REACTOME_RA_BIOSYNTHESIS_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ADH4 Alcohol dehydrogenase 4 [1] -3.40[2] -3.90[3] -9.65[4] -13.60[5] -8.98[6] -1.19[7]
2 ALDH1A1 Retinal dehydrogenase 1 [8] 1.56[9] 0.72[10] 2.20[11] 1.44[12] -4.28[13] -0.12[14]
3 ADH1A Alcohol dehydrogenase 1A [15] -12.03[16] [17] -9.01[18] -16.69[19] [20] -0.66[21]
4 AKR1C3 Aldo-keto reductase family 1 member C3 [22] 0.79[23] 1.42[24] -6.78[25] 1.69[26] -2.72[27] -0.91[28]
5 RDH16 Retinol dehydrogenase 16 [29] -9.19[30] -7.21[31] -8.52[32] -10.00[33] -7.98[34] 0.59[35]
6 ADH1C Alcohol dehydrogenase 1C [36] -12.41[37] -10.23[38] -10.40[39] -10.50[40] -10.19[41] 0.16[42]
7 DHRS3 Short-chain dehydrogenase/reductase 3 [43] 0.73[44] 1.81[45] -1.01[46] -0.69[47] 1.66[48] 1.59[49]
8 RDH11 Retinol dehydrogenase 11 [50] 0.94[51] 2.45[52] 0.88[53] -0.36[54] 2.38[55] 1.78[56]
9 DHRS4 Dehydrogenase/reductase SDR family member 4 [57] -0.06[58] -2.32[59] -2.99[60] -3.34[61] -1.11[62] -1.12[63]
10 ALDH8A1 Aldehyde dehydrogenase family 8 member A1 [64] -1.25[65] -1.86[66] -4.40[67] -6.53[68] -4.79[69] 2.65[70]
11 RDH5 11-cis retinol dehydrogenase [71] -4.74[72] -2.75[73] -4.30[74] -7.17[75] -3.98[76] -1.53[77]
12 DHRS9 Dehydrogenase/reductase SDR family member 9 [78] -5.47[79] -5.65[80] -8.49[81] -4.68[82] -1.60[83] -4.58[84]
13 RDH14 Retinol dehydrogenase 14 [85] -0.30[86] -0.22[87] -2.73[88] -2.45[89] 0.96[90] -0.57[91]
14 RDH10 Retinol dehydrogenase 10 [92] 3.18[93] 3.90[94] 1.29[95] 1.76[96] 3.01[97] 2.29[98]
15 RDH13 Retinol dehydrogenase 13 [99] 2.71[100] 2.61[101] 1.00[102] -0.09[103] 2.66[104] 1.48[105]
16 CRABP1 Cellular retinoic acid-binding protein 1 [106] [107] [108] [109] -2.82[110] -1.93[111] [112]
17 CYP26A1 Cytochrome P450 26A1 [113] 6.22[114] 0.40[115] 2.38[116] 1.46[117] -1.57[118] 2.28[119]
18 ALDH1A2 Retinal dehydrogenase 2 [120] -0.87[121] -0.78[122] 1.06[123] 0.51[124] 10.76[125] 3.48[126]
19 ALDH1A3 Aldehyde dehydrogenase family 1 member A3 [127] 3.21[128] -0.80[129] 0.24[130] 5.36[131] 13.13[132] 4.98[133]
20 CYP26B1 Cytochrome P450 26B1 [134] 7.95[135] 4.90[136] 10.56[137] 8.02[138] 9.91[139] 6.81[140]
21 SDR16C5 Epidermal retinol dehydrogenase 2 [141] [142] [143] [144] [145] [146] [147]
22 CYP26C1 Cytochrome P450 26C1 [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte ADH4
Mean 397
Standard deviation 7e+02
Values 29 4.9 1.5 3.3e+02 1.6e+03
[2]
HepG2 ADH4
Mean 9.95
Standard deviation 0.32
Values 9.7 10
[3]
HepG2.C3A ADH4
Mean 6.21
Standard deviation 2.8
Values 4.3 8.2
[4]
HuH.7 ADH4
Mean 0.326
Standard deviation 0.33
Values 0.2 0.71 0.075
[5]
SNU475 ADH4
Mean 0.0236
Standard deviation 0.019
Values 0.037 0.01
[6]
THLE ADH4
