REACTOME_RAC3_GTPASE_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | IL32 | Interleukin-32 | [1] | -2.78[2] | -3.38[3] | -7.00[4] | -6.95[5] | -7.94[6] | -3.81[7] |
2 | ITGB1 | Integrin beta-1 | [8] | 0.34[9] | 0.42[10] | 0.49[11] | 1.38[12] | 1.55[13] | 0.64[14] |
3 | CDC42 | Cell division control protein 42 homolog | [15] | -0.72[16] | 0.05[17] | -1.01[18] | -0.61[19] | -1.24[20] | -1.60[21] |
4 | RAB7A | Ras-related protein Rab-7a | [22] | -0.69[23] | -1.16[24] | -1.01[25] | -1.15[26] | -0.52[27] | -0.83[28] |
5 | BRK1 | Protein BRICK1 | [29] | -1.27[30] | -1.42[31] | -0.91[32] | -2.34[33] | -1.31[34] | -1.66[35] |
6 | LMAN1 | Protein ERGIC-53 | [36] | -0.08[37] | 1.10[38] | 1.05[39] | -0.05[40] | 0.51[41] | 2.22[42] |
7 | STBD1 | Starch-binding domain-containing protein 1 | [43] | -4.42[44] | -4.58[45] | -4.73[46] | -5.68[47] | -7.19[48] | -2.55[49] |
8 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [50] | -0.51[51] | -1.20[52] | -1.36[53] | -1.16[54] | -1.11[55] | -0.82[56] |
9 | CDC42EP1 | Cdc42 effector protein 1 | [57] | 0.26[58] | -0.49[59] | -0.21[60] | -2.65[61] | -0.78[62] | -0.12[63] |
10 | CAV1 | Caveolin-1 | [64] | -6.73[65] | -9.50[66] | -3.28[67] | 1.30[68] | 0.04[69] | -1.52[70] |
11 | VAMP3 | Vesicle-associated membrane protein 3 | [71] | 0.34[72] | 0.94[73] | 0.07[74] | 0.64[75] | 0.29[76] | -0.54[77] |
12 | YKT6 | Synaptobrevin homolog YKT6 | [78] | 0.50[79] | 0.17[80] | -0.42[81] | 0.43[82] | 0.29[83] | -1.43[84] |
13 | SNAP23 | Synaptosomal-associated protein 23 | [85] | 0.07[86] | 0.17[87] | -0.63[88] | -0.13[89] | -0.22[90] | -0.15[91] |
14 | FERMT2 | Fermitin family homolog 2 | [92] | -0.53[93] | -0.63[94] | -0.77[95] | 1.16[96] | 0.34[97] | 0.80[98] |
15 | ESYT1 | Extended synaptotagmin-1 | [99] | 1.26[100] | 0.69[101] | 0.52[102] | 0.65[103] | 0.92[104] | 1.54[105] |
16 | EMD | Emerin | [106] | -0.98[107] | -0.98[108] | -1.31[109] | -0.50[110] | -0.42[111] | -1.57[112] |
17 | PGRMC2 | Membrane-associated progesterone receptor component 2 | [113] | -0.22[114] | 0.58[115] | 0.16[116] | -0.55[117] | 0.32[118] | 0.22[119] |
18 | TFRC | Transferrin receptor protein 1 | [120] | 3.55[121] | 3.09[122] | 3.16[123] | 1.37[124] | 2.95[125] | 2.06[126] |
19 | CYBA | Cytochrome b-245 light chain | [127] | 1.60[128] | 1.69[129] | 0.53[130] | 0.14[131] | 0.12[132] | -0.93[133] |
20 | ABI1 | Abl interactor 1 | [134] | -0.67[135] | 0.35[136] | 0.36[137] | 0.62[138] | -0.23[139] | 0.37[140] |
21 | NCF2 | Neutrophil cytosol factor 2 | [141] | -1.70[142] | -4.35[143] | -8.17[144] | -2.96[145] | -9.49[146] | -1.94[147] |
22 | NCKAP1 | Nck-associated protein 1 | [148] | 1.27[149] | 2.33[150] | 2.37[151] | 2.72[152] | 2.47[153] | 1.84[154] |
23 | PAK2 | Serine/threonine-protein kinase PAK 2 | [155] | 1.56[156] | 1.36[157] | 1.59[158] | 0.68[159] | 1.31[160] | 1.84[161] |
24 | LBR | Lamin-B receptor | [162] | 0.85[163] | 1.61[164] | 2.41[165] | 1.26[166] | 0.40[167] | 1.26[168] |
