REACTOME_PYRIMIDINE_CATABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DPYS Dihydropyrimidinase [1] [2] [3] -13.99[4] -9.66[5] [6] 0.50[7]
2 TYMP Thymidine phosphorylase [8] -0.48[9] -1.61[10] -5.08[11] -5.60[12] -3.66[13] -2.42[14]
3 UPB1 Beta-ureidopropionase [15] -4.32[16] -3.68[17] -2.51[18] -5.10[19] -10.81[20] -0.21[21]
4 AGXT2 Alanine--glyoxylate aminotransferase 2, mitochondrial [22] -5.54[23] -8.19[24] 0.57[25] -7.28[26] -9.27[27] -0.03[28]
5 NT5C 5'(3')-deoxyribonucleotidase, cytosolic type [29] 2.74[30] 1.99[31] 0.41[32] 1.88[33] 1.34[34] -2.19[35]
6 UPP1 Uridine phosphorylase 1 [36] 1.63[37] -0.17[38] -0.39[39] 1.57[40] 1.92[41] -2.43[42]
7 NT5E 5'-nucleotidase [43] 2.83[44] 4.56[45] 4.06[46] 2.67[47] 4.12[48] 1.14[49]
8 DPYD Dihydropyrimidine dehydrogenase [NADP(+)] [50] -0.84[51] -1.61[52] 3.52[53] 4.09[54] 2.86[55] 3.14[56]
9 UPP2 Uridine phosphorylase 2 [57] -3.34[58] [59] -3.15[60] [61] -5.68[62] 1.14[63]
10 NT5M 5'(3')-deoxyribonucleotidase, mitochondrial [64] 3.61[65] 3.42[66] 2.45[67] 4.68[68] 2.98[69] -1.51[70]
11 NT5C3A Cytosolic 5'-nucleotidase 3A [71] [72] [73] [74] [75] [76] [77]
12 NT5C1A Cytosolic 5'-nucleotidase 1A [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte DPYS
Mean 68
Standard deviation 1e+02
Values 0 3.8 1.4 96 2.4e+02
[2]
HepG2 DPYS
Mean 0
Standard deviation 0
Values 0 0
[3]
HepG2.C3A DPYS
Mean 0
Standard deviation 0
Values 0 0
[4]
HuH.7 DPYS
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[5]
SNU475 DPYS
Mean 0.0152
Standard deviation 0.022
Values 0 0.03
[6]
THLE DPYS
Mean 0
Standard deviation 0
Values 0 0
[7]
liver DPYS
Mean 161
Standard deviation 36
Values 1.6e+02 2.1e+02 1.2e+02 1.6e+02
[8]
ref_hepatocyte TYMP
Mean 63.3
Standard deviation 55
Values 1.8 1.5e+02 70 56 38
[9]
HepG2 TYMP
Mean 5.73
Standard deviation 3.7
Values 8.4 3.1
[10]
HepG2.C3A TYMP
Mean 7.77
Standard deviation 1.5
Values 8.9 6.7
[11]
HuH.7 TYMP
Mean 0.958
Standard deviation 0.51
Values 0.41 1.4 1
[12]
SNU475 TYMP
Mean 0.235
Standard deviation 0.14
Values 0.33 0.14
[13]
THLE TYMP
Mean 1.49
Standard deviation 0.28
Values 1.3 1.7
[14]
liver TYMP
Mean 19.9
Standard deviation 5.7
Values 17 19 15 28
[15]
ref_hepatocyte UPB1
Mean 34.1
Standard deviation 46
Values 0.23 4 8 52 1.1e+02
[16]
HepG2 UPB1
Mean 0.216
Standard deviation 0.0023
Values 0.22 0.21
[17]
HepG2.C3A UPB1
Mean 1
Standard deviation 0.041
Values 0.97 1
[18]
HuH.7 UPB1
Mean 3.08
Standard deviation 0.98
Values 3.2 2 4
[19]
SNU475 UPB1
Mean 0.181
Standard deviation 0.11
Values 0.26 0.1
[20]
THLE UPB1
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[21]
liver UPB1
Mean 49.6
Standard deviation 25
Values 75 30 67 26
[22]
ref_hepatocyte AGXT2
Mean 23.4
Standard deviation 33
Values 0 0.88 1.4 43 72
[23]
HepG2 AGXT2
Mean 0.0637
Standard deviation 0.05
Values 0.029 0.099
[24]
HepG2.C3A AGXT2
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[25]
HuH.7 AGXT2
Mean 17.8
Standard deviation 1.5
Values 16 18 19
[26]
SNU475 AGXT2
Mean 0.0272
Standard deviation 0.019
Values 0.014 0.041
[27]
THLE AGXT2
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[28]
liver AGXT2
Mean 38.5
Standard deviation 15
Values 50 25 54 25
[29]
ref_hepatocyte NT5C
Mean 14.1
Standard deviation 2
Values 12 16 16 12 14
[30]
HepG2 NT5C
Mean 11.9
Standard deviation 0.64
Values 12 11
[31]
HepG2.C3A NT5C
