REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCNA Proliferating cell nuclear antigen [1] 0.80[2] 0.58[3] -1.02[4] -0.61[5] -0.21[6] -2.46[7]
2 POLD2 DNA polymerase delta subunit 2 [8] -0.69[9] -0.72[10] -0.40[11] -1.26[12] -0.77[13] 0.49[14]
3 POLD4 DNA polymerase delta subunit 4 [15] -2.22[16] -2.77[17] -0.88[18] 1.05[19] -2.42[20] 0.13[21]
4 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 [22] -0.70[23] -0.57[24] -0.76[25] -1.31[26] -0.78[27] -0.27[28]
5 CHTF8 Chromosome transmission fidelity protein 8 homolog isoform 2 [29] 0.29[30] -0.07[31] 0.09[32] -0.14[33] -0.02[34] -0.03[35]
6 RFC4 Replication factor C subunit 4 [36] -1.06[37] -0.64[38] -0.24[39] -1.37[40] 0.09[41] -2.14[42]
7 TEN1 CST complex subunit TEN1 [43] [44] [45] [46] [47] [48] [49]
8 RFC1 Replication factor C subunit 1 [50] 0.05[51] 1.13[52] 1.33[53] -0.08[54] 0.89[55] 1.39[56]
9 RFC2 Replication factor C subunit 2 [57] -0.35[58] -0.70[59] -0.85[60] -0.22[61] 0.36[62] -0.16[63]
10 TINF2 TERF1-interacting nuclear factor 2 [64] 0.68[65] -0.87[66] -1.06[67] -0.49[68] -0.37[69] 0.41[70]
11 RFC5 Replication factor C subunit 5 [71] 0.04[72] 0.29[73] 0.30[74] -0.13[75] 0.52[76] -0.27[77]
12 TERF1 Telomeric repeat-binding factor 1 [78] -0.99[79] -0.05[80] 0.01[81] 0.83[82] 0.04[83] 0.58[84]
13 TERF2 Telomeric repeat-binding factor 2 [85] 0.22[86] 0.02[87] 0.60[88] -0.48[89] 0.05[90] 0.17[91]
14 RFC3 Replication factor C subunit 3 [92] 1.09[93] 1.74[94] 1.70[95] 0.85[96] 1.57[97] -0.26[98]
15 POLA2 DNA polymerase alpha subunit B [99] 0.55[100] -0.02[101] 0.36[102] 1.12[103] 1.54[104] -0.23[105]
16 PRIM1 DNA primase small subunit [106] 0.58[107] 1.70[108] 1.84[109] 0.76[110] 1.47[111] -0.30[112]
17 POLD1 DNA polymerase delta catalytic subunit [113] 1.77[114] 1.79[115] 2.42[116] 1.43[117] 2.31[118] 1.28[119]
18 PRIM2 DNA primase large subunit [120] 1.19[121] 0.79[122] 0.22[123] 0.78[124] 1.15[125] -0.97[126]
19 POT1 Protection of telomeres protein 1 [127] -0.08[128] 1.00[129] 1.06[130] 1.37[131] 1.25[132] 1.40[133]
20 ACD Adrenocortical dysplasia protein homolog [134] 1.61[135] 1.67[136] 1.26[137] 0.36[138] 1.21[139] -0.08[140]
21 DSCC1 Sister chromatid cohesion protein DCC1 [141] 0.66[142] 1.16[143] 1.85[144] 1.31[145] 0.93[146] -1.24[147]
22 POLD3 DNA polymerase delta subunit 3 [148] 1.08[149] 0.75[150] 1.54[151] 1.72[152] 2.33[153] 1.60[154]
23 CTC1 CST complex subunit CTC1 [155] 1.88[156] 1.86[157] 2.65[158] 1.33[159] 1.48[160] 2.69[161]
24 POLA1 DNA polymerase alpha catalytic subunit [162] 1.92[163] 1.82[164] 2.19[165] 2.59[166] 2.68[167] 2.28[168]
25 CHTF18 Chromosome transmission fidelity protein 18 homolog [169] 1.32[170] 1.95[171] 2.35[172] 0.95[173] 1.89[174] 0.34[175]