Mean 0.103
Standard deviation 0.02
Values 0.089 0.12
[7]
liver ADH4
Mean 102
Standard deviation 66
Values 1.9e+02 40 58 1.2e+02
[8]
ref_hepatocyte ALDH1A1
Mean 382
Standard deviation 2.7e+02
Values 4.1e+02 7.6e+02 20 2.8e+02 4.3e+02
[9]
HepG2 ALDH1A1
Mean 298
Standard deviation 51
Values 2.6e+02 3.3e+02
[10]
HepG2.C3A ALDH1A1
Mean 148
Standard deviation 48
Values 1.1e+02 1.8e+02
[11]
HuH.7 ALDH1A1
Mean 1.17e+03
Standard deviation 3.9e+02
Values 1.4e+03 7.1e+02 1.4e+03
[12]
SNU475 ALDH1A1
Mean 768
Standard deviation 3.3e+02
Values 1e+03 5.4e+02
[13]
THLE ALDH1A1
Mean 2.59
Standard deviation 1.5
Values 3.6 1.6
[14]
liver ALDH1A1
Mean 207
Standard deviation 1.4e+02
Values 1.2e+02 2.8e+02 3.6e+02 68
[15]
ref_hepatocyte ADH1A
Mean 362
Standard deviation 6e+02
Values 0 0.45 9.8 4.1e+02 1.4e+03
[16]
HepG2 ADH1A
Mean 0.0229
Standard deviation 0.016
Values 0.011 0.034
[17]
HepG2.C3A ADH1A
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 ADH1A
Mean 0.465
Standard deviation 0.75
Values 0.057 1.3 0.0094
[19]
SNU475 ADH1A
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[20]
THLE ADH1A
Mean 0
Standard deviation 0
Values 0 0
[21]
liver ADH1A
Mean 135
Standard deviation 1.5e+02
Values 3.6e+02 47 93 38
[22]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 1.1e+02 4.3e+02 1.2e+02
[23]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[24]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[25]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[26]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[27]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[28]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 51 67 1.5e+02 32
[29]
ref_hepatocyte RDH16
Mean 193
Standard deviation 2.8e+02
Values 0 0.34 10 3.4e+02 6.1e+02
[30]
HepG2 RDH16
Mean 0.0873
Standard deviation 0.014
Values 0.097 0.077
[31]
HepG2.C3A RDH16
Mean 0.306
Standard deviation 0.16
Values 0.42 0.19
[32]
HuH.7 RDH16
Mean 0.346
Standard deviation 0.14
Values 0.24 0.3 0.51
[33]
SNU475 RDH16
Mean 0.14
Standard deviation 0.046
Values 0.11 0.17
[34]
THLE RDH16
Mean 0.101
Standard deviation 0.067
Values 0.15 0.053
[35]
liver RDH16
Mean 170
Standard deviation 54
Values 2.1e+02 91 2.1e+02 1.7e+02
[36]
ref_hepatocyte ADH1C
Mean 132
Standard deviation 2e+02
Values 0.14 2.1 4 2e+02 4.5e+02
[37]
HepG2 ADH1C
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[38]
HepG2.C3A ADH1C
Mean 0.0258
Standard deviation 0.009
Values 0.019 0.032
[39]
HuH.7 ADH1C
Mean 0.0645
Standard deviation 0.029
Values 0.041 0.096 0.056
[40]
SNU475 ADH1C
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[41]
THLE ADH1C
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[42]
