REACTOME_PURINE_CATABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NUDT5 ADP-sugar pyrophosphatase [1] -0.31[2] -0.58[3] -1.45[4] 0.25[5] -0.30[6] -0.94[7]
2 PNP Purine nucleoside phosphorylase [8] -0.17[9] -1.26[10] -0.71[11] -1.04[12] 0.08[13] -2.09[14]
3 ITPA Inosine triphosphate pyrophosphatase [15] 0.39[16] 0.16[17] -1.64[18] -0.11[19] -1.24[20] -1.88[21]
4 NT5C 5'(3')-deoxyribonucleotidase, cytosolic type [22] -0.92[23] -0.27[24] -1.43[25] -0.66[26] -0.91[27] -2.10[28]
5 NUDT9 ADP-ribose pyrophosphatase, mitochondrial [29] -1.06[30] -1.72[31] -2.42[32] -0.81[33] -0.54[34] -0.25[35]
6 NT5C2 Cytosolic purine 5'-nucleotidase [36] 1.04[37] 1.22[38] 1.76[39] 1.56[40] 1.11[41] 0.16[42]
7 NUDT16 U8 snoRNA-decapping enzyme [43] -0.28[44] -0.58[45] 0.58[46] -0.64[47] -0.30[48] 0.77[49]
8 GDA Guanine deaminase [50] -1.57[51] -8.34[52] 0.57[53] -7.63[54] -5.58[55] 1.40[56]
9 NUDT15 Nucleotide triphosphate diphosphatase NUDT15 [57] 0.95[58] 0.76[59] 0.60[60] 0.38[61] 0.57[62] -0.88[63]
10 NT5E 5'-nucleotidase [64] -0.83[65] 2.30[66] 2.23[67] 0.13[68] 1.87[69] 1.24[70]
11 XDH Xanthine dehydrogenase/oxidase [71] -9.61[72] -8.78[73] -3.37[74] -6.59[75] -4.82[76] 2.63[77]
12 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase [78] 0.03[79] -0.63[80] 0.69[81] 0.19[82] 0.78[83] -3.22[84]
13 NUDT18 8-oxo-dGDP phosphatase NUDT18 [85] 0.59[86] -0.39[87] -0.19[88] 0.00[89] -0.67[90] -1.34[91]
14 NT5C1A Cytosolic 5'-nucleotidase 1A [92] [93] [94] [95] [96] [97] [98]
15 NT5C1B Cytosolic 5'-nucleotidase 1B [99] [100] [101] [102] [103] [104] [105]
16 ADPRM Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [106] [107] [108] [109] [110] [111] [112]
17 DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte NUDT5
Mean 31.7
Standard deviation 9.1
Values 20 31 31 45 32
[2]
HepG2 NUDT5
Mean 40.6
Standard deviation 1.8
Values 39 42
[3]
HepG2.C3A NUDT5
Mean 38
Standard deviation 9
Values 32 44
[4]
HuH.7 NUDT5
Mean 21.2
Standard deviation 4.2
Values 24 16 23
[5]
SNU475 NUDT5
Mean 39.6
Standard deviation 0.066
Values 40 40
[6]
THLE NUDT5
Mean 36.3
Standard deviation 5.1
Values 33 40
[7]
liver NUDT5
Mean 26
Standard deviation 18
Values 45 15 37 7.9
[8]
ref_hepatocyte PNP
Mean 30
Standard deviation 33
Values 2.3 23 86 26 12
[9]
HepG2 PNP
Mean 42.3
Standard deviation 2.8
Values 44 40
[10]
HepG2.C3A PNP
Mean 22.5
Standard deviation 12
Values 14 31
[11]
HuH.7 PNP
Mean 33.5
Standard deviation 12
Values 31 23 46
[12]
SNU475 PNP
Mean 15.3
Standard deviation 6.3
Values 11 20
[13]
THLE PNP
Mean 44.5
Standard deviation 6.2
Values 40 49
[14]
liver PNP
Mean 11
Standard deviation 6
Values 20 6.1 8.7 9.7
[15]
ref_hepatocyte ITPA
Mean 21
Standard deviation 5.1
Values 17 22 28 22 15
[16]
HepG2 ITPA
Mean 44
Standard deviation 4.2
Values 47 41
[17]
HepG2.C3A ITPA
Mean 42.1
Standard deviation 1.5
Values 43 41
[18]
HuH.7 ITPA
Mean 12.3
Standard deviation 5.6
Values 14 6 17
[19]
SNU475 ITPA
Mean 20.4
Standard deviation 4.7
Values 24 17
[20]
THLE ITPA
Mean 12.5
Standard deviation 2.1
Values 11 14
[21]
liver ITPA
Mean 8.99
Standard deviation 7.5
Values 16 2.6 15 2.4
[22]
ref_hepatocyte NT5C
Mean 14.1
Standard deviation 2
Values 12 16 16 12 14
[23]
HepG2 NT5C
Mean 11.9
Standard deviation 0.64
Values 12 11
[24]
HepG2.C3A NT5C
