REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSP90AB1 | Heat shock protein HSP 90-beta | [1] | -0.13[2] | -0.04[3] | -0.77[4] | -0.80[5] | -1.31[6] | -1.68[7] |
2 | HSP90AA1 | Heat shock protein HSP 90-alpha | [8] | -1.00[9] | -0.04[10] | -0.73[11] | -0.17[12] | -0.37[13] | -0.83[14] |
3 | TUBB | Tubulin beta chain | [15] | 1.43[16] | 0.69[17] | 1.16[18] | 1.31[19] | 0.74[20] | -0.35[21] |
4 | PTGES3 | Prostaglandin E synthase 3 | [22] | -1.13[23] | -0.80[24] | -0.37[25] | -0.93[26] | -0.87[27] | -1.65[28] |
5 | ITGB1 | Integrin beta-1 | [29] | -0.13[30] | -0.11[31] | 0.11[32] | 1.21[33] | 1.40[34] | 0.58[35] |
6 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [36] | -0.47[37] | -0.88[38] | -2.36[39] | -0.51[40] | -0.82[41] | -0.95[42] |
7 | FXYD1 | Phospholemman | [43] | -6.54[44] | -5.15[45] | -12.86[46] | -15.26[47] | -13.24[48] | -2.67[49] |
8 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | [50] | 2.00[51] | 1.09[52] | 1.38[53] | -0.01[54] | 0.53[55] | 0.47[56] |
9 | SIGMAR1 | Sigma non-opioid intracellular receptor 1 | [57] | -1.57[58] | -1.20[59] | -1.74[60] | -3.37[61] | -1.74[62] | 0.48[63] |
10 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [64] | -2.42[65] | -1.99[66] | -2.02[67] | -2.96[68] | -2.42[69] | -1.68[70] |
11 | IMPDH2 | Inosine-5'-monophosphate dehydrogenase 2 | [71] | -0.16[72] | 0.27[73] | 1.82[74] | -1.42[75] | -0.88[76] | -1.83[77] |
12 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | [78] | -0.68[79] | -0.25[80] | -0.15[81] | -0.93[82] | -2.10[83] | -0.35[84] |
13 | AP2M1 | AP-2 complex subunit mu | [85] | -0.14[86] | -0.35[87] | -0.76[88] | 0.72[89] | 1.35[90] | 0.26[91] |
14 | COMT | Catechol O-methyltransferase | [92] | -0.99[93] | -0.40[94] | -2.48[95] | -1.99[96] | -1.83[97] | 0.79[98] |
15 | AP2S1 | AP-2 complex subunit sigma | [99] | -1.98[100] | -2.01[101] | -1.22[102] | -1.00[103] | -0.45[104] | -0.60[105] |
16 | FURIN | Furin | [106] | 1.27[107] | -2.49[108] | -0.24[109] | -1.52[110] | -0.95[111] | 2.07[112] |
17 | FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 | [113] | -0.50[114] | -0.93[115] | 0.25[116] | -1.56[117] | -0.06[118] | -0.32[119] |
18 | IFNGR1 | Interferon gamma receptor 1 | [120] | 0.42[121] | -0.70[122] | -2.08[123] | -0.63[124] | -0.77[125] | 0.11[126] |
19 | SAP18 | Histone deacetylase complex subunit SAP18 | [127] | -0.41[128] | -0.21[129] | -0.37[130] | -0.41[131] | -0.46[132] | 0.29[133] |
20 | RBBP7 | Histone-binding protein RBBP7 | [134] | -0.49[135] | -0.32[136] | -0.55[137] | 0.39[138] | 1.25[139] | -0.24[140] |
21 | HDAC1 | Histone deacetylase 1 | [141] | 0.15[142] | 0.16[143] | 0.93[144] | 0.39[145] | 0.29[146] | -0.04[147] |
22 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | -1.26[148] | -0.30[149] | 0.33[150] | -1.87[151] | -1.25[152] | -0.48[153] | |
