REACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial -1.03[1] -1.32[2] -1.34[3] -1.89[4] -2.00[5] -1.44[6]
2 BAX Apoptosis regulator BAX [7] 0.35[8] -0.54[9] -0.92[10] -1.48[11] -1.13[12] -3.55[13]
3 GSDMD Gasdermin-D [14] -1.90[15] -1.18[16] -1.77[17] -1.14[18] -2.24[19] -0.25[20]
4 DIABLO Diablo homolog, mitochondrial [21] -0.13[22] 0.03[23] -0.19[24] -0.21[25] -0.48[26] -0.33[27]
5 CYCS Cytochrome c [28] 1.35[29] 1.45[30] 1.61[31] 1.46[32] 1.83[33] 1.72[34]
6 APIP Methylthioribulose-1-phosphate dehydratase [35] -1.65[36] -1.03[37] -0.73[38] -1.41[39] -1.97[40] -0.82[41]
7 CASP3 Caspase-3 [42] 0.15[43] 0.73[44] -1.73[45] -0.77[46] 0.19[47] -0.40[48]
8 MAPK1 Mitogen-activated protein kinase 1 [49] 1.73[50] 1.77[51] 1.68[52] 1.97[53] 1.59[54] 2.18[55]
9 CASP7 Caspase-7 [56] -0.29[57] -0.75[58] -0.23[59] -0.77[60] -0.60[61] -0.08[62]
10 BAK1 Bcl-2 homologous antagonist/killer [63] 0.91[64] 0.36[65] 0.41[66] 1.31[67] 0.76[68] -1.38[69]
11 AVEN Cell death regulator Aven [70] -0.96[71] -1.32[72] -3.32[73] -0.93[74] -0.87[75] -0.80[76]
12 MAPK3 Mitogen-activated protein kinase 3 [77] 1.87[78] 1.82[79] 1.94[80] 0.55[81] 0.53[82] -0.64[83]
13 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats [84] -0.28[85] 1.83[86] 1.97[87] 3.00[88] 1.64[89] 2.18[90]
14 XIAP E3 ubiquitin-protein ligase XIAP [91] 1.54[92] 2.03[93] 2.57[94] 2.72[95] 2.10[96] 3.09[97]
15 CASP9 Caspase-9 [98] 0.17[99] 1.04[100] 0.24[101] 0.37[102] -0.35[103] -0.13[104]
16 CARD8 Caspase recruitment domain-containing protein 8 [105] -0.17[106] 0.54[107] 1.75[108] 0.83[109] 0.82[110] 1.83[111]
17 APAF1 Apoptotic protease-activating factor 1 [112] 1.68[113] 2.01[114] 2.34[115] 2.75[116] 1.82[117] 1.89[118]
18 CDKN2A Cyclin-dependent kinase inhibitor 2A [119] 4.10[120] 1.77[121] 5.26[122] 5.33[123] 7.08[124] -1.75[125]
19 SEPTIN4 [126] [127] [128] [129] [130] [131] [132]
20 GSDME Gasdermin-E [133] [134] [135] [136] [137] [138] [139]
[1]
ref_hepatocyte C1QBP
Mean 101
Standard deviation 47
Values 85 1.2e+02 1.7e+02 84 44
[2]
HepG2 C1QBP
Mean 108
Standard deviation 11
Values 1.2e+02 1e+02
[3]
HepG2.C3A C1QBP
Mean 83.6
Standard deviation 25
Values 66 1e+02
[4]
HuH.7 C1QBP
Mean 74.6
Standard deviation 24
Values 79 49 96
[5]
SNU475 C1QBP
Mean 45.6
Standard deviation 3
Values 44 48
[6]
THLE C1QBP
Mean 48.9
Standard deviation 16
Values 37 60
[7]
liver C1QBP
Mean 40
Standard deviation 24
Values 55 22 66 17
[8]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 30 21 34 27 11
[9]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 80 58
[10]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 38 33
[11]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 26 14 34
[12]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 14 16
[13]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[14]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 2.3 2.5 2.9 1.4
[15]
ref_hepatocyte GSDMD
Mean 24
Standard deviation 21
Values 5.5 9.4 14 55 36
[16]
HepG2 GSDMD
Mean 14
Standard deviation 2.3
Values 12 16
[17]
HepG2.C3A GSDMD
Mean 22
Standard deviation 2.9
Values 24 20
[18]
HuH.7 GSDMD
Mean 13.3
Standard deviation 4.2
Values 14 8.8 17
[19]
SNU475 GSDMD
Mean 18.4
Standard deviation 3.2
Values 21 16
[20]
THLE GSDMD
Mean 9.83
Standard deviation 1.7
Values 11 8.6
[21]
liver GSDMD
Mean 21.7
Standard deviation 5.3
Values 29 16 19 23
[22]
ref_hepatocyte DIABLO
Mean 16.2
Standard deviation 5.1
Values 11 14 24 15 17
[23]
HepG2 DIABLO
Mean 32.4
Standard deviation 1.1
Values 32 33
[24]
HepG2.C3A DIABLO
Mean 34.5
Standard deviation 2.7
Values 33 36
[25]
HuH.7 DIABLO
Mean 26.8
