REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -0.87[2] | -0.91[3] | -0.75[4] | -0.82[5] | -0.60[6] | -1.30[7] |
2 | GDI2 | Rab GDP dissociation inhibitor beta | [8] | -0.20[9] | 0.67[10] | -0.60[11] | -0.14[12] | -0.93[13] | -0.30[14] |
3 | RAB7A | Ras-related protein Rab-7a | [15] | -0.43[16] | -1.10[17] | -1.10[18] | -1.02[19] | -0.32[20] | -1.05[21] |
4 | RAB13 | Ras-related protein Rab-13 | [22] | -2.18[23] | -2.30[24] | -1.40[25] | -0.55[26] | -0.51[27] | -2.25[28] |
5 | RAB5C | Ras-related protein Rab-5C | [29] | 0.61[30] | -0.71[31] | -0.35[32] | -0.49[33] | -0.28[34] | -1.14[35] |
6 | RAB1A | Ras-related protein Rab-1A | [36] | 0.22[37] | 0.38[38] | -0.23[39] | -0.44[40] | -0.58[41] | -0.21[42] |
7 | TRAPPC5 | Trafficking protein particle complex subunit 5 | [43] | -2.22[44] | -2.47[45] | -3.11[46] | -3.51[47] | -2.55[48] | -1.30[49] |
8 | RAB1B | Ras-related protein Rab-1B | [50] | 0.21[51] | -0.72[52] | 0.83[53] | 0.48[54] | 0.10[55] | -0.30[56] |
9 | RAB10 | Ras-related protein Rab-10 | [57] | 0.12[58] | 0.23[59] | -0.33[60] | 0.10[61] | 0.10[62] | -0.40[63] |
10 | RAB32 | Ras-related protein Rab-32 | [64] | -0.82[65] | -1.52[66] | -3.43[67] | -2.18[68] | -1.40[69] | -1.46[70] |
11 | AKT1 | RAC-alpha serine/threonine-protein kinase | [71] | 0.45[72] | 0.07[73] | -1.21[74] | -0.01[75] | 0.19[76] | 0.01[77] |
12 | TRAPPC1 | Trafficking protein particle complex subunit 1 | [78] | -0.80[79] | -1.48[80] | -1.70[81] | -1.24[82] | -1.36[83] | -1.71[84] |
13 | RAB6A | Ras-related protein Rab-6A | [85] | 0.24[86] | -0.02[87] | -0.42[88] | -0.61[89] | -0.54[90] | 0.57[91] |
14 | RAB8A | Ras-related protein Rab-8A | [92] | -1.04[93] | -1.23[94] | -0.67[95] | -1.99[96] | -0.95[97] | -0.23[98] |
15 | TRAPPC2L | Trafficking protein particle complex subunit 2-like protein | [99] | -1.38[100] | -1.72[101] | -1.98[102] | -2.97[103] | -2.04[104] | -2.20[105] |
16 | TRAPPC3 | Trafficking protein particle complex subunit 3 | [106] | -0.31[107] | -0.74[108] | -1.16[109] | -1.10[110] | -0.62[111] | -1.85[112] |
17 | RAB14 | Ras-related protein Rab-14 | [113] | 0.53[114] | 0.64[115] | 1.16[116] | 0.65[117] | 0.94[118] | 1.39[119] |
18 | RAB18 | Ras-related protein Rab-18 | [120] | -0.16[121] | 0.82[122] | -0.21[123] | 1.49[124] | 0.52[125] | 0.83[126] |
19 | RAB12 | Ras-related protein Rab-12 | [127] | -1.47[128] | -1.02[129] | -1.15[130] | -0.39[131] | -0.69[132] | -0.82[133] |
20 | CCZ1 | Vacuolar fusion protein CCZ1 homolog | [134] | -4.49[135] | -4.71[136] | -3.73[137] | -4.07[138] | -4.14[139] | -3.13[140] |
21 | CCZ1B | Vacuolar fusion protein CCZ1 homolog B | [141] | -3.28[142] | -3.41[143] | -3.20[144] | -3.17[145] | -3.62[146] | -4.21[147] |
22 | RAB9A | Ras-related protein Rab-9A | [148] | -1.72[149] | -2.30[150] | -1.85[151] | -1.99[152] | -0.56[153] | -1.30[154] |
23 | GDI1 | Rab GDP dissociation inhibitor alpha | [155] | 0.67[156] | -0.25[157] | 0.08[158] | 0.95[159] | 1.21[160] | -0.40[161] |
