REACTOME_RAC2_GTPASE_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ITGB1 | Integrin beta-1 | [1] | -0.13[2] | -0.14[3] | 0.00[4] | 0.76[5] | 0.87[6] | 0.02[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -1.19[9] | -0.51[10] | -1.51[11] | -1.24[12] | -1.92[13] | -2.22[14] |
3 | RAB7A | Ras-related protein Rab-7a | [15] | -1.16[16] | -1.72[17] | -1.51[18] | -1.77[19] | -1.20[20] | -1.45[21] |
4 | ARHGDIA | Rho GDP-dissociation inhibitor 1 | [22] | -0.88[23] | -1.60[24] | -2.34[25] | -1.70[26] | -1.30[27] | -1.97[28] |
5 | BRK1 | Protein BRICK1 | [29] | -1.75[30] | -1.98[31] | -1.41[32] | -2.97[33] | -1.99[34] | -2.28[35] |
6 | LMAN1 | Protein ERGIC-53 | [36] | -0.55[37] | 0.53[38] | 0.55[39] | -0.67[40] | -0.17[41] | 1.60[42] |
7 | STBD1 | Starch-binding domain-containing protein 1 | [43] | -4.89[44] | -5.14[45] | -5.22[46] | -6.31[47] | -7.87[48] | -3.17[49] |
8 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [50] | -0.99[51] | -1.77[52] | -1.85[53] | -1.78[54] | -1.79[55] | -1.44[56] |
9 | CDC42EP1 | Cdc42 effector protein 1 | [57] | -0.22[58] | -1.05[59] | -0.70[60] | -3.28[61] | -1.46[62] | -0.75[63] |
10 | CAV1 | Caveolin-1 | [64] | -7.20[65] | -10.06[66] | -3.78[67] | 0.67[68] | -0.64[69] | -2.14[70] |
11 | VAMP3 | Vesicle-associated membrane protein 3 | [71] | -0.13[72] | 0.38[73] | -0.42[74] | 0.01[75] | -0.40[76] | -1.16[77] |
12 | SAMM50 | Sorting and assembly machinery component 50 homolog | [78] | -0.61[79] | -0.28[80] | -0.64[81] | -1.98[82] | -1.65[83] | -1.07[84] |
13 | ESYT1 | Extended synaptotagmin-1 | [85] | 0.78[86] | 0.13[87] | 0.03[88] | 0.02[89] | 0.24[90] | 0.92[91] |
14 | EMD | Emerin | [92] | -1.45[93] | -1.54[94] | -1.81[95] | -1.13[96] | -1.10[97] | -2.20[98] |
15 | PGRMC2 | Membrane-associated progesterone receptor component 2 | [99] | -0.69[100] | 0.02[101] | -0.34[102] | -1.18[103] | -0.36[104] | -0.40[105] |
16 | TFRC | Transferrin receptor protein 1 | [106] | 3.07[107] | 2.53[108] | 2.66[109] | 0.74[110] | 2.27[111] | 1.44[112] |
17 | CYBA | Cytochrome b-245 light chain | [113] | 1.13[114] | 1.13[115] | 0.04[116] | -0.49[117] | -0.56[118] | -1.56[119] |
18 | ARMCX3 | Armadillo repeat-containing X-linked protein 3 | [120] | -1.14[121] | -0.59[122] | 0.07[123] | -0.63[124] | -1.30[125] | 0.00[126] |
19 | ABI1 | Abl interactor 1 | [127] | -1.14[128] | -0.22[129] | -0.14[130] | -0.01[131] | -0.92[132] | -0.25[133] |
20 | NCF2 | Neutrophil cytosol factor 2 | [134] | -2.17[135] | -4.91[136] | -8.66[137] | -3.59[138] | -10.17[139] | -2.56[140] |
21 | NCKAP1 | Nck-associated protein 1 | [141] | 0.80[142] | 1.77[143] | 1.88[144] | 2.09[145] | 1.79[146] | 1.22[147] |
22 | MTX1 | Metaxin-1 | [148] | -0.42[149] | -0.47[150] | 0.32[151] | -0.51[152] | -0.80[153] | -0.77[154] |
