REACTOME_PYROPTOSIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HMGB1 High mobility group protein B1 [1] 0.19[2] 0.89[3] 0.79[4] 0.85[5] 0.57[6] 0.53[7]
2 CHMP2A Charged multivesicular body protein 2a [8] -2.61[9] -3.13[10] -3.16[11] -1.83[12] -2.36[13] -1.05[14]
3 CHMP4B Charged multivesicular body protein 4b [15] -0.24[16] -0.87[17] -1.28[18] -0.28[19] -0.94[20] -3.47[21]
4 CASP4 Caspase-4 [22] -0.80[23] -1.21[24] -0.44[25] -0.96[26] -0.74[27] -1.19[28]
5 CHMP4A Charged multivesicular body protein 4a [29] 0.34[30] -1.76[31] -1.24[32] -1.57[33] -1.87[34] -1.10[35]
6 BAX Apoptosis regulator BAX [36] 0.82[37] -0.01[38] -0.32[39] -1.21[40] -0.59[41] -2.87[42]
7 GSDMD Gasdermin-D [43] -1.43[44] -0.65[45] -1.16[46] -0.87[47] -1.71[48] 0.43[49]
8 CYCS Cytochrome c [50] 1.82[51] 1.98[52] 2.22[53] 1.73[54] 2.36[55] 2.40[56]
9 IL18 Interleukin-18 [57] -0.37[58] -4.25[59] 0.05[60] -0.78[61] -1.21[62] -3.08[63]
10 CASP3 Caspase-3 [64] 0.62[65] 1.26[66] -1.13[67] -0.50[68] 0.73[69] 0.28[70]
11 CHMP2B Charged multivesicular body protein 2b [71] -0.53[72] 0.28[73] 1.18[74] -0.35[75] 0.51[76] 1.04[77]
12 CHMP3 Charged multivesicular body protein 3 [78] -1.84[79] -1.97[80] -2.50[81] -2.67[82] -2.88[83] -3.70[84]
13 CHMP6 Charged multivesicular body protein 6 [85] 0.13[86] 0.19[87] -1.63[88] -0.44[89] -0.96[90] 0.75[91]
14 IRF2 Interferon regulatory factor 2 [92] -0.60[93] -0.25[94] -1.26[95] -0.70[96] -0.41[97] 0.75[98]
15 IRF1 Interferon regulatory factor 1 [99] -0.02[100] -0.53[101] -0.23[102] 1.65[103] 0.88[104] 1.92[105]
16 BAK1 Bcl-2 homologous antagonist/killer [106] 1.38[107] 0.89[108] 1.01[109] 1.58[110] 1.29[111] -0.70[112]
17 TP53 Cellular tumor antigen p53 [113] 2.13[114] 1.65[115] 2.57[116] 1.69[117] 1.58[118] 1.05[119]
18 CHMP7 Charged multivesicular body protein 7 [120] 1.67[121] 1.25[122] 1.88[123] 1.10[124] 1.47[125] 1.93[126]
19 CHMP4C Charged multivesicular body protein 4c [127] 0.93[128] 0.92[129] -0.92[130] 0.01[131] -1.72[132] -0.42[133]
20 CASP1 Caspase-1 [134] -2.54[135] -5.98[136] -4.29[137] 0.48[138] 0.86[139] 0.35[140]
21 IL1B Interleukin-1 beta [141] -8.21[142] -8.11[143] -3.63[144] -3.20[145] 2.62[146] -4.11[147]
22 GZMB Granzyme B [148] -4.13[149] [150] [151] [152] [153] 0.38[154]
23 TP63 Tumor protein 63 [155] [156] [157] -1.46[158] -0.98[159] -4.33[160] -0.39[161]
24 IL1A Interleukin-1 alpha [162] 0.06[163] -0.37[164] -1.39[165] -0.25[166] 6.74[167] -0.50[168]
25 ELANE Neutrophil elastase [169] [170] [171] -1.83[172] -1.26[173] -3.62[174] 3.14[175]
26 CASP5 Caspase-5 [176] -3.42[177] [178] 1.24[179] -3.25[180] -1.95[181] 1.60[182]
27 GSDME Gasdermin-E [183] [184] [185] [186] [187] [188] [189]
[1]
ref_hepatocyte HMGB1
Mean 96.9
Standard deviation 78
Values 1.5e+02 2.1e+02 24 42 63
[2]
HepG2 HMGB1
Mean 174
Standard deviation 48
Values 1.4e+02 2.1e+02
[3]
HepG2.C3A HMGB1
Mean 259
Standard deviation 1.5e+02
Values 1.5e+02 3.7e+02
[4]
HuH.7 HMGB1
Mean 207
Standard deviation 1.1e+02
Values 2.5e+02 85 2.9e+02
[5]
SNU475 HMGB1
Mean 245
Standard deviation 23
Values 2.6e+02 2.3e+02
[6]
THLE HMGB1
Mean 191
Standard deviation 52
