REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RHOA Transforming protein RhoA [1] -0.71[2] -1.08[3] -1.09[4] -1.21[5] -0.79[6] -1.01[7]
2 RAC1 Ras-related C3 botulinum toxin substrate 1 [8] -0.16[9] -0.36[10] 0.11[11] 0.02[12] -0.02[13] -0.65[14]
3 CRK Adapter molecule crk [15] 0.03[16] 0.09[17] -0.08[18] -0.23[19] 0.14[20] 1.15[21]
4 NRAS GTPase NRas [22] 0.86[23] 1.42[24] 1.59[25] 1.01[26] 0.55[27] 0.06[28]
5 HRAS GTPase HRas [29] -0.77[30] -1.35[31] -2.38[32] -0.94[33] -1.18[34] -2.35[35]
6 BCAR1 Breast cancer anti-estrogen resistance protein 1 [36] 1.36[37] 1.37[38] 0.00[39] 1.38[40] 1.08[41] 0.38[42]
7 PXN Paxillin [43] 1.23[44] 1.08[45] 0.88[46] 2.13[47] 2.06[48] -0.04[49]
8 KRAS GTPase KRas [50] -0.28[51] -0.17[52] 1.19[53] 0.81[54] 0.44[55] 0.99[56]
9 ELMO2 Engulfment and cell motility protein 2 [57] 1.20[58] 1.49[59] -0.36[60] 1.45[61] 0.43[62] 0.47[63]
10 ARHGAP35 Rho GTPase-activating protein 35 [64] 2.58[65] 2.84[66] 3.14[67] 2.75[68] 2.29[69] 3.57[70]
11 RASA1 Ras GTPase-activating protein 1 [71] 0.61[72] 1.65[73] 1.51[74] 1.93[75] 0.95[76] 1.53[77]
12 DOCK1 Dedicator of cytokinesis protein 1 [78] 2.22[79] 2.88[80] 2.63[81] -2.64[82] 2.14[83] 2.83[84]
13 ELMO1 Engulfment and cell motility protein 1 [85] -5.58[86] -3.76[87] 0.20[88] -3.55[89] -6.38[90] 3.16[91]
14 PTK6 Protein-tyrosine kinase 6 [92] -0.89[93] 1.45[94] -0.55[95] -1.65[96] -2.10[97] -0.26[98]
[1]
ref_hepatocyte RHOA
Mean 177
Standard deviation 1.2e+02
Values 2.2e+02 3.8e+02 1.4e+02 75 79
[2]
HepG2 RHOA
Mean 204
Standard deviation 38
Values 2.3e+02 1.8e+02
[3]
HepG2.C3A RHOA
Mean 129
Standard deviation 1.6
Values 1.3e+02 1.3e+02
[4]
HuH.7 RHOA
Mean 144
Standard deviation 23
Values 1.6e+02 1.2e+02 1.6e+02
[5]
SNU475 RHOA
Mean 139
Standard deviation 21
Values 1.5e+02 1.2e+02
[6]
THLE RHOA
Mean 214
Standard deviation 38
Values 1.9e+02 2.4e+02
[7]
liver RHOA
Mean 101
Standard deviation 59
Values 1.6e+02 54 1.4e+02 46
[8]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[9]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[10]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[11]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[12]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[13]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[14]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[15]
ref_hepatocyte CRK
Mean 18.5
Standard deviation 12
Values 16 38 19 11 8.5
[16]
HepG2 CRK
Mean 35.5
Standard deviation 2.8
Values 34 38
[17]
HepG2.C3A CRK
Mean 30.2
Standard deviation 5.3
Values 27 34
[18]
HuH.7 CRK
Mean 30.3
Standard deviation 2.4
Values 32 32 28
[19]
SNU475 CRK
Mean 28.8
Standard deviation 1.2
Values 30 28
[20]
THLE CRK
Mean 42.5
Standard deviation 6.6
Values 38 47
[21]
liver CRK
Mean 47.1
Standard deviation 5.8
Values 41 55 45 47
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte BCAR1
Mean 10.7
Standard deviation 5.1
Values 8.8 8.9 19 10 6
[37]
HepG2 BCAR1
Mean 51.6
Standard deviation 8.8
Values 58 45
[38]
HepG2.C3A BCAR1
Mean 42.3
Standard deviation 12
Values 51 33
[39]
HuH.7 BCAR1
Mean 18.6
Standard deviation 1.5
Values 18 20 17
[40]
SNU475 BCAR1
Mean 50.8
Standard deviation 8.7
Values 57 45
[41]
THLE BCAR1
Mean 47.1
Standard deviation 3.6
Values 45 50
[42]
liver BCAR1
Mean 15.9
Standard deviation 1.8
Values 16 13 18 16
[43]
ref_hepatocyte PXN
Mean 9.17
Standard deviation 8.7
Values 3.1 8.2 24 4 6.1
