REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DUSP1 Dual specificity protein phosphatase 1 [1] -3.21[2] -3.92[3] -4.18[4] -4.85[5] -1.55[6] -0.99[7]
2 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [8] -1.16[9] -1.87[10] -0.94[11] -0.60[12] -0.74[13] -2.06[14]
3 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [15] -0.18[16] -0.88[17] 0.34[18] -0.90[19] -1.06[20] -2.57[21]
4 PEA15 Astrocytic phosphoprotein PEA-15 [22] -0.68[23] -2.34[24] -2.47[25] 1.28[26] 0.48[27] -2.77[28]
5 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [29] 0.21[30] 0.26[31] 0.57[32] 0.83[33] 0.81[34] 0.39[35]
6 IL6ST Interleukin-6 receptor subunit beta [36] 0.03[37] 0.89[38] 0.77[39] 1.67[40] 2.19[41] 2.91[42]
7 DUSP6 Dual specificity protein phosphatase 6 [43] -0.72[44] 0.98[45] 0.61[46] -3.97[47] -0.83[48] -0.62[49]
8 JAK1 Tyrosine-protein kinase JAK1 [50] 0.28[51] -0.62[52] -0.08[53] 0.57[54] 0.56[55] 0.66[56]
9 DUSP5 Dual specificity protein phosphatase 5 [57] -1.49[58] -5.73[59] -0.16[60] -1.60[61] -2.94[62] -3.32[63]
10 MAPK1 Mitogen-activated protein kinase 1 [64] 1.48[65] 1.23[66] 1.42[67] 1.79[68] 0.79[69] 0.90[70]
11 IL6R Interleukin-6 receptor subunit alpha [71] -0.45[72] -0.51[73] -0.97[74] -0.93[75] -5.68[76] 0.78[77]
12 DUSP9 Dual specificity protein phosphatase 9 [78] 3.23[79] 3.19[80] 2.03[81] -5.08[82] -5.88[83] -5.15[84]
13 DUSP16 Dual specificity protein phosphatase 16 [85] 1.34[86] 0.97[87] 1.06[88] -1.46[89] -1.21[90] 0.58[91]
14 DUSP10 Dual specificity protein phosphatase 10 [92] -3.23[93] -4.36[94] -2.56[95] -0.86[96] -2.49[97] -0.87[98]
15 CDK1 Cyclin-dependent kinase 1 [99] 1.02[100] 2.70[101] 1.79[102] 2.21[103] 2.38[104] -3.34[105]
16 TYK2 Non-receptor tyrosine-protein kinase TYK2 [106] 0.91[107] 0.88[108] 1.37[109] 0.69[110] 0.96[111] 1.12[112]
17 MAPK3 Mitogen-activated protein kinase 3 [113] 1.62[114] 1.28[115] 1.68[116] 0.36[117] -0.26[118] -1.91[119]
18 DUSP8 Dual specificity protein phosphatase 8 [120] 0.91[121] -0.04[122] -0.50[123] -1.49[124] -1.56[125] -4.70[126]
19 IL6 Interleukin-6 [127] -8.67[128] [129] -5.10[130] -0.92[131] 0.95[132] [133]
20 DUSP7 Dual specificity protein phosphatase 7 [134] 1.32[135] 0.02[136] 1.63[137] -0.49[138] 1.26[139] -0.84[140]
21 JAK2 Tyrosine-protein kinase JAK2 [141] 0.00[142] -0.40[143] -0.48[144] 0.70[145] 0.65[146] 1.83[147]
22 DUSP2 Dual specificity protein phosphatase 2 [148] -2.99[149] [150] -7.75[151] -0.34[152] -0.94[153] -0.82[154]
23 DUSP4 Dual specificity protein phosphatase 4 [155] 5.28[156] 1.88[157] 8.13[158] 7.67[159] 4.96[160] 2.96[161]
[1]
ref_hepatocyte DUSP1
Mean 86.9
Standard deviation 80
Values 13 43 1.2e+02 2.1e+02 49
[2]
HepG2 DUSP1
Mean 24.4
Standard deviation 17
Values 36 12
[3]
HepG2.C3A DUSP1
Mean 17.4
Standard deviation 9.2
Values 24 11
[4]
HuH.7 DUSP1
Mean 10.9
Standard deviation 8.1
Values 5.7 20 6.7
[5]
SNU475 DUSP1
Mean 5.79
Standard deviation 1.2
Values 5 6.6
[6]
THLE DUSP1
Mean 100
Standard deviation 2.2
Values 1e+02 98
[7]
liver DUSP1
Mean 114
Standard deviation 83
Values 2.2e+02 62 1.3e+02 38