liver ADH1C
Mean 86.2
Standard deviation 1.1e+02
Values 2.6e+02 32 44 13
[43]
ref_hepatocyte DHRS3
Mean 60.2
Standard deviation 46
Values 13 28 44 97 1.2e+02
[44]
HepG2 DHRS3
Mean 26.5
Standard deviation 1.6
Values 28 25
[45]
HepG2.C3A DHRS3
Mean 49.5
Standard deviation 22
Values 65 34
[46]
HuH.7 DHRS3
Mean 19.8
Standard deviation 4.5
Values 17 25 18
[47]
SNU475 DHRS3
Mean 27.7
Standard deviation 3.2
Values 30 25
[48]
THLE DHRS3
Mean 24.9
Standard deviation 3.5
Values 27 22
[49]
liver DHRS3
Mean 107
Standard deviation 71
Values 1.4e+02 49 1.9e+02 46
[50]
ref_hepatocyte RDH11
Mean 49.5
Standard deviation 12
Values 38 60 36 54 60
[51]
HepG2 RDH11
Mean 25.2
Standard deviation 3.8
Values 23 28
[52]
HepG2.C3A RDH11
Mean 63.3
Standard deviation 21
Values 78 49
[53]
HuH.7 RDH11
Mean 60.2
Standard deviation 6.3
Values 54 67 60
[54]
SNU475 RDH11
Mean 28.5
Standard deviation 0.012
Values 28 29
[55]
THLE RDH11
Mean 33.8
Standard deviation 2.5
Values 32 36
[56]
liver RDH11
Mean 99.7
Standard deviation 22
Values 1.1e+02 89 1.3e+02 77
[57]
ref_hepatocyte DHRS4
Mean 36.8
Standard deviation 23
Values 34 24 9.7 45 71
[58]
HepG2 DHRS4
Mean 9.37
Standard deviation 1.4
Values 8.4 10
[59]
HepG2.C3A DHRS4
Mean 1.73
Standard deviation 0.2
Values 1.9 1.6
[60]
HuH.7 DHRS4
Mean 3.07
Standard deviation 0.58
Values 3.2 2.5 3.6
[61]
SNU475 DHRS4
Mean 2.69
Standard deviation 1.2
Values 3.5 1.9
[62]
THLE DHRS4
Mean 2.24
Standard deviation 0.27
Values 2.1 2.4
[63]
liver DHRS4
Mean 9.96
Standard deviation 5
Values 17 5.5 11 7
[64]
ref_hepatocyte ALDH8A1
Mean 29
Standard deviation 37
Values 4.5 1.9 2.4 57 80
[65]
HepG2 ALDH8A1
Mean 3.25
Standard deviation 3.3
Values 0.91 5.6
[66]
HepG2.C3A ALDH8A1
Mean 1.88
Standard deviation 1.2
Values 1.1 2.7
[67]
HuH.7 ALDH8A1
Mean 0.913
Standard deviation 0.4
Values 0.68 1.4 0.68
[68]
SNU475 ALDH8A1
Mean 0.233
Standard deviation 0.071
Values 0.28 0.18
[69]
THLE ALDH8A1
Mean 0.138
Standard deviation 0.014
Values 0.15 0.13
[70]
liver ALDH8A1
Mean 107
Standard deviation 12
Values 1.1e+02 90 1.1e+02 1.1e+02
[71]
ref_hepatocyte RDH5
Mean 23.8
Standard deviation 26
Values 0.53 17 3.6 35 64
[72]
HepG2 RDH5
Mean 0.238
Standard deviation 0.045
Values 0.27 0.21
[73]
HepG2.C3A RDH5
Mean 0.829
Standard deviation 0.051
Values 0.87 0.79
[74]
HuH.7 RDH5
Mean 0.802
Standard deviation 0.21
Values 0.58 0.99 0.83
[75]
SNU475 RDH5
Mean 0.123
Standard deviation 0.023
Values 0.14 0.11
[76]
THLE RDH5
Mean 0.198
Standard deviation 0.021
Values 0.18 0.21
[77]
liver RDH5
Mean 4.84
Standard deviation 3.7
Values 4.5 4 9.8 1.1
[78]
ref_hepatocyte DHRS9
Mean 11.8
Standard deviation 22
Values 0 8.5 50 0.39 0.55
[79]
HepG2 DHRS9
Mean 0.0708
