REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_C_STRAND_OF_THE_TELOMERE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCNA Proliferating cell nuclear antigen [1] 0.75[2] 0.64[3] -1.06[4] -0.67[5] -0.15[6] -2.41[7]
2 POLD2 DNA polymerase delta subunit 2 [8] -0.74[9] -0.66[10] -0.43[11] -1.32[12] -0.71[13] 0.54[14]
3 POLD4 DNA polymerase delta subunit 4 [15] -2.27[16] -2.71[17] -0.91[18] 0.99[19] -2.36[20] 0.18[21]
4 RPA2 Replication protein A 32 kDa subunit [22] -1.60[23] -1.62[24] -1.34[25] -1.19[26] -0.88[27] -1.74[28]
5 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 [29] -0.75[30] -0.51[31] -0.79[32] -1.36[33] -0.71[34] -0.22[35]
6 FEN1 Flap endonuclease 1 [36] 0.89[37] 0.58[38] 1.16[39] 0.23[40] 1.37[41] -0.43[42]
7 RPA1 Replication protein A 70 kDa DNA-binding subunit [43] 1.17[44] 0.81[45] 0.80[46] 1.40[47] 1.66[48] 0.67[49]
8 RPA3 Replication protein A 14 kDa subunit [50] -0.51[51] 0.20[52] 0.64[53] -1.36[54] -0.83[55] -0.03[56]
9 TINF2 TERF1-interacting nuclear factor 2 [57] 0.63[58] -0.81[59] -1.10[60] -0.55[61] -0.31[62] 0.47[63]
10 TERF1 Telomeric repeat-binding factor 1 [64] -1.04[65] 0.01[66] -0.02[67] 0.78[68] 0.10[69] 0.63[70]
11 TERF2 Telomeric repeat-binding factor 2 [71] 0.17[72] 0.08[73] 0.57[74] -0.54[75] 0.11[76] 0.22[77]
12 LIG1 DNA ligase 1 [78] 1.49[79] 1.42[80] 1.77[81] 0.06[82] 1.04[83] 0.29[84]
13 POLD1 DNA polymerase delta catalytic subunit [85] 1.72[86] 1.85[87] 2.38[88] 1.37[89] 2.37[90] 1.33[91]
14 POT1 Protection of telomeres protein 1 [92] -0.13[93] 1.06[94] 1.02[95] 1.32[96] 1.31[97] 1.46[98]
15 ACD Adrenocortical dysplasia protein homolog [99] 1.56[100] 1.73[101] 1.23[102] 0.31[103] 1.27[104] -0.03[105]
16 POLD3 DNA polymerase delta subunit 3 [106] 1.03[107] 0.81[108] 1.50[109] 1.66[110] 2.39[111] 1.65[112]
17 WRN Werner syndrome ATP-dependent helicase [113] 0.47[114] 1.84[115] 3.49[116] 1.25[117] 1.30[118] 2.63[119]
18 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2 [120] 1.62[121] 3.30[122] 2.22[123] 2.20[124] 2.10[125] 2.22[126]
19 BLM Bloom syndrome protein [127] 1.40[128] 2.66[129] 3.19[130] 2.45[131] 2.76[132] 0.28[133]
[1]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[2]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[3]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[4]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[5]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[6]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[7]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[8]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[9]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[10]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[11]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[12]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[13]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[14]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[15]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[16]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[17]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[18]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[19]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[20]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[21]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[22]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[23]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[24]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[25]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[26]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[27]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[28]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[29]