24 | RAB5B | Ras-related protein Rab-5B | [162] | 0.68[163] | 1.38[164] | 1.05[165] | 1.11[166] | 1.16[167] | 1.12[168] |
25 | RAB5A | Ras-related protein Rab-5A | [169] | -0.50[170] | -0.48[171] | 0.35[172] | -0.20[173] | 0.35[174] | 0.07[175] |
26 | TRAPPC4 | Trafficking protein particle complex subunit 4 | [176] | 0.67[177] | 0.88[178] | -0.69[179] | -0.01[180] | 0.04[181] | -0.80[182] |
27 | TRAPPC6B | Trafficking protein particle complex subunit 6B | [183] | 0.03[184] | -0.37[185] | -0.36[186] | -0.58[187] | -0.24[188] | 0.34[189] |
28 | AKT2 | RAC-beta serine/threonine-protein kinase | [190] | 1.33[191] | 1.45[192] | 1.39[193] | 0.90[194] | 0.87[195] | 1.39[196] |
29 | TRAPPC6A | Trafficking protein particle complex subunit 6A | [197] | -1.77[198] | -1.16[199] | 0.27[200] | -2.76[201] | -3.34[202] | -0.46[203] |
30 | RAB35 | Ras-related protein Rab-35 | [204] | 1.06[205] | 1.00[206] | 0.25[207] | 0.74[208] | 0.81[209] | -0.97[210] |
31 | RAB21 | Ras-related protein Rab-21 | [211] | 0.09[212] | 0.26[213] | -0.30[214] | 0.13[215] | 0.67[216] | 0.09[217] |
32 | RAB27A | Ras-related protein Rab-27A | [218] | -1.11[219] | -0.66[220] | -0.88[221] | -0.42[222] | 0.93[223] | 0.90[224] |
33 | RAB3GAP | Rab3 GTPase-activating protein catalytic subunit | [225] | 1.47[226] | 1.78[227] | 1.98[228] | 1.46[229] | 1.74[230] | 1.07[231] |
34 | HPS1 | Hermansky-Pudlak syndrome 1 protein | [232] | 1.12[233] | 1.19[234] | 1.68[235] | -0.68[236] | 1.01[237] | 1.48[238] |
35 | ALS2 | Alsin | [239] | 0.85[240] | 1.19[241] | 1.65[242] | 1.00[243] | 1.04[244] | 2.01[245] |
36 | TRAPPC12 | Trafficking protein particle complex subunit 12 | [246] | 0.77[247] | 0.95[248] | 0.07[249] | 0.17[250] | -0.25[251] | 0.80[252] |
37 | DENND5A | DENN domain-containing protein 5A | [253] | 2.26[254] | 1.53[255] | 1.50[256] | 2.37[257] | 1.73[258] | 1.13[259] |
38 | MON1B | Vacuolar fusion protein MON1 homolog B | [260] | 1.17[261] | 0.94[262] | 1.12[263] | 0.40[264] | 0.58[265] | 1.05[266] |
39 | RABGEF1 | Rab5 GDP/GTP exchange factor | [267] | -0.07[268] | 0.38[269] | 0.36[270] | 0.46[271] | 0.42[272] | 0.16[273] |
40 | CHM | Rab proteins geranylgeranyltransferase component A 1 | [274] | 0.28[275] | 1.36[276] | -2.19[277] | 1.38[278] | 1.36[279] | 0.75[280] |
41 | RAB8B | Ras-related protein Rab-8B | [281] | 0.03[282] | 0.82[283] | 3.27[284] | 2.32[285] | 2.42[286] | 1.01[287] |
42 | TRAPPC8 | Trafficking protein particle complex subunit 8 | [288] | 0.47[289] | 1.88[290] | 0.63[291] | 1.85[292] | 1.70[293] | 2.99[294] |
43 | RAB3GAP | Rab3 GTPase-activating protein non-catalytic subunit | [295] | 1.15[296] | 1.94[297] | 2.39[298] | 2.40[299] | 1.79[300] | 2.48[301] |
44 | MON1A | Vacuolar fusion protein MON1 homolog A | [302] | -0.12[303] | 0.17[304] | -0.93[305] | -1.18[306] | -0.12[307] | 0.09[308] |