Mean 21
Standard deviation 3.6
Values 24 19
[32]
HuH.7 NT5C
Mean 9.58
Standard deviation 3.9
Values 8.1 6.7 14
[33]
SNU475 NT5C
Mean 9.37
Standard deviation 2.2
Values 11 7.8
[34]
THLE NT5C
Mean 10.5
Standard deviation 0.81
Values 9.9 11
[35]
liver NT5C
Mean 5.18
Standard deviation 4
Values 8.2 1.9 9.2 1.5
[36]
ref_hepatocyte UPP1
Mean 12.8
Standard deviation 18
Values 0.33 9.2 44 7 3.2
[37]
HepG2 UPP1
Mean 4.99
Standard deviation 3.1
Values 7.2 2.8
[38]
HepG2.C3A UPP1
Mean 4.26
Standard deviation 0.42
Values 4 4.6
[39]
HuH.7 UPP1
Mean 4.99
Standard deviation 0.45
Values 4.9 4.6 5.5
[40]
SNU475 UPP1
Mean 6.88
Standard deviation 4.7
Values 3.6 10
[41]
THLE UPP1
Mean 14.3
Standard deviation 0.9
Values 14 15
[42]
liver UPP1
Mean 3.98
Standard deviation 3
Values 4.1 2.2 8.1 1.5
[43]
ref_hepatocyte NT5E
Mean 5.59
Standard deviation 3.2
Values 0.3 5.8 8.3 5.6 8
[44]
HepG2 NT5E
Mean 5.01
Standard deviation 1.5
Values 4 6
[45]
HepG2.C3A NT5E
Mean 49.3
Standard deviation 7.9
Values 55 44
[46]
HuH.7 NT5E
Mean 47.8
Standard deviation 5.7
Values 53 42 49
[47]
SNU475 NT5E
Mean 6.43
Standard deviation 1.3
Values 5.5 7.4
[48]
THLE NT5E
Mean 28.7
Standard deviation 11
Values 21 36
[49]
liver NT5E
Mean 20.8
Standard deviation 5.2
Values 23 19 14 26
[50]
ref_hepatocyte DPYD
Mean 5.41
Standard deviation 7.8
Values 0.66 1.2 0.79 5.5 19
[51]
HepG2 DPYD
Mean 0.381
Standard deviation 0.23
Values 0.22 0.54
[52]
HepG2.C3A DPYD
Mean 0.663
Standard deviation 0.13
Values 0.76 0.57
[53]
HuH.7 DPYD
Mean 31.7
Standard deviation 5.8
Values 29 38 28
[54]
SNU475 DPYD
Mean 16.6
Standard deviation 0.43
Values 17 16
[55]
THLE DPYD
Mean 11.6
Standard deviation 1
Values 11 12
[56]
liver DPYD
Mean 80.3
Standard deviation 30
Values 69 93 45 1.1e+02
[57]
ref_hepatocyte UPP2
Mean 0.919
Standard deviation 1.8
Values 0 0 0.2 4.1 0.33
[58]
HepG2 UPP2
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[59]
HepG2.C3A UPP2
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 UPP2
Mean 0.053
Standard deviation 0.014
Values 0.057 0.064 0.037
[61]
SNU475 UPP2
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE UPP2
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[63]
liver UPP2
Mean 3.41
Standard deviation 4.2
Values 9.7 1.8 1.5 0.62
[64]
ref_hepatocyte NT5M
Mean 0.313
Standard deviation 0.22
Values 0.073 0.075 0.43 0.53 0.46
[65]
HepG2 NT5M
Mean 0.483
Standard deviation 0.34
Values 0.72 0.24
[66]
HepG2.C3A NT5M
Mean 1.26
Standard deviation 0.57
Values 1.7 0.86
[67]
HuH.7 NT5M
Mean 0.875
Standard deviation 0.27
Values 0.89 0.6 1.1
[68]
SNU475 NT5M
Mean 1.45
Standard deviation 0.43
Values 1.8 1.1
[69]
THLE NT5M
Mean 0.729
Standard deviation 0.32
Values 0.96 0.5
[70]
liver NT5M
Mean 0.186
Standard deviation 0.11
Values 0.33 0.13 0.21 0.079
[71]
ref_hepatocyte NT5C3A
Missing
[72]
HepG2 NT5C3A
Missing
[73]
HepG2.C3A NT5C3A
Missing
[74]
HuH.7 NT5C3A
Missing
[75]
SNU475 NT5C3A
Missing
[76]
THLE NT5C3A
Missing
[77]
liver NT5C3A
Missing
[78]
ref_hepatocyte NT5C1A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 NT5C1A
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[82]
SNU475 NT5C1A
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[83]
THLE NT5C1A
Mean 0.0787
Standard deviation 0.0059
Values 0.083 0.074
[84]
liver NT5C1A
Mean 0.00688
Standard deviation 0.008
Values 0 0.014 0 0.013