ref_hepatocyte TERF2IP
Mean 20.1
Standard deviation 5.4
Values 22 25 25 16 13
[30]
HepG2 TERF2IP
Mean 29
Standard deviation 0.8
Values 30 28
[31]
HepG2.C3A TERF2IP
Mean 32.6
Standard deviation 7.5
Values 38 27
[32]
HuH.7 TERF2IP
Mean 31.3
Standard deviation 5
Values 27 30 37
[33]
SNU475 TERF2IP
Mean 19.6
Standard deviation 0.25
Values 19 20
[34]
THLE TERF2IP
Mean 29.2
Standard deviation 1
Values 28 30
[35]
liver TERF2IP
Mean 15.5
Standard deviation 7.4
Values 23 9.1 21 9.1
[36]
ref_hepatocyte FEN1
Mean 8.88
Standard deviation 4.9
Values 17 9.6 7.8 7 3.4
[37]
HepG2 FEN1
Mean 40
Standard deviation 13
Values 31 49
[38]
HepG2.C3A FEN1
Mean 30.8
Standard deviation 20
Values 17 45
[39]
HuH.7 FEN1
Mean 53.6
Standard deviation 31
Values 63 19 79
[40]
SNU475 FEN1
Mean 26.1
Standard deviation 5.2
Values 22 30
[41]
THLE FEN1
Mean 54.6
Standard deviation 11
Values 47 62
[42]
liver FEN1
Mean 5.91
Standard deviation 2.9
Values 3.7 5.8 10 4.1
[43]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[44]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[45]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[46]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[47]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[48]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[49]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[50]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[51]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[52]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[53]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[54]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[55]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[56]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[57]
ref_hepatocyte TINF2
Mean 8.21
Standard deviation 1.3
Values 10 7.4 8.3 7.2 7.7
[58]
HepG2 TINF2
Mean 30.8
Standard deviation 1.5
Values 30 32
[59]
HepG2.C3A TINF2
Mean 10.8
Standard deviation 0.3
Values 11 11
[60]
HuH.7 TINF2
Mean 10.4
Standard deviation 1.3
Values 10 9 12
[61]
SNU475 TINF2
Mean 14.1
Standard deviation 0.013
Values 14 14
[62]
THLE TINF2
Mean 15.8
Standard deviation 1.4
Values 15 17
[63]
liver TINF2
Mean 10.2
Standard deviation 2.5
Values 12 7.3 12 8.9
[64]
ref_hepatocyte TERF1
Mean 4.67
Standard deviation 2
Values 2.2 3.5 6.2 4.5 6.9
[65]
HepG2 TERF1
Mean 5.51
Standard deviation 1.4
Values 4.5 6.5
[66]
HepG2.C3A TERF1
Mean 10.9
Standard deviation 3
Values 8.8 13
[67]
HuH.7 TERF1
Mean 12.4
Standard deviation 1.1
Values 13 11 12
[68]
SNU475 TERF1
Mean 20.1
Standard deviation 0.86
Values 21 19
[69]
THLE TERF1
Mean 11.9
Standard deviation 0.88
Values 11 13
[70]
liver TERF1
Mean 6.49
Standard deviation 1.9
Values 8.7 6.1 6.9 4.2
[71]
ref_hepatocyte TERF2
Mean 4.13
Standard deviation 0.67
Values 4.9 4.3 4.6 3.7 3.2
[72]
HepG2 TERF2
Mean 11.3
Standard deviation 0.25
Values 11 11
[73]
HepG2.C3A TERF2
Mean 10.1
Standard deviation 0.26
Values 9.9 10
[74]
HuH.7 TERF2
Mean 16.5
Standard deviation 2.9
Values 17 13 19
[75]
SNU475 TERF2
Mean 7.14
Standard deviation 0.058
Values 7.1 7.2
[76]
THLE TERF2
Mean 10.6
Standard deviation 0.15
Values 11 11
[77]
liver TERF2
Mean 4.32
Standard deviation 1.4
Values 6.4 3.6 3.6 3.7
