REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 [1] -0.68[2] -0.40[3] 0.64[4] -1.18[5] -1.08[6] -1.45[7]
2 PAICS Multifunctional protein ADE2 [8] 0.63[9] 0.91[10] 0.27[11] 0.35[12] 0.74[13] 0.87[14]
3 ADSL Adenylosuccinate lyase [15] -0.72[16] -0.68[17] -0.70[18] -1.00[19] -1.26[20] -0.45[21]
4 ATIC Bifunctional purine biosynthesis protein PURH [22] 0.26[23] -0.05[24] -0.51[25] -0.39[26] -0.39[27] -0.45[28]
5 GART Trifunctional purine biosynthetic protein adenosine-3 [29] -0.07[30] -0.45[31] -1.45[32] 0.15[33] 0.14[34] 0.30[35]
6 GMPS GMP synthase [glutamine-hydrolyzing] [36] -0.63[37] -0.63[38] -0.84[39] 0.86[40] 0.67[41] 0.17[42]
7 IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 [43] 1.03[44] 0.16[45] -0.51[46] 2.04[47] 1.18[48] -0.43[49]
8 PPAT Amidophosphoribosyltransferase [50] 0.36[51] 0.74[52] 0.44[53] 0.72[54] 0.95[55] 1.09[56]
9 PFAS Phosphoribosylformylglycinamidine synthase [57] 1.87[58] 1.28[59] 1.60[60] 2.16[61] 2.12[62] 2.36[63]
10 ADSS1 [64] [65] [66] [67] [68] [69] [70]
11 ADSS2 [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte IMPDH2
Mean 45.4
Standard deviation 20
Values 52 62 61 38 15
[2]
HepG2 IMPDH2
Mean 115
Standard deviation 9.1
Values 1.2e+02 1.1e+02
[3]
HepG2.C3A IMPDH2
Mean 139
Standard deviation 31
Values 1.6e+02 1.2e+02
[4]
HuH.7 IMPDH2
Mean 368
Standard deviation 41
Values 3.5e+02 3.4e+02 4.2e+02
[5]
SNU475 IMPDH2
Mean 37.3
Standard deviation 14
Values 28 47
[6]
THLE IMPDH2
Mean 56.1
Standard deviation 6.5
Values 51 61
[7]
liver IMPDH2
Mean 13.5
Standard deviation 5.2
Values 13 13 20 7.8
[8]
ref_hepatocyte PAICS
Mean 28.4
Standard deviation 8.1
Values 34 32 14 28 33
[9]
HepG2 PAICS
Mean 178
Standard deviation 24
Values 1.6e+02 1.9e+02
[10]
HepG2.C3A PAICS
Mean 215
Standard deviation 76
Values 1.6e+02 2.7e+02
[11]
HuH.7 PAICS
Mean 177
Standard deviation 52
Values 1.9e+02 1.2e+02 2.2e+02
[12]
SNU475 PAICS
Mean 67.2
Standard deviation 4.6
Values 64 70
[13]
THLE PAICS
Mean 124
Standard deviation 21
Values 1.1e+02 1.4e+02
[14]
liver PAICS
Mean 42.1
Standard deviation 21
Values 62 24 57 25
[15]
ref_hepatocyte ADSL
Mean 25
Standard deviation 12
Values 34 40 21 17 12
[16]
HepG2 ADSL
Mean 61.7
Standard deviation 4
Values 65 59
[17]
HepG2.C3A ADSL
Mean 63.3
Standard deviation 4.7
Values 60 67
[18]
HuH.7 ADSL
Mean 79.7
Standard deviation 15
Values 81 64 94
[19]
SNU475 ADSL
Mean 23.2
Standard deviation 2.7
Values 21 25
[20]
THLE ADSL
Mean 27.3
Standard deviation 7.7
Values 22 33
[21]
liver ADSL
Mean 14.9
Standard deviation 3.2
Values 14 16 18 11
[22]
ref_hepatocyte ATIC
Mean 24.9
Standard deviation 8.1
Values 32 32 28 19 14
[23]
HepG2 ATIC
Mean 121
Standard deviation 12
Values 1.3e+02 1.1e+02
[24]
HepG2.C3A ATIC
Mean 97.3
Standard deviation 10
Values 1e+02 90
[25]
HuH.7 ATIC
Mean 90.3
Standard deviation 22
Values 1e+02 65 1.1e+02
[26]
SNU475 ATIC
Mean 35.2
Standard deviation 3.4