23 | HMG20B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | -1.20[154] | -0.81[155] | 0.23[156] | -1.15[157] | -0.50[158] | -0.41[159] | |
24 | BRMS1 | Breast cancer metastasis-suppressor 1 | [160] | -0.63[161] | -1.40[162] | 0.29[163] | -0.54[164] | -1.22[165] | -0.85[166] |
25 | IL1R1 | Interleukin-1 receptor type 1 | [167] | -0.93[168] | -1.30[169] | -1.86[170] | -1.08[171] | 1.71[172] | 1.19[173] |
26 | IFNGR2 | Interferon gamma receptor 2 | [174] | -0.39[175] | 0.16[176] | -1.78[177] | -1.62[178] | -0.22[179] | -0.16[180] |
27 | NFE2L2 | Nuclear factor erythroid 2-related factor 2 | [181] | 0.40[182] | 1.33[183] | 1.02[184] | 0.21[185] | 0.56[186] | 0.59[187] |
28 | VEGFA | Vascular endothelial growth factor A | [188] | 0.86[189] | 2.19[190] | 0.87[191] | 0.18[192] | 1.01[193] | 1.20[194] |
29 | JAK1 | Tyrosine-protein kinase JAK1 | [195] | 0.15[196] | -0.37[197] | -0.10[198] | 0.37[199] | 1.13[200] | 1.95[201] |
30 | KDM1A | Lysine-specific histone demethylase 1A | [202] | 0.72[203] | 1.30[204] | 0.90[205] | 0.62[206] | 0.26[207] | -0.40[208] |
31 | CHD4 | Chromodomain-helicase-DNA-binding protein 4 | [209] | 1.68[210] | 1.20[211] | 1.34[212] | 1.73[213] | 1.71[214] | 1.99[215] |
32 | KEAP1 | Kelch-like ECH-associated protein 1 | [216] | -0.15[217] | -0.25[218] | -0.44[219] | -1.07[220] | 0.03[221] | 0.97[222] |
33 | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | [223] | 0.60[224] | -0.14[225] | 0.11[226] | 0.55[227] | 1.35[228] | -1.59[229] |
34 | IFNAR2 | Interferon alpha/beta receptor 2 | [230] | -1.57[231] | -1.92[232] | -1.15[233] | -1.65[234] | -1.54[235] | -0.36[236] |
35 | MTA1 | Metastasis-associated protein MTA1 | [237] | -0.07[238] | -0.15[239] | 0.08[240] | -0.36[241] | -0.37[242] | -1.60[243] |
36 | MTA2 | Metastasis-associated protein MTA2 | [244] | 0.66[245] | -0.18[246] | 0.25[247] | 0.37[248] | 0.71[249] | -0.01[250] |
37 | MBD3 | Methyl-CpG-binding domain protein 3 | [251] | 0.11[252] | 0.67[253] | -0.08[254] | -0.56[255] | 0.54[256] | 0.33[257] |
38 | AP2A1 | AP-2 complex subunit alpha-1 | [258] | 0.85[259] | 0.50[260] | 1.42[261] | 1.15[262] | 1.33[263] | 1.37[264] |
39 | IL6R | Interleukin-6 receptor subunit alpha | [265] | -0.58[266] | -0.26[267] | -1.00[268] | -1.13[269] | -5.11[270] | 2.08[271] |
40 | AP2B1 | AP-2 complex subunit beta | [272] | 1.88[273] | 1.60[274] | 3.41[275] | 2.30[276] | 2.27[277] | 1.35[278] |
41 | AP2A2 | AP-2 complex subunit alpha-2 | [279] | 0.90[280] | 0.74[281] | 0.95[282] | 0.59[283] | 0.35[284] | 1.09[285] |
42 | GATAD2A | Transcriptional repressor p66-alpha | [286] | 0.80[287] | -0.01[288] | 1.43[289] | 0.03[290] | 1.01[291] | 0.48[292] |
43 | MTA3 | Metastasis-associated protein MTA3 | [293] | 0.17[294] | -0.14[295] | -0.93[296] | -0.18[297] | -0.43[298] | -1.23[299] |