23 | PAK2 | Serine/threonine-protein kinase PAK 2 | [155] | 1.08[156] | 0.79[157] | 1.10[158] | 0.05[159] | 0.63[160] | 1.22[161] |
24 | LBR | Lamin-B receptor | [162] | 0.37[163] | 1.05[164] | 1.91[165] | 0.63[166] | -0.28[167] | 0.64[168] |
25 | CYFIP1 | Cytoplasmic FMR1-interacting protein 1 | [169] | 0.91[170] | 0.46[171] | 0.10[172] | 0.42[173] | 0.21[174] | 1.18[175] |
26 | TMPO | Lamina-associated polypeptide 2, isoform alpha | [176] | 0.59[177] | 1.32[178] | 1.60[179] | 1.45[180] | 1.38[181] | 0.66[182] |
27 | BAIAP2L1 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 | 0.58[183] | -0.04[184] | 0.40[185] | -1.38[186] | -0.95[187] | -0.58[188] | |
28 | CDC42EP4 | Cdc42 effector protein 4 | [189] | 0.51[190] | -0.05[191] | 0.20[192] | -0.32[193] | -0.87[194] | 0.36[195] |
29 | VAV2 | Guanine nucleotide exchange factor VAV2 | [196] | 0.94[197] | 1.15[198] | 0.65[199] | -1.24[200] | -0.78[201] | 0.37[202] |
30 | DSG2 | Desmoglein-2 | [203] | 1.28[204] | 1.72[205] | 0.93[206] | 1.85[207] | 1.41[208] | 0.40[209] |
31 | ANKLE2 | Ankyrin repeat and LEM domain-containing protein 2 | [210] | -0.09[211] | 0.37[212] | 0.09[213] | 0.41[214] | 0.95[215] | -0.04[216] |
32 | ARHGAP1 | Rho GTPase-activating protein 17 | [217] | 0.13[218] | 0.26[219] | -0.41[220] | -0.33[221] | -0.73[222] | -0.91[223] |
33 | EPHA2 | Ephrin type-A receptor 2 | [224] | 1.89[225] | 2.06[226] | -0.10[227] | 0.24[228] | 0.83[229] | -0.92[230] |
34 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [231] | -0.83[232] | -0.75[233] | 0.35[234] | 1.36[235] | 0.90[236] | 2.86[237] |
35 | VAPB | Vesicle-associated membrane protein-associated protein B/C | [238] | 1.36[239] | 1.45[240] | 0.97[241] | 1.41[242] | 0.75[243] | 1.21[244] |
36 | WASF2 | Wiskott-Aldrich syndrome protein family member 2 | [245] | 1.65[246] | 0.85[247] | 1.87[248] | 2.23[249] | 1.56[250] | 1.42[251] |
37 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [252] | 1.51[253] | 1.70[254] | 2.32[255] | 0.00[256] | 0.60[257] | -0.43[258] |
38 | GIT2 | ARF GTPase-activating protein GIT2 | [259] | -0.04[260] | 0.44[261] | 0.02[262] | 0.46[263] | 0.30[264] | 0.92[265] |
39 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [266] | 1.49[267] | 1.00[268] | 1.42[269] | 3.27[270] | 3.15[271] | 1.88[272] |
40 | PAK4 | Serine/threonine-protein kinase PAK 4 | [273] | 0.53[274] | 0.53[275] | 1.24[276] | 0.32[277] | 0.08[278] | -0.47[279] |
41 | TAOK3 | Serine/threonine-protein kinase TAO3 | [280] | -0.79[281] | -0.16[282] | 1.31[283] | -0.04[284] | 0.16[285] | 1.10[286] |
42 | VRK2 | Serine/threonine-protein kinase VRK2 | [287] | -1.43[288] | -0.32[289] | -1.49[290] | -0.91[291] | -1.23[292] | -0.74[293] |
43 | ARHGAP2 | Rho GTPase-activating protein 21 | [294] | 0.20[295] | 1.15[296] | 2.04[297] | 2.41[298] | 1.19[299] | 1.59[300] |
