REACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CALM1 Calmodulin-1 [1] -0.37[2] -0.48[3] -0.35[4] 0.25[5] 0.18[6] 0.65[7]
2 NRAS GTPase NRas [8] 0.18[9] 0.47[10] 0.54[11] -0.34[12] -0.11[13] -1.22[14]
3 HRAS GTPase HRas [15] -1.46[16] -2.30[17] -3.43[18] -2.28[19] -1.84[20] -3.63[21]
4 KRAS GTPase KRas [22] -0.96[23] -1.13[24] 0.14[25] -0.53[26] -0.21[27] -0.29[28]
5 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta [29] -0.32[30] -0.15[31] 1.03[32] -0.66[33] -0.81[34] 0.44[35]
6 DLG1 Disks large homolog 1 [36] 0.62[37] 0.82[38] 0.35[39] -0.03[40] 0.63[41] 0.34[42]
7 CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 0.33[43] 1.40[44] 0.67[45] 0.35[46] 0.57[47] -0.02[48]
8 RASGRF2 Ras-specific guanine nucleotide-releasing factor 2 [49] 3.39[50] 2.51[51] -2.15[52] -4.27[53] -1.38[54] -0.45[55]
9 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta [56] -2.98[57] -4.45[58] -7.75[59] -4.20[60] -2.90[61] 0.18[62]
10 DLG3 Disks large homolog 3 [63] 3.11[64] 2.57[65] -5.70[66] 0.71[67] 2.69[68] -0.43[69]
11 DLG4 Disks large homolog 4 [70] 2.33[71] 2.48[72] 0.89[73] 0.63[74] 3.50[75] 0.73[76]
12 DLG2 Disks large homolog 2 [77] -2.07[78] -1.96[79] -1.25[80] -2.04[81] -2.28[82] 1.76[83]
13 GRIN2D Glutamate receptor ionotropic, NMDA 2D [84] 4.04[85] 3.79[86] 3.77[87] 1.45[88] 1.06[89] -1.02[90]
14 NEFL Neurofilament light polypeptide [91] -2.46[92] [93] -1.13[94] 8.33[95] 1.65[96] [97]
15 GRIN2B Glutamate receptor ionotropic, NMDA 2B [98] -2.91[99] [100] [101] -0.25[102] -2.40[103] 0.89[104]
16 ACTN2 Alpha-actinin-2 [105] -0.18[106] -0.12[107] -2.75[108] 0.89[109] 1.27[110] 1.95[111]
17 RASGRF1 Ras-specific guanine nucleotide-releasing factor 1 [112] 3.77[113] 4.49[114] -3.12[115] 1.38[116] -0.87[117] [118]
18 CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha [119] [120] [121] [122] [123] [124] [125]
19 GRIN1 Glutamate receptor ionotropic, NMDA 1 [126] [127] [128] [129] [130] [131] [132]
20 LRRC7 Leucine-rich repeat-containing protein 7 [133] [134] [135] [136] [137] [138] [139]
[1]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[2]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[3]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[4]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[5]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[6]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[7]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[22]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[23]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[24]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[25]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[26]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[27]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[28]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[29]
ref_hepatocyte CAMK2D
Mean 6.27
Standard deviation 4.6
Values 12 11 1.6 2.7 4.7
[30]
HepG2 CAMK2D
Mean 15.2
Standard deviation 5.9
Values 11 19
[31]
HepG2.C3A CAMK2D
Mean 16.7
Standard deviation 1.9
Values 15 18
[32]
HuH.7 CAMK2D
Mean 46.1
Standard deviation 5.5
Values 51 47 40
[33]
SNU475 CAMK2D
Mean 18.4
Standard deviation 4.5
Values 22 15
[34]
THLE CAMK2D
Mean 11.8
Standard deviation 1.2
Values 13 11
[35]
liver CAMK2D
Mean 23.7
Standard deviation 6.1
Values 33 21 22 19
[36]
ref_hepatocyte DLG1
Mean 6.05
Standard deviation 3.6
Values 12 6.5 3.2 3.8 4.7
[37]
HepG2 DLG1
Mean 28
Standard deviation 17
Values 16 40
[38]
HepG2.C3A DLG1
Mean 31.6
Standard deviation 2.9
Values 30 34
[39]
HuH.7 DLG1
Mean 27.7
Standard deviation 2.4
Values 30 25 28
[40]
SNU475 DLG1
Mean 27.5
Standard deviation 5.4