44 | NR3C1 | Glucocorticoid receptor | [300] | -0.32[301] | -0.75[302] | -0.37[303] | 1.22[304] | 1.45[305] | 2.19[306] |
45 | IFNAR1 | Interferon alpha/beta receptor 1 | [307] | -0.30[308] | 0.17[309] | -0.04[310] | 0.73[311] | 0.83[312] | 2.85[313] |
46 | RBBP4 | Histone-binding protein RBBP4 | [314] | 1.58[315] | 1.69[316] | 1.59[317] | 1.42[318] | 1.92[319] | 1.92[320] |
47 | TBK1 | Serine/threonine-protein kinase TBK1 | [321] | -1.00[322] | 0.68[323] | -0.10[324] | 0.24[325] | 0.43[326] | 0.90[327] |
48 | ROCK1 | Rho-associated protein kinase 1 | [328] | -1.31[329] | 0.20[330] | 1.06[331] | 1.11[332] | 0.56[333] | 2.00[334] |
49 | HDAC2 | Histone deacetylase 2 | [335] | 1.36[336] | 2.68[337] | 2.14[338] | 1.91[339] | 2.16[340] | 0.62[341] |
50 | BRD4 | Bromodomain-containing protein 4 | [342] | 0.97[343] | 0.33[344] | 1.08[345] | 0.28[346] | 1.03[347] | 1.29[348] |
51 | CRBN | Protein cereblon | [349] | -1.26[350] | 0.23[351] | 0.48[352] | -1.37[353] | -0.13[354] | 1.40[355] |
52 | STAT2 | Signal transducer and activator of transcription 2 | [356] | -0.33[357] | 1.03[358] | 0.27[359] | 1.28[360] | 0.84[361] | 3.45[362] |
53 | CUL3 | Cullin-3 | [363] | 0.25[364] | 1.16[365] | 0.96[366] | 1.21[367] | 1.41[368] | 1.36[369] |
54 | SUDS3 | Sin3 histone deacetylase corepressor complex component SDS3 | [370] | 0.59[371] | 1.25[372] | 1.16[373] | 0.86[374] | 0.46[375] | 1.53[376] |
55 | ROCK2 | Rho-associated protein kinase 2 | [377] | 1.11[378] | 2.35[379] | 0.90[380] | 2.38[381] | 0.26[382] | 2.35[383] |
56 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [384] | 0.78[385] | 1.13[386] | 1.34[387] | 0.49[388] | 1.53[389] | 2.41[390] |
57 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | [391] | 1.55[392] | 0.83[393] | 0.66[394] | 1.80[395] | 1.38[396] | -0.82[397] |
58 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [398] | -0.07[399] | 0.08[400] | -0.15[401] | 0.82[402] | 0.46[403] | 1.90[404] |
59 | SAP30 | Histone deacetylase complex subunit SAP30 | [405] | -0.89[406] | -0.31[407] | 0.38[408] | -1.23[409] | 0.54[410] | -2.03[411] |
60 | ARID4A | AT-rich interactive domain-containing protein 4A | [412] | -1.88[413] | 0.75[414] | 0.70[415] | 0.14[416] | -0.33[417] | 2.21[418] |
61 | ARID4B | AT-rich interactive domain-containing protein 4B | [419] | -0.80[420] | 0.99[421] | 1.20[422] | 1.56[423] | 0.80[424] | 2.41[425] |
62 | S1PR1 | Sphingosine 1-phosphate receptor 1 | [426] | -8.75[427] | [428] | -3.61[429] | -2.80[430] | -1.05[431] | 1.45[432] |
63 | RCOR1 | REST corepressor 1 | [433] | 1.43[434] | 1.22[435] | 1.36[436] | 2.58[437] | 1.87[438] | 1.51[439] |
64 | SAP30L | Histone deacetylase complex subunit SAP30L | [440] | 0.88[441] | 1.37[442] | 1.66[443] | 0.90[444] | 1.77[445] | 2.15[446] |
65 | REST | RE1-silencing transcription factor | [447] | 0.93[448] | 1.64[449] | 1.88[450] | 1.92[451] | 2.31[452] | 3.55[453] |