45 | ALS2CL | ALS2 C-terminal-like protein | [309] | -7.15[310] | -8.17[311] | 0.80[312] | -3.41[313] | -1.78[314] | 1.33[315] |
46 | DENND2D | DENN domain-containing protein 2D | [316] | -5.94[317] | -7.28[318] | -4.20[319] | -5.54[320] | -1.81[321] | 0.79[322] |
47 | HPS4 | Hermansky-Pudlak syndrome 4 protein | [323] | 1.21[324] | 1.48[325] | 2.17[326] | 1.08[327] | 0.69[328] | 1.24[329] |
48 | ULK1 | Serine/threonine-protein kinase ULK1 | [330] | 1.68[331] | 1.81[332] | 2.82[333] | 2.02[334] | 1.54[335] | 2.15[336] |
49 | SBF1 | Myotubularin-related protein 5 | [337] | 3.55[338] | 3.02[339] | 4.30[340] | 2.22[341] | 2.92[342] | 2.53[343] |
50 | ANKRD27 | Ankyrin repeat domain-containing protein 27 | [344] | 1.74[345] | 1.95[346] | 2.57[347] | 1.50[348] | 1.32[349] | 0.83[350] |
51 | TRAPPC2 | Trafficking protein particle complex subunit 2 | [351] | -1.06[352] | -0.23[353] | 0.62[354] | -0.40[355] | 0.24[356] | 0.62[357] |
52 | TRAPPC11 | Trafficking protein particle complex subunit 11 | [358] | 0.80[359] | 1.91[360] | -0.17[361] | 1.14[362] | 1.92[363] | 2.32[364] |
53 | RGP1 | RAB6A-GEF complex partner protein 2 | [365] | 0.59[366] | 0.04[367] | 0.58[368] | -0.29[369] | 0.60[370] | -0.09[371] |
54 | RIN3 | Ras and Rab interactor 3 | [372] | 1.46[373] | 0.32[374] | -1.53[375] | 0.43[376] | 0.17[377] | 0.97[378] |
55 | DENND1A | DENN domain-containing protein 1A | [379] | 1.67[380] | 2.01[381] | 2.41[382] | 0.96[383] | 0.53[384] | 1.84[385] |
56 | TRAPPC10 | Trafficking protein particle complex subunit 10 | [386] | 2.02[387] | 2.12[388] | 1.48[389] | 2.14[390] | 2.37[391] | 2.52[392] |
57 | GAPVD1 | GTPase-activating protein and VPS9 domain-containing protein 1 | [393] | 1.87[394] | 2.24[395] | 2.61[396] | 2.58[397] | 3.12[398] | 3.24[399] |
58 | DENND4A | C-myc promoter-binding protein | [400] | 1.57[401] | 2.99[402] | 2.88[403] | 0.91[404] | 1.28[405] | 3.25[406] |
59 | DENND4C | DENN domain-containing protein 4C | [407] | 2.03[408] | 2.22[409] | 2.77[410] | 1.77[411] | 2.22[412] | 3.66[413] |
60 | RINL | Ras and Rab interactor-like protein | [414] | 1.62[415] | 2.03[416] | -0.32[417] | -3.06[418] | -0.58[419] | -0.01[420] |
61 | DENND4B | DENN domain-containing protein 4B | [421] | 2.79[422] | 2.21[423] | 3.07[424] | 2.75[425] | 2.71[426] | 2.02[427] |
62 | CHML | Rab proteins geranylgeranyltransferase component A 2 | [428] | 0.95[429] | 2.09[430] | 1.95[431] | 3.21[432] | 1.66[433] | 1.30[434] |
63 | MADD | MAP kinase-activating death domain protein | [435] | 2.93[436] | 2.64[437] | 2.86[438] | 2.13[439] | 2.00[440] | 2.82[441] |
64 | DENND5B | DENN domain-containing protein 5B | [442] | 1.71[443] | 2.14[444] | 3.36[445] | 4.27[446] | 1.39[447] | 3.59[448] |
65 | TRAPPC9 | Trafficking protein particle complex subunit 9 | [449] | 1.73[450] | 0.77[451] | 1.76[452] | 0.73[453] | 0.43[454] | 2.46[455] |
66 | RAB3IP | Rab-3A-interacting protein | [456] | 1.52[457] | 2.62[458] | 2.20[459] | 1.23[460] | 1.04[461] | 2.86[462] |