Values 31 24
[41]
THLE DLG1
Mean 30.8
Standard deviation 0.63
Values 31 30
[42]
liver DLG1
Mean 21.3
Standard deviation 8.3
Values 17 30 12 26
[43]
ref_hepatocyte CAMK2G
Mean 2.9
Standard deviation 1.2
Values 2.8 2.3 4.9 1.9 2.6
[44]
HepG2 CAMK2G
Mean 11
Standard deviation 0.61
Values 11 11
[45]
HepG2.C3A CAMK2G
Mean 22.6
Standard deviation 3.2
Values 25 20
[46]
HuH.7 CAMK2G
Mean 16.6
Standard deviation 0.56
Values 16 17 17
[47]
SNU475 CAMK2G
Mean 17.1
Standard deviation 1.1
Values 18 16
[48]
THLE CAMK2G
Mean 14.2
Standard deviation 0.22
Values 14 14
[49]
liver CAMK2G
Mean 7.98
Standard deviation 1
Values 9.1 7 7.2 8.6
[50]
ref_hepatocyte RASGRF2
Mean 0.852
Standard deviation 1
Values 2.6 0.63 0.81 0.086 0.15
[51]
HepG2 RASGRF2
Mean 27
Standard deviation 1.9
Values 28 26
[52]
HepG2.C3A RASGRF2
Mean 14.3
Standard deviation 3.3
Values 12 17
[53]
HuH.7 RASGRF2
Mean 0.691
Standard deviation 0.073
Values 0.62 0.68 0.77
[54]
SNU475 RASGRF2
Mean 0.204
Standard deviation 0.033
Values 0.18 0.23
[55]
THLE RASGRF2
Mean 1.08
Standard deviation 0.38
Values 0.8 1.3
[56]
liver RASGRF2
Mean 1.73
Standard deviation 2.1
Values 0.8 0.9 0.39 4.8
[57]
ref_hepatocyte CAMK2B
Mean 0.643
Standard deviation 0.6
Values 0 1.1 0 0.9 1.3
[58]
HepG2 CAMK2B
Mean 0.245
Standard deviation 0.067
Values 0.29 0.2
[59]
HepG2.C3A CAMK2B
Mean 0.0871
Standard deviation 0.013
Values 0.078 0.097
[60]
HuH.7 CAMK2B
Mean 0.0107
Standard deviation 0.0051
Values 0.016 0.0064 0.0094
[61]
SNU475 CAMK2B
Mean 0.162
Standard deviation 0.072
Values 0.21 0.11
[62]
THLE CAMK2B
Mean 0.283
Standard deviation 0.15
Values 0.39 0.18
[63]
liver CAMK2B
Mean 2.02
Standard deviation 0.9
Values 1.5 2.2 3.2 1.2
[64]
ref_hepatocyte DLG3
Mean 0.517
Standard deviation 0.81
Values 2 0.18 0.23 0.095 0.12
[65]
HepG2 DLG3
Mean 13.5
Standard deviation 0.46
Values 14 13
[66]
HepG2.C3A DLG3
Mean 9.12
Standard deviation 0.22
Values 9.3 9
[67]
HuH.7 DLG3
Mean 0.0357
Standard deviation 0.01
Values 0.025 0.045 0.037
[68]
SNU475 DLG3
Mean 3.93
Standard deviation 0.59
Values 3.5 4.3
[69]
THLE DLG3
Mean 11
Standard deviation 0.3
Values 11 11
[70]
liver DLG3
Mean 1.07
Standard deviation 0.61
Values 0.78 1.3 0.41 1.8
[71]
ref_hepatocyte DLG4
Mean 0.259
Standard deviation 0.21
Values 0.17 0 0.16 0.45 0.51
[72]
HepG2 DLG4
Mean 3.93
Standard deviation 2.2
Values 5.5 2.3
[73]
HepG2.C3A DLG4
Mean 4.27
Standard deviation 0.27
Values 4.5 4.1
[74]
HuH.7 DLG4
Mean 1.73
Standard deviation 0.71
Values 1.3 2.5 1.3
[75]
SNU475 DLG4
Mean 1.85
Standard deviation 0.71
Values 1.3 2.4
[76]
THLE DLG4
Mean 9.6
Standard deviation 0.94
Values 10 8.9
[77]
liver DLG4
Mean 1.19
Standard deviation 1.3
Values 0.26 1.2 0.28 3
[78]
ref_hepatocyte DLG2
Mean 0.0959
Standard deviation 0.094
Values 0 0.21 0 0.12 0.15
[79]
HepG2 DLG2
Mean 0.0687
Standard deviation 0.024
Values 0.052 0.086
[80]
HepG2.C3A DLG2
Mean 0.0731
Standard deviation 0.048
Values 0.039 0.11
[81]
HuH.7 DLG2
Mean 0.145
Standard deviation 0.069
Values 0.098 0.22 0.11
[82]
SNU475 DLG2
Mean 0.108
Standard deviation 0.055
Values 0.07 0.15
[83]
THLE DLG2
Mean 0.0648
Standard deviation 0.0088
Values 0.071 0.059
[84]
liver DLG2
Mean 0.904
Standard deviation 0.38
Values 0.85 0.84 0.51 1.4
[85]
ref_hepatocyte GRIN2D
Mean 0.0598
Standard deviation 0.13
Values 0.3 0 0 0 0
[86]
HepG2 GRIN2D
Mean 2.96
Standard deviation 2.4
Values 4.6 1.3
[87]
HepG2.C3A GRIN2D
Mean 2.45
Standard deviation 0.75
Values 3 1.9
[88]
HuH.7 GRIN2D
Mean 2.93
Standard deviation 0.45
Values 3.5 2.7 2.6
[89]
SNU475 GRIN2D
Mean 0.755
Standard deviation 0.44
Values 0.44 1.1
[90]
THLE GRIN2D
Mean 0.41
Standard deviation 0.031