Standard deviation 4.5
Values 26 23 32
[26]
SNU475 DIABLO
Mean 23.7
Standard deviation 0.05
Values 24 24
[27]
THLE DIABLO
Mean 22.5
Standard deviation 0.81
Values 22 23
[28]
liver DIABLO
Mean 13.9
Standard deviation 8.5
Values 22 7.3 21 5.8
[29]
ref_hepatocyte CYCS
Mean 14.3
Standard deviation 4.3
Values 16 19 7.5 15 14
[30]
HepG2 CYCS
Mean 79.8
Standard deviation 18
Values 67 93
[31]
HepG2.C3A CYCS
Mean 81.4
Standard deviation 39
Values 54 1.1e+02
[32]
HuH.7 CYCS
Mean 82.3
Standard deviation 19
Values 93 60 94
[33]
SNU475 CYCS
Mean 66.3
Standard deviation 0.99
Values 66 67
[34]
THLE CYCS
Mean 98.4
Standard deviation 7.6
Values 93 1e+02
[35]
liver CYCS
Mean 50.8
Standard deviation 34
Values 59 30 95 19
[36]
ref_hepatocyte APIP
Mean 13.7
Standard deviation 4.9
Values 21 15 7.6 11 14
[37]
HepG2 APIP
Mean 9.53
Standard deviation 0.68
Values 9 10
[38]
HepG2.C3A APIP
Mean 14
Standard deviation 2.8
Values 12 16
[39]
HuH.7 APIP
Mean 15.6
Standard deviation 6.5
Values 16 8.8 22
[40]
SNU475 APIP
Mean 8.67
Standard deviation 2.2
Values 10 7.1
[41]
THLE APIP
Mean 6.76
Standard deviation 0.32
Values 6.5 7
[42]
liver APIP
Mean 8.35
Standard deviation 5.9
Values 16 4.2 11 2.9
[43]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 33 13 6.8 4.9 5.1
[44]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 25 36
[45]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 27 59
[46]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 5.9 7.5 7.8
[47]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 13 12
[48]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[49]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 9.5 9 16 6.1
[50]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[51]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[52]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[53]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[54]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[55]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[56]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[57]
ref_hepatocyte CASP7
Mean 10
Standard deviation 4.1
Values 7.8 14 15 7.6 6
[58]
HepG2 CASP7
Mean 17.9
Standard deviation 4
Values 15 21
[59]
HepG2.C3A CASP7
Mean 12.4
Standard deviation 4
Values 9.5 15
[60]
HuH.7 CASP7
Mean 16.1
Standard deviation 1.8
Values 15 15 18
[61]
SNU475 CASP7
Mean 9.89
Standard deviation 0.26
Values 10 9.7
[62]
THLE CASP7
Mean 12.8
Standard deviation 0.29
Values 13 13
[63]
liver CASP7
Mean 10.2
Standard deviation 3.1
Values 14 6.6 9.7 10
[64]
ref_hepatocyte BAK1
Mean 6.08
Standard deviation 5.2
Values 2.6 8.3 14 2.7 2.6
[65]
HepG2 BAK1
Mean 24.9
Standard deviation 3.2
Values 27 23
[66]
HepG2.C3A BAK1
Mean 16.2
Standard deviation 1.2
Values 15 17
[67]
HuH.7 BAK1
Mean 15.2
Standard deviation 1.3
Values 16 14 16
[68]
SNU475 BAK1
Mean 25.4
Standard deviation 4.7
Values 29 22
[69]
THLE BAK1
Mean 19.9
Standard deviation 2.1
Values 18 21
[70]
liver BAK1
Mean 2.5
Standard deviation 0.66
Values 2.5 2.5 3.3 1.7
[71]
ref_hepatocyte AVEN
Mean 5.37
Standard deviation 2.6
Values 2.9 6 2.8 9.2 5.9
[72]
HepG2 AVEN
Mean 6.02
Standard deviation 1.2
Values 5.2 6.9
[73]
HepG2.C3A AVEN
Mean 4.47
Standard deviation 0.39
Values 4.2 4.7
[74]
HuH.7 AVEN
Mean 1.01
Standard deviation 0.28
Values 1 0.72 1.3
[75]
SNU475 AVEN
Mean 4.74
Standard deviation 1.1
Values 5.5 4
[76]
THLE AVEN
Mean 5.67
Standard deviation 1.7
Values 4.5 6.9
[77]
liver AVEN
Mean 3.31
Standard deviation 0.69
Values 4 3.1 2.4 3.6