Mean 21
Standard deviation 3.6
Values 24 19
[25]
HuH.7 NT5C
Mean 9.58
Standard deviation 3.9
Values 8.1 6.7 14
[26]
SNU475 NT5C
Mean 9.37
Standard deviation 2.2
Values 11 7.8
[27]
THLE NT5C
Mean 10.5
Standard deviation 0.81
Values 9.9 11
[28]
liver NT5C
Mean 5.18
Standard deviation 4
Values 8.2 1.9 9.2 1.5
[29]
ref_hepatocyte NUDT9
Mean 12.2
Standard deviation 5.2
Values 4.9 17 8.7 15 15
[30]
HepG2 NUDT9
Mean 9.27
Standard deviation 0.56
Values 8.9 9.7
[31]
HepG2.C3A NUDT9
Mean 6.61
Standard deviation 0.31
Values 6.4 6.8
[32]
HuH.7 NUDT9
Mean 4.15
Standard deviation 0.32
Values 4.3 3.8 4.4
[33]
SNU475 NUDT9
Mean 7.27
Standard deviation 0.098
Values 7.3 7.2
[34]
THLE NUDT9
Mean 11.8
Standard deviation 1.1
Values 11 13
[35]
liver NUDT9
Mean 16.1
Standard deviation 10
Values 28 9.2 20 6.8
[36]
ref_hepatocyte NT5C2
Mean 10.7
Standard deviation 5.7
Values 14 19 7.1 6.7 6.3
[37]
HepG2 NT5C2
Mean 35
Standard deviation 8.8
Values 29 41
[38]
HepG2.C3A NT5C2
Mean 44.8
Standard deviation 0.63
Values 45 44
[39]
HuH.7 NT5C2
Mean 66
Standard deviation 5.7
Values 62 73 63
[40]
SNU475 NT5C2
Mean 33.1
Standard deviation 12
Values 42 25
[41]
THLE NT5C2
Mean 32.4
Standard deviation 5.7
Values 28 36
[42]
liver NT5C2
Mean 18.8
Standard deviation 2.6
Values 15 21 21 18
[43]
ref_hepatocyte NUDT16
Mean 9.76
Standard deviation 4.6
Values 4.8 11 5 14 14
[44]
HepG2 NUDT16
Mean 12.8
Standard deviation 0.68
Values 12 13
[45]
HepG2.C3A NUDT16
Mean 11.7
Standard deviation 0.15
Values 12 12
[46]
HuH.7 NUDT16
Mean 26.6
Standard deviation 4.1
Values 30 22 27
[47]
SNU475 NUDT16
Mean 6.57
Standard deviation 1.5
Values 7.6 5.5
[48]
THLE NUDT16
Mean 11.1
Standard deviation 1.5
Values 10 12
[49]
liver NUDT16
Mean 26.1
Standard deviation 5.6
Values 26 27 19 33
[50]
ref_hepatocyte GDA
Mean 7.4
Standard deviation 5.4
Values 0.066 15 5.2 8 9.1
[51]
HepG2 GDA
Mean 3.97
Standard deviation 0.87
Values 4.6 3.4
[52]
HepG2.C3A GDA
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[53]
HuH.7 GDA
Mean 20.1
Standard deviation 1.9
Values 21 21 18
[54]
SNU475 GDA
Mean 0.0393
Standard deviation 0.016
Values 0.028 0.051
[55]
THLE GDA
Mean 0.218
Standard deviation 0.14
Values 0.31 0.12
[56]
liver GDA
Mean 30.6
Standard deviation 7.9
Values 32 34 38 19
[57]
ref_hepatocyte NUDT15
Mean 6.43
Standard deviation 2.9
Values 8.7 9.8 2.5 5.4 5.9
[58]
HepG2 NUDT15
Mean 19.8
Standard deviation 6.4
Values 15 24
[59]
HepG2.C3A NUDT15
Mean 19.6
Standard deviation 12
Values 11 28
[60]
HuH.7 NUDT15
Mean 17.8
Standard deviation 7.1
Values 21 9.7 23
[61]
SNU475 NUDT15
Mean 8.75
Standard deviation 0.46
Values 9.1 8.4
[62]
THLE NUDT15
Mean 13.5
Standard deviation 3.7
Values 11 16
[63]
liver NUDT15
Mean 5.49
Standard deviation 2.4
Values 7.1 4.3 7.9 2.7
[64]
ref_hepatocyte NT5E
Mean 5.59
Standard deviation 3.2
Values 0.3 5.8 8.3 5.6 8
[65]
HepG2 NT5E
Mean 5.01
Standard deviation 1.5
Values 4 6
[66]
HepG2.C3A NT5E
Mean 49.3
Standard deviation 7.9
Values 55 44
[67]
HuH.7 NT5E
Mean 47.8
Standard deviation 5.7
Values 53 42 49
[68]
SNU475 NT5E
Mean 6.43
Standard deviation 1.3
Values 5.5 7.4
[69]
THLE NT5E
Mean 28.7
Standard deviation 11
Values 21 36
[70]
liver NT5E
Mean 20.8
Standard deviation 5.2
Values 23 19 14 26
[71]
ref_hepatocyte XDH
Mean 5.26
Standard deviation 5.8