26 STN1 CST complex subunit STN1 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[2]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[3]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[4]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[5]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[6]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[7]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[8]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[9]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[10]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[11]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[12]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[13]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[14]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[15]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[16]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[17]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[18]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[19]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[20]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[21]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[22]
ref_hepatocyte TERF2IP
Mean 20.1
Standard deviation 5.4
Values 22 25 25 16 13
[23]
HepG2 TERF2IP
Mean 29
Standard deviation 0.8
Values 30 28
[24]
HepG2.C3A TERF2IP
Mean 32.6
Standard deviation 7.5
Values 38 27
[25]
HuH.7 TERF2IP
Mean 31.3
Standard deviation 5
Values 27 30 37
[26]
SNU475 TERF2IP
Mean 19.6
Standard deviation 0.25
Values 19 20
[27]
THLE TERF2IP
Mean 29.2
Standard deviation 1
Values 28 30
[28]
liver TERF2IP
Mean 15.5
Standard deviation 7.4
Values 23 9.1 21 9.1
[29]
ref_hepatocyte CHTF8
Mean 15.3
Standard deviation 4.6
Values 9.3 12 17 21 17
[30]
HepG2 CHTF8
Mean 44
Standard deviation 2.7
Values 46 42
[31]
HepG2.C3A CHTF8
Mean 35.2
Standard deviation 6.4
Values 31 40
[32]
HuH.7 CHTF8
Mean 43
Standard deviation 8.3
Values 49 33 47
[33]
SNU475 CHTF8
Mean 33.6
Standard deviation 2.5
Values 32 35
[34]
THLE CHTF8
Mean 37.6
Standard deviation 8.5
Values 32 44
[35]
liver CHTF8
Mean 13.9
Standard deviation 2.6
Values 10 15 14 16
[36]
ref_hepatocyte RFC4
Mean 11
Standard deviation 7.9
Values 17 21 9.8 4.7 2.4
[37]
HepG2 RFC4
Mean 12.4
Standard deviation 2.7
Values 10 14
[38]
HepG2.C3A RFC4
Mean 17
Standard deviation 7.7
Values 12 22
[39]
HuH.7 RFC4
Mean 24.4
Standard deviation 12
Values 26 12 35
[40]
SNU475 RFC4
Mean 10.3
Standard deviation 3.5
Values 7.8 13
[41]
THLE RFC4
Mean 29.1
Standard deviation 0.079
Values 29 29
[42]
liver RFC4
Mean 2.31
Standard deviation 1.2
Values 2.3 1.9 4 1
[43]
ref_hepatocyte TEN1
Mean 10
Standard deviation 5.9
Values 3 4.6 13 17 13
[44]
HepG2 TEN1
Missing
[45]
HepG2.C3A TEN1
Missing
[46]
HuH.7 TEN1
Missing
[47]
SNU475 TEN1
Missing
[48]
THLE TEN1
Missing
[49]
liver TEN1
Missing
[50]
ref_hepatocyte RFC1
Mean 9.26
Standard deviation 5.4
Values 15 15 7.1 4.1 5
[51]
HepG2 RFC1
Mean 22.5
Standard deviation 11
Values 15 30
[52]
HepG2.C3A RFC1