Values 0.43 0.39
[91]
liver GRIN2D
Mean 0.0818
Standard deviation 0.083
Values 0.024 0.17 0 0.13
[92]
ref_hepatocyte NEFL
Mean 0.0366
Standard deviation 0.031
Values 0 0.031 0.084 0.043 0.024
[93]
HepG2 NEFL
Mean 0.02
Standard deviation 0.0041
Values 0.023 0.017
[94]
HepG2.C3A NEFL
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NEFL
Mean 0.0598
Standard deviation 0.045
Values 0.074 0.096 0.0094
[96]
SNU475 NEFL
Mean 54.6
Standard deviation 25
Values 73 37
[97]
THLE NEFL
Mean 0.376
Standard deviation 0.12
Values 0.29 0.46
[98]
liver NEFL
Mean 0
Standard deviation 0
Values 0 0 0 0
[99]
ref_hepatocyte GRIN2B
Mean 0.0213
Standard deviation 0.039
Values 0 0 0 0.017 0.089
[100]
HepG2 GRIN2B
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[101]
HepG2.C3A GRIN2B
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 GRIN2B
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 GRIN2B
Mean 0.0833
Standard deviation 0.046
Values 0.12 0.051
[104]
THLE GRIN2B
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[105]
liver GRIN2B
Mean 0.11
Standard deviation 0.05
Values 0.12 0.1 0.051 0.17
[106]
ref_hepatocyte ACTN2
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[107]
HepG2 ACTN2
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[108]
HepG2.C3A ACTN2
Mean 0.055
Standard deviation 0.032
Values 0.078 0.032
[109]
HuH.7 ACTN2
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[110]
SNU475 ACTN2
Mean 0.173
Standard deviation 0.035
Values 0.15 0.2
[111]
THLE ACTN2
Mean 0.16
Standard deviation 0.075
Values 0.21 0.11
[112]
liver ACTN2
Mean 0.215
Standard deviation 0.35
Values 0.73 0.014 0 0.12
[113]
ref_hepatocyte RASGRF1
Mean 0.0103
Standard deviation 0.023
Values 0 0 0.052 0 0
[114]
HepG2 RASGRF1
Mean 0.426
Standard deviation 0.18
Values 0.56 0.3
[115]
HepG2.C3A RASGRF1
Mean 0.687
Standard deviation 0.032
Values 0.71 0.66
[116]
HuH.7 RASGRF1
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[117]
SNU475 RASGRF1
Mean 0.125
Standard deviation 0.11
Values 0.046 0.2
[118]
THLE RASGRF1
Mean 0.0186
Standard deviation 0.026
Values 0 0.037
[119]
liver RASGRF1
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte CAMK2A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 CAMK2A
Mean 0.0787
Standard deviation 0.022
Values 0.063 0.094
[122]
HepG2.C3A CAMK2A
Mean 0.0468
Standard deviation 0.025
Values 0.029 0.064
[123]
HuH.7 CAMK2A
Mean 0.0232
Standard deviation 0.016
Values 0.041 0.019 0.0094
[124]
SNU475 CAMK2A
Mean 1.25
Standard deviation 0.78
Values 1.8 0.69
[125]
THLE CAMK2A
Mean 0.231
Standard deviation 0.034
Values 0.21 0.26
[126]
liver CAMK2A
Mean 0.0104
Standard deviation 0.014
Values 0 0.029 0 0.013
[127]
ref_hepatocyte GRIN1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 GRIN1
Mean 0.68
Standard deviation 0.6
Values 1.1 0.25
[129]
HepG2.C3A GRIN1
Mean 0.154
Standard deviation 0.11
Values 0.23 0.075
[130]
HuH.7 GRIN1
Mean 0.0602
Standard deviation 0.028
Values 0.082 0.071 0.028
[131]
SNU475 GRIN1
Mean 0.0414
Standard deviation 0.006
Values 0.037 0.046
[132]
THLE GRIN1
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[133]
liver GRIN1
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte LRRC7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 LRRC7
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A LRRC7
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 LRRC7
Mean 1.23
Standard deviation 0.58
Values 1 1.9 0.79
[138]
SNU475 LRRC7
Mean 0.0559
Standard deviation 0.0069
Values 0.051 0.061
[139]
THLE LRRC7
Mean 0.156
Standard deviation 0.012
Values 0.15 0.16
[140]
liver LRRC7
Mean 0.238
Standard deviation 0.2
Values 0.14 0.26 0.051 0.5