[78]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[79]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[80]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[81]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[82]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[83]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[84]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[85]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[86]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[87]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[88]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[89]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[90]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[91]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[92]
ref_hepatocyte POT1
Mean 2.27
Standard deviation 0.82
Values 3.2 2.4 0.96 2.2 2.5
[93]
HepG2 POT1
Mean 5.04
Standard deviation 1.2
Values 4.2 5.9
[94]
HepG2.C3A POT1
Mean 10.9
Standard deviation 2
Values 9.5 12
[95]
HuH.7 POT1
Mean 12.4
Standard deviation 0.67
Values 12 13 12
[96]
SNU475 POT1
Mean 14.1
Standard deviation 0.62
Values 14 15
[97]
THLE POT1
Mean 13.4
Standard deviation 2.1
Values 15 12
[98]
liver POT1
Mean 5.58
Standard deviation 1.5
Values 4.5 7.1 6.7 4.1
[99]
ref_hepatocyte ACD
Mean 2.1
Standard deviation 0.79
Values 3 2.7 2.2 1.6 1
[100]
HepG2 ACD
Mean 15.1
Standard deviation 1.5
Values 16 14
[101]
HepG2.C3A ACD
Mean 16.2
Standard deviation 0.61
Values 16 17
[102]
HuH.7 ACD
Mean 13.3
Standard deviation 3.4
Values 15 9.4 15
[103]
SNU475 ACD
Mean 6.51
Standard deviation 0.88
Values 5.9 7.1
[104]
THLE ACD
Mean 12.1
Standard deviation 0.43
Values 12 12
[105]
liver ACD
Mean 1.85
Standard deviation 1.2
Values 3.2 0.64 2.5 1
[106]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[107]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[108]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[109]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[110]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[111]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[112]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[113]
ref_hepatocyte WRN
Mean 1.33
Standard deviation 0.66
Values 1.8 1.8 1.8 0.68 0.54
[114]
HepG2 WRN
Mean 4.47
Standard deviation 1.6
Values 3.3 5.6
[115]
HepG2.C3A WRN
Mean 11
Standard deviation 2.1
Values 9.5 12
[116]
HuH.7 WRN
Mean 40.4
Standard deviation 6.8
Values 43 46 33
[117]
SNU475 WRN
Mean 7.93
Standard deviation 0.72
Values 8.4 7.4
[118]
THLE WRN
Mean 7.81
Standard deviation 1.9
Values 9.2 6.5
[119]
liver WRN
Mean 7.39
Standard deviation 3.4
Values 4.3 10 4.7 10
[120]
ref_hepatocyte DNA2
Mean 0.686
Standard deviation 0.42
Values 1.2 1.1 0.52 0.36 0.28
[121]
HepG2 DNA2
Mean 5.13
Standard deviation 3.4
Values 2.7 7.6
[122]
HepG2.C3A DNA2
Mean 15.6
Standard deviation 12
Values 7.4 24
[123]
HuH.7 DNA2
Mean 8.62
Standard deviation 3.7
Values 11 4.3 11
[124]
SNU475 DNA2
Mean 7.89
Standard deviation 1.4
Values 6.9 8.9
[125]
THLE DNA2
Mean 7
Standard deviation 0.46
Values 6.7 7.3
[126]
liver DNA2
Mean 2.88
Standard deviation 1.1
Values 2.8 3.6 1.3 3.8
[127]
ref_hepatocyte BLM
Mean 0.47
Standard deviation 0.48
Values 1.3 0.54 0.16 0.18 0.18
[128]
HepG2 BLM
Mean 3.02
Standard deviation 1.6
Values 1.9 4.1
[129]
HepG2.C3A BLM
Mean 6.88
Standard deviation 4.6
Values 3.6 10
[130]
HuH.7 BLM
Mean 11.6
Standard deviation 6.1
Values 16 4.6 14
[131]
SNU475 BLM
Mean 6.41
Standard deviation 2.4
Values 4.7 8.1
[132]
THLE BLM
Mean 7.59
Standard deviation 0.46
Values 7.3 7.9
[133]
liver BLM
Mean 0.512
Standard deviation 0.32
Values 0.38 0.87 0.67 0.13