Values 1.5e+02 2.3e+02
[7]
liver HMGB1
Mean 93.7
Standard deviation 62
Values 1.7e+02 50 1.3e+02 34
[8]
ref_hepatocyte CHMP2A
Mean 74.2
Standard deviation 29
Values 26 74 1e+02 87 84
[9]
HepG2 CHMP2A
Mean 19.1
Standard deviation 1.2
Values 20 18
[10]
HepG2.C3A CHMP2A
Mean 12.2
Standard deviation 0.8
Values 13 12
[11]
HuH.7 CHMP2A
Mean 10.3
Standard deviation 2.8
Values 10 7.4 13
[12]
SNU475 CHMP2A
Mean 29.1
Standard deviation 4.8
Values 32 26
[13]
THLE CHMP2A
Mean 19.3
Standard deviation 1.4
Values 18 20
[14]
liver CHMP2A
Mean 23.9
Standard deviation 19
Values 37 8.7 43 6.8
[15]
ref_hepatocyte CHMP4B
Mean 62.5
Standard deviation 41
Values 62 69 1.3e+02 32 24
[16]
HepG2 CHMP4B
Mean 83.2
Standard deviation 7.7
Values 89 78
[17]
HepG2.C3A CHMP4B
Mean 49
Standard deviation 1.1
Values 50 48
[18]
HuH.7 CHMP4B
Mean 31.8
Standard deviation 9.8
Values 32 22 41
[19]
SNU475 CHMP4B
Mean 72
Standard deviation 10
Values 79 65
[20]
THLE CHMP4B
Mean 43.3
Standard deviation 7.3
Values 38 48
[21]
liver CHMP4B
Mean 3.76
Standard deviation 2.4
Values 2 6.6 1.5 4.9
[22]
ref_hepatocyte CASP4
Mean 32.7
Standard deviation 29
Values 6.5 15 55 72 16
[23]
HepG2 CASP4
Mean 29.5
Standard deviation 0.45
Values 29 30
[24]
HepG2.C3A CASP4
Mean 20.3
Standard deviation 2.9
Values 22 18
[25]
HuH.7 CASP4
Mean 29.7
Standard deviation 7.2
Values 23 37 29
[26]
SNU475 CASP4
Mean 23.6
Standard deviation 0.9
Values 23 24
[27]
THLE CASP4
Mean 26
Standard deviation 2.8
Values 24 28
[28]
liver CASP4
Mean 9.6
Standard deviation 4.3
Values 6.3 15 11 5.9
[29]
ref_hepatocyte CHMP4A
Mean 29.4
Standard deviation 16
Values 56 35 17 21 18
[30]
HepG2 CHMP4A
Mean 58.4
Standard deviation 2.2
Values 60 57
[31]
HepG2.C3A CHMP4A
Mean 12.4
Standard deviation 2.7
Values 11 14
[32]
HuH.7 CHMP4A
Mean 15.3
Standard deviation 5.6
Values 16 9.5 21
[33]
SNU475 CHMP4A
Mean 13.9
Standard deviation 2
Values 15 12
[34]
THLE CHMP4A
Mean 10.7
Standard deviation 0.89
Values 10 11
[35]
liver CHMP4A
Mean 9.16
Standard deviation 7.2
Values 14 3.6 16 2.4
[36]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 30 21 34 27 11
[37]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 80 58
[38]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 38 33
[39]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 26 14 34
[40]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 14 16
[41]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[42]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 2.3 2.5 2.9 1.4
[43]
ref_hepatocyte GSDMD
Mean 24
Standard deviation 21
Values 5.5 9.4 14 55 36
[44]
HepG2 GSDMD
Mean 14
Standard deviation 2.3
Values 12 16
[45]
HepG2.C3A GSDMD
Mean 22
Standard deviation 2.9
Values 24 20
[46]
HuH.7 GSDMD
Mean 13.3
Standard deviation 4.2
Values 14 8.8 17
[47]
SNU475 GSDMD
Mean 18.4
Standard deviation 3.2
Values 21 16
[48]
THLE GSDMD
Mean 9.83
Standard deviation 1.7
Values 11 8.6
[49]
liver GSDMD
Mean 21.7
Standard deviation 5.3
Values 29 16 19 23
[50]
ref_hepatocyte CYCS
Mean 14.3
Standard deviation 4.3
Values 16 19 7.5 15 14
[51]
HepG2 CYCS
Mean 79.8
Standard deviation 18
Values 67 93
[52]
