REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAB 14-3-3 protein beta/alpha [1] 0.37[2] 0.17[3] -0.63[4] 0.57[5] 0.21[6] -0.46[7]
2 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [8] -1.59[9] -1.84[10] -1.34[11] -1.27[12] -0.57[13] -1.56[14]
3 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [15] -0.61[16] -0.85[17] -0.06[18] -1.57[19] -0.89[20] -2.07[21]
4 CRK Adapter molecule crk [22] -0.87[23] -0.85[24] -0.86[25] -0.97[26] -0.37[27] 0.48[28]
5 RAP1A Ras-related protein Rap-1A [29] -1.71[30] -1.69[31] -0.93[32] -0.94[33] -0.98[34] -1.66[35]
6 MAPK1 Mitogen-activated protein kinase 1 [36] 1.04[37] 1.26[38] 1.02[39] 1.12[40] 0.97[41] 1.41[42]
7 CRKL Crk-like protein [43] 1.04[44] 1.22[45] 1.75[46] 0.40[47] 0.80[48] 1.09[49]
8 RAPGEF1 Rap guanine nucleotide exchange factor 1 [50] 1.42[51] 1.34[52] 0.98[53] 0.53[54] 0.40[55] 0.81[56]
9 MAPK3 Mitogen-activated protein kinase 3 [57] 1.18[58] 1.31[59] 1.28[60] -0.30[61] -0.09[62] -1.41[63]
10 KIDINS220 Kinase D-interacting substrate of 220 kDa [64] 0.92[65] 1.63[66] 1.17[67] 2.19[68] 1.84[69] 2.90[70]
11 FRS2 Fibroblast growth factor receptor substrate 2 [71] 0.62[72] 1.80[73] 2.22[74] 2.18[75] 2.00[76] 2.98[77]
12 BRAF Serine/threonine-protein kinase B-raf [78] -0.42[79] -0.61[80] 1.35[81] 0.02[82] -0.10[83] 1.49[84]
13 NTRK1 High affinity nerve growth factor receptor [85] [86] [87] [88] [89] [90] [91]
14 NGF Beta-nerve growth factor [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte YWHAB
Mean 42.6
Standard deviation 20
Values 74 47 41 28 22
[2]
HepG2 YWHAB
Mean 193
Standard deviation 37
Values 1.7e+02 2.2e+02
[3]
HepG2.C3A YWHAB
Mean 141
Standard deviation 27
Values 1.2e+02 1.6e+02
[4]
HuH.7 YWHAB
Mean 82.2
Standard deviation 26
Values 98 52 97
[5]
SNU475 YWHAB
Mean 193
Standard deviation 7
Values 2e+02 1.9e+02
[6]
THLE YWHAB
Mean 146
Standard deviation 23
Values 1.3e+02 1.6e+02
[7]
liver YWHAB
Mean 56.6
Standard deviation 26
Values 78 39 80 30
[8]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[9]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[10]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[11]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[12]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[13]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[14]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[15]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[16]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[17]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[18]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[19]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[20]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[21]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[22]
ref_hepatocyte CRK
Mean 18.5
Standard deviation 12
Values 16 38 19 11 8.5
[23]
HepG2 CRK
Mean 35.5
Standard deviation 2.8
Values 34 38
[24]
HepG2.C3A CRK
Mean 30.2
Standard deviation 5.3
Values 27 34
[25]
HuH.7 CRK
Mean 30.3
Standard deviation 2.4
Values 32 32 28
[26]
SNU475 CRK
Mean 28.8
Standard deviation 1.2
Values 30 28
[27]
THLE CRK
Mean 42.5
Standard deviation 6.6
Values 38 47
[28]
liver CRK
Mean 47.1
Standard deviation 5.8
Values 41 55 45 47
[29]
ref_hepatocyte RAP1A
Mean 17.1
Standard deviation 7.2
Values 17 20 8.5 13 28
[30]
HepG2 RAP1A
Mean 18.3
Standard deviation 5.4
Values 14 22
[31]
HepG2.C3A RAP1A
Mean 15.6
Standard deviation 1.3
Values 15 17
[32]
HuH.7 RAP1A
Mean 26.7
Standard deviation 1.9
Values 25 29 26
[33]
SNU475 RAP1A
Mean 27.1
Standard deviation 7
Values 32 22
[34]
THLE RAP1A
Mean 25.7
Standard deviation 2.2
Values 24 27
[35]
liver RAP1A
Mean 9.95
Standard deviation 5.1
Values 17 7.4 10 5.3