[8]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[9]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[10]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[11]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[12]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[13]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[14]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[15]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[16]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[17]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[18]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[19]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[20]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[21]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[22]
ref_hepatocyte PEA15
Mean 25.1
Standard deviation 26
Values 5.3 47 59 7.8 6.6
[23]
HepG2 PEA15
Mean 40.5
Standard deviation 8.4
Values 47 35
[24]
HepG2.C3A PEA15
Mean 15
Standard deviation 1.1
Values 14 16
[25]
HuH.7 PEA15
Mean 10.2
Standard deviation 1.5
Values 8.5 11 11
[26]
SNU475 PEA15
Mean 117
Standard deviation 9.9
Values 1.2e+02 1.1e+02
[27]
THLE PEA15
Mean 118
Standard deviation 13
Values 1.1e+02 1.3e+02
[28]
liver PEA15
Mean 9.57
Standard deviation 4.8
Values 8.9 6.9 17 5.9
[29]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[30]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[31]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[32]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[33]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[34]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[35]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[36]
ref_hepatocyte IL6ST
Mean 16.5
Standard deviation 5.8
Values 24 18 9.5 12 19
[37]
HepG2 IL6ST
Mean 43.6
Standard deviation 25
Values 26 61
[38]
HepG2.C3A IL6ST
Mean 92.3
Standard deviation 8.3
Values 86 98
[39]
HuH.7 IL6ST
Mean 63.5
Standard deviation 38
Values 50 1.1e+02 35
[40]
SNU475 IL6ST
Mean 100
Standard deviation 15
Values 90 1.1e+02
[41]
THLE IL6ST
Mean 252
Standard deviation 68
Values 3e+02 2e+02
[42]
liver IL6ST
Mean 321
Standard deviation 1.1e+02
Values 2.5e+02 4.2e+02 2.1e+02 4.1e+02
[43]
ref_hepatocyte DUSP6
Mean 15.3
Standard deviation 12
Values 1.5 4.5 29 26 15
[44]
HepG2 DUSP6
Mean 24.2
Standard deviation 10
Values 31 17
[45]
HepG2.C3A DUSP6
Mean 91
Standard deviation 18
Values 1e+02 78
[46]
HuH.7 DUSP6
Mean 52.9
Standard deviation 18
Values 62 32 65
[47]
SNU475 DUSP6
Mean 1.87
Standard deviation 2.3
Values 0.26 3.5
[48]
THLE DUSP6
Mean 28.9
Standard deviation 3.7
Values 26 32
[49]
liver DUSP6
Mean 25.9
Standard deviation 9.5
Values 38 19 28 18
[50]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 6.8 27 18 14 10
[51]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 40 56
[52]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 31 29
[53]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 36 32 29
[54]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 47 39
[55]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[56]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 54 75 58 62
[57]
ref_hepatocyte DUSP5
Mean 14.8
Standard deviation 22
Values 0 16 52 3.6 2
[58]
HepG2 DUSP5
Mean 13.7
Standard deviation 10
Values 21 6.5
[59]
HepG2.C3A DUSP5
Mean 0.842
Standard deviation 0.16
Values 0.73 0.95
[60]
HuH.7 DUSP5
Mean 29.8
Standard deviation 5.2
Values 24 34 31
[61]
SNU475 DUSP5
Mean 9.32
Standard deviation 4.3
Values 6.3 12
[62]
THLE DUSP5
Mean 6.48
