REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCNA Proliferating cell nuclear antigen [1] 0.68[2] 0.58[3] -1.04[4] -0.80[5] -0.28[6] -2.30[7]
2 POLD2 DNA polymerase delta subunit 2 [8] -0.81[9] -0.72[10] -0.42[11] -1.45[12] -0.84[13] 0.65[14]
3 POLD4 DNA polymerase delta subunit 4 [15] -2.34[16] -2.77[17] -0.90[18] 0.86[19] -2.49[20] 0.30[21]
4 RPA2 Replication protein A 32 kDa subunit [22] -1.66[23] -1.67[24] -1.33[25] -1.32[26] -1.01[27] -1.62[28]
5 FEN1 Flap endonuclease 1 [29] 0.82[30] 0.53[31] 1.17[32] 0.10[33] 1.23[34] -0.32[35]
6 RPA1 Replication protein A 70 kDa DNA-binding subunit [36] 1.11[37] 0.76[38] 0.82[39] 1.27[40] 1.52[41] 0.78[42]
7 RPA3 Replication protein A 14 kDa subunit [43] -0.57[44] 0.14[45] 0.65[46] -1.48[47] -0.97[48] 0.08[49]
8 LIG1 DNA ligase 1 [50] 1.42[51] 1.36[52] 1.78[53] -0.07[54] 0.90[55] 0.40[56]
9 POLA2 DNA polymerase alpha subunit B [57] 0.44[58] -0.01[59] 0.33[60] 0.94[61] 1.47[62] -0.06[63]
10 PRIM1 DNA primase small subunit [64] 0.46[65] 1.71[66] 1.82[67] 0.58[68] 1.40[69] -0.13[70]
11 POLD1 DNA polymerase delta catalytic subunit [71] 1.65[72] 1.79[73] 2.40[74] 1.24[75] 2.24[76] 1.44[77]
12 PRIM2 DNA primase large subunit [78] 1.07[79] 0.79[80] 0.19[81] 0.60[82] 1.08[83] -0.81[84]
13 POLD3 DNA polymerase delta subunit 3 [85] 0.97[86] 0.76[87] 1.51[88] 1.53[89] 2.25[90] 1.76[91]
14 POLA1 DNA polymerase alpha catalytic subunit [92] 1.80[93] 1.83[94] 2.17[95] 2.41[96] 2.61[97] 2.44[98]
15 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2 [99] 1.55[100] 3.24[101] 2.23[102] 2.07[103] 1.96[104] 2.33[105]
[1]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[2]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[3]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[4]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[5]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[6]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[7]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[8]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[9]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[10]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[11]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[12]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[13]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[14]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[15]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[16]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[17]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[18]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[19]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[20]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[21]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[22]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[23]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[24]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[25]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[26]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[27]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[28]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[29]
ref_hepatocyte FEN1
Mean 8.88
Standard deviation 4.9
Values 17 9.6 7.8 7 3.4
[30]
HepG2 FEN1
Mean 40
Standard deviation 13
Values 31 49
[31]
HepG2.C3A FEN1
Mean 30.8
Standard deviation 20
Values 17 45
[32]
HuH.7 FEN1
Mean 53.6
Standard deviation 31
Values 63 19 79
[33]
SNU475 FEN1
Mean 26.1
Standard deviation 5.2
Values 22 30
[34]
THLE FEN1
Mean 54.6
Standard deviation 11
Values 47 62
[35]
liver FEN1
Mean 5.91
Standard deviation 2.9
Values 3.7 5.8 10 4.1