25 | CYFIP1 | Cytoplasmic FMR1-interacting protein 1 | [169] | 1.38[170] | 1.02[171] | 0.60[172] | 1.05[173] | 0.89[174] | 1.80[175] |
26 | TMPO | Lamina-associated polypeptide 2, isoform alpha | [176] | 1.06[177] | 1.89[178] | 2.10[179] | 2.08[180] | 2.06[181] | 1.28[182] |
27 | BAIAP2L1 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 | 1.06[183] | 0.52[184] | 0.89[185] | -0.75[186] | -0.27[187] | 0.04[188] | |
28 | VAV2 | Guanine nucleotide exchange factor VAV2 | [189] | 1.41[190] | 1.71[191] | 1.15[192] | -0.61[193] | -0.10[194] | 0.99[195] |
29 | DSG2 | Desmoglein-2 | [196] | 1.76[197] | 2.28[198] | 1.42[199] | 2.47[200] | 2.09[201] | 1.02[202] |
30 | BAIAP2 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | [203] | -0.04[204] | -0.62[205] | -1.45[206] | 0.18[207] | 0.21[208] | 1.53[209] |
31 | ARHGAP1 | Rho GTPase-activating protein 17 | [210] | 0.60[211] | 0.82[212] | 0.09[213] | 0.29[214] | -0.05[215] | -0.29[216] |
32 | EPHA2 | Ephrin type-A receptor 2 | [217] | 2.36[218] | 2.62[219] | 0.39[220] | 0.86[221] | 1.51[222] | -0.30[223] |
33 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [224] | -0.36[225] | -0.19[226] | 0.84[227] | 1.99[228] | 1.58[229] | 3.48[230] |
34 | ARHGDIB | Rho GDP-dissociation inhibitor 2 | [231] | -4.94[232] | -5.09[233] | -6.10[234] | -1.68[235] | -1.16[236] | 1.21[237] |
35 | SLC1A5 | Neutral amino acid transporter B(0) | [238] | 3.73[239] | 2.98[240] | 2.84[241] | 3.12[242] | 2.40[243] | -1.45[244] |
36 | WASF2 | Wiskott-Aldrich syndrome protein family member 2 | [245] | 2.12[246] | 1.41[247] | 2.37[248] | 2.86[249] | 2.24[250] | 2.04[251] |
37 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [252] | 1.98[253] | 2.26[254] | 2.81[255] | 0.63[256] | 1.28[257] | 0.19[258] |
38 | GIT2 | ARF GTPase-activating protein GIT2 | [259] | 0.43[260] | 1.00[261] | 0.51[262] | 1.08[263] | 0.98[264] | 1.54[265] |
39 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [266] | 2.20[267] | 2.08[268] | 1.74[269] | 1.18[270] | 0.94[271] | 1.65[272] |
40 | PAK4 | Serine/threonine-protein kinase PAK 4 | [273] | 1.00[274] | 1.10[275] | 1.73[276] | 0.94[277] | 0.76[278] | 0.15[279] |
41 | TAOK3 | Serine/threonine-protein kinase TAO3 | [280] | -0.32[281] | 0.40[282] | 1.80[283] | 0.58[284] | 0.84[285] | 1.72[286] |
42 | VRK2 | Serine/threonine-protein kinase VRK2 | [287] | -0.95[288] | 0.24[289] | -1.00[290] | -0.28[291] | -0.55[292] | -0.11[293] |
43 | ARHGAP2 | Rho GTPase-activating protein 21 | [294] | 0.67[295] | 1.71[296] | 2.53[297] | 3.04[298] | 1.87[299] | 2.21[300] |
44 | ARHGAP3 | Rho GTPase-activating protein 35 | [301] | 2.45[302] | 2.64[303] | 3.12[304] | 2.66[305] | 2.33[306] | 3.74[307] |
45 | ARHGAP1 | Rho GTPase-activating protein 1 | [308] | 1.89[309] | 1.55[310] | 1.98[311] | 0.42[312] | 0.72[313] | 2.11[314] |
46 | TRIO | Triple functional domain protein | [315] | 2.11[316] | 1.89[317] | 2.08[318] | 2.53[319] | 3.51[320] | 3.23[321] |