Standard deviation 0.82
Values 7.1 5.9
[63]
liver DUSP5
Mean 3.85
Standard deviation 1.1
Values 2.4 5 3.8 4.2
[64]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[65]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[66]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[67]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[68]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[69]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[70]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[71]
ref_hepatocyte IL6R
Mean 10.5
Standard deviation 4.3
Values 6.9 11 17 6.6 11
[72]
HepG2 IL6R
Mean 20
Standard deviation 0.31
Values 20 20
[73]
HepG2.C3A IL6R
Mean 22.3
Standard deviation 0.4
Values 22 23
[74]
HuH.7 IL6R
Mean 12.1
Standard deviation 3.9
Values 10 17 9.4
[75]
SNU475 IL6R
Mean 10.6
Standard deviation 4
Values 13 7.7
[76]
THLE IL6R
Mean 0.69
Standard deviation 0.095
Values 0.76 0.62
[77]
liver IL6R
Mean 47.1
Standard deviation 10
Values 49 49 33 57
[78]
ref_hepatocyte DUSP9
Mean 8.55
Standard deviation 19
Values 42 0 0.022 0.06 0.16
[79]
HepG2 DUSP9
Mean 207
Standard deviation 22
Values 2.2e+02 1.9e+02
[80]
HepG2.C3A DUSP9
Mean 236
Standard deviation 24
Values 2.5e+02 2.2e+02
[81]
HuH.7 DUSP9
Mean 79
Standard deviation 11
Values 67 87 83
[82]
SNU475 DUSP9
Mean 0.485
Standard deviation 0.1
Values 0.41 0.56
[83]
THLE DUSP9
Mean 0.487
Standard deviation 0.019
Values 0.47 0.5
[84]
liver DUSP9
Mean 0.625
Standard deviation 0.59
Values 0.82 0.2 0.1 1.4
[85]
ref_hepatocyte DUSP16
Mean 7.61
Standard deviation 4
Values 4.7 12 12 6.1 3.5
[86]
HepG2 DUSP16
Mean 49.8
Standard deviation 0.41
Values 50 50
[87]
HepG2.C3A DUSP16
Mean 44.8
Standard deviation 6.7
Values 50 40
[88]
HuH.7 DUSP16
Mean 35.9
Standard deviation 14
Values 33 51 24
[89]
SNU475 DUSP16
Mean 5.29
Standard deviation 0.16
Values 5.4 5.2
[90]
THLE DUSP16
Mean 11.1
Standard deviation 0.034
Values 11 11
[91]
liver DUSP16
Mean 29.5
Standard deviation 18
Values 14 47 14 43
[92]
ref_hepatocyte DUSP10
Mean 7.44
Standard deviation 3.9
Values 1.9 7.2 5.9 12 10
[93]
HepG2 DUSP10
Mean 2.05
Standard deviation 0.45
Values 2.4 1.7
[94]
HepG2.C3A DUSP10
Mean 1.09
Standard deviation 0.49
Values 1.4 0.74
[95]
HuH.7 DUSP10
Mean 2.85
Standard deviation 1.9
Values 1.8 5.1 1.6
[96]
SNU475 DUSP10
Mean 7.88
Standard deviation 4.2
Values 11 4.9
[97]
THLE DUSP10
Mean 4.44
Standard deviation 0.4
Values 4.2 4.7
[98]
liver DUSP10
Mean 10.6
Standard deviation 2.1
Values 14 8.9 10 9.7
[99]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[100]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[101]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[102]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[103]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[104]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[105]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[106]
ref_hepatocyte TYK2
Mean 4.82
Standard deviation 1.6
Values 2.6 4 5.2 6.8 5.6
[107]
HepG2 TYK2
Mean 23.5
Standard deviation 0.9
Values 23 24
[108]
HepG2.C3A TYK2
Mean 26.8
Standard deviation 2.6
Values 29 25
[109]
HuH.7 TYK2
Mean 28.1
Standard deviation 8.5
Values 35 19 31
[110]
SNU475 TYK2
Mean 14.9
Standard deviation 0.21
Values 15 15
[111]
THLE TYK2
Mean 31.6
Standard deviation 1.6
Values 33 31