66 | PHF21A | PHD finger protein 21A | [454] | 1.96[455] | 1.46[456] | 3.03[457] | 1.21[458] | 1.56[459] | 1.65[460] |
67 | GATAD2B | Transcriptional repressor p66-beta | [461] | 1.28[462] | 0.89[463] | 2.40[464] | 2.52[465] | 2.44[466] | 2.54[467] |
68 | FNTB | Protein farnesyltransferase subunit beta | [468] | -1.44[469] | -1.72[470] | -3.90[471] | -2.07[472] | -2.62[473] | -1.87[474] |
69 | FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | [475] | -0.93[476] | -2.85[477] | [478] | [479] | [480] | 0.25[481] |
70 | JAK2 | Tyrosine-protein kinase JAK2 | [482] | -0.13[483] | -0.14[484] | -0.50[485] | 0.51[486] | 1.22[487] | 3.13[488] |
71 | CHD3 | Chromodomain-helicase-DNA-binding protein 3 | [489] | 2.44[490] | 3.04[491] | 5.25[492] | 6.04[493] | 5.33[494] | 2.94[495] |
72 | FXYD6 | FXYD domain-containing ion transport regulator 6 | [496] | -8.38[497] | [498] | [499] | -3.31[500] | -8.17[501] | 3.14[502] |
73 | ACE2 | Angiotensin-converting enzyme 2 | [503] | -0.67[504] | 0.66[505] | -0.22[506] | -7.27[507] | -6.56[508] | 0.34[509] |
74 | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | [510] | -2.70[511] | -1.97[512] | -0.67[513] | -0.94[514] | -1.67[515] | 2.23[516] |
75 | JAK3 | Tyrosine-protein kinase JAK3 | [517] | 1.89[518] | 4.15[519] | -1.77[520] | -0.89[521] | -0.04[522] | 3.52[523] |
76 | CYSLTR1 | Cysteinyl leukotriene receptor 1 | [524] | [525] | [526] | [527] | [528] | [529] | 0.58[530] |
77 | ITGA4 | Integrin alpha-4 | [531] | -4.01[532] | [533] | -1.45[534] | 7.34[535] | 4.10[536] | 3.85[537] |
78 | ZBP1 | Z-DNA-binding protein 1 | [538] | -4.66[539] | -3.86[540] | -4.69[541] | -2.96[542] | -3.11[543] | -0.08[544] |
79 | TLR7 | Toll-like receptor 7 | [545] | -1.19[546] | -0.41[547] | -0.02[548] | -0.84[549] | -1.16[550] | 1.69[551] |
80 | ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | [552] | 0.48[553] | [554] | -4.49[555] | -1.01[556] | -1.06[557] | -0.79[558] |
81 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | [559] | 2.13[560] | 0.61[561] | -0.14[562] | 2.17[563] | 0.10[564] | 2.90[565] |
82 | FXYD3 | FXYD domain-containing ion transport regulator 3 | [566] | 3.04[567] | 7.07[568] | 3.33[569] | -3.03[570] | -4.80[571] | 0.63[572] |
83 | PDCD1 | Programmed cell death protein 1 | [573] | 4.47[574] | 1.16[575] | [576] | -0.49[577] | [578] | 3.04[579] |
84 | TLR9 | Toll-like receptor 9 | [580] | [581] | [582] | [583] | [584] | [585] | [586] |
85 | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | [587] | [588] | [589] | [590] | [591] | [592] | [593] |
86 | FXYD7 | FXYD domain-containing ion transport regulator 7 | [594] | [595] | [596] | [597] | [598] | [599] | [600] |
87 | FXYD4 | FXYD domain-containing ion transport regulator 4 | [601] | [602] | [603] | [604] | [605] | [606] | [607] |