47 | ARHGAP5 | Rho GTPase-activating protein 5 | [322] | 2.52[323] | 2.18[324] | 5.42[325] | 2.49[326] | 2.17[327] | 3.62[328] |
48 | BCR | Breakpoint cluster region protein | [329] | 2.34[330] | 1.64[331] | 1.83[332] | 0.94[333] | 1.41[334] | 2.18[335] |
49 | GIT1 | ARF GTPase-activating protein GIT1 | [336] | 2.08[337] | 2.01[338] | 1.36[339] | 1.88[340] | 1.68[341] | 0.01[342] |
50 | SWAP70 | Switch-associated protein 70 | [343] | 0.92[344] | 0.43[345] | 1.35[346] | 1.69[347] | 1.57[348] | 1.26[349] |
51 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [350] | -0.26[351] | 2.85[352] | 1.63[353] | 0.03[354] | -1.36[355] | -2.99[356] |
52 | MCAM | Cell surface glycoprotein MUC18 | [357] | 3.52[358] | 0.81[359] | -1.26[360] | 4.20[361] | 1.49[362] | 0.71[363] |
53 | OCRL | Inositol polyphosphate 5-phosphatase OCRL-1 | [364] | 2.17[365] | 2.54[366] | 2.95[367] | 2.32[368] | 2.33[369] | 1.75[370] |
54 | JAG1 | Protein jagged-1 | [371] | 4.89[372] | 3.53[373] | 2.93[374] | 1.44[375] | 0.17[376] | 1.53[377] |
55 | LEMD3 | Inner nuclear membrane protein Man1 | [378] | 1.01[379] | 2.04[380] | 1.93[381] | 1.14[382] | 1.71[383] | 1.94[384] |
56 | ABI2 | Abl interactor 2 | [385] | 1.79[386] | 2.55[387] | 2.80[388] | 2.64[389] | 2.75[390] | 2.08[391] |
57 | PAK1 | Serine/threonine-protein kinase PAK 1 | [392] | 0.10[393] | -0.61[394] | 1.74[395] | -1.93[396] | 1.94[397] | 0.75[398] |
58 | RACGAP1 | Rac GTPase-activating protein 1 | [399] | 2.21[400] | 2.73[401] | 2.91[402] | 3.10[403] | 3.74[404] | -0.23[405] |
59 | DEPDC1B | DEP domain-containing protein 1B | [406] | 1.29[407] | 2.88[408] | 3.04[409] | 0.93[410] | 1.56[411] | -2.51[412] |
60 | SRGAP2 | SLIT-ROBO Rho GTPase-activating protein 2 | [413] | 1.85[414] | 1.99[415] | 1.64[416] | 2.33[417] | 2.45[418] | 0.88[419] |
61 | DIAPH3 | Protein diaphanous homolog 3 | [420] | 0.07[421] | 1.21[422] | 1.64[423] | 1.48[424] | 2.43[425] | -2.11[426] |
62 | NOXA1 | NADPH oxidase activator 1 | [427] | -2.25[428] | -0.43[429] | -1.53[430] | -2.47[431] | -3.59[432] | -0.49[433] |
63 | NCF1 | Neutrophil cytosol factor 1 | [434] | -7.05[435] | -9.06[436] | [437] | [438] | -9.28[439] | -2.32[440] |
64 | WASF1 | Wiskott-Aldrich syndrome protein family member 1 | [441] | 1.45[442] | 1.18[443] | 2.47[444] | 1.08[445] | 1.82[446] | 0.87[447] |
65 | ARHGAP4 | Rho GTPase-activating protein 42 | [448] | -1.17[449] | -4.68[450] | -0.85[451] | 1.66[452] | 0.38[453] | 2.25[454] |
66 | CYBB | Cytochrome b-245 heavy chain | [455] | [456] | [457] | -10.11[458] | -4.55[459] | -10.01[460] | 3.53[461] |
67 | ABL2 | Abelson tyrosine-protein kinase 2 | [462] | 2.18[463] | 2.26[464] | 3.14[465] | 3.81[466] | 4.09[467] | 3.40[468] |
68 | MPP7 | MAGUK p55 subfamily member 7 | [469] | 0.20[470] | 2.83[471] | -1.77[472] | 3.25[473] | -1.77[474] | 1.62[475] |
69 | ARHGAP2 | Rho GTPase-activating protein 26 | [476] | 2.77[477] | 3.17[478] | 1.63[479] | 1.72[480] | 1.79[481] | 2.76[482] |
