REACTOME_RAP1_SIGNALLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAZ 14-3-3 protein zeta/delta [1] -0.22[2] -0.34[3] -0.04[4] 0.34[5] -0.33[6] -0.79[7]
2 RAP1B Ras-related protein Rap-1b [8] -1.95[9] -1.30[10] -1.55[11] -1.09[12] -0.59[13] -1.04[14]
3 YWHAB 14-3-3 protein beta/alpha [15] 1.39[16] 1.14[17] 0.39[18] 0.74[19] 0.92[20] 0.76[21]
4 RAP1A Ras-related protein Rap-1A [22] -0.70[23] -0.72[24] 0.09[25] -0.78[26] -0.27[27] -0.44[28]
5 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [29] 0.19[30] 0.05[31] 0.02[32] -1.03[33] 0.30[34] 0.07[35]
6 RAF1 RAF proto-oncogene serine/threonine-protein kinase [36] 0.29[37] 0.73[38] 1.97[39] -0.75[40] 0.86[41] 1.95[42]
7 RAP1GAP Rap1 GTPase-activating protein 1 [43] 1.55[44] 2.28[45] -0.16[46] -1.78[47] -4.50[48] 0.77[49]
8 PRKACB cAMP-dependent protein kinase catalytic subunit beta [50] -0.48[51] 0.33[52] 1.59[53] 1.67[54] 1.28[55] 2.56[56]
9 SIPA1 Signal-induced proliferation-associated protein 1 [57] 1.55[58] 0.26[59] 1.03[60] 0.89[61] 2.10[62] 2.14[63]
10 RAPGEF4 Rap guanine nucleotide exchange factor 4 [64] -3.67[65] -1.83[66] -0.94[67] -2.23[68] 0.92[69] 3.75[70]
11 RAP1GAP2 Rap1 GTPase-activating protein 2 [71] 4.44[72] 4.42[73] 2.23[74] 0.06[75] 3.47[76] 1.43[77]
12 RASGRP2 RAS guanyl-releasing protein 2 [78] -3.73[79] -1.50[80] 1.49[81] -3.10[82] -1.38[83] 2.90[84]
13 RAPGEF3 Rap guanine nucleotide exchange factor 3 [85] 2.18[86] 1.89[87] 1.30[88] 1.32[89] 0.72[90] 4.67[91]
14 PRKG1 cGMP-dependent protein kinase 1 [92] 0.19[93] [94] 1.58[95] 2.62[96] 5.27[97] 7.36[98]
15 RASGRP1 RAS guanyl-releasing protein 1 [99] 1.59[100] 2.32[101] 2.94[102] 3.58[103] 5.41[104] 7.66[105]
16 PRKACG cAMP-dependent protein kinase catalytic subunit gamma [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte YWHAZ
Mean 161
Standard deviation 1.6e+02
Values 1.3e+02 4.3e+02 1.6e+02 40 41
[2]
HepG2 YWHAZ
Mean 239
Standard deviation 21
Values 2.2e+02 2.5e+02
[3]
HepG2.C3A YWHAZ
Mean 191
Standard deviation 28
Values 1.7e+02 2.1e+02
[4]
HuH.7 YWHAZ
Mean 229
Standard deviation 23
Values 2.5e+02 2.1e+02 2.3e+02
[5]
SNU475 YWHAZ
Mean 552
Standard deviation 94
Values 6.2e+02 4.9e+02
[6]
THLE YWHAZ
Mean 232
Standard deviation 39
Values 2e+02 2.6e+02
[7]
liver YWHAZ
Mean 73.1
Standard deviation 31
Values 81 60 1.1e+02 39
[8]
ref_hepatocyte RAP1B
Mean 100
Standard deviation 77
Values 1.1e+02 2.1e+02 1.3e+02 25 29
[9]
HepG2 RAP1B
Mean 44.7
Standard deviation 8.8
Values 39 51
[10]
HepG2.C3A RAP1B
Mean 61.1
Standard deviation 18
Values 48 74
[11]
HuH.7 RAP1B
Mean 50.2
Standard deviation 5.6
Values 52 44 54
[12]
SNU475 RAP1B
Mean 128
Standard deviation 17
Values 1.4e+02 1.2e+02
[13]
THLE RAP1B
Mean 121
Standard deviation 4
Values 1.2e+02 1.2e+02
[14]
liver RAP1B
Mean 38.3
Standard deviation 18
Values 53 27 54 20
[15]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[16]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[17]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[18]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[19]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[20]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[21]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[22]