Values 0 0.81 2.8 9.2 13
[72]
HepG2 XDH
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[73]
HepG2.C3A XDH
Mean 0.0215
Standard deviation 0.03
Values 0 0.043
[74]
HuH.7 XDH
Mean 0.929
Standard deviation 0.041
Values 0.9 0.98 0.91
[75]
SNU475 XDH
Mean 0.0574
Standard deviation 0.055
Values 0.019 0.096
[76]
THLE XDH
Mean 0.262
Standard deviation 0.11
Values 0.18 0.34
[77]
liver XDH
Mean 51.2
Standard deviation 29
Values 19 61 38 87
[78]
ref_hepatocyte NUDT1
Mean 2.92
Standard deviation 1.8
Values 4.4 5.2 2.5 0.88 1.6
[79]
HepG2 NUDT1
Mean 4.75
Standard deviation 0.73
Values 4.2 5.3
[80]
HepG2.C3A NUDT1
Mean 3.39
Standard deviation 1.7
Values 2.2 4.6
[81]
HuH.7 NUDT1
Mean 8.58
Standard deviation 5.1
Values 9.6 3.1 13
[82]
SNU475 NUDT1
Mean 3.5
Standard deviation 0.11
Values 3.6 3.4
[83]
THLE NUDT1
Mean 7.05
Standard deviation 1.2
Values 6.2 7.9
[84]
liver NUDT1
Mean 0.491
Standard deviation 0.36
Values 0.63 0.27 0.92 0.13
[85]
ref_hepatocyte NUDT18
Mean 1.85
Standard deviation 0.68
Values 1.6 1.1 1.5 2.6 2.5
[86]
HepG2 NUDT18
Mean 4.45
Standard deviation 1
Values 3.7 5.2
[87]
HepG2.C3A NUDT18
Mean 2.55
Standard deviation 0.51
Values 2.9 2.2
[88]
HuH.7 NUDT18
Mean 2.97
Standard deviation 0.79
Values 2.9 2.2 3.8
[89]
SNU475 NUDT18
Mean 1.94
Standard deviation 0.71
Values 2.4 1.4
[90]
THLE NUDT18
Mean 1.64
Standard deviation 0.016
Values 1.7 1.6
[91]
liver NUDT18
Mean 1.15
Standard deviation 0.45
Values 1.8 0.78 0.85 1.2
[92]
ref_hepatocyte NT5C1A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A NT5C1A
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NT5C1A
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[96]
SNU475 NT5C1A
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[97]
THLE NT5C1A
Mean 0.0787
Standard deviation 0.0059
Values 0.083 0.074
[98]
liver NT5C1A
Mean 0.00688
Standard deviation 0.008
Values 0 0.014 0 0.013
[99]
ref_hepatocyte NT5C1B
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 NT5C1B
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[101]
HepG2.C3A NT5C1B
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 NT5C1B
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 NT5C1B
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[104]
THLE NT5C1B
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[105]
liver NT5C1B
Mean 0.18
Standard deviation 0.11
Values 0.094 0.24 0.077 0.3
[106]
ref_hepatocyte ADPRM
Missing
[107]
HepG2 ADPRM
Mean 3.06
Standard deviation 1.1
Values 3.9 2.2
[108]
HepG2.C3A ADPRM
Mean 3.53
Standard deviation 1.8
Values 4.8 2.2
[109]
HuH.7 ADPRM
Mean 8.17
Standard deviation 2.7
Values 5.9 11 7.4
[110]
SNU475 ADPRM
Mean 1.62
Standard deviation 0.17
Values 1.5 1.7
[111]
THLE ADPRM
Mean 2.93
Standard deviation 0.065
Values 2.9 3
[112]
liver ADPRM
Mean 2.88
Standard deviation 1.9
Values 5.4 1 3.3 1.7
[113]
ref_hepatocyte DNPH1
Missing
[114]
HepG2 DNPH1
Mean 16
Standard deviation 1.6
Values 17 15
[115]
HepG2.C3A DNPH1
Mean 20.2
Standard deviation 3.8
Values 23 18
[116]
HuH.7 DNPH1
Mean 10.6
Standard deviation 4.7
Values 11 5.7 15
[117]
SNU475 DNPH1
Mean 12.7
Standard deviation 6
Values 17 8.5
[118]
THLE DNPH1
Mean 9.86
Standard deviation 0.24
Values 9.7 10
[119]
liver DNPH1
Mean 24.6
Standard deviation 24
Values 53 5.2 36 4.6