REACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NRAS GTPase NRas [1] 0.05[2] 0.23[3] 0.17[4] -0.25[5] -0.47[6] -1.02[7]
2 HRAS GTPase HRas [8] -1.59[9] -2.54[10] -3.81[11] -2.20[12] -2.20[13] -3.43[14]
3 KRAS GTPase KRas [15] -1.09[16] -1.36[17] -0.24[18] -0.45[19] -0.58[20] -0.10[21]
4 SPRED2 Sprouty-related, EVH1 domain-containing protein 2 [22] 1.51[23] 1.51[24] 0.79[25] -0.10[26] 0.51[27] 0.14[28]
5 NF1 Neurofibromin [29] 1.88[30] 1.97[31] 2.31[32] 2.72[33] 2.37[34] 3.34[35]
6 SPRED1 Sprouty-related, EVH1 domain-containing protein 1 [36] 1.84[37] 2.10[38] 1.53[39] 2.73[40] 3.43[41] 2.02[42]
7 SPRED3 Sprouty-related, EVH1 domain-containing protein 3 [43] 3.11[44] 1.26[45] 1.24[46] 1.33[47] 3.46[48] -1.20[49]
[1]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[2]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[3]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[4]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[5]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[6]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[7]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[8]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[9]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[10]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[11]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[12]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[13]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[14]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[15]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[16]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[17]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[18]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[19]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[20]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[21]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[22]
ref_hepatocyte SPRED2
Mean 2.72
Standard deviation 1.4
Values 1.2 2.1 4.9 3.2 2.3
[23]
HepG2 SPRED2
Mean 25.5
Standard deviation 1.3
Values 25 26
[24]
HepG2.C3A SPRED2
Mean 27
Standard deviation 5
Values 31 23
[25]
HuH.7 SPRED2
Mean 22
Standard deviation 5.4
Values 28 17 21
[26]
SNU475 SPRED2
Mean 11.1
Standard deviation 5.1
Values 7.4 15
[27]
THLE SPRED2
Mean 16.4
Standard deviation 2.1
Values 15 18
[28]
liver SPRED2
Mean 7.3
Standard deviation 3.7
Values 13 4.5 6.7 5.3
[29]
ref_hepatocyte NF1
Mean 1.76
Standard deviation 0.43
Values 1.9 2.4 1.7 1.3 1.5
[30]
HepG2 NF1
Mean 21.4
Standard deviation 7.6
Values 16 27
[31]
HepG2.C3A NF1
Mean 24
Standard deviation 0.77
Values 23 25
[32]
HuH.7 NF1
Mean 40.5
Standard deviation 13
Values 48 48 26
[33]
SNU475 NF1
Mean 50.6
Standard deviation 4.9
Values 54 47
[34]
THLE NF1
Mean 38.4
Standard deviation 0.9
Values 38 39
[35]
liver NF1
Mean 43.1
Standard deviation 30
Values 22 73 13 64
[36]
ref_hepatocyte SPRED1
Mean 0.719
Standard deviation 0.37
Values 1.1 1.1 0.36 0.37 0.67
[37]
HepG2 SPRED1
Mean 8.47
Standard deviation 0.51
Values 8.1 8.8
[38]
HepG2.C3A SPRED1
Mean 10.7
Standard deviation 0.75
Values 11 10
[39]
HuH.7 SPRED1
Mean 9.7
Standard deviation 2.9
Values 13 6.9 9.5
[40]
SNU475 SPRED1
Mean 20.8
Standard deviation 6.4
Values 16 25
[41]
THLE SPRED1
Mean 32.6
Standard deviation 0.87
Values 32 33
[42]
liver SPRED1
Mean 7.06
Standard deviation 3.6
Values 3.9 11 4.3 8.8
[43]
ref_hepatocyte SPRED3
Mean 0.0552
Standard deviation 0.12
Values 0 0 0 0.28 0
[44]
HepG2 SPRED3
Mean 1.57
Standard deviation 0.09
Values 1.6 1.5
[45]
HepG2.C3A SPRED3
Mean 0.461
Standard deviation 0.061
Values 0.42 0.5
[46]
HuH.7 SPRED3
Mean 0.608
Standard deviation 0.26
Values 0.42 0.9 0.51
[47]
SNU475 SPRED3
Mean 0.607
Standard deviation 0.21
Values 0.46 0.76
[48]
THLE SPRED3
Mean 2.57
Standard deviation 0.011
Values 2.6 2.6
[49]
liver SPRED3
Mean 0.0584
Standard deviation 0.057
Values 0 0.13 0.026 0.079