HepG2.C3A CYCS
Mean 81.4
Standard deviation 39
Values 54 1.1e+02
[53]
HuH.7 CYCS
Mean 82.3
Standard deviation 19
Values 93 60 94
[54]
SNU475 CYCS
Mean 66.3
Standard deviation 0.99
Values 66 67
[55]
THLE CYCS
Mean 98.4
Standard deviation 7.6
Values 93 1e+02
[56]
liver CYCS
Mean 50.8
Standard deviation 34
Values 59 30 95 19
[57]
ref_hepatocyte IL18
Mean 13.1
Standard deviation 19
Values 0 45 18 0.77 2
[58]
HepG2 IL18
Mean 15.9
Standard deviation 5.6
Values 20 12
[59]
HepG2.C3A IL18
Mean 0.993
Standard deviation 0.7
Values 0.5 1.5
[60]
HuH.7 IL18
Mean 16.7
Standard deviation 4.3
Values 13 21 16
[61]
SNU475 IL18
Mean 10.7
Standard deviation 5.7
Values 6.7 15
[62]
THLE IL18
Mean 7.57
Standard deviation 2
Values 6.2 9
[63]
liver IL18
Mean 1.04
Standard deviation 0.48
Values 1.4 0.56 1.5 0.7
[64]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 33 13 6.8 4.9 5.1
[65]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 25 36
[66]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 27 59
[67]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 5.9 7.5 7.8
[68]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 13 12
[69]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[70]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 9.5 9 16 6.1
[71]
ref_hepatocyte CHMP2B
Mean 12.3
Standard deviation 3.6
Values 11 15 17 8 11
[72]
HepG2 CHMP2B
Mean 13.4
Standard deviation 3.4
Values 11 16
[73]
HepG2.C3A CHMP2B
Mean 21.5
Standard deviation 3.4
Values 19 24
[74]
HuH.7 CHMP2B
Mean 34.6
Standard deviation 3
Values 33 33 38
[75]
SNU475 CHMP2B
Mean 13.5
Standard deviation 0.64
Values 14 13
[76]
THLE CHMP2B
Mean 23.4
Standard deviation 2.8
Values 21 25
[77]
liver CHMP2B
Mean 17
Standard deviation 12
Values 32 8.9 20 6.5
[78]
ref_hepatocyte CHMP3
Mean 10.5
Standard deviation 7.5
Values 23 11 6.4 6.8 5.1
[79]
HepG2 CHMP3
Mean 4.61
Standard deviation 0.42
Values 4.3 4.9
[80]
HepG2.C3A CHMP3
Mean 3.85
Standard deviation 0.94
Values 3.2 4.5
[81]
HuH.7 CHMP3
Mean 2.29
Standard deviation 0.16
Values 2.3 2.5 2.1
[82]
SNU475 CHMP3
Mean 2.3
Standard deviation 1.2
Values 3.1 1.5
[83]
THLE CHMP3
Mean 1.9
Standard deviation 0.61
Values 1.5 2.3
[84]
liver CHMP3
Mean 0.539
Standard deviation 0.63
Values 1.3 0 0.82 0.04
[85]
ref_hepatocyte CHMP6
Mean 9.63
Standard deviation 3.2
Values 6 6.6 11 12 13
[86]
HepG2 CHMP6
Mean 16.5
Standard deviation 0.51
Values 16 17
[87]
HepG2.C3A CHMP6
Mean 15.8
Standard deviation 1.5
Values 15 17
[88]
HuH.7 CHMP6
Mean 3.85
Standard deviation 0.76
Values 4.3 3 4.3
[89]
SNU475 CHMP6
Mean 9.94
Standard deviation 1.8
Values 11 8.6
[90]
THLE CHMP6
Mean 6.58
Standard deviation 1.3
Values 5.7 7.5
[91]
liver CHMP6
Mean 10.8
Standard deviation 7.8
Values 19 4.1 16 4.1
[92]
ref_hepatocyte IRF2
Mean 9.14
Standard deviation 2.1
Values 8 6.7 8.3 11 11
[93]
HepG2 IRF2
Mean 9.46
Standard deviation 0.75
Values 8.9 10
[94]
HepG2.C3A IRF2
Mean 11
Standard deviation 2.2
Values 13 9.5
[95]
HuH.7 IRF2
Mean 4.73
Standard deviation 1.6
Values 4.1 6.5 3.6
[96]
SNU475 IRF2
Mean 7.85
Standard deviation 1.6
Values 9 6.7
[97]
THLE IRF2
Mean 9.18
Standard deviation 0.46