67 | SBF2 | Myotubularin-related protein 13 | [463] | 2.88[464] | 2.88[465] | 3.24[466] | 2.92[467] | 1.79[468] | 3.82[469] |
68 | DENND1C | DENN domain-containing protein 1C | [470] | 2.22[471] | 1.58[472] | 1.30[473] | -2.97[474] | -6.19[475] | 0.56[476] |
69 | RAB3IL1 | Guanine nucleotide exchange factor for Rab-3A | [477] | 0.41[478] | -1.59[479] | 2.20[480] | 0.39[481] | 0.99[482] | 1.04[483] |
70 | RAB3A | Ras-related protein Rab-3A | [484] | 0.29[485] | -0.92[486] | 1.01[487] | -0.76[488] | -0.40[489] | -0.96[490] |
71 | RIN1 | Ras and Rab interactor 1 | [491] | 2.36[492] | 1.98[493] | -0.94[494] | 2.80[495] | 1.96[496] | -2.55[497] |
72 | RIN2 | Ras and Rab interactor 2 | [498] | 2.71[499] | 2.74[500] | 2.99[501] | 4.19[502] | 3.41[503] | 3.32[504] |
73 | DENND1B | DENN domain-containing protein 1B | [505] | 1.20[506] | 2.75[507] | 2.75[508] | 3.60[509] | 1.57[510] | 4.00[511] |
74 | RAB31 | Ras-related protein Rab-31 | [512] | 3.70[513] | -0.27[514] | 4.40[515] | 4.70[516] | 5.21[517] | 2.98[518] |
75 | RAB38 | Ras-related protein Rab-38 | [519] | -7.89[520] | -4.86[521] | -1.64[522] | -0.28[523] | -0.39[524] | -1.73[525] |
76 | AKT3 | RAC-gamma serine/threonine-protein kinase | [526] | -1.47[527] | -4.18[528] | -3.69[529] | 5.89[530] | 5.01[531] | 3.87[532] |
77 | DENND2C | DENN domain-containing protein 2C | [533] | -0.71[534] | -3.05[535] | -2.21[536] | 0.91[537] | 0.25[538] | 2.85[539] |
78 | RAB27B | Ras-related protein Rab-27B | [540] | -2.18[541] | -4.80[542] | 0.88[543] | 4.46[544] | 5.38[545] | 0.88[546] |
79 | DENND3 | DENN domain-containing protein 3 | [547] | 2.38[548] | 1.86[549] | 1.12[550] | 3.97[551] | 2.19[552] | 3.66[553] |
80 | RAB6B | Ras-related protein Rab-6B | [554] | 1.90[555] | 1.35[556] | 1.58[557] | 4.94[558] | 2.06[559] | 2.16[560] |
81 | RAB39B | Ras-related protein Rab-39B | [561] | 0.34[562] | -2.24[563] | 3.04[564] | -0.16[565] | 2.40[566] | 0.13[567] |
82 | RAB39A | Ras-related protein Rab-39A | [568] | [569] | [570] | -5.28[571] | 0.45[572] | -1.42[573] | 2.15[574] |
83 | DENND2A | DENN domain-containing protein 2A | [575] | 4.30[576] | 1.40[577] | 6.17[578] | 6.68[579] | 4.43[580] | 8.76[581] |
84 | DENND6B | Protein DENND6B | [582] | [583] | [584] | [585] | [586] | [587] | [588] |
85 | RAB9B | Ras-related protein Rab-9B | [589] | [590] | [591] | [592] | [593] | [594] | [595] |
86 | DENND2B | [596] | [597] | [598] | [599] | [600] | [601] | [602] | |
87 | TRAPPC13 | Trafficking protein particle complex subunit 13 | [603] | [604] | [605] | [606] | [607] | [608] | [609] |
88 | DENND6A | Protein DENND6A | [610] | [611] | [612] | [613] | [614] | [615] | [616] |
89 | RIC1 | RAB6A-GEF complex partner protein 1 | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | RAB7B | Ras-related protein Rab-7b | [624] | [625] | [626] | [627] | [628] | [629] | [630] |