44 | ARHGAP3 | Rho GTPase-activating protein 35 | [301] | 1.98[302] | 2.08[303] | 2.63[304] | 2.03[305] | 1.65[306] | 3.12[307] |
45 | ARHGAP1 | Rho GTPase-activating protein 1 | [308] | 1.42[309] | 0.99[310] | 1.49[311] | -0.21[312] | 0.03[313] | 1.49[314] |
46 | TRIO | Triple functional domain protein | [315] | 1.64[316] | 1.33[317] | 1.59[318] | 1.90[319] | 2.82[320] | 2.61[321] |
47 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [322] | -2.07[323] | -8.10[324] | -8.70[325] | -2.10[326] | 1.75[327] | -1.37[328] |
48 | BCR | Breakpoint cluster region protein | [329] | 1.86[330] | 1.07[331] | 1.34[332] | 0.31[333] | 0.73[334] | 1.56[335] |
49 | GIT1 | ARF GTPase-activating protein GIT1 | [336] | 1.61[337] | 1.45[338] | 0.86[339] | 1.25[340] | 1.00[341] | -0.61[342] |
50 | SWAP70 | Switch-associated protein 70 | [343] | 0.44[344] | -0.13[345] | 0.86[346] | 1.06[347] | 0.89[348] | 0.64[349] |
51 | MCAM | Cell surface glycoprotein MUC18 | [350] | 3.05[351] | 0.25[352] | -1.75[353] | 3.57[354] | 0.81[355] | 0.09[356] |
52 | DOCK1 | Dedicator of cytokinesis protein 1 | [357] | 1.62[358] | 2.12[359] | 2.11[360] | -3.35[361] | 1.49[362] | 2.38[363] |
53 | LEMD3 | Inner nuclear membrane protein Man1 | [364] | 0.53[365] | 1.48[366] | 1.43[367] | 0.52[368] | 1.03[369] | 1.32[370] |
54 | ABI2 | Abl interactor 2 | [371] | 1.31[372] | 1.99[373] | 2.30[374] | 2.01[375] | 2.07[376] | 1.46[377] |
55 | PAK1 | Serine/threonine-protein kinase PAK 1 | [378] | -0.37[379] | -1.17[380] | 1.25[381] | -2.56[382] | 1.26[383] | 0.13[384] |
56 | RACGAP1 | Rac GTPase-activating protein 1 | [385] | 1.73[386] | 2.17[387] | 2.42[388] | 2.47[389] | 3.06[390] | -0.85[391] |
57 | DEPDC1B | DEP domain-containing protein 1B | [392] | 0.82[393] | 2.32[394] | 2.54[395] | 0.30[396] | 0.88[397] | -3.13[398] |
58 | PLD2 | Phospholipase D2 | [399] | 0.59[400] | 1.08[401] | 0.98[402] | 0.05[403] | -0.06[404] | 0.76[405] |
59 | DIAPH3 | Protein diaphanous homolog 3 | [406] | -0.41[407] | 0.65[408] | 1.14[409] | 0.86[410] | 1.75[411] | -2.73[412] |
60 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.74[413] | 0.86[414] | 1.06[415] | 0.42[416] | 0.67[417] | 1.77[418] | |
61 | NCF1 | Neutrophil cytosol factor 1 | [419] | -7.52[420] | -9.62[421] | [422] | [423] | -9.96[424] | -2.94[425] |
62 | ARHGAP4 | Rho GTPase-activating protein 42 | [426] | -1.64[427] | -5.24[428] | -1.34[429] | 1.04[430] | -0.30[431] | 1.63[432] |
63 | DOCK4 | Dedicator of cytokinesis protein 4 | [433] | 2.24[434] | 1.84[435] | 2.06[436] | 1.62[437] | -0.02[438] | 3.52[439] |
64 | CYBB | Cytochrome b-245 heavy chain | [440] | [441] | [442] | -10.61[443] | -5.18[444] | -10.70[445] | 2.91[446] |
65 | DEF6 | Differentially expressed in FDCP 6 homolog | [447] | 1.49[448] | 1.73[449] | 0.16[450] | 1.29[451] | -3.74[452] | -0.68[453] |