[78]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[79]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[80]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[81]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[82]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[83]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[84]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[85]
ref_hepatocyte UACA
Mean 2.85
Standard deviation 2.7
Values 2.4 7.4 2.3 1 1
[86]
HepG2 UACA
Mean 5.11
Standard deviation 0.11
Values 5.2 5
[87]
HepG2.C3A UACA
Mean 21
Standard deviation 3.6
Values 18 24
[88]
HuH.7 UACA
Mean 21.1
Standard deviation 3
Values 20 24 19
[89]
SNU475 UACA
Mean 38.4
Standard deviation 0.9
Values 39 38
[90]
THLE UACA
Mean 17.2
Standard deviation 8.3
Values 23 11
[91]
liver UACA
Mean 13.9
Standard deviation 3.3
Values 13 17 16 9.8
[92]
ref_hepatocyte XIAP
Mean 2.63
Standard deviation 0.63
Values 2.6 3.3 2.1 1.9 3.2
[93]
HepG2 XIAP
Mean 16.7
Standard deviation 3.8
Values 14 19
[94]
HepG2.C3A XIAP
Mean 22.3
Standard deviation 5.6
Values 18 26
[95]
HuH.7 XIAP
Mean 29.4
Standard deviation 6.2
Values 34 31 22
[96]
SNU475 XIAP
Mean 29.2
Standard deviation 5.9
Values 33 25
[97]
THLE XIAP
Mean 21.9
Standard deviation 3.4
Values 19 24
[98]
liver XIAP
Mean 24
Standard deviation 7.9
Values 19 34 16 27
[99]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 1.9 1.9 2 2.7 4.4
[100]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 5.8 7
[101]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[102]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.7 4.1 6.6
[103]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 6.3 5
[104]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[105]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 2.4 1.9 4.2 1.6
[106]
ref_hepatocyte CARD8
Mean 2.48
Standard deviation 1.1
Values 1.5 2.2 4 3.1 1.6
[107]
HepG2 CARD8
Mean 4.79
Standard deviation 2.6
Values 2.9 6.7
[108]
HepG2.C3A CARD8
Mean 7.46
Standard deviation 0.12
Values 7.4 7.6
[109]
HuH.7 CARD8
Mean 15.7
Standard deviation 2.4
Values 18 13 16
[110]
SNU475 CARD8
Mean 7.44
Standard deviation 0.33
Values 7.2 7.7
[111]
THLE CARD8
Mean 8.44
Standard deviation 0.72
Values 7.9 8.9
[112]
liver CARD8
Mean 9.46
Standard deviation 1.7
Values 10 9.7 7.1 11
[113]
ref_hepatocyte APAF1
Mean 1.36
Standard deviation 0.48
Values 1.9 1.8 1.2 0.79 1.1
[114]
HepG2 APAF1
Mean 9.46
Standard deviation 4.9
Values 6 13
[115]
HepG2.C3A APAF1
Mean 11.3
Standard deviation 2.5
Values 9.5 13
[116]
HuH.7 APAF1
Mean 12.9
Standard deviation 2.1
Values 15 12 12
[117]
SNU475 APAF1
Mean 15.4
Standard deviation 1.9
Values 17 14
[118]
THLE APAF1
Mean 9.25
Standard deviation 1.4
Values 8.2 10
[119]
liver APAF1
Mean 5.4
Standard deviation 3.4
Values 2.4 8.5 2.5 8.2
[120]
ref_hepatocyte CDKN2A
Mean 0.323
Standard deviation 0.62
Values 1.4 0 0 0.13 0.065
[121]
HepG2 CDKN2A
Mean 12.1
Standard deviation 5.5
Values 16 8.2
[122]
HepG2.C3A CDKN2A
Mean 2.29
Standard deviation 0.19
Values 2.1 2.4
[123]
HuH.7 CDKN2A
Mean 23.3
Standard deviation 9
Values 24 14 32
[124]
SNU475 CDKN2A
Mean 21.9
Standard deviation 6.8
Values 27 17
[125]
THLE CDKN2A
Mean 84.5
Standard deviation 8.9
Values 78 91
[126]
liver CDKN2A
Mean 0.103
Standard deviation 0.079
Values 0.21 0.071 0.1 0.026
[127]
ref_hepatocyte SEPTIN4
Missing
[128]
HepG2 SEPTIN4
Missing
[129]
HepG2.C3A SEPTIN4
Missing
[130]
HuH.7 SEPTIN4
Missing
[131]
SNU475 SEPTIN4
Missing
[132]
THLE SEPTIN4
Missing
[133]
liver SEPTIN4
Missing
[134]
ref_hepatocyte GSDME
Missing
[135]
HepG2 GSDME
Missing
[136]
HepG2.C3A GSDME
Missing
[137]
HuH.7 GSDME
Missing
[138]
SNU475 GSDME
Missing
[139]
THLE GSDME
Missing
[140]
liver GSDME
Missing