Values 8.9 9.5
[98]
liver IRF2
Mean 10.2
Standard deviation 4.5
Values 17 7.3 9.6 7.3
[99]
ref_hepatocyte IRF1
Mean 6.09
Standard deviation 3.2
Values 3.2 4.7 11 7.1 4.2
[100]
HepG2 IRF1
Mean 9.46
Standard deviation 1.7
Values 8.2 11
[101]
HepG2.C3A IRF1
Mean 6.08
Standard deviation 0.89
Values 6.7 5.4
[102]
HuH.7 IRF1
Mean 6.43
Standard deviation 1.6
Values 5.1 8.1 6.1
[103]
SNU475 IRF1
Mean 26.8
Standard deviation 8.1
Values 32 21
[104]
THLE IRF1
Mean 15
Standard deviation 0.58
Values 15 15
[105]
liver IRF1
Mean 15.4
Standard deviation 7.2
Values 23 6.7 19 13
[106]
ref_hepatocyte BAK1
Mean 6.08
Standard deviation 5.2
Values 2.6 8.3 14 2.7 2.6
[107]
HepG2 BAK1
Mean 24.9
Standard deviation 3.2
Values 27 23
[108]
HepG2.C3A BAK1
Mean 16.2
Standard deviation 1.2
Values 15 17
[109]
HuH.7 BAK1
Mean 15.2
Standard deviation 1.3
Values 16 14 16
[110]
SNU475 BAK1
Mean 25.4
Standard deviation 4.7
Values 29 22
[111]
THLE BAK1
Mean 19.9
Standard deviation 2.1
Values 18 21
[112]
liver BAK1
Mean 2.5
Standard deviation 0.66
Values 2.5 2.5 3.3 1.7
[113]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[114]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[115]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[116]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[117]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[118]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[119]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[120]
ref_hepatocyte CHMP7
Mean 4.42
Standard deviation 1.3
Values 3.1 4.2 5.9 5.6 3.2
[121]
HepG2 CHMP7
Mean 22.1
Standard deviation 0.65
Values 23 22
[122]
HepG2.C3A CHMP7
Mean 15.1
Standard deviation 1.3
Values 14 16
[123]
HuH.7 CHMP7
Mean 20.1
Standard deviation 3.1
Values 22 17 22
[124]
SNU475 CHMP7
Mean 13.3
Standard deviation 0.56
Values 14 13
[125]
THLE CHMP7
Mean 16.3
Standard deviation 0.34
Values 17 16
[126]
liver CHMP7
Mean 11.2
Standard deviation 2.7
Values 13 9.2 14 8.6
[127]
ref_hepatocyte CHMP4C
Mean 4.03
Standard deviation 2.6
Values 3 3 8.6 3.1 2.5
[128]
HepG2 CHMP4C
Mean 12.1
Standard deviation 0.24
Values 12 12
[129]
HepG2.C3A CHMP4C
Mean 11
Standard deviation 1
Values 10 12
[130]
HuH.7 CHMP4C
Mean 2.63
Standard deviation 0.45
Values 2.1 3 2.8
[131]
SNU475 CHMP4C
Mean 5.67
Standard deviation 0.49
Values 6 5.3
[132]
THLE CHMP4C
Mean 1.63
Standard deviation 0.24
Values 1.8 1.5
[133]
liver CHMP4C
Mean 2.01
Standard deviation 1.6
Values 4.1 0.73 2.3 0.87
[134]
ref_hepatocyte CASP1
Mean 3.66
Standard deviation 3.7
Values 0.5 9.1 0.076 3.7 4.9
[135]
HepG2 CASP1
Mean 0.987
Standard deviation 0.74
Values 0.46 1.5
[136]
HepG2.C3A CASP1
Mean 0.0833
Standard deviation 0.049
Values 0.049 0.12
[137]
HuH.7 CASP1
Mean 0.231
Standard deviation 0.041
Values 0.19 0.27 0.23
[138]
SNU475 CASP1
Mean 7.12
Standard deviation 0.23
Values 7.3 6.9
[139]
THLE CASP1
Mean 8.87
Standard deviation 1.2
Values 9.7 8
[140]
liver CASP1
Mean 3.13
Standard deviation 0.99
Values 3.7 2.6 4.2 2
[141]
ref_hepatocyte IL1B
Mean 3.09
Standard deviation 5.4
Values 0 0.08 13 2 0.76
[142]
HepG2 IL1B
Mean 0.0165
Standard deviation 0.017