Mean 49.1
Standard deviation 4.6
Values 46 52
[53]
HuH.7 RFC1
Mean 61.4
Standard deviation 8.8
Values 66 67 51
[54]
SNU475 RFC1
Mean 21.2
Standard deviation 2
Values 20 23
[55]
THLE RFC1
Mean 42.7
Standard deviation 3.9
Values 45 40
[56]
liver RFC1
Mean 22.6
Standard deviation 3.4
Values 24 26 18 23
[57]
ref_hepatocyte RFC2
Mean 8.95
Standard deviation 3.2
Values 7.3 13 6.2 11 6.5
[58]
HepG2 RFC2
Mean 16.5
Standard deviation 2.8
Values 14 18
[59]
HepG2.C3A RFC2
Mean 13.3
Standard deviation 5.7
Values 9.3 17
[60]
HuH.7 RFC2
Mean 13.1
Standard deviation 6.2
Values 15 6.1 18
[61]
SNU475 RFC2
Mean 18.6
Standard deviation 4.4
Values 16 22
[62]
THLE RFC2
Mean 28.7
Standard deviation 3.4
Values 26 31
[63]
liver RFC2
Mean 7.44
Standard deviation 4.1
Values 10 4.9 11 3.1
[64]
ref_hepatocyte TINF2
Mean 8.21
Standard deviation 1.3
Values 10 7.4 8.3 7.2 7.7
[65]
HepG2 TINF2
Mean 30.8
Standard deviation 1.5
Values 30 32
[66]
HepG2.C3A TINF2
Mean 10.8
Standard deviation 0.3
Values 11 11
[67]
HuH.7 TINF2
Mean 10.4
Standard deviation 1.3
Values 10 9 12
[68]
SNU475 TINF2
Mean 14.1
Standard deviation 0.013
Values 14 14
[69]
THLE TINF2
Mean 15.8
Standard deviation 1.4
Values 15 17
[70]
liver TINF2
Mean 10.2
Standard deviation 2.5
Values 12 7.3 12 8.9
[71]
ref_hepatocyte RFC5
Mean 5.54
Standard deviation 4.9
Values 13 7.4 0.42 3.6 3.2
[72]
HepG2 RFC5
Mean 13.4
Standard deviation 5.4
Values 9.6 17
[73]
HepG2.C3A RFC5
Mean 16.4
Standard deviation 10
Values 9 24
[74]
HuH.7 RFC5
Mean 18.1
Standard deviation 6.8
Values 23 10 21
[75]
SNU475 RFC5
Mean 12.2
Standard deviation 2.4
Values 11 14
[76]
THLE RFC5
Mean 19.8
Standard deviation 2.4
Values 18 22
[77]
liver RFC5
Mean 4.29
Standard deviation 1.7
Values 4.9 3.5 6.3 2.5
[78]
ref_hepatocyte TERF1
Mean 4.67
Standard deviation 2
Values 2.2 3.5 6.2 4.5 6.9
[79]
HepG2 TERF1
Mean 5.51
Standard deviation 1.4
Values 4.5 6.5
[80]
HepG2.C3A TERF1
Mean 10.9
Standard deviation 3
Values 8.8 13
[81]
HuH.7 TERF1
Mean 12.4
Standard deviation 1.1
Values 13 11 12
[82]
SNU475 TERF1
Mean 20.1
Standard deviation 0.86
Values 21 19
[83]
THLE TERF1
Mean 11.9
Standard deviation 0.88
Values 11 13
[84]
liver TERF1
Mean 6.49
Standard deviation 1.9
Values 8.7 6.1 6.9 4.2
[85]
ref_hepatocyte TERF2
Mean 4.13
Standard deviation 0.67
Values 4.9 4.3 4.6 3.7 3.2
[86]
HepG2 TERF2
Mean 11.3
Standard deviation 0.25
Values 11 11
[87]
HepG2.C3A TERF2
Mean 10.1
Standard deviation 0.26
Values 9.9 10
[88]
HuH.7 TERF2
Mean 16.5
Standard deviation 2.9
Values 17 13 19
[89]
SNU475 TERF2
Mean 7.14
Standard deviation 0.058
Values 7.1 7.2
[90]
THLE TERF2
Mean 10.6
Standard deviation 0.15
Values 11 11
[91]
liver TERF2
Mean 4.32
Standard deviation 1.4
Values 6.4 3.6 3.6 3.7
[92]
ref_hepatocyte RFC3
Mean 3.17
Standard deviation 3.1
Values 6.3 6.7 1.4 0.35 1.1
[93]
HepG2 RFC3
Mean 15.8
Standard deviation 7.8
Values 10 21
[94]
HepG2.C3A RFC3
