0.06 0.36
[93]
HepG2 SLCO1A2
Mean 0.0816
Standard deviation 0.018
Values 0.069 0.094
[94]
HepG2.C3A SLCO1A2
Mean 0.0925
Standard deviation 0.021
Values 0.078 0.11
[95]
HuH.7 SLCO1A2
Mean 21.5
Standard deviation 7.6
Values 18 30 16
[96]
SNU475 SLCO1A2
Mean 2
Standard deviation 0.3
Values 1.8 2.2
[97]
THLE SLCO1A2
Mean 0.0565
Standard deviation 0.012
Values 0.065 0.048
[98]
liver SLCO1A2
Mean 3.26
Standard deviation 2.6
Values 1.3 5 0.82 5.9
[99]
ref_hepatocyte SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE SLC10A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[105]
liver SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0
[106]
ref_hepatocyte SLC51B
Missing
[107]
HepG2 SLC51B
Mean 5.2
Standard deviation 0.49
Values 5.5 4.9
[108]
HepG2.C3A SLC51B
Mean 6.12
Standard deviation 2.1
Values 4.6 7.6
[109]
HuH.7 SLC51B
Mean 13.2
Standard deviation 4
Values 9.5 13 17
[110]
SNU475 SLC51B
Mean 0.158
Standard deviation 0.18
Values 0.032 0.28
[111]
THLE SLC51B
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[112]
liver SLC51B
Mean 0.29
Standard deviation 0.29
Values 0.16 0.19 0.72 0.093
[113]
ref_hepatocyte FABP6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FABP6
Mean 0.127
Standard deviation 0.095
Values 0.19 0.06
[115]
HepG2.C3A FABP6
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[116]
HuH.7 FABP6
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 FABP6
Mean 0.146
Standard deviation 0.0091
Values 0.14 0.15
[118]
THLE FABP6
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[119]
liver FABP6
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte SLC51A
Missing
[121]
HepG2 SLC51A
Mean 2.9
Standard deviation 0.024
Values 2.9 2.9
[122]
HepG2.C3A SLC51A
Mean 10.5
Standard deviation 3.2
Values 13 8.2
[123]
HuH.7 SLC51A
Mean 4.67
Standard deviation 0.7
Values 4 5.3 4.7
[124]
SNU475 SLC51A
Mean 0.0895
Standard deviation 0.0047
Values 0.093 0.086
[125]
THLE SLC51A
Mean 0.0943
Standard deviation 0.025
Values 0.077 0.11
[126]
liver SLC51A
Mean 12.1
Standard deviation 5.5
Values 19 5.5 14 11