[36]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[37]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[38]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[39]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[40]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[41]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[42]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[43]
ref_hepatocyte CRKL
Mean 7.86
Standard deviation 3.2
Values 13 7.5 7.1 6.1 5.2
[44]
HepG2 CRKL
Mean 56.6
Standard deviation 7.1
Values 52 62
[45]
HepG2.C3A CRKL
Mean 53.9
Standard deviation 8
Values 60 48
[46]
HuH.7 CRKL
Mean 78.7
Standard deviation 6.8
Values 86 76 74
[47]
SNU475 CRKL
Mean 31.5
Standard deviation 0.52
Values 32 31
[48]
THLE CRKL
Mean 40.6
Standard deviation 0.46
Values 41 40
[49]
liver CRKL
Mean 30.6
Standard deviation 3.9
Values 25 32 32 33
[50]
ref_hepatocyte RAPGEF1
Mean 4.9
Standard deviation 2.3
Values 6.6 5.4 7.5 2.5 2.6
[51]
HepG2 RAPGEF1
Mean 46
Standard deviation 2.9
Values 48 44
[52]
HepG2.C3A RAPGEF1
Mean 36.5
Standard deviation 6.8
Values 41 32
[53]
HuH.7 RAPGEF1
Mean 28.7
Standard deviation 4.9
Values 30 33 23
[54]
SNU475 RAPGEF1
Mean 21.5
Standard deviation 2.8
Values 23 20
[55]
THLE RAPGEF1
Mean 19.2
Standard deviation 5.1
Values 16 23
[56]
liver RAPGEF1
Mean 15.7
Standard deviation 4.8
Values 16 19 8.9 19
[57]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[58]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[59]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[60]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[61]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[62]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[63]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[64]
ref_hepatocyte KIDINS220
Mean 2.78
Standard deviation 1
Values 4.3 3.1 2 1.9 2.5
[65]
HepG2 KIDINS220
Mean 18.5
Standard deviation 6.6
Values 14 23
[66]
HepG2.C3A KIDINS220
Mean 25.4
Standard deviation 0.54
Values 26 25
[67]
HuH.7 KIDINS220
Mean 18.6
Standard deviation 2.9
Values 21 19 15
[68]
SNU475 KIDINS220
Mean 38.6
Standard deviation 5.8
Values 43 34
[69]
THLE KIDINS220
Mean 29.6
Standard deviation 0.18
Values 30 30
[70]
liver KIDINS220
Mean 37.9
Standard deviation 14
Values 27 50 25 50
[71]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[72]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[73]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[74]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[75]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[76]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[77]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[78]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 0.56 1.2 2.3 0.67 0.67
[79]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 2.4 3.2
[80]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 1.6 2.5
[81]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 6.4 15 3.4
[82]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.2 3.4
[83]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[84]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 3.1 8 2.9 7.9
[85]
ref_hepatocyte NTRK1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 NTRK1
Mean 0.0172
Standard deviation 0.024
Values 0.034 0
[87]
HepG2.C3A NTRK1
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 NTRK1
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 NTRK1
Mean 0.439
Standard deviation 0.25
Values 0.26 0.62
[90]
THLE NTRK1
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[91]
liver NTRK1
Mean 0.0711
Standard deviation 0.026
Values 0.071 0.071 0.1 0.04
[92]
ref_hepatocyte NGF
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NGF
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A NGF
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NGF
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 NGF
Mean 1.32
Standard deviation 0.58
Values 0.91 1.7
[97]
THLE NGF
Mean 0.258
Standard deviation 0.011
Values 0.27 0.25
[98]
liver NGF
Mean 0.426
Standard deviation 0.42
Values 1 0.071 0.46 0.16