70 | SLITRK3 | SLIT and NTRK-like protein 3 | [483] | -8.66[484] | -5.39[485] | -4.62[486] | -9.35[487] | -6.09[488] | 1.78[489] |
71 | ABR | Active breakpoint cluster region-related protein | [490] | 4.06[491] | 3.69[492] | 3.16[493] | 3.35[494] | 4.15[495] | 2.32[496] |
72 | ARAP2 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 | -1.34[497] | 1.74[498] | -7.65[499] | -1.38[500] | 1.75[501] | 4.22[502] | |
73 | VANGL1 | Vang-like protein 1 | [503] | 3.08[504] | 2.57[505] | 1.94[506] | 4.13[507] | 3.90[508] | 3.18[509] |
74 | NCF4 | Neutrophil cytosol factor 4 | [510] | -5.66[511] | -7.92[512] | [513] | -8.13[514] | [515] | 1.39[516] |
75 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [517] | -4.59[518] | -1.86[519] | -7.11[520] | -1.44[521] | 0.70[522] | 3.83[523] |
76 | DOCK10 | Dedicator of cytokinesis protein 10 | [524] | -5.64[525] | -6.40[526] | -5.18[527] | 4.78[528] | 2.39[529] | 3.82[530] |
77 | OPHN1 | Oligophrenin-1 | [531] | 1.82[532] | 1.89[533] | 2.41[534] | 3.11[535] | 1.77[536] | 5.22[537] |
78 | NCKAP1L | Nck-associated protein 1-like | [538] | [539] | [540] | [541] | -4.08[542] | -5.45[543] | 3.57[544] |
79 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -0.31[545] | -6.08[546] | -3.83[547] | 5.03[548] | 3.47[549] | 4.69[550] | |
80 | ARHGAP3 | Rho GTPase-activating protein 32 | [551] | 3.84[552] | 3.69[553] | 2.70[554] | 4.39[555] | 3.05[556] | 4.65[557] |
81 | ARAP3 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | 0.94[558] | -3.08[559] | -0.80[560] | 2.56[561] | 4.21[562] | 3.20[563] | |
82 | ARHGAP1 | Rho GTPase-activating protein 15 | [564] | [565] | -6.73[566] | -5.24[567] | -2.89[568] | -7.95[569] | 3.32[570] |
83 | NOXO1 | NADPH oxidase organizer 1 | [571] | -0.39[572] | 0.97[573] | -1.78[574] | -2.58[575] | -2.25[576] | -0.24[577] |
84 | SYDE1 | Rho GTPase-activating protein SYDE1 | [578] | 4.30[579] | 2.47[580] | 3.21[581] | 4.39[582] | 5.49[583] | 2.64[584] |
85 | ARHGAP3 | Rho GTPase-activating protein 39 | [585] | 3.06[586] | 2.98[587] | 2.91[588] | 2.65[589] | 1.04[590] | 1.23[591] |
86 | AMIGO2 | Amphoterin-induced protein 2 | [592] | -1.20[593] | -0.98[594] | 4.85[595] | 6.06[596] | 5.53[597] | 3.50[598] |
87 | NHS | Nance-Horan syndrome protein | [599] | -1.01[600] | [601] | -1.59[602] | 4.80[603] | 3.92[604] | 3.48[605] |
88 | NOX1 | NADPH oxidase 1 | [606] | 0.47[607] | -0.25[608] | 4.86[609] | -0.14[610] | 1.33[611] | 1.32[612] |
89 | ARHGAP6 | Rho GTPase-activating protein 6 | [613] | [614] | -1.46[615] | -1.07[616] | 2.69[617] | 4.75[618] | 5.09[619] |
90 | SLITRK5 | SLIT and NTRK-like protein 5 | [620] | -1.80[621] | -0.68[622] | [623] | -0.40[624] | 7.05[625] | 0.47[626] |
91 | MCF2 | Proto-oncogene DBL | [627] | [628] | [629] | [630] | [631] | [632] | [633] |
92 | NOX3 | NADPH oxidase 3 | [634] | [635] | [636] | [637] | [638] | [639] | [640] |
93 | GARRE1 | [641] | [642] | [643] | [644] | [645] | [646] | [647] | |
94 | ERBIN | Erbin | [648] | [649] | [650] | [651] | [652] | [653] | [654] |