REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.87[2] | -1.28[3] | -1.32[4] | -1.36[5] | -1.11[6] | -0.38[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.43[16] | -0.53[17] | -0.95[18] | -0.51[19] | -0.73[20] | 0.07[21] |
4 | SUMO1 | Small ubiquitin-related modifier 1 | [22] | -0.27[23] | -0.33[24] | -0.87[25] | -0.05[26] | -0.31[27] | -0.05[28] |
5 | SUMO2 | Small ubiquitin-related modifier 2 | [29] | 1.36[30] | 1.35[31] | 1.21[32] | 0.78[33] | 0.55[34] | -0.08[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 2.01[37] | 1.70[38] | 2.56[39] | 0.89[40] | 1.49[41] | 0.84[42] |
7 | PPP4C | Serine/threonine-protein phosphatase 4 catalytic subunit | [43] | 1.07[44] | 1.07[45] | 0.36[46] | -0.40[47] | -0.56[48] | 0.04[49] |
8 | BABAM1 | BRISC and BRCA1-A complex member 1 | [50] | 0.51[51] | 0.50[52] | 1.21[53] | 0.38[54] | 0.85[55] | 0.02[56] |
9 | RPA2 | Replication protein A 32 kDa subunit | [57] | -0.13[58] | -0.27[59] | 0.11[60] | 0.67[61] | 0.54[62] | -0.91[63] |
10 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [64] | 2.02[65] | 2.28[66] | 0.92[67] | 1.73[68] | 1.42[69] | 0.77[70] |
11 | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 | [71] | -0.12[72] | 0.67[73] | 0.97[74] | 1.49[75] | 1.08[76] | 0.89[77] |
12 | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | [78] | 0.20[79] | 1.08[80] | 0.00[81] | 0.00[82] | 0.61[83] | 0.69[84] |
13 | CDK2 | Cyclin-dependent kinase 2 | [85] | 0.92[86] | 0.87[87] | 1.06[88] | 1.40[89] | 1.78[90] | -0.69[91] |
14 | RFC4 | Replication factor C subunit 4 | [92] | 0.36[93] | 0.77[94] | 1.17[95] | 0.45[96] | 1.57[97] | -1.26[98] |
15 | UBE2I | SUMO-conjugating enzyme UBC9 | [99] | 2.62[100] | 2.08[101] | 2.28[102] | 1.74[103] | 2.10[104] | 0.94[105] |
16 | RNF4 | E3 ubiquitin-protein ligase RNF4 | [106] | 2.45[107] | 1.65[108] | 2.92[109] | 3.35[110] | 2.16[111] | 1.67[112] |
17 | RFC2 | Replication factor C subunit 2 | [113] | 1.07[114] | 0.71[115] | 0.57[116] | 1.59[117] | 1.85[118] | 0.72[119] |
18 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [120] | 2.64[121] | 2.16[122] | 2.25[123] | 3.27[124] | 3.08[125] | 1.49[126] |
19 | RPA3 | Replication protein A 14 kDa subunit | [127] | 0.96[128] | 1.55[129] | 2.08[130] | 0.51[131] | 0.59[132] | 0.80[133] |
20 | RAD17 | Cell cycle checkpoint protein RAD17 | [134] | 0.48[135] | 1.35[136] | 1.22[137] | 1.07[138] | 1.22[139] | 1.06[140] |
21 | KAT5 | Histone acetyltransferase KAT5 | [141] | 0.55[142] | 0.75[143] | -0.47[144] | 0.58[145] | 0.29[146] | 0.42[147] |
22 | NBN | Nibrin | [148] | 0.91[149] | 1.88[150] | 1.45[151] | 2.92[152] | 1.83[153] | 2.76[154] |
23 | RFC5 | Replication factor C subunit 5 | [155] | 1.46[156] | 1.70[157] | 1.72[158] | 1.68[159] | 2.01[160] | 0.61[161] |
24 | SIRT6 | NAD-dependent protein deacetylase sirtuin-6 | [162] | 0.64[163] | 0.13[164] | 0.66[165] | 0.25[166] | 0.55[167] | -0.16[168] |
25 | UIMC1 | BRCA1-A complex subunit RAP80 | [169] | 1.70[170] | 1.72[171] | 1.98[172] | 1.49[173] | 1.43[174] | 1.20[175] |
26 | BRCC3 | Lys-63-specific deubiquitinase BRCC36 | [176] | 0.86[177] | 1.59[178] | 0.69[179] | 1.19[180] | 1.15[181] | 1.93[182] |
27 | RAD50 | DNA repair protein RAD50 | [183] | 1.48[184] | 3.40[185] | 2.37[186] | 2.68[187] | 2.96[188] | 3.70[189] |
28 | RMI2 | RecQ-mediated genome instability protein 2 | [190] | 2.58[191] | 1.65[192] | 1.42[193] | 0.22[194] | 0.32[195] | -2.94[196] |