Mean 25.6
Standard deviation 17
Values 14 37
[95]
HuH.7 RFC3
Mean 27.1
Standard deviation 12
Values 35 14 33
[96]
SNU475 RFC3
Mean 13.8
Standard deviation 3.5
Values 11 16
[97]
THLE RFC3
Mean 23.5
Standard deviation 5.4
Values 20 27
[98]
liver RFC3
Mean 2.46
Standard deviation 0.85
Values 2 2.9 3.4 1.5
[99]
ref_hepatocyte POLA2
Mean 2.46
Standard deviation 0.96
Values 1.8 2.8 3.9 2.3 1.5
[100]
HepG2 POLA2
Mean 8.49
Standard deviation 2.2
Values 6.9 10
[101]
HepG2.C3A POLA2
Mean 5.87
Standard deviation 3.6
Values 3.3 8.4
[102]
HuH.7 POLA2
Mean 8.32
Standard deviation 5.1
Values 11 2.5 11
[103]
SNU475 POLA2
Mean 12.9
Standard deviation 3.1
Values 11 15
[104]
THLE POLA2
Mean 17.9
Standard deviation 4
Values 15 21
[105]
liver POLA2
Mean 1.96
Standard deviation 0.6
Values 1.2 1.9 2.6 2.2
[106]
ref_hepatocyte PRIM1
Mean 2.43
Standard deviation 1.4
Values 4.4 2.6 0.57 2.6 1.9
[107]
HepG2 PRIM1
Mean 8.54
Standard deviation 0.87
Values 7.9 9.2
[108]
HepG2.C3A PRIM1
Mean 19.1
Standard deviation 8.1
Values 13 25
[109]
HuH.7 PRIM1
Mean 23.1
Standard deviation 6.2
Values 27 16 26
[110]
SNU475 PRIM1
Mean 9.98
Standard deviation 3.1
Values 7.8 12
[111]
THLE PRIM1
Mean 16.8
Standard deviation 2.1
Values 15 18
[112]
liver PRIM1
Mean 1.84
Standard deviation 0.34
Values 2.1 1.6 2.1 1.5
[113]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[114]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[115]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[116]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[117]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[118]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[119]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[120]
ref_hepatocyte PRIM2
Mean 2.32
Standard deviation 2.3
Values 6.1 2.9 0.46 1.4 0.78
[121]
HepG2 PRIM2
Mean 12.4
Standard deviation 3.6
Values 9.9 15
[122]
HepG2.C3A PRIM2
Mean 9.66
Standard deviation 4.4
Values 6.5 13
[123]
HuH.7 PRIM2
Mean 7.1
Standard deviation 1.5
Values 7.8 5.4 8.1
[124]
SNU475 PRIM2
Mean 9.65
Standard deviation 1.6
Values 8.5 11
[125]
THLE PRIM2
Mean 12.8
Standard deviation 1.5
Values 12 14
[126]
liver PRIM2
Mean 1.1
Standard deviation 0.41
Values 0.68 1.5 0.82 1.4
[127]
ref_hepatocyte POT1
Mean 2.27
Standard deviation 0.82
Values 3.2 2.4 0.96 2.2 2.5
[128]
HepG2 POT1
Mean 5.04
Standard deviation 1.2
Values 4.2 5.9
[129]
HepG2.C3A POT1
Mean 10.9
Standard deviation 2
Values 9.5 12
[130]
HuH.7 POT1
Mean 12.4
Standard deviation 0.67
Values 12 13 12
[131]
SNU475 POT1
Mean 14.1
Standard deviation 0.62
Values 14 15
[132]
THLE POT1
Mean 13.4
Standard deviation 2.1
Values 15 12
[133]
liver POT1
Mean 5.58
Standard deviation 1.5
Values 4.5 7.1 6.7 4.1
[134]
ref_hepatocyte ACD
Mean 2.1
Standard deviation 0.79
Values 3 2.7 2.2 1.6 1
[135]
HepG2 ACD
Mean 15.1
Standard deviation 1.5
Values 16 14
[136]
HepG2.C3A ACD
Mean 16.2
Standard deviation 0.61