Standard deviation 0.052
Values 0.034 0.11
[80]
HepG2.C3A DHRS9
Mean 0.0555
Standard deviation 0.018
Values 0.068 0.043
[81]
HuH.7 DHRS9
Mean 0.0218
Standard deviation 0.015
Values 0.0082 0.039 0.019
[82]
SNU475 DHRS9
Mean 0.342
Standard deviation 0.33
Values 0.11 0.58
[83]
THLE DHRS9
Mean 0.514
Standard deviation 0.043
Values 0.54 0.48
[84]
liver DHRS9
Mean 0.291
Standard deviation 0.14
Values 0.16 0.3 0.49 0.21
[85]
ref_hepatocyte RDH14
Mean 8.84
Standard deviation 4
Values 14 12 3.2 8 7.8
[86]
HepG2 RDH14
Mean 1.91
Standard deviation 0.6
Values 2.3 1.5
[87]
HepG2.C3A RDH14
Mean 1.78
Standard deviation 0.049
Values 1.8 1.7
[88]
HuH.7 RDH14
Mean 0.88
Standard deviation 0.45
Values 0.63 1.4 0.61
[89]
SNU475 RDH14
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[90]
THLE RDH14
Mean 2.26
Standard deviation 0.76
Values 1.7 2.8
[91]
liver RDH14
Mean 3.5
Standard deviation 0.58
Values 4.2 2.9 3.2 3.7
[92]
ref_hepatocyte RDH10
Mean 6.75
Standard deviation 3.6
Values 7.6 3.6 2.3 9.8 10
[93]
HepG2 RDH10
Mean 16.3
Standard deviation 4.8
Values 20 13
[94]
HepG2.C3A RDH10
Mean 23.6
Standard deviation 3.5
Values 26 21
[95]
HuH.7 RDH10
Mean 10.9
Standard deviation 1.6
Values 9.1 12 12
[96]
SNU475 RDH10
Mean 16.9
Standard deviation 5
Values 20 13
[97]
THLE RDH10
Mean 7.13
Standard deviation 1.4
Values 6.1 8.1
[98]
liver RDH10
Mean 19.3
Standard deviation 7.3
Values 22 22 8.6 25
[99]
ref_hepatocyte RDH13
Mean 3.84
Standard deviation 1.7
Values 3.2 6.5 4.5 2.6 2.5
[100]
HepG2 RDH13
Mean 6.66
Standard deviation 1.3
Values 7.6 5.8
[101]
HepG2.C3A RDH13
Mean 5.51
Standard deviation 0.26
Values 5.3 5.7
[102]
HuH.7 RDH13
Mean 5.09
Standard deviation 0.75
Values 5.8 4.3 5.1
[103]
SNU475 RDH13
Mean 2.68
Standard deviation 0.35
Values 2.9 2.4
[104]
THLE RDH13
Mean 3.18
Standard deviation 0.49
Values 2.8 3.5
[105]
liver RDH13
Mean 6.3
Standard deviation 2.7
Values 7.4 4.5 9.6 3.7
[106]
ref_hepatocyte CRABP1
Mean 0.412
Standard deviation 0.86
Values 0 0 1.9 0 0.11
[107]
HepG2 CRABP1
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A CRABP1
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 CRABP1
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 CRABP1
Mean 0.0431
Standard deviation 0.061
Values 0 0.086
[111]
THLE CRABP1
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[112]
liver CRABP1
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte CYP26A1
Mean 0.247
Standard deviation 0.38
Values 0 0 0 0.86 0.37
[114]
HepG2 CYP26A1
Mean 4.9
Standard deviation 3.4
Values 7.3 2.5
[115]
HepG2.C3A CYP26A1
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[116]
HuH.7 CYP26A1
Mean 0.853
Standard deviation 0.36
Values 0.55 1.3 0.76