[44]
HepG2 PXN
Mean 40.5
Standard deviation 4
Values 43 38
[45]
HepG2.C3A PXN
Mean 29.7
Standard deviation 0.97
Values 30 29
[46]
HuH.7 PXN
Mean 29.2
Standard deviation 3.3
Values 33 27 27
[47]
SNU475 PXN
Mean 73
Standard deviation 6.8
Values 78 68
[48]
THLE PXN
Mean 79.6
Standard deviation 9.5
Values 73 86
[49]
liver PXN
Mean 10.2
Standard deviation 5.9
Values 16 3.9 14 6.6
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte ELMO2
Mean 5.66
Standard deviation 5.4
Values 15 6 2.7 2.6 2.2
[58]
HepG2 ELMO2
Mean 24.5
Standard deviation 5.3
Values 21 28
[59]
HepG2.C3A ELMO2
Mean 24.4
Standard deviation 1.1
Values 25 24
[60]
HuH.7 ELMO2
Mean 7.68
Standard deviation 0.93
Values 8.1 6.6 8.3
[61]
SNU475 ELMO2
Mean 28.3
Standard deviation 0.82
Values 28 29
[62]
THLE ELMO2
Mean 15.9
Standard deviation 1.4
Values 15 17
[63]
liver ELMO2
Mean 9
Standard deviation 2.3
Values 8 8.8 12 6.9
[64]
ref_hepatocyte ARHGAP35
Mean 4.46
Standard deviation 0.51
Values 4.9 3.9 3.9 4.9 4.7
[65]
HepG2 ARHGAP35
Mean 50
Standard deviation 5.1
Values 54 46
[66]
HepG2.C3A ARHGAP35
Mean 48.8
Standard deviation 9
Values 55 42
[67]
HuH.7 ARHGAP35
Mean 68.1
Standard deviation 17
Values 74 82 49
[68]
SNU475 ARHGAP35
Mean 54.6
Standard deviation 6.9
Values 59 50
[69]
THLE ARHGAP35
Mean 45.6
Standard deviation 4.8
Values 42 49
[70]
liver ARHGAP35
Mean 60.7
Standard deviation 27
Values 49 78 28 87
[71]
ref_hepatocyte RASA1
Mean 2.68
Standard deviation 1.4
Values 3.2 4.9 1.6 1.4 2.4
[72]
HepG2 RASA1
Mean 7.68
Standard deviation 3
Values 5.6 9.8
[73]
HepG2.C3A RASA1
Mean 12.9
Standard deviation 0.039
Values 13 13
[74]
HuH.7 RASA1
Mean 13.3
Standard deviation 0.87
Values 14 14 12
[75]
SNU475 RASA1
Mean 18.6
Standard deviation 2.3
Values 20 17
[76]
THLE RASA1
Mean 10.8
Standard deviation 0.049
Values 11 11
[77]
liver RASA1
Mean 8.83
Standard deviation 3.2
Values 7.7 13 6.2 8
[78]
ref_hepatocyte DOCK1
Mean 2.65
Standard deviation 1.4
Values 5 3 2.1 1.6 1.5
[79]
HepG2 DOCK1
Mean 23.1
Standard deviation 5.8
Values 19 27
[80]
HepG2.C3A DOCK1
Mean 29.8
Standard deviation 3.1
Values 28 32
[81]
HuH.7 DOCK1
Mean 28.4
Standard deviation 6
Values 35 23 27
[82]
SNU475 DOCK1
Mean 0.775
Standard deviation 0.14
Values 0.88 0.67
[83]
THLE DOCK1
Mean 24.3
Standard deviation 4.6
Values 21 28
[84]
liver DOCK1
Mean 21.5
Standard deviation 13
Values 8.5 36 13 29
[85]
ref_hepatocyte ELMO1
Mean 1.36
Standard deviation 0.9
Values 0 1.7 1.2 1.4 2.5
[86]
HepG2 ELMO1
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[87]
HepG2.C3A ELMO1
Mean 0.154
Standard deviation 0.025
Values 0.14 0.17
[88]
HuH.7 ELMO1
Mean 2.71
Standard deviation 1.2
Values 1.9 4.1 2.1
[89]
SNU475 ELMO1
Mean 0.213
Standard deviation 0.072
Values 0.16 0.26
[90]
THLE ELMO1
Mean 0.034
Standard deviation 0.01
Values 0.041 0.027
[91]
liver ELMO1
Mean 14
Standard deviation 5.5
Values 12 11 11 22
[92]
ref_hepatocyte PTK6
Mean 0.543
Standard deviation 0.59
Values 0 0.55 1.5 0.39 0.24
[93]
HepG2 PTK6
Mean 0.551
Standard deviation 0.28
Values 0.75 0.35
[94]
HepG2.C3A PTK6
Mean 2.27
Standard deviation 0.8
Values 2.8 1.7
[95]
HuH.7 PTK6
Mean 0.643
Standard deviation 0.082
Values 0.66 0.55 0.71
[96]
SNU475 PTK6
Mean 0.316
Standard deviation 0.047
Values 0.28 0.35
[97]
THLE PTK6
Mean 0.264
Standard deviation 0.02
Values 0.28 0.25
[98]
liver PTK6
Mean 0.517
Standard deviation 0.32
Values 0.12 0.64 0.44 0.87