Values 16 17
[137]
HuH.7 ACD
Mean 13.3
Standard deviation 3.4
Values 15 9.4 15
[138]
SNU475 ACD
Mean 6.51
Standard deviation 0.88
Values 5.9 7.1
[139]
THLE ACD
Mean 12.1
Standard deviation 0.43
Values 12 12
[140]
liver ACD
Mean 1.85
Standard deviation 1.2
Values 3.2 0.64 2.5 1
[141]
ref_hepatocyte DSCC1
Mean 1.52
Standard deviation 1.3
Values 2 3.6 0.69 0.56 0.78
[142]
HepG2 DSCC1
Mean 5.65
Standard deviation 2.9
Values 3.6 7.7
[143]
HepG2.C3A DSCC1
Mean 8.23
Standard deviation 5.3
Values 4.5 12
[144]
HuH.7 DSCC1
Mean 14.4
Standard deviation 6.4
Values 19 7.1 18
[145]
SNU475 DSCC1
Mean 9.14
Standard deviation 2.1
Values 7.6 11
[146]
THLE DSCC1
Mean 7.24
Standard deviation 1.1
Values 6.5 8
[147]
liver DSCC1
Mean 0.599
Standard deviation 0.23
Values 0.63 0.7 0.8 0.26
[148]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[149]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[150]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[151]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[152]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[153]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[154]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[155]
ref_hepatocyte CTC1
Mean 1.16
Standard deviation 0.53
Values 1.5 0.59 1.9 0.9 0.9
[156]
HepG2 CTC1
Mean 10
Standard deviation 1.9
Values 11 8.6
[157]
HepG2.C3A CTC1
Mean 10.2
Standard deviation 0.91
Values 11 9.6
[158]
HuH.7 CTC1
Mean 19.2
Standard deviation 1.9
Values 21 17 19
[159]
SNU475 CTC1
Mean 7.04
Standard deviation 1.1
Values 7.8 6.3
[160]
THLE CTC1
Mean 8.04
Standard deviation 0.32
Values 8.3 7.8
[161]
liver CTC1
Mean 6.96
Standard deviation 0.61
Values 7.1 6.1 7.4 7.2
[162]
ref_hepatocyte POLA1
Mean 0.985
Standard deviation 0.81
Values 1.8 2 0.27 0.52 0.41
[163]
HepG2 POLA1
Mean 8.75
Standard deviation 4.7
Values 5.4 12
[164]
HepG2.C3A POLA1
Mean 8.42
Standard deviation 3.5
Values 5.9 11
[165]
HuH.7 POLA1
Mean 11.9
Standard deviation 5.3
Values 17 6.3 13
[166]
SNU475 POLA1
Mean 14.3
Standard deviation 5.6
Values 10 18
[167]
THLE POLA1
Mean 15.7
Standard deviation 1.1
Values 15 17
[168]
liver POLA1
Mean 4.45
Standard deviation 2.4
Values 1.9 7.6 3.5 4.8
[169]
ref_hepatocyte CHTF18
Mean 0.819
Standard deviation 0.21
Values 0.8 0.76 1.2 0.72 0.64
[170]
HepG2 CHTF18
Mean 4.8
Standard deviation 0.4
Values 4.5 5.1
[171]
HepG2.C3A CHTF18
Mean 7.62
Standard deviation 2
Values 6.2 9
[172]
HuH.7 CHTF18
Mean 11
Standard deviation 6
Values 12 4.6 16
[173]
SNU475 CHTF18
Mean 3.83
Standard deviation 0.59
Values 3.4 4.2
[174]
THLE CHTF18
Mean 7.56
Standard deviation 0.8
Values 8.1 7
[175]
liver CHTF18
Mean 0.964
Standard deviation 0.13
Values 1 0.86 1.1 0.86
[176]
ref_hepatocyte STN1
Missing
[177]
HepG2 STN1
Missing
[178]
HepG2.C3A STN1
Missing
[179]
HuH.7 STN1
Missing
[180]
SNU475 STN1
Missing
[181]
THLE STN1
Missing
[182]
liver STN1
Missing