Values 33 38
[27]
THLE ATIC
Mean 49.5
Standard deviation 10
Values 42 57
[28]
liver ATIC
Mean 14.7
Standard deviation 12
Values 21 5.3 29 4.1
[29]
ref_hepatocyte GART
Mean 21.4
Standard deviation 16
Values 17 43 33 8 7.1
[30]
HepG2 GART
Mean 83.2
Standard deviation 13
Values 92 74
[31]
HepG2.C3A GART
Mean 63.6
Standard deviation 1.3
Values 63 65
[32]
HuH.7 GART
Mean 40.7
Standard deviation 14
Values 48 25 50
[33]
SNU475 GART
Mean 44.2
Standard deviation 5.5
Values 40 48
[34]
THLE GART
Mean 61.8
Standard deviation 11
Values 54 69
[35]
liver GART
Mean 21.4
Standard deviation 7.5
Values 12 26 29 20
[36]
ref_hepatocyte GMPS
Mean 11.5
Standard deviation 5.8
Values 14 21 7.9 8.4 6.5
[37]
HepG2 GMPS
Mean 30
Standard deviation 2.7
Values 28 32
[38]
HepG2.C3A GMPS
Mean 29.9
Standard deviation 0.16
Values 30 30
[39]
HuH.7 GMPS
Mean 33.2
Standard deviation 3.7
Values 37 31 32
[40]
SNU475 GMPS
Mean 38.6
Standard deviation 7.3
Values 33 44
[41]
THLE GMPS
Mean 47.7
Standard deviation 4.7
Values 44 51
[42]
liver GMPS
Mean 10.5
Standard deviation 1.7
Values 11 10 12 8.1
[43]
ref_hepatocyte IMPDH1
Mean 4.53
Standard deviation 3.3
Values 8.6 6.6 5.1 1.2 1.2
[44]
HepG2 IMPDH1
Mean 37.5
Standard deviation 10
Values 45 30
[45]
HepG2.C3A IMPDH1
Mean 20.5
Standard deviation 4.3
Values 24 17
[46]
HuH.7 IMPDH1
Mean 16.5
Standard deviation 2.6
Values 19 14 17
[47]
SNU475 IMPDH1
Mean 34.6
Standard deviation 1.1
Values 34 35
[48]
THLE IMPDH1
Mean 26.8
Standard deviation 3.7
Values 24 29
[49]
liver IMPDH1
Mean 2.72
Standard deviation 0.62
Values 2.2 2.2 3.1 3.4
[50]
ref_hepatocyte PPAT
Mean 3.8
Standard deviation 3
Values 7.8 6.1 1.8 1.5 1.7
[51]
HepG2 PPAT
Mean 19.7
Standard deviation 5
Values 16 23
[52]
HepG2.C3A PPAT
Mean 25.7
Standard deviation 7.5
Values 20 31
[53]
HuH.7 PPAT
Mean 26.6
Standard deviation 9.2
Values 34 16 30
[54]
SNU475 PPAT
Mean 11.6
Standard deviation 2.8
Values 9.6 14
[55]
THLE PPAT
Mean 19.1
Standard deviation 1.8
Values 18 20
[56]
liver PPAT
Mean 6.55
Standard deviation 0.98
Values 6.5 6.4 7.9 5.5
[57]
ref_hepatocyte PFAS
Mean 2.15
Standard deviation 0.73
Values 2.2 3.1 2.6 1.5 1.4
[58]
HepG2 PFAS
Mean 31.9
Standard deviation 2.2
Values 33 30
[59]
HepG2.C3A PFAS
Mean 21.1
Standard deviation 1.9
Values 20 22
[60]
HuH.7 PFAS
Mean 33.9
Standard deviation 17
Values 49 15 38
[61]
SNU475 PFAS
Mean 17.8
Standard deviation 1.9
Values 16 19
[62]
THLE PFAS
Mean 24.4
Standard deviation 5.7
Values 20 28
[63]
liver PFAS
Mean 8.96
Standard deviation 1.7
Values 6.5 9.8 9.5 10
[64]
ref_hepatocyte ADSS1
Missing
[65]
HepG2 ADSS1
Missing
[66]
HepG2.C3A ADSS1
Missing
[67]
HuH.7 ADSS1
Missing
[68]
SNU475 ADSS1
Missing
[69]
THLE ADSS1
Missing
[70]
liver ADSS1
Missing
[71]
ref_hepatocyte ADSS2
Missing
[72]
HepG2 ADSS2
Missing
[73]
HepG2.C3A ADSS2
Missing
[74]
HuH.7 ADSS2
Missing
[75]
SNU475 ADSS2
Missing
[76]
THLE ADSS2
Missing
[77]
liver ADSS2
Missing