66 | MPP7 | MAGUK p55 subfamily member 7 | [454] | -0.28[455] | 2.26[456] | -2.27[457] | 2.62[458] | -2.45[459] | 0.99[460] |
67 | ARHGAP2 | Rho GTPase-activating protein 26 | [461] | 2.30[462] | 2.61[463] | 1.13[464] | 1.09[465] | 1.11[466] | 2.14[467] |
68 | ABR | Active breakpoint cluster region-related protein | [468] | 3.59[469] | 3.12[470] | 2.67[471] | 2.73[472] | 3.47[473] | 1.69[474] |
69 | VANGL1 | Vang-like protein 1 | [475] | 2.61[476] | 2.01[477] | 1.44[478] | 3.51[479] | 3.22[480] | 2.55[481] |
70 | NCF4 | Neutrophil cytosol factor 4 | [482] | -6.13[483] | -8.48[484] | [485] | -8.76[486] | [487] | 0.77[488] |
71 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [489] | -5.06[490] | -2.43[491] | -7.61[492] | -2.06[493] | 0.02[494] | 3.20[495] |
72 | VAV3 | Guanine nucleotide exchange factor VAV3 | [496] | 1.45[497] | -0.30[498] | 1.88[499] | 2.98[500] | -2.96[501] | 1.21[502] |
73 | DOCK10 | Dedicator of cytokinesis protein 10 | [503] | -6.12[504] | -6.96[505] | -5.67[506] | 4.15[507] | 1.71[508] | 3.20[509] |
74 | OPHN1 | Oligophrenin-1 | [510] | 1.35[511] | 1.33[512] | 1.92[513] | 2.48[514] | 1.09[515] | 4.60[516] |
75 | NCKAP1L | Nck-associated protein 1-like | [517] | [518] | [519] | [520] | -4.70[521] | -6.13[522] | 2.95[523] |
76 | VAV1 | Proto-oncogene vav | [524] | -8.86[525] | -4.07[526] | -5.77[527] | -6.79[528] | -8.02[529] | 1.04[530] |
77 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [531] | 1.36[532] | 1.33[533] | 2.19[534] | 2.46[535] | 1.52[536] | 2.53[537] |
78 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -0.78[538] | -6.64[539] | -4.32[540] | 4.41[541] | 2.79[542] | 4.06[543] | |
79 | ARHGAP3 | Rho GTPase-activating protein 32 | [544] | 3.36[545] | 3.13[546] | 2.20[547] | 3.77[548] | 2.37[549] | 4.03[550] |
80 | DOCK2 | Dedicator of cytokinesis protein 2 | [551] | -4.81[552] | [553] | -7.00[554] | 1.78[555] | 0.71[556] | 4.19[557] |
81 | SYDE1 | Rho GTPase-activating protein SYDE1 | [558] | 3.83[559] | 1.91[560] | 2.72[561] | 3.76[562] | 4.81[563] | 2.01[564] |
82 | ARHGAP3 | Rho GTPase-activating protein 39 | [565] | 2.58[566] | 2.42[567] | 2.42[568] | 2.03[569] | 0.36[570] | 0.61[571] |
83 | DOCK3 | Dedicator of cytokinesis protein 3 | [572] | 0.36[573] | 0.23[574] | 1.14[575] | 4.32[576] | 0.81[577] | 2.88[578] |
84 | NHS | Nance-Horan syndrome protein | [579] | -1.48[580] | [581] | -2.08[582] | 4.18[583] | 3.24[584] | 2.86[585] |
85 | SLITRK5 | SLIT and NTRK-like protein 5 | [586] | -2.27[587] | -1.24[588] | [589] | -1.03[590] | 6.37[591] | -0.15[592] |
86 | ERBIN | Erbin | [593] | [594] | [595] | [596] | [597] | [598] | [599] |
87 | GARRE1 | [600] | [601] | [602] | [603] | [604] | [605] | [606] | |
88 | MCF2 | Proto-oncogene DBL | [607] | [608] | [609] | [610] | [611] | [612] | [613] |