ref_hepatocyte RAP1A
Mean 17.1
Standard deviation 7.2
Values 17 20 8.5 13 28
[23]
HepG2 RAP1A
Mean 18.3
Standard deviation 5.4
Values 14 22
[24]
HepG2.C3A RAP1A
Mean 15.6
Standard deviation 1.3
Values 15 17
[25]
HuH.7 RAP1A
Mean 26.7
Standard deviation 1.9
Values 25 29 26
[26]
SNU475 RAP1A
Mean 27.1
Standard deviation 7
Values 32 22
[27]
THLE RAP1A
Mean 25.7
Standard deviation 2.2
Values 24 27
[28]
liver RAP1A
Mean 9.95
Standard deviation 5.1
Values 17 7.4 10 5.3
[29]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[30]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[31]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[32]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[33]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[34]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[35]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[36]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 6 14 20 20 17
[37]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 29 36
[38]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 41 37
[39]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 85 93 89
[40]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 22 28
[41]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[42]
liver RAF1
Mean 47
Standard deviation 3.6
Values 51 42 49 46
[43]
ref_hepatocyte RAP1GAP
Mean 6.04
Standard deviation 2.9
Values 5.4 3.8 3 9.7 8.3
[44]
HepG2 RAP1GAP
Mean 30.6
Standard deviation 4.6
Values 34 27
[45]
HepG2.C3A RAP1GAP
Mean 43.9
Standard deviation 14
Values 53 34
[46]
HuH.7 RAP1GAP
Mean 7.92
Standard deviation 1
Values 8.2 6.8 8.8
[47]
SNU475 RAP1GAP
Mean 4.78
Standard deviation 1.5
Values 5.8 3.7
[48]
THLE RAP1GAP
Mean 0.484
Standard deviation 0.06
Values 0.53 0.44
[49]
liver RAP1GAP
Mean 8.1
Standard deviation 2.7
Values 12 6.5 6.3 7.6
[50]
ref_hepatocyte PRKACB
Mean 2.75
Standard deviation 1.3
Values 2.1 3.1 1.4 2.4 4.8
[51]
HepG2 PRKACB
Mean 3.41
Standard deviation 1.6
Values 2.3 4.6
[52]
HepG2.C3A PRKACB
Mean 5.2
Standard deviation 0.9
Values 4.6 5.8
[53]
HuH.7 PRKACB
Mean 12.2
Standard deviation 3.4
Values 11 16 9.5
[54]
SNU475 PRKACB
Mean 23.8
Standard deviation 4.4
Values 27 21
[55]
THLE PRKACB
Mean 12.1
Standard deviation 0.96
Values 13 11
[56]
liver PRKACB
Mean 12.8
Standard deviation 2
Values 12 14 14 10
[57]
ref_hepatocyte SIPA1
Mean 2.56
Standard deviation 1.8
Values 0.066 1.2 4.1 4.2 3.2
[58]
HepG2 SIPA1
Mean 12.9
Standard deviation 3.9
Values 16 10
[59]
HepG2.C3A SIPA1
Mean 4.59
Standard deviation 0.34
Values 4.8 4.4
[60]
HuH.7 SIPA1
Mean 7.67
Standard deviation 2
Values 9 5.4 8.6
[61]
SNU475 SIPA1
Mean 12.8
Standard deviation 1.3
Values 12 14
[62]
THLE SIPA1
Mean 19.8
Standard deviation 0.59
Values 19 20
[63]
liver SIPA1
Mean 8.83
Standard deviation 3
Values 11 7 5.6 12
[64]
ref_hepatocyte RAPGEF4
Mean 1.04
Standard deviation 1.2
Values 0.028 0.4 0.35 1.6 2.8
[65]
HepG2 RAPGEF4
Mean 0.142
Standard deviation 0.043
Values 0.17 0.11
[66]
HepG2.C3A RAPGEF4
Mean 0.439
Standard deviation 0.14
Values 0.53 0.34
[67]
HuH.7 RAPGEF4
Mean 0.794
Standard deviation 0.52
Values 0.45 1.4 0.54
[68]
SNU475 RAPGEF4
Mean 0.603
Standard deviation 0.15
Values 0.5 0.71
[69]
THLE RAPGEF4
Mean 3.57