Values 0.029 0.0043
[143]
HepG2.C3A IL1B
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[144]
HuH.7 IL1B
Mean 0.309
Standard deviation 0.06
Values 0.25 0.37 0.3
[145]
SNU475 IL1B
Mean 0.472
Standard deviation 0.21
Values 0.32 0.62
[146]
THLE IL1B
Mean 25.4
Standard deviation 8.5
Values 31 19
[147]
liver IL1B
Mean 0.12
Standard deviation 0.051
Values 0.14 0.11 0.051 0.17
[148]
ref_hepatocyte GZMB
Mean 0.318
Standard deviation 0.4
Values 0 0.39 0.23 0 0.98
[149]
HepG2 GZMB
Mean 0.0286
Standard deviation 0.0081
Values 0.023 0.034
[150]
HepG2.C3A GZMB
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GZMB
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 GZMB
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE GZMB
Mean 0
Standard deviation 0
Values 0 0
[154]
liver GZMB
Mean 0.276
Standard deviation 0.29
Values 0.59 0.029 0.46 0.026
[155]
ref_hepatocyte TP63
Mean 0.0845
Standard deviation 0.17
Values 0 0.026 0.4 0 0
[156]
HepG2 TP63
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A TP63
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 TP63
Mean 0.038
Standard deviation 0.033
Values 0 0.058 0.056
[159]
SNU475 TP63
Mean 0.06
Standard deviation 0.059
Values 0.019 0.1
[160]
THLE TP63
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[161]
liver TP63
Mean 0.0431
Standard deviation 0.045
Values 0.024 0.043 0 0.11
[162]
ref_hepatocyte IL1A
Mean 0.05
Standard deviation 0.11
Values 0 0 0.25 0 0
[163]
HepG2 IL1A
Mean 0.0823
Standard deviation 0.035
Values 0.057 0.11
[164]
HepG2.C3A IL1A
Mean 0.0555
Standard deviation 0.018
Values 0.068 0.043
[165]
HuH.7 IL1A
Mean 0.0235
Standard deviation 0.041
Values 0 0.071 0
[166]
SNU475 IL1A
Mean 0.0589
Standard deviation 0.024
Values 0.042 0.076
[167]
THLE IL1A
Mean 7.11
Standard deviation 1.8
Values 8.4 5.8
[168]
liver IL1A
Mean 0.0237
Standard deviation 0.034
Values 0.024 0.071 0 0
[169]
ref_hepatocyte ELANE
Mean 0.0489
Standard deviation 0.071
Values 0 0 0 0.16 0.089
[170]
HepG2 ELANE
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A ELANE
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 ELANE
Mean 0.017
Standard deviation 0.011
Values 0.016 0.0064 0.028
[173]
SNU475 ELANE
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[174]
THLE ELANE
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[175]
liver ELANE
Mean 0.288
Standard deviation 0.34
Values 0.35 0.029 0.74 0.026
[176]
ref_hepatocyte CASP5
Mean 0.0488
Standard deviation 0.11
Values 0 0 0 0 0.24
[177]
HepG2 CASP5
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[178]
HepG2.C3A CASP5
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 CASP5
Mean 0.143
Standard deviation 0.14
Values 0.033 0.3 0.094
[180]
SNU475 CASP5
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[181]
THLE CASP5
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[182]
liver CASP5
Mean 0.0989
Standard deviation 0.032
Values 0.12 0.057 0.13 0.093
[183]
ref_hepatocyte GSDME
Missing
[184]
HepG2 GSDME
Missing
[185]
HepG2.C3A GSDME
Missing
[186]
HuH.7 GSDME
Missing
[187]
SNU475 GSDME
Missing
[188]
THLE GSDME
Missing
[189]
liver GSDME
Missing