[117]
SNU475 CYP26A1
Mean 0.504
Standard deviation 0.37
Values 0.77 0.24
[118]
THLE CYP26A1
Mean 0.0109
Standard deviation 0.0071
Values 0.0059 0.016
[119]
liver CYP26A1
Mean 0.705
Standard deviation 0.82
Values 0.19 0.74 1.8 0.04
[120]
ref_hepatocyte ALDH1A2
Mean 0.153
Standard deviation 0.15
Values 0 0.075 0.37 0.086 0.24
[121]
HepG2 ALDH1A2
Mean 0.0222
Standard deviation 0.025
Values 0.04 0.0043
[122]
HepG2.C3A ALDH1A2
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[123]
HuH.7 ALDH1A2
Mean 0.211
Standard deviation 0.19
Values 0.09 0.43 0.11
[124]
SNU475 ALDH1A2
Mean 0.162
Standard deviation 0.0069
Values 0.17 0.16
[125]
THLE ALDH1A2
Mean 34.9
Standard deviation 6.3
Values 30 39
[126]
liver ALDH1A2
Mean 1
Standard deviation 0.59
Values 0.47 1.1 0.64 1.8
[127]
ref_hepatocyte ALDH1A3
Mean 0.115
Standard deviation 0.2
Values 0 0.47 0 0.043 0.065
[128]
HepG2 ALDH1A3
Mean 0.283
Standard deviation 0.2
Values 0.42 0.14
[129]
HepG2.C3A ALDH1A3
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[130]
HuH.7 ALDH1A3
Mean 0.0903
Standard deviation 0.069
Values 0.16 0.096 0.019
[131]
SNU475 ALDH1A3
Mean 3.5
Standard deviation 1.1
Values 2.7 4.3
[132]
THLE ALDH1A3
Mean 136
Standard deviation 53
Values 99 1.7e+02
[133]
liver ALDH1A3
Mean 2.13
Standard deviation 0.67
Values 1.3 2.4 1.9 2.9
[134]
ref_hepatocyte CYP26B1
Mean 0.0121
Standard deviation 0.027
Values 0 0 0 0.06 0
[135]
HepG2 CYP26B1
Mean 0.791
Standard deviation 0.35
Values 1 0.54
[136]
HepG2.C3A CYP26B1
Mean 0.0848
Standard deviation 0.092
Values 0.019 0.15
[137]
HuH.7 CYP26B1
Mean 12
Standard deviation 3.7
Values 14 7.7 14
[138]
SNU475 CYP26B1
Mean 2.31
Standard deviation 2.1
Values 0.84 3.8
[139]
THLE CYP26B1
Mean 1.52
Standard deviation 0.59
Values 1.9 1.1
[140]
liver CYP26B1
Mean 0.794
Standard deviation 0.48
Values 0.78 0.43 0.49 1.5
[141]
ref_hepatocyte SDR16C5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 SDR16C5
Mean 0.0193
Standard deviation 0.003
Values 0.017 0.021
[143]
HepG2.C3A SDR16C5
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 SDR16C5
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 SDR16C5
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE SDR16C5
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[147]
liver SDR16C5
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[148]
ref_hepatocyte CYP26C1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 CYP26C1
Mean 0.176
Standard deviation 0.084
Values 0.26 0.17 0.094
[152]
SNU475 CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE CYP26C1
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[154]
liver CYP26C1
Mean 0.0165
Standard deviation 0.033
Values 0 0 0 0.066