[112]
liver TYK2
Mean 27.2
Standard deviation 3.5
Values 31 24 24 30
[113]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[114]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[115]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[116]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[117]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[118]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[119]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[120]
ref_hepatocyte DUSP8
Mean 1.65
Standard deviation 1.8
Values 1.4 1.4 4.7 0.78 0
[121]
HepG2 DUSP8
Mean 8.05
Standard deviation 3
Values 10 5.9
[122]
HepG2.C3A DUSP8
Mean 4.84
Standard deviation 3.1
Values 7.1 2.6
[123]
HuH.7 DUSP8
Mean 2.64
Standard deviation 2.5
Values 1.2 5.5 1.2
[124]
SNU475 DUSP8
Mean 1.13
Standard deviation 0.22
Values 1.3 0.97
[125]
THLE DUSP8
Mean 1.88
Standard deviation 0.61
Values 2.3 1.5
[126]
liver DUSP8
Mean 0.165
Standard deviation 0.085
Values 0.12 0.086 0.18 0.28
[127]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 0 0 5.9 0.6 0.28
[128]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[129]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.082 0.083 0.1
[131]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 0.15 2.6
[132]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[133]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte DUSP7
Mean 1.21
Standard deviation 1.1
Values 1.2 0.72 3.1 0.56 0.45
[135]
HepG2 DUSP7
Mean 7.84
Standard deviation 0.41
Values 8.1 7.6
[136]
HepG2.C3A DUSP7
Mean 3.71
Standard deviation 0.37
Values 3.5 4
[137]
HuH.7 DUSP7
Mean 8.47
Standard deviation 1.7
Values 9.6 6.5 9.2
[138]
SNU475 DUSP7
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[139]
THLE DUSP7
Mean 9.74
Standard deviation 1.7
Values 8.5 11
[140]
liver DUSP7
Mean 1.76
Standard deviation 0.63
Values 2.3 1.3 1.2 2.3
[141]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[142]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[143]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[144]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[145]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[146]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[147]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[148]
ref_hepatocyte DUSP2
Mean 0.519
Standard deviation 0.46
Values 0 0.14 0.5 1 0.95
[149]
HepG2 DUSP2
Mean 0.169
Standard deviation 0.24
Values 0.34 0
[150]
HepG2.C3A DUSP2
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 DUSP2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[152]
SNU475 DUSP2
Mean 0.788
Standard deviation 0.35
Values 0.54 1
[153]
THLE DUSP2
Mean 0.913
Standard deviation 0.065
Values 0.96 0.87
[154]
liver DUSP2
Mean 0.762
Standard deviation 0.25
Values 0.75 0.74 1.1 0.48
[155]
ref_hepatocyte DUSP4
Mean 0.0303
Standard deviation 0.044
Values 0 0 0 0.095 0.057
[156]
HepG2 DUSP4
Mean 3.05
Standard deviation 2.7
Values 4.9 1.2
[157]
HepG2.C3A DUSP4
Mean 0.336
Standard deviation 0.0055
Values 0.34 0.33
[158]
HuH.7 DUSP4
Mean 19.3
Standard deviation 5.6
Values 23 13 22
[159]
SNU475 DUSP4
Mean 11.8
Standard deviation 7.2
Values 6.8 17
[160]
THLE DUSP4
Mean 3.18
Standard deviation 0.19
Values 3 3.3
[161]
liver DUSP4
Mean 0.614
Standard deviation 0.19
Values 0.45 0.73 0.46 0.82