Standard deviation 2.6
Values 5.4 1.7
[70]
liver RAPGEF4
Mean 11
Standard deviation 0.7
Values 11 12 10 11
[71]
ref_hepatocyte RAP1GAP2
Mean 0.663
Standard deviation 0.79
Values 1.9 0.12 0.96 0.2 0.11
[72]
HepG2 RAP1GAP2
Mean 24.9
Standard deviation 11
Values 33 17
[73]
HepG2.C3A RAP1GAP2
Mean 21.3
Standard deviation 2.2
Values 23 20
[74]
HuH.7 RAP1GAP2
Mean 4.55
Standard deviation 1.4
Values 5.9 3 4.8
[75]
SNU475 RAP1GAP2
Mean 1.88
Standard deviation 0.63
Values 1.4 2.3
[76]
THLE RAP1GAP2
Mean 13.3
Standard deviation 3.1
Values 11 15
[77]
liver RAP1GAP2
Mean 1.4
Standard deviation 0.73
Values 1.1 2.2 0.51 1.8
[78]
ref_hepatocyte RASGRP2
Mean 0.297
Standard deviation 0.48
Values 0 0 0.046 0.31 1.1
[79]
HepG2 RASGRP2
Mean 0.0387
Standard deviation 0.018
Values 0.052 0.026
[80]
HepG2.C3A RASGRP2
Mean 0.157
Standard deviation 0.13
Values 0.068 0.25
[81]
HuH.7 RASGRP2
Mean 1.22
Standard deviation 0.28
Values 0.99 1.1 1.5
[82]
SNU475 RASGRP2
Mean 0.0939
Standard deviation 0.018
Values 0.11 0.081
[83]
THLE RASGRP2
Mean 0.207
Standard deviation 0.13
Values 0.3 0.11
[84]
liver RASGRP2
Mean 1.74
Standard deviation 0.45
Values 1.6 1.4 1.6 2.4
[85]
ref_hepatocyte RAPGEF3
Mean 0.0823
Standard deviation 0.11
Values 0 0 0.27 0.078 0.065
[86]
HepG2 RAPGEF3
Mean 0.643
Standard deviation 0.53
Values 1 0.27
[87]
HepG2.C3A RAPGEF3
Mean 0.459
Standard deviation 0.3
Values 0.67 0.25
[88]
HuH.7 RAPGEF3
Mean 0.297
Standard deviation 0.15
Values 0.34 0.42 0.13
[89]
SNU475 RAPGEF3
Mean 0.557
Standard deviation 0.31
Values 0.34 0.78
[90]
THLE RAPGEF3
Mean 0.245
Standard deviation 0.046
Values 0.28 0.21
[91]
liver RAPGEF3
Mean 1.64
Standard deviation 0.68
Values 1.7 1.5 0.85 2.5
[92]
ref_hepatocyte PRKG1
Mean 0.0174
Standard deviation 0.027
Values 0 0 0.062 0 0.024
[93]
HepG2 PRKG1
Mean 0.0343
Standard deviation 0.024
Values 0.017 0.051
[94]
HepG2.C3A PRKG1
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 PRKG1
Mean 0.0764
Standard deviation 0.034
Values 0.057 0.12 0.056
[96]
SNU475 PRKG1
Mean 0.289
Standard deviation 0.11
Values 0.21 0.36
[97]
THLE PRKG1
Mean 1.22
Standard deviation 0.23
Values 1.4 1.1
[98]
liver PRKG1
Mean 2.25
Standard deviation 1
Values 1.3 3.1 1.4 3.2
[99]
ref_hepatocyte RASGRP1
Mean 0.00813
Standard deviation 0.018
Values 0 0 0 0 0.041
[100]
HepG2 RASGRP1
Mean 0.0422
Standard deviation 0.0051
Values 0.046 0.039
[101]
HepG2.C3A RASGRP1
Mean 0.0608
Standard deviation 0.01
Values 0.068 0.054
[102]
HuH.7 RASGRP1
Mean 0.0912
Standard deviation 0.044
Values 0.057 0.14 0.075
[103]
SNU475 RASGRP1
Mean 0.264
Standard deviation 0.23
Values 0.1 0.43
[104]
THLE RASGRP1
Mean 0.628
Standard deviation 0.099
Values 0.7 0.56
[105]
liver RASGRP1
Mean 1.29
Standard deviation 0.68
Values 0.61 1.9 0.8 1.9
[106]
ref_hepatocyte PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 PRKACG
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[108]
HepG2.C3A PRKACG
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 PRKACG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[110]
SNU475 PRKACG
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE PRKACG
Mean 0
Standard deviation 0
Values 0 0
[112]
liver PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0