[36]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[37]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[38]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[39]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[40]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[41]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[42]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[43]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[44]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[45]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[46]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[47]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[48]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[49]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[50]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[51]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[52]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[53]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[54]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[55]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[56]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[57]
ref_hepatocyte POLA2
Mean 2.46
Standard deviation 0.96
Values 1.8 2.8 3.9 2.3 1.5
[58]
HepG2 POLA2
Mean 8.49
Standard deviation 2.2
Values 6.9 10
[59]
HepG2.C3A POLA2
Mean 5.87
Standard deviation 3.6
Values 3.3 8.4
[60]
HuH.7 POLA2
Mean 8.32
Standard deviation 5.1
Values 11 2.5 11
[61]
SNU475 POLA2
Mean 12.9
Standard deviation 3.1
Values 11 15
[62]
THLE POLA2
Mean 17.9
Standard deviation 4
Values 15 21
[63]
liver POLA2
Mean 1.96
Standard deviation 0.6
Values 1.2 1.9 2.6 2.2
[64]
ref_hepatocyte PRIM1
Mean 2.43
Standard deviation 1.4
Values 4.4 2.6 0.57 2.6 1.9
[65]
HepG2 PRIM1
Mean 8.54
Standard deviation 0.87
Values 7.9 9.2
[66]
HepG2.C3A PRIM1
Mean 19.1
Standard deviation 8.1
Values 13 25
[67]
HuH.7 PRIM1
Mean 23.1
Standard deviation 6.2
Values 27 16 26
[68]
SNU475 PRIM1
Mean 9.98
Standard deviation 3.1
Values 7.8 12
[69]
THLE PRIM1
Mean 16.8
Standard deviation 2.1
Values 15 18
[70]
liver PRIM1
Mean 1.84
Standard deviation 0.34
Values 2.1 1.6 2.1 1.5
[71]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[72]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[73]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[74]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[75]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[76]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[77]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[78]
ref_hepatocyte PRIM2
Mean 2.32
Standard deviation 2.3
Values 6.1 2.9 0.46 1.4 0.78
[79]
HepG2 PRIM2
Mean 12.4
Standard deviation 3.6
Values 9.9 15
[80]
HepG2.C3A PRIM2
Mean 9.66
Standard deviation 4.4
Values 6.5 13
[81]
HuH.7 PRIM2
Mean 7.1
Standard deviation 1.5
Values 7.8 5.4 8.1
[82]
SNU475 PRIM2
Mean 9.65
Standard deviation 1.6
Values 8.5 11
[83]
THLE PRIM2
Mean 12.8
Standard deviation 1.5
Values 12 14
[84]
liver PRIM2
Mean 1.1
Standard deviation 0.41
Values 0.68 1.5 0.82 1.4
[85]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[86]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[87]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[88]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[89]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[90]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[91]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[92]
ref_hepatocyte POLA1
Mean 0.985
Standard deviation 0.81
Values 1.8 2 0.27 0.52 0.41
[93]
HepG2 POLA1
Mean 8.75
Standard deviation 4.7
Values 5.4 12
[94]
HepG2.C3A POLA1
Mean 8.42
Standard deviation 3.5
Values 5.9 11
[95]
HuH.7 POLA1
Mean 11.9
Standard deviation 5.3
Values 17 6.3 13
[96]
SNU475 POLA1
Mean 14.3
Standard deviation 5.6
Values 10 18
[97]
THLE POLA1
Mean 15.7
Standard deviation 1.1
Values 15 17
[98]
liver POLA1
Mean 4.45
Standard deviation 2.4
Values 1.9 7.6 3.5 4.8
[99]
ref_hepatocyte DNA2
Mean 0.686
Standard deviation 0.42
Values 1.2 1.1 0.52 0.36 0.28
[100]
HepG2 DNA2
Mean 5.13
Standard deviation 3.4
Values 2.7 7.6
[101]
HepG2.C3A DNA2
Mean 15.6
Standard deviation 12
Values 7.4 24
[102]
HuH.7 DNA2
Mean 8.62
Standard deviation 3.7
Values 11 4.3 11
[103]
SNU475 DNA2
Mean 7.89
Standard deviation 1.4
Values 6.9 8.9
[104]
THLE DNA2
Mean 7
Standard deviation 0.46
Values 6.7 7.3
[105]
liver DNA2
Mean 2.88
Standard deviation 1.1
Values 2.8 3.6 1.3 3.8