29 | RBBP8 | DNA endonuclease RBBP8 | [197] | 1.52[198] | 2.72[199] | 1.16[200] | 2.85[201] | 2.85[202] | 1.74[203] |
30 | TIMELESS | Protein timeless homolog | [204] | 3.26[205] | 3.32[206] | 3.67[207] | 3.33[208] | 3.76[209] | 2.75[210] |
31 | PIAS4 | E3 SUMO-protein ligase PIAS4 | [211] | 1.57[212] | 0.87[213] | 1.44[214] | 0.89[215] | 0.79[216] | 1.08[217] |
32 | TOPBP1 | DNA topoisomerase 2-binding protein 1 | [218] | 2.35[219] | 3.17[220] | 3.14[221] | 3.54[222] | 3.75[223] | 2.37[224] |
33 | CCNA2 | Cyclin-A2 | [225] | 3.53[226] | 4.33[227] | 3.49[228] | 3.42[229] | 4.60[230] | 0.26[231] |
34 | RNF8 | E3 ubiquitin-protein ligase RNF8 | [232] | 2.67[233] | 2.53[234] | 1.00[235] | 2.69[236] | 1.97[237] | 1.40[238] |
35 | RFC3 | Replication factor C subunit 3 | [239] | 2.50[240] | 3.15[241] | 3.11[242] | 2.67[243] | 3.06[244] | 0.62[245] |
36 | HUS1 | Checkpoint protein HUS1 | [246] | 0.61[247] | 0.67[248] | 1.03[249] | 1.30[250] | 0.90[251] | 2.86[252] |
37 | TIPIN | TIMELESS-interacting protein | [253] | 1.15[254] | 0.65[255] | 1.11[256] | 1.56[257] | 1.91[258] | -0.56[259] |
38 | CHEK1 | Serine/threonine-protein kinase Chk1 | [260] | 2.87[261] | 3.01[262] | 2.40[263] | 3.57[264] | 3.59[265] | -0.53[266] |
39 | RNF168 | E3 ubiquitin-protein ligase RNF168 | [267] | 1.72[268] | 2.15[269] | 2.96[270] | 1.49[271] | 2.45[272] | 3.58[273] |
40 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [274] | 3.82[275] | 4.01[276] | 4.16[277] | 4.31[278] | 4.03[279] | 2.94[280] |
41 | TOP3A | DNA topoisomerase 3-alpha | [281] | 3.29[282] | 2.75[283] | 2.87[284] | 3.26[285] | 3.45[286] | 3.29[287] |
42 | RAD1 | Cell cycle checkpoint protein RAD1 | [288] | 2.69[289] | 3.16[290] | 3.51[291] | 3.22[292] | 3.91[293] | 2.40[294] |
43 | RAD9A | Cell cycle checkpoint control protein RAD9A | [295] | 1.40[296] | 1.47[297] | 3.09[298] | 3.74[299] | 1.36[300] | 1.32[301] |
44 | BRCA1 | Breast cancer type 1 susceptibility protein | [302] | 3.00[303] | 4.03[304] | 4.24[305] | 3.56[306] | 3.88[307] | 3.17[308] |
45 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [309] | 3.79[310] | 3.27[311] | 3.64[312] | 4.50[313] | 4.36[314] | 5.66[315] |
46 | ATRIP | ATR-interacting protein | [316] | 1.57[317] | 1.60[318] | 2.29[319] | 1.07[320] | 1.94[321] | 1.33[322] |
47 | ATR | Serine/threonine-protein kinase ATR | [323] | 2.42[324] | 3.21[325] | 3.10[326] | 3.94[327] | 3.70[328] | 5.04[329] |
48 | TP53BP1 | TP53-binding protein 1 | [330] | 3.91[331] | 3.20[332] | 3.98[333] | 5.35[334] | 4.60[335] | 3.77[336] |
49 | WRN | Werner syndrome ATP-dependent helicase | [337] | 1.94[338] | 3.18[339] | 4.94[340] | 3.11[341] | 2.72[342] | 3.46[343] |
50 | CLSPN | Claspin | [344] | 2.69[345] | 2.90[346] | 3.00[347] | 4.16[348] | 4.35[349] | 0.35[350] |
51 | RMI1 | RecQ-mediated genome instability protein 1 | [351] | 1.91[352] | 2.93[353] | 3.20[354] | 3.49[355] | 4.13[356] | 2.48[357] |
52 | ATM | Serine-protein kinase ATM | [358] | 4.36[359] | 5.75[360] | 5.29[361] | 5.57[362] | 4.85[363] | 6.48[364] |
53 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [365] | 3.09[366] | 4.64[367] | 3.66[368] | 4.06[369] | 3.52[370] | 3.05[371] |
54 | EXO1 | Exonuclease 1 | [372] | 3.23[373] | 3.30[374] | 4.29[375] | 5.19[376] | 4.27[377] | 0.02[378] |
55 | BRIP1 | Fanconi anemia group J protein | [379] | 3.48[380] | 4.66[381] | 4.49[382] | 4.62[383] | 4.46[384] | 3.45[385] |
56 | BLM | Bloom syndrome protein | [386] | 2.87[387] | 4.01[388] | 4.64[389] | 4.31[390] | 4.18[391] | 1.11[392] |
57 | BARD1 | BRCA1-associated RING domain protein 1 | [393] | 2.64[394] | 3.42[395] | 3.25[396] | 4.11[397] | 3.99[398] | 3.36[399] |
58 | RAD9B | Cell cycle checkpoint control protein RAD9B | [400] | -2.00[401] | 0.98[402] | 0.11[403] | 1.85[404] | 0.98[405] | 0.70[406] |
59 | CCNA1 | Cyclin-A1 | [407] | [408] | -2.28[409] | [410] | 0.62[411] | 7.82[412] | [413] |
60 | BABAM2 | BRISC and BRCA1-A complex member 2 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |
61 | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | H4C9 | [428] | [429] | [430] | [431] | [432] | [433] | [434] | |
63 | H2BC7 | [435] | [436] | [437] | [438] | [439] | [440] | [441] | |
64 | H4C5 | [442] | [443] | [444] | [445] | [446] | [447] | [448] | |
65 | H2BU1 | [449] | [450] | [451] | [452] | [453] | [454] | [455] | |
66 | H2BC6 | [456] | [457] | [458] | [459] | [460] | [461] | [462] | |
67 | H4C6 | [463] | [464] | [465] | [466] | [467] | [468] | [469] | |
68 | H4C14 | [470] | [471] | [472] | [473] | [474] | [475] | [476] | |
69 | H2BC4 | [477] | [478] | [479] | [480] | [481] | [482] | [483] | |
70 | H4C1 | [484] | [485] | [486] | [487] | [488] | [489] | [490] | |
71 | H2BC8 | [491] | [492] | [493] | [494] | [495] | [496] | [497] | |
72 | H2BC13 | [498] | [499] | [500] | [501] | [502] | [503] | [504] | |
73 | H4C3 | [505] | [506] | [507] | [508] | [509] | [510] | [511] | |
74 | H2BS1 | [512] | [513] | [514] | [515] | [516] | [517] | [518] | |
75 | H4C12 | [519] | [520] | [521] | [522] | [523] | [524] | [525] | |
76 | H4C13 | [526] | [527] | [528] | [529] | [530] | [531] | [532] | |
77 | H2BC9 | [533] | [534] | [535] | [536] | [537] | [538] | [539] | |
78 | H4-16 | [540] | [541] | [542] | [543] | [544] | [545] | [546] | |
79 | H2BC3 | [547] | [548] | [549] | [550] | [551] | [552] | [553] | |
80 | H2BC1 | [554] | [555] | [556] | [557] | [558] | [559] | [560] | |
81 | H4C8 | [561] | [562] | [563] | [564] | [565] | [566] | [567] | |
82 | H2BC15 | [568] | [569] | [570] | [571] | [572] | [573] | [574] | |
83 | H3-4 | [575] | [576] | [577] | [578] | [579] | [580] | [581] | |
84 | H4C4 | [582] | [583] | [584] | [585] | [586] | [587] | [588] | |
85 | H4C11 | [589] | [590] | [591] | [592] | [593] | [594] | [595] | |
86 | H2BC10 | [596] | [597] | [598] | [599] | [600] | [601] | [602] | |
87 | H2AX | [603] | [604] | [605] | [606] | [607] | [608] | [609] | |
88 | H2BC17 | [610] | [611] | [612] | [613] | [614] | [615] | [616] | |
89 | H2BC21 | [617] | [618] | [619] | [620] | [621] | [622] | [623] | |
90 | ABRAXAS | BRCA1-A complex subunit Abraxas 1 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | NSD2 | Histone-lysine N-methyltransferase NSD2 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | MRE11 | Double-strand break repair protein MRE11 | [638] | [639] | [640] | [641] | [642] | [643] | [644] |
93 | H4C15 | [645] | [646] | [647] | [648] | [649] | [650] | [651] | |
94 | H2BC14 | [652] | [653] | [654] | [655] | [656] | [657] | [658] | |
95 | H2BC5 | [659] | [660] | [661] | [662] | [663] | [664] | [665] | |
96 | H2BC11 | [666] | [667] | [668] | [669] | [670] | [671] | [672] | |
97 | H2BC12 | [673] | [674] | [675] | [676] | [677] | [678] | [679] | |
98 | H4C2 | [680] | [681] | [682